High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

Authors: Abeler-Dörner, Lucie, Laing, Adam G., Lorenc, Anna, Ushakov, Dmitry S., Clare, Simon, Speak, Anneliese O., Duque-Correa, Maria A., White, Jacqueline K., Ramirez-Solis, Ramiro, Saran, Namita, Bull, Katherine R., Morón, Belén, Iwasaki, Jua, Barton, Philippa R., Caetano, Susana, Hng, Keng I., Cambridge, Emma, Forman, Simon, Crockford, Tanya L., Griffiths, Mark, Kane, Leanne, Harcourt, Katherine, Brandt, Cordelia, Notley, George, Babalola, Kolawole O., Warren, Jonathan, Mason, Jeremy C., Meeniga, Amrutha, Karp, Natasha A., Melvin, David, Cawthorne, Eleanor, Weinrick, Brian, Rahim, Albina, Drissler, Sibyl, Meskas, Justin, Yue, Alice, Lux, Markus, Song-Zhao, George X., Chan, Anna, Ballesteros Reviriego, Carmen, Abeler, Johannes, Wilson, Heather, Przemska-Kosicka, Agnieszka, Edmans, Matthew, Strevens, Natasha, Pasztorek, Markus, Meehan, Terrence F., Powrie, Fiona, Brinkman, Ryan, Dougan, Gordon, Jacobs, William, Lloyd, Clare M., Cornall, Richard J., Maloy, Kevin J., Grencis, Richard K., Griffiths, Gillian M., Adams, David J., Hayday, Adrian C.

Source: Nature immunology. 21(1):86-100

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193494124.0x000001&indx=1&recIds=ETOCvdc_100193494124.0x000001

The AMP-activated protein kinase beta 1 subunit modulates erythrocyte integrity

Authors: Cambridge, Emma L., McIntyre, Zoe, Clare, Simon, Arends, Mark J., Goulding, David, Isherwood, Christopher, Caetano, Susana S., Reviriego, Carmen Ballesteros, Swiatkowska, Agnieszka, Kane, Leanne, Harcourt, Katherine, Adams, David J., White, Jacqueline K., Speak, Anneliese O.

Source: In Experimental Hematology January 2017 45:64-68

Gray platelet syndrome: proinflammatory megakaryocytes and α-granule loss cause myelofibrosis and confer metastasis resistance in mice

Authors: Guerrero, Jose A. ^*, Bennett, Cavan, van der Weyden, Louise, McKinney, Harriet, Chin, Melody, Nurden, Paquita, McIntyre, Zoe, Cambridge, Emma L., Estabel, Jeanne, Wardle-Jones, Hannah, Speak, Anneliese O., Erber, Wendy N., Rendon, Augusto, Ouwehand, Willem H., Ghevaert, Cedric ^*

Source: In Blood 4 December 2014 124(24):3624-3635

Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia

Authors: Salsbury, Grace, Cambridge, Emma L., McIntyre, Zoe, Arends, Mark J., Karp, Natasha A., Isherwood, Christopher, Shannon, Carl, Hooks, Yvette, Ramirez-Solis, Ramiro, Adams, David J., White, Jacqueline K., Speak, Anneliese O.

Source: In Experimental Hematology July 2014

Models of KPTN-related disorder implicate mTOR signalling in cognitive and overgrowth phenotypes.

Authors: Levitin, Maria O^1,2, Rawlins, Lettie E^3,4, Sanchez-Andrade, Gabriela¹, Arshad, Osama A¹, Collins, Stephan C⁵, Sawiak, Stephen J^6,7, Iffland, Phillip H⁸, Andersson, Malin H L¹, Bupp, Caleb⁹, Cambridge, Emma L¹, Coomber, Eve L¹, Ellis, Ian¹⁰, Herkert, Johanna C¹¹, Ironfield, Holly¹, Jory, Logan¹², Kretz, Perrine F¹³, Kant, Sarina G^14,15, Neaverson, Alexandra^1,16,17, Nibbeling, Esther¹⁸, Rowley, Christine^1,19

Source: Brain: A Journal of Neurology; Nov2023, Vol. 146 Issue 11, p4766-4783, 18p

