Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study

Authors: Feys, Simon, Vanmassenhove, Sam, Kraisin, Sirima, Yu, Karen, Jacobs, Cato, Boeckx, Bram, Cambier, Seppe, Cunha, Cristina, Debaveye, Yves, Gonçalves, Samuel M, Hermans, Greet, Humblet-Baron, Stephanie, Jansen, Sander, Lagrou, Katrien, Meersseman, Philippe, Neyts, Johan, Peetermans, Marijke, Rocha-Pereira, Joana, Schepers, Rogier, Spalart, Valérie, Starick, Marick R, Thevissen, Karin, Van Brussel, Thomas, Van Buyten, Tina, Van Mol, Pierre, Vandenbriele, Christophe, Vanderbeke, Lore, Wauters, Els, Wilmer, Alexander, Van Weyenbergh, Johan, Van De Veerdonk, Frank L, Carvalho, Agostinho, Proost, Paul, Martinod, Kimberly, Lambrechts, Diether, Wauters, Joost

Source: In The Lancet Microbe March 2024 5(3):e247-e260

HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect

Authors: Foo, Caroline S., Abdelnabi, Rana, Kaptein, Suzanne J.F., Zhang, Xin, ter Horst, Sebastiaan, Mols, Raf, Delang, Leen, Rocha-Pereira, Joana, Coelmont, Lotte, Leyssen, Pieter, Dallmeier, Kai, Vergote, Valentijn, Heylen, Elisabeth, Vangeel, Laura, Chatterjee, Arnab K., Annaert, Pieter P., Augustijns, Patrick F., De Jonghe, Steven, Jochmans, Dirk, Gouwy, Mieke, Cambier, Seppe, Vandooren, Jennifer, Proost, Paul, van Laer, Christine, Weynand, Birgit, Neyts, Johan

Source: In Antiviral Research June 2022 202

Heterogeneous neutrophils in lung transplantation and proteolytic CXCL8 activation in COVID-19, influenza and lung transplant patient lungs.

Authors: Cambier, Seppe¹ (AUTHOR), Beretta, Fabio¹ (AUTHOR), Nooyens, Amber¹ (AUTHOR), Metzemaekers, Mieke¹ (AUTHOR), Pörtner, Noëmie¹ (AUTHOR), Kaes, Janne² (AUTHOR), de Carvalho, Ana Carolina^1,3,4 (AUTHOR), Cortesi, Emanuela E.² (AUTHOR), Beeckmans, Hanne² (AUTHOR), Hooft, Charlotte² (AUTHOR), Gouwy, Mieke¹ (AUTHOR), Struyf, Sofie¹ (AUTHOR), Marques, Rafael E.³ (AUTHOR), Ceulemans, Laurens J.^2,5 (AUTHOR), Wauters, Joost^6,7 (AUTHOR), Vanaudenaerde, Bart M.² (AUTHOR), Vos, Robin^2,8 (AUTHOR), Proost, Paul¹ (AUTHOR) paul.proost@kuleuven.be

Source: Cellular & Molecular Life Sciences. 12/3/2024, Vol. 81 Issue 1, p1-21. 21p.

Subject Terms: *TANDEM mass spectrometry, *PATHOLOGY, *LUNG transplantation, *GRAFT rejection, *COVID-19

The Immunopathology of Pulmonary Rejection after Murine Lung Transplantation.

Authors: Kaes, Janne, Pollenus, Emilie, Hooft, Charlotte, Liu, Hengshuo, Aelbrecht, Celine, Cambier, Seppe, Jin, Xin, Van Slambrouck, Jan, Beeckmans, Hanne, Kerckhof, Pieterjan, Velde, Greetje Vande, Van Raemdonck, Dirk, Yildirim, Ali Önder, Van den Steen, Philippe E., Vos, Robin, Ceulemans, Laurens J., Vanaudenaerde, Bart M.

Source: Cells (2073-4409); Feb2024, Vol. 13 Issue 3, p241, 13p

Subject Terms: LUNG transplantation, LUNGS, KILLER cells, B cells, T cells, CYCLOSPORINE

Kinetics of peripheral blood neutrophils in severe coronavirus disease 2019

Authors: Metzemaekers, Mieke, Cambier, Seppe, Blanter, Marfa, Vandooren, Jennifer, Carvalho, Ana Carolina, Malengier‐Devlies, Bert, Vanderbeke, Lore, Jacobs, Cato, Coenen, Sofie, Martens, Erik, Pörtner, Noëmie, Vanbrabant, Lotte, Van Mol, Pierre, Van Herck, Yannick, Van Aerde, Nathalie, Hermans, Greet, Gunst, Jan, Borin, Alexandre, Toledo N Pereira, Bruna, SP Gomes, Arilson Bernardo, Primon Muraro, Stéfanie, Fabiano de Souza, Gabriela, S Farias, Alessandro, Proenca‐Modena, José Luiz, R Vinolo, Marco Aurélio, Marques, Pedro Elias, Wouters, Carine, Wauters, Els, Struyf, Sofie, Matthys, Patrick, Opdenakker, Ghislain, Marques, Rafael Elias, Wauters, Joost, Gouwy, Mieke, Proost, Paul, Wilmer, Alexander, Meersseman, Philippe, Lambrechts, Diether, Casaer, Michael, Rex, Steffen, Lorent, Nathalie, Thevissen, Karin, Martinod, Kim

