IRAK4 Is Overexpressed in Hidradenitis Suppurativa Skin and Correlates with Inflammatory Biomarkers

Authors: McDonald, Alice ^{1, ∗}, Karnik, Rahul ¹, Campbell, Veronica ¹, Davis, Jeff ¹, Chavoshi, Sara ², Slavin, Anthony ¹, Sharma, Kirti ¹, Gollob, Jared ¹, Alavi, Afsaneh ³

Source: In Journal of Investigative Dermatology February 2025 145(2):323-333

Pharmacokinetics and Pharmacodynamics of KT‐474, a Novel Selective Interleukin‐1 Receptor–Associated Kinase 4 (IRAK4) Degrader, in Healthy Adults.

Authors: Agarwal, Sagar, McDonald, Alice A., Campbell, Veronica, Chen, Dapeng, Davis, Jeff, Rong, Haojing, Mishkin, Aimee, Slavin, Anthony, Gollerkeri, Ashwin, Gollob, Jared A.

Source: CTS: Clinical & Translational Science; Mar2025, Vol. 18 Issue 3, p1-11, 11p

Subject Terms: PHARMACOKINETICS, PHARMACODYNAMICS, CLINICAL trials, ADULTS, PHARMACEUTICAL chemistry, TOLL-like receptors, CYTOKINES

Point-of-Need Diagnostics for Foodborne Pathogen Screening

Authors: Campbell, Veronica R. ^*, Carson, Mariam S. ^*, Lao, Amelia ^*, Maran, Kajal ^*, Yang, Eric J. ^*, Kamei, Daniel T. ^*

Source: In SLAS Technology February 2021 26(1):55-79

Discovery of KT-474a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases.

Authors: Zheng, Xiaozhang, Ji, Nan, Campbell, Veronica, Slavin, Anthony, Zhu, Xiao, Chen, Dapeng, Rong, Haojing, Enerson, Brad, Mayo, Michele, Sharma, Kirti, Browne, Chris M., Klaus, Christine R., Li, Haoran, Massa, Ginny, McDonald, Alice A., Shi, Yatao, Sintchak, Mike, Skouras, Stephanie, Walther, Dirk M., Yuan, Karen

Source: Journal of Medicinal Chemistry; 10/24/2024, Vol. 67 Issue 20, p18022-18037, 16p

Profile of cortical N-methyl-D-aspartate receptor subunit expression associates with inherent motor impulsivity in rats

Authors: Davis-Reyes, Brionna D., Campbell, Veronica M., Land, Michelle A., Chapman, Holly L., Stafford, Susan J., Anastasio, Noelle C.

Source: In Biochemical Pharmacology October 2019 168:204-213

Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B‑Cell Lymphoma.

Authors: Weiss, Matthew M., Zheng, Xiaozhang, Ji, Nan, Browne, Chris M., Campbell, Veronica, Chen, Dapeng, Enerson, Brad, Fei, Xue, Huang, Xin, Klaus, Christine R., Li, Haoran, Mayo, Michele, McDonald, Alice A., Paul, Atanu, Rong, Haojing, Sharma, Kirti, Shi, Yatao, Slavin, Anthony, Walther, Dirk M., Yuan, Karen

Source: Journal of Medicinal Chemistry; 7/11/2024, Vol. 67 Issue 13, p10548-10566, 19p

Prediction of pharmacokinetics and pharmacodynamics in human for IRAK4 targeted protein degrader

Authors: Chen, Dapeng, Rong, Haojing, Mayo, Michele, McDonald, Alice, Campbell, Veronica, Zheng, Xiaozhang, Agarwal, Sagar, Weiss, Matt, Slavin, Anthony

Source: In Drug Metabolism and Pharmacokinetics April 2024 55 Supplement

Phenotypic Motor Impulsivity is Dynamically Altered Following Oxycodone Self‐Administration in Male Rats

Authors: Smith, Ashley, Campbell, Veronica, Chapman, Holly, Stutz, Sonja, Fox, Robert, Moeller, F. Gerard, Cunningham, Kathryn, Anastasio, Noelle

Source: FASEB journal. 35

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123845488.0x000001&indx=1&recIds=ETOCvdc_100123845488.0x000001

Effect of membrane stiffness and cytoskeletal element density on mechanical stimuli within cells: an analysis of the consequences of ageing in cells

Authors: Xue, Feng, Lennon, Alex B., McKayed, Katey K., Campbell, Veronica A., Prendergast, Patrick J.

Source: Computer methods in biomechanics and biomedical engineering. 18(5):468-476

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100032880739.0x000001&indx=1&recIds=ETOCvdc_100032880739.0x000001

Targeted degradation of MERTK and other TAM receptor paralogs by heterobifunctional targeted protein degraders.