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

Authors: Baker, Lauren, Barnes, Caroline, Beveridge, Ryan, Cambridge, Emma, Carragher, Damian, Chana, Prabhjoat, Clarke, Kay, Hooks, Yvette, Igosheva, Natalia, Ismail, Ozama, Jackson, Hannah, Kane, Leanne, Lacey, Rosalind, Lafont, David Tino, Lucas, Mark, Maguire, Simon, McGill, Katherine, McIntyre, Rebecca E., Messager, Sophie, Mottram, Lynda, Mulderrig, Lee, Pearson, Selina, Protheroe, Hayley J., Roberson, Laura-Anne, Salsbury, Grace, Sanderson, Mark, Sanger, Daniel, Shannon, Carl, Thompson, Paul C., Tuck, Elizabeth, Vancollie, Valerie E., Brackenbury, Lisa, Bushell, Wendy, Cook, Ross, Dalvi, Priya, Gleeson, Diane, Habib, Bishoy, Hardy, Matt, Liakath-Ali, Kifayathullah, Miklejewska, Evelina, Price, Stacey, Sethi, Debarati, Trenchard, Elizabeth, von Schiller, Dominique, Vyas, Sapna, West, Anthony P., Woodward, John, Wynn, Elizabeth, Evans, Arthur, Gannon, David, Griffiths, Mark, Holroyd, Simon, Iyer, Vivek, Kipp, Christian, Lewis, Morag, Li, Wei, Oakley, Darren, Richardson, David, Smedley, Damian, Agu, Chukwuma, Bryant, Jackie, Delaney, Liz, Gueorguieva, Nadia I., Tharagonnet, Helen, Townsend, Anne J., Biggs, Daniel, Brown, Ellen, Collinson, Adam, Dumeau, Charles-Etienne, Grau, Evelyn, Harrison, Sarah, Harrison, James, Ingle, Catherine E., Kundi, Helen, Madich, Alla, Mayhew, Danielle, Metcalf, Tom, Newman, Stuart, Pass, Johanna, Pearson, Laila, Reynolds, Helen, Sinclair, Caroline, Wardle-Jones, Hannah, Woods, Michael, Alexander, Liam, Brown, Terry, Flack, Francesca, Frost, Carole, Griggs, Nicola, Hrnciarova, Silvia, Kirton, Andrea, McDermott, Jordan, Rogerson, Claire, White, Gemma, Zielezinski, Pawel, DiTommaso, Tia, Edwards, Andrew, Heath, Emma, Mahajan, Mary Ann, Yalcin, Binnaz, White, Jacqueline K., Gerdin, Anna-Karin, Karp, Natasha A., Ryder, Ed, Buljan, Marija, Bussell, James N., Salisbury, Jennifer, Clare, Simon, Ingham, Neil J., Podrini, Christine, Houghton, Richard, Estabel, Jeanne, Bottomley, Joanna R., Melvin, David G., Sunter, David, Adams, Niels C., Tannahill, David, Logan, Darren W., MacArthur, Daniel G., Flint, Jonathan, Mahajan, Vinit B., Tsang, Stephen H., Smyth, Ian, Watt, Fiona M., Skarnes, William C., Dougan, Gordon, Adams, David J., Ramirez-Solis, Ramiro, Bradley, Allan, Steel, Karen P.

Source: In Cell 18 July 2013 154(2):452-464

Experimental and husbandry procedures as potential modifiers of the results of phenotyping tests

Authors: Gerdin, Anna-Karin, Igosheva, Natalia, Roberson, Laura-Anne, Ismail, Ozama, Karp, Natasha, Sanderson, Mark, Cambridge, Emma, Shannon, Carl, Sunter, David, Ramirez-Solis, Ramiro, Bussell, James, White, Jacqueline K.

Source: In Physiology & Behavior 16 July 2012 106(5):602-611

Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency

Authors: Kuijpers, Taco W., Tool, Anton T.J., van der Bijl, Ivo, de Boer, Martin, van Houdt, Michel, de Cuyper, Iris M., Roos, Dirk, van Alphen, Floris, van Leeuwen, Karin, Cambridge, Emma L., Arends, Mark J., Dougan, Gordon, Clare, Simon, Ramirez-Solis, Ramiro, Pals, Steven T., Adams, David J., Meijer, Alexander B., van den Berg, Timo K.

Source: journal of allergy and clinical immunology. 140(1):273-277.e10

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100046434045.0x000001&indx=1&recIds=ETOCvdc_100046434045.0x000001

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection.

Authors: Duque-Correa, María A.¹, Karp, Natasha A.¹, McCarthy, Catherine¹, Goulding, David¹, Sankaranarayanan, Geetha¹, Reid, Adam J.¹, Cambridge, Emma L.¹, Ballesteros Reviriego, Carmen¹, Dougan, Gordon¹, Berriman, Matthew¹, null, null¹, Forman, Simon², Grencis, Richard K.², Jenkins, Timothy P.³, Cantacessi, Cinzia³, Müller, Werner⁴

Source: PLoS Pathogens; 1/14/2019, Vol. 15 Issue 1, p1-34, 34p

Cage side determination of post-mortem interval in mice.