Source: Clinical & translational immunology. 10(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121044609.0x000001&indx=1&recIds=ETOCvdc_100121044609.0x000001

Proteolytic inactivation of CXCL12 in the lungs and circulation of COVID-19 patients.

Authors: Cambier, Seppe¹ (AUTHOR), Beretta, Fabio¹ (AUTHOR), Pörtner, Noëmie¹ (AUTHOR), Metzemaekers, Mieke¹ (AUTHOR), de Carvalho, Ana Carolina^1,2,3 (AUTHOR), Martens, Erik⁴ (AUTHOR), Kaes, Janne⁵ (AUTHOR), Aelbrecht, Celine⁵ (AUTHOR), Jacobs, Cato⁶ (AUTHOR), Van Mol, Pierre⁷ (AUTHOR), Wauters, Els^5,8 (AUTHOR), Meersseman, Philippe⁶ (AUTHOR), Hermans, Greet^6,9 (AUTHOR), Marques, Rafael Elias² (AUTHOR), Vanaudenaerde, Bart⁵ (AUTHOR), Vos, Robin^5,8 (AUTHOR), Wauters, Joost^6,10 (AUTHOR), Gouwy, Mieke¹ (AUTHOR), Proost, Paul¹ (AUTHOR) paul.proost@kuleuven.be

Source: Cellular & Molecular Life Sciences. Aug2023, Vol. 80 Issue 8, p1-21. 21p.

Nitration of chemokine CXCL8 acts as a natural mechanism to limit acute inflammation.

Authors: Thompson, Sarah, Pang, Chong Yun, Sepuru, Krishna Mohan, Cambier, Seppe, Hellyer, Thomas P., Scott, Jonathan, Simpson, A. John, Proost, Paul, Kirby, John A., Rajarathnam, Krishna, Sheerin, Neil S., Ali, Simi

Source: Cellular & Molecular Life Sciences; Jan2023, Vol. 80 Issue 1, p1-14, 14p

Method Matters: Effect of Purification Technology on Neutrophil Phenotype and Function.

Authors: Blanter, Marfa, Cambier, Seppe, De Bondt, Mirre, Vanbrabant, Lotte, Pörtner, Noëmie, Abouelasrar Salama, Sara, Metzemaekers, Mieke, Marques, Pedro Elias, Struyf, Sofie, Proost, Paul, Gouwy, Mieke

Source: Frontiers in Immunology; 2/10/2022, Vol. 13, p1-16, 16p

Subject Terms: NEUTROPHILS, IMMUNOMAGNETIC separation, BLOOD cells, PEPTIDE receptors, REACTIVE oxygen species

Affinity and Specificity for Binding to Glycosaminoglycans Can Be Tuned by Adapting Peptide Length and Sequence.

Authors: Crijns, Helena, Adyns, Lowie, Ganseman, Eva, Cambier, Seppe, Vandekerckhove, Eline, Pörtner, Noëmie, Vanbrabant, Lotte, Struyf, Sofie, Gerlza, Tanja, Kungl, Andreas, Proost, Paul

Source: International Journal of Molecular Sciences; Jan2022, Vol. 23 Issue 1, p447, 1p

Subject Terms: GLYCOSAMINOGLYCANS, AMINO acid sequence, LOW-molecular-weight heparin, PEPTIDES, HEPARAN sulfate, AMINO acids

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C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps.

Authors: Silva, Bruna M., Gomes, Giovanni F., Veras, Flavio P., Cambier, Seppe, Silva, Gabriel V. L., Quadros, Andreza U., Caetité, Diego B., Nascimento, Daniele C., Silva, Camilla M., Silva, Juliana C., Damasceno, Samara, Schneider, Ayda H., Beretta, Fabio, Batah, Sabrina S., Castro, Icaro M. S., Paiva, Isadora M., Rodrigues, Tamara, Salina, Ana, Martins, Ronaldo, Cebinelli, Guilherme C. M.

Source: Journal of Clinical Investigation. 6/15/2023, Vol. 133 Issue 12, p1-17. 17p.

Subjects: COVID-19, THYROID crisis, CYTOKINE release syndrome, ADULT respiratory distress syndrome, IMMUNOPATHOLOGY, LUNGS