Hepatic lipid metabolism is altered in Ubiad1 +/− mice of both sexes

Authors: Ryoko Higa, Shirin Pourteymour, Pratibha S. Kolan, Simon N. Dankel, Johan Fernø, Gunnar Mellgren, Calvin Pan, Marcus M. Seldin, Aldons J. Lusis, Christian A. Drevon, Knut T. Dalen, Frode A. Norheim

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-15 (2025)

Subject Terms: NAFLD, Ubiad1, Sex differences, Lipid metabolism, RNA-seq, HPLC-qTOF/MS, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/ac5421f8daf64d40a558e098882d709a

Role of Matrix Gla Protein in Transforming Growth Factor-β Signaling and Nonalcoholic Steatohepatitis in MiceSummary

Authors: Simon T. Hui, Lili Gong, Chantle Swichkow, Montgomery Blencowe, Dorota Kaminska, Graciel Diamante, Calvin Pan, Meet Dalsania, Samuel W. French, Clara E. Magyar, Päivi Pajukanta, Jussi Pihlajamäki, Kristina I. Boström, Xia Yang, Aldons J. Lusis

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 6, Pp 943-960 (2023)

Subject Terms: Gene Network Analysis, Liver Fibrosis, Nonalcoholic Steatohepatitis, Systems Genetics, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X23001522; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/17f948e14a694036a2a9724de594eb98

Shared and distinct pathways and networks genetically linked to coronary artery disease between human and mouse

Authors: Zeyneb Kurt, Jenny Cheng, Rio Barrere-Cain, Caden N McQuillen, Zara Saleem, Neil Hsu, Nuoya Jiang, Calvin Pan, Oscar Franzén, Simon Koplev, Susanna Wang, Johan Björkegren, Aldons J Lusis, Montgomery Blencowe, Xia Yang

Source: eLife, Vol 12 (2023)

Subject Terms: atherosclerosis, coronary artery disease, gene regulatory networks, multiomics, cross-species comparison, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/88266; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/e87fc1a00ff440dc9b28b69b90ccd82d

Sex differences in heart mitochondria regulate diastolic dysfunction

Authors: Yang Cao, Laurent Vergnes, Yu-Chen Wang, Calvin Pan, Karthickeyan Chella Krishnan, Timothy M. Moore, Manuel Rosa-Garrido, Todd H. Kimball, Zhiqiang Zhou, Sarada Charugundla, Christoph D. Rau, Marcus M. Seldin, Jessica Wang, Yibin Wang, Thomas M. Vondriska, Karen Reue, Aldons J. Lusis

Source: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/89de6b77175046a88778990393d83932

Relationships and Mendelian Randomization of Gut Microbe-Derived Metabolites with Metabolic Syndrome Traits in the METSIM Cohort

Authors: Sahereh Mirzaei, Holli A. DeVon, Rita M. Cantor, Arjen J. Cupido, Calvin Pan, Sung Min Ha, Lilian Fernandes Silva, James R. Hilser, Jaana Hartiala, Hooman Allayee, Federico E. Rey, Markku Laakso, Aldons J. Lusis

Source: Metabolites, Vol 14, Iss 3, p 174 (2024)

Subject Terms: metabolic syndrome, gut microbes, gut metabolites, insulin resistance, Mendelian randomization, GWAS, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/14/3/174; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/1237cc0e945a40e497d0690efed8b753

Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy

Authors: Karthickeyan Chella Krishnan, Elie-Julien El Hachem, Mark P Keller, Sanjeet G Patel, Luke Carroll, Alexis Diaz Vegas, Isabela Gerdes Gyuricza, Christine Light, Yang Cao, Calvin Pan, Karolina Elżbieta Kaczor-Urbanowicz, Varun Shravah, Diana Anum, Matteo Pellegrini, Chi Fung Lee, Marcus M Seldin, Nadia A Rosenthal, Gary A Churchill, Alan D Attie, Benjamin Parker, David E James, Aldons J Lusis

Source: eLife, Vol 12 (2023)

Subject Terms: proteomics, metabolic syndrome, genetic, association studies, mitochondria, hypertrophy, heart failure, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/82619; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/2a1b6fe7048b41d5bd20badbfb9d149f

Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice

Authors: Timothy M. Moore, Sindre Lee, Thomas Olsen, Marco Morselli, Alexander R. Strumwasser, Amanda J. Lin, Zhenqi Zhou, Aaron Abrishami, Steven M. Garcia, Jennifer Bribiesca, Kevin Cory, Kate Whitney, Theodore Ho, Timothy Ho, Joseph L. Lee, Daniel H. Rucker, Christina Q.A. Nguyen, Akshay T.S. Anand, Aidan Yackly, Lorna Q. Mendoza, Brayden K. Leyva, Claudia Aliman, Daniel J. Artiga, Yonghong Meng, Sarada Charugundla, Calvin Pan, Vida Jedian, Marcus M. Seldin, In Sook Ahn, Graciel Diamante, Montgomery Blencowe, Xia Yang, Etienne Mouisel, Matteo Pellegrini, Lorraine P. Turcotte, Kåre I. Birkeland, Frode Norheim, Christian A. Drevon, Aldons J. Lusis, Andrea L. Hevener