Authors: BALLANTYNE, SELINA, HITCHAM, MARIE, HUGHES-HALLETT, LENA, WATSON, CLAUDIA, WOOLMER, OLGA, FROST, CAROLE, LAFONT, DAVID, BUCKMASTER, RACHEL, CAMBRIDGE, EMMA, THOMAS, AURELIE

Source: Animal Technology & Welfare; Dec2021, Vol. 20 Issue 3, p250-253, 4p

Subject Terms: ANIMAL cages, ANIMAL mortality, MICE, AUTOPSY, ORGANS (Anatomy)

High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice.

Authors: Podrini, Christine, Cambridge, Emma¹, Lelliott, Christopher¹, Carragher, Damian, Estabel, Jeanne¹, Gerdin, Anna-Karin¹, Karp, Natasha¹, Scudamore, Cheryl, Ramirez-Solis, Ramiro¹, White, Jacqueline¹ jkw@sanger.ac.uk

Source: Mammalian Genome. Jun2013, Vol. 24 Issue 5/6, p240-251. 12p. 2 Charts, 6 Graphs.

Subject Terms: *HIGH-fat diet, *LABORATORY mice, *OBESITY, *PHYSIOLOGICAL effects of lipids, *FATTY liver, *METABOLIC syndrome

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FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele.

Authors: Ballesteros Reviriego, Carmen, Clare, Simon, Arends, Mark J., Cambridge, Emma L., Swiatkowska, Agnieszka, Caetano, Susana, Abu-Helil, Bushra, Kane, Leanne, Harcourt, Katherine, Goulding, David A., Gleeson, Diane, Ryder, Edward, Doe, Brendan, White, Jacqueline K., van der Weyden, Louise, Dougan, Gordon, Adams, David J., Speak, Anneliese O.

Source: PLoS ONE; 3/6/2019, Vol. 14 Issue 3, p1-18, 18p

Subject Terms: HUMAN phenotype, ALLELES, PROTEIN-protein interactions, UBIQUITIN ligases, GENETIC mutation, PARKINSONIAN disorders

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Corrigendum to 'Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia' [Experimental Hematology, Vol. 42, Issue 12, p1053–1058.e1]

Authors: Salsbury, Grace, Cambridge, Emma L., McIntyre, Zoe, Arends, Mark J., Karp, Natasha A., Isherwood, Christopher, Shannon, Carl, Hooks, Yvette, Ramirez-Solis, Ramiro, Adams, David J., White, Jacqueline K., Speak, Anneliese O.

Source: Experimental hematology. 43(5):424-424

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100091987684.0x000001&indx=1&recIds=ETOCvdc_100091987684.0x000001

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization.

Authors: Weyden, Louise van der, Arends, Mark J., Campbell, Andrew D., Bald, Tobias, Wardle-Jones, Hannah, Griggs, Nicola, Velasco-Herrera, Martin Del Castillo, Tüting, Thomas, Sansom, Owen J., Karp, Natasha A., Clare, Simon, Gleeson, Diane, Ryder, Edward, Galli, Antonella, Tuck, Elizabeth, Cambridge, Emma L., Voet, Thierry, Macaulay, Iain C., Wong, Kim, Spiegel, Sarah

Source: Nature; 1/12/2017, Vol. 541 Issue 7636, p233-236, 4p, 14 Graphs

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Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes.

Authors: White, Jacqueline?K.¹, Gerdin, Anna-Karin¹, Karp, Natasha?A.¹, Ryder, Ed¹, Buljan, Marija¹, Bussell, James?N.¹, Salisbury, Jennifer¹, Clare, Simon¹, Ingham, Neil?J.¹, Podrini, Christine¹, Houghton, Richard¹, Estabel, Jeanne¹, Bottomley, Joanna?R.¹, Melvin, David?G.¹, Sunter, David¹, Adams, Niels?C.¹, Baker, Lauren, Barnes, Caroline, Beveridge, Ryan, Cambridge, Emma

Source: Cell; Jul2013, Vol. 154 Issue 2, p452-464, 13p

Infection Susceptibility in Gastric Intrinsic Factor (Vitamin B12)-Defective Mice Is Subject to Maternal Influences

Authors: Mottram, Lynda, Speak, Anneliese O., Selek, Reza M., Cambridge, Emma L., McIntyre, Zoe, Kane, Leanne, Mukhopadhyay, Subhankar, Grove, Carolyn, Colin, Amy, Brandt, Cordelia, Duque-Correa, Maria A., Forbester, Jessica, Nguyen, Tu Anh Pham, Hale, Christine, Vasilliou, George S., Arends, Mark J., Wren, Brendan W., Dougan, Gordon, Clare, Simon

Source: mBio; May 2016, Vol. 7 Issue: 3