Authors: Gadiyar, Varsha, Patel, Gopi, Chen, Jesse, Vigil, Dominico, Nan Ji, Campbell, Veronica, Sharma, Kirti, Yatao Shi, Weiss, Matthew M., Birge, Raymond B., Davra, Viralkumar

Source: Frontiers in Immunology; 2023, p1-14, 14p

Subject Terms: MEMBRANE proteins, UBIQUITIN ligases, SMALL molecules, PROTEIN-tyrosine kinase inhibitors, PROTEINS

The Endocannabinoid, Anandamide, Augments Notch-1 Signaling in Cultured Cortical Neurons Exposed to Amyloid-β and in the Cortex of Aged Rats

Authors: Tanveer, Riffat, Gowran, Aoife, Noonan, Janis, Keating, Sinead E., Bowie, Andrew G., Campbell, Veronica A.

Source: In Journal of Biological Chemistry 5 October 2012 287(41):34709-34721

The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway

Authors: Smith, Sherri, Hoyt, Jennifer, Whitebread, Nigel, Manna, Joseph, Peluso, Marisa, Faia, Kerrie, Campbell, Veronica, Tremblay, Martin, Nair, Somarajan, Grogan, Michael, Castro, Alfredo, Campbell, Matthew, Ferguson, Jeanne, Arsenault, Brendan, Nevejans, Jylle, Carter, Bennett, Lee, John, Dunbar, Joi, McGovern, Karen, Read, Margaret, Adams, Julian, Constan, Alexander, Loewen, Gordon, Sydor, Jens, Palombella, Vito, Soglia, John

Source: Xenobiotica. 43(10):875-885

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103932438.0x000001&indx=1&recIds=ETOCvdc_100103932438.0x000001

Endocannabinoids Prevent β-Amyloid-mediated Lysosomal Destabilization in Cultured Neurons

Authors: Noonan, Janis, Tanveer, Riffat, Klompas, Allan, Gowran, Aoife, McKiernan, Joanne, Campbell, Veronica A.

Source: In Journal of Biological Chemistry 3 December 2010 285(49):38543-38554

A role for p53 in the β-amyloid-mediated regulation of the lysosomal system

Authors: Fogarty, Marie P., McCormack, Róisín M., Noonan, Janis, Murphy, Declan, Gowran, Aoife, Campbell, Veronica A.

Source: In Neurobiology of Aging 2010 31(10):1774-1786

Application of the aqueous two-phase system and nanozyme signal enhancement for the improved detection of Plasmodium lactate dehydrogenase in serum.

Authors: Nicklen, Frances D., Diaz, Alexia J., Lu, Jiakun, Patel, Salil T., Zheng, Elaine M., Campbell, Veronica R., Wu, Benjamin M., Kamei, Daniel T.

Source: Analytical & Bioanalytical Chemistry; Nov2022, Vol. 414 Issue 28, p7949-7956, 8p

Subject Terms: LACTATE dehydrogenase, EARLY diagnosis, PLASMODIUM, PARASITES, POINT-of-care testing, COMMUNICABLE diseases

The tumour suppressor protein, p53, is involved in the activation of the apoptotic cascade by Δ9-tetrahydrocannabinol in cultured cortical neurons

Authors: Downer, Eric J., Gowran, Aoife, Murphy, Áine C., Campbell, Veronica A.

Source: In European Journal of Pharmacology 14 June 2007 564(1-3):57-65

A comparison of the apoptotic effect of Δ 9-tetrahydrocannabinol in the neonatal and adult rat cerebral cortex

Authors: Downer, Eric J., Gowran, Aoife, Campbell, Veronica A.

Source: In Brain Research 2007 1175:39-47

METHODS AND COMPOSITIONS FOR IDENTIFICATION, ASSESSMENT AND TREATMENT OF CANCERS ASSOCIATED WITH HEDGEHOG SIGNALING

IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial

Authors: Ackerman, Lindsay, Acloque, Gerard, Bacchelli, Sandro, Schwartz, Howard, Feinstein, Brian J., La Stella, Phillip, Alavi, Afsaneh, Gollerkeri, Ashwin, Davis, Jeffrey, Campbell, Veronica, McDonald, Alice, Agarwal, Sagar, Karnik, Rahul, Shi, Kelvin, Mishkin, Aimee, Culbertson, Jennifer, Klaus, Christine, Enerson, Bradley, Massa, Virginia, Kuhn, Eric, Sharma, Kirti, Keaney, Erin, Barnes, Randy, Chen, Dapeng, Zheng, Xiaozhang, Rong, Haojing, Sabesan, Vijay, Ho, Chris, Mainolfi, Nello, Slavin, Anthony, Gollob, Jared A.

Source: Nature Medicine; 20230101, Issue: Preprints p1-10, 10p

Determination of the molecular structures of bis(methylsilyl) sulphide and bis(dimethylsilyl) sulphide in the gas phase by electron diffraction, supported by molecular mechanics calculations.

Authors: Anderson, David G., Campbell, Veronica A., Forsyth, George A.

Source: Journal of the Chemical Society, Dalton Transactions; July 1990, Issue 7, p2125-2130, 6p