Priming and release of cytokine IL-1β in microglial cells from the retina

Authors: Campagno, Keith E. ^{a, 1}, Lu, Wennan ^{a, 1}, Sripinun, Puttipong ^c, Albalawi, Farraj ^{c, d, e}, Cenaj, Aurora ^a, Mitchell, Claire H. ^{a, b, ⁎}

Source: In Experimental Eye Research March 2025 252

Increased Pan-Type, A1-Type, and A2-Type Astrocyte Activation and Upstream Inflammatory Markers Are Induced by the P2X7 Receptor.

Authors: Campagno, Keith E.¹ (AUTHOR), Sripinun, Puttipong² (AUTHOR), See, Lily P.³ (AUTHOR), Li, Jiaqi⁴ (AUTHOR), Lu, Wennan¹ (AUTHOR), Jassim, Assraa Hassan¹ (AUTHOR), Más Gómez, Néstor¹ (AUTHOR), Mitchell, Claire H.⁵ (AUTHOR) chm@upenn.edu

Source: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 16, p8784. 14p.

Subject Terms: *RETINAL ganglion cells, *GENETIC regulation, *INTRAOCULAR pressure, *INTRAVITREAL injections, *GENE expression

Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation

Authors: Gómez, Néstor Más, Lu, Wennan, Lim, Jason C., Kiselyov, Kirill, Campagno, Keith E., Grishchuk, Yulia, Slaugenhaupt, Susan A., Pfeffer, Bruce A., Fliesler, Steven J., Mitchell, Claire H.

Source: FASEB journal. 32(2):782-794

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103529178.0x000001&indx=1&recIds=ETOCvdc_100103529178.0x000001

Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure.

Authors: Campagno, Keith E.¹ (AUTHOR), Lu, Wennan¹ (AUTHOR), Jassim, Assraa Hassan¹ (AUTHOR), Albalawi, Farraj^2,3,4 (AUTHOR), Cenaj, Aurora¹ (AUTHOR), Tso, Huen-Yee¹ (AUTHOR), Clark, Sophia P.¹ (AUTHOR), Sripinun, Puttipong² (AUTHOR), Gómez, Néstor Más¹ (AUTHOR), Mitchell, Claire H.^1,5,6 (AUTHOR) chm@upenn.edu

Source: Journal of Neuroinflammation. 9/20/2021, Vol. 18 Issue 1, p1-18. 18p.

Subject Terms: *MICROGLIA, *MELANOPSIN, *INTRAOCULAR pressure, *RETINAL ganglion cells, *INTRAVITREAL injections, *STRAINS & stresses (Mechanics)

Stimulation of TLR3 triggers release of lysosomal ATP in astrocytes and epithelial cells that requires TRPML1 channels

Authors: Beckel, Jonathan M., Gómez, Néstor Más, Lu, Wennan, Campagno, Keith E., Nabet, Bardia, Albalawi, Farraj, Lim, Jason C., Boesze-Battaglia, Kathleen, Mitchell, Claire H.

Source: Scientific reports. 8(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131318563.0x000001&indx=1&recIds=ETOCvdc_100131318563.0x000001

The P2X7 Receptor in Microglial Cells Modulates the Endolysosomal Axis, Autophagy, and Phagocytosis.

Authors: Campagno, Keith E., Mitchell, Claire H.

Source: Frontiers in Cellular Neuroscience; 3/15/2021, Vol. 15, pN.PAG-N.PAG, 15p

Subject Terms: CELL receptors, PHAGOCYTOSIS, LYSOSOMES, MICROGLIA, AUTOPHAGY, CATHEPSIN B, IMMUNE response

This result is not displayed to guests.
Login for full access.

The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4^-/- Mouse Model of Retinal.

Authors: Lu, Wennan, Gómez, Néstor M., Lim, Jason C., Guha, Sonia, O’Brien-Jenkins, Ann, Coffey, Erin E., Campagno, Keith E., McCaughey, Stuart A., Laties, Alan M., Carlsson, Leif G., Mitchell, Claire H.

Source: Frontiers in Pharmacology; 4/19/2018, p1-N.PAG, 10p

Subject Terms: PLATELET aggregation inhibitors, RHODOPSIN, BIOFLUORESCENCE, THERAPEUTICS

Polarized Cytokine Release Triggered by P2X7 Receptor from Retinal Pigmented Epithelial Cells Dependent on Calcium Influx.

Authors: Shao, Xiaolei, Guha, Sonia, Lu, Wennan, Campagno, Keith E., Beckel, Jonathan M., Mills, Jason A., Yang, Wenli, Mitchell, Claire H.

Source: Cells (2073-4409); Dec2020, Vol. 9 Issue 12, p2537, 1p

Subject Terms: EPITHELIAL cells, HYPERPOLARIZATION (Cytology), PURINERGIC receptors, RETINAL degeneration, CALCIUM, INTERLEUKIN-6, NATURAL immunity