Source: Cell Reports, Vol 42, Iss 5, Pp 112499- (2023)

Subject Terms: CP: Metabolism, CP: Molecular biology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723005107; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/b7fc251ad3f8402f805e30077697069d

MBOAT7-driven lysophosphatidylinositol acylation in adipocytes contributes to systemic glucose homeostasis

Authors: William J. Massey, Venkateshwari Varadharajan, Rakhee Banerjee, Amanda L. Brown, Anthony J. Horak, Rachel C. Hohe, Bryan M. Jung, Yunguang Qiu, E. Ricky Chan, Calvin Pan, Renliang Zhang, Daniela S. Allende, Belinda Willard, Feixiong Cheng, Aldons J. Lusis, J. Mark Brown

Source: Journal of Lipid Research, Vol 64, Iss 4, Pp 100349- (2023)

Subject Terms: non-alcoholic fatty liver disease, obesity, metabolism, diabetes, hyperinsulinemia, systemic insulin resistance, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227523000226; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/4c86927b018244dab52502931112ad14

Placental genomics mediates genetic associations with complex health traits and disease

Authors: Arjun Bhattacharya, Anastasia N. Freedman, Vennela Avula, Rebeca Harris, Weifang Liu, Calvin Pan, Aldons J. Lusis, Robert M. Joseph, Lisa Smeester, Hadley J. Hartwell, Karl C. K. Kuban, Carmen J. Marsit, Yun Li, T. Michael O’Shea, Rebecca C. Fry, Hudson P. Santos

Source: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f834790b97534f809de5e0b70af87c2e

The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in MiceSummary

Authors: Iina Tuominen, Brie K. Fuqua, Calvin Pan, Nicole Renaud, Kevin Wroblewski, Mete Civelek, Kara Clerkin, Ashot Asaryan, Sara G. Haroutunian, Joseph Loureiro, Jason Borawski, Guglielmo Roma, Judith Knehr, Walter Carbone, Samuel French, Brian W. Parks, Simon T. Hui, Margarete Mehrabian, Clara Magyar, Rita M. Cantor, Chinweike Ukomadu, Aldons J. Lusis, Simon W. Beaven

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 199-220 (2021)

Subject Terms: CCl4, Systems Genetics, Liver Toxicity and Injury, Genome-Wide Association Study, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X2030134X; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/805a57b68c664391ba2c3054c6d2c50d

Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis

Authors: Frode Norheim, Karthickeyan Chella Krishnan, Thomas Bjellaas, Laurent Vergnes, Calvin Pan, Brian W Parks, Yonghong Meng, Jennifer Lang, James A Ward, Karen Reue, Margarete Mehrabian, Thomas E Gundersen, Miklós Péterfy, Knut T Dalen, Christian A Drevon, Simon T Hui, Aldons J Lusis, Marcus M Seldin

Source: Molecular Systems Biology, Vol 17, Iss 1, Pp 1-16 (2021)

Subject Terms: genome‐wide association studies, hepatic lipidome, Hybrid Mouse Diversity Panel, non‐alcoholic fatty liver disease, quantitative trait loci for lipids, Biology (General), QH301-705.5, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1744-4292

Access URL: https://doaj.org/article/79a471c7fc2a4e9faa35faa4f6221234

Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma

Authors: Yi Han, Qiong Jia, Pedram Shafiei Jahani, Benjamin P. Hurrell, Calvin Pan, Pin Huang, Janet Gukasyan, Nicholas C. Woodward, Eleazar Eskin, Frank D. Gilliland, Omid Akbari, Jaana A. Hartiala, Hooman Allayee

Source: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f8d9585256e74637bddfa208274a4cd5

Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice

Authors: Zhengyi Zhang, An-Chieh Feng, David Salisbury, Xin Liu, Xiaohui Wu, Jason Kim, Irina Lapina, Dan Wang, Brennan Lee, Josue Fraga, Calvin Pan, Kevin J. Williams, Aldons J. Lusis, Phil Scumpia, Tamer Sallam

Source: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/646bf0de5fae4234ab6ca6f891819503

Sex-specific metabolic functions of adipose Lipocalin-2

Authors: Karthickeyan Chella Krishnan, Simon Sabir, Michaël Shum, Yonghong Meng, Rebeca Acín-Pérez, Jennifer M. Lang, Raquel R. Floyd, Laurent Vergnes, Marcus M. Seldin, Brie K. Fuqua, Dulshan W. Jayasekera, Sereena K. Nand, Diana C. Anum, Calvin Pan, Linsey Stiles, Miklós Péterfy, Karen Reue, Marc Liesa, Aldons J. Lusis

Source: Molecular Metabolism, Vol 30, Iss , Pp 30-47 (2019)

Subject Terms: Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877819309123; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/a839a782c02a421289dfd3caac2fec75

Dietary and Pharmacologic Manipulations of Host Lipids and Their Interaction With the Gut Microbiome in Non-human Primates

Authors: Jennifer M. Lang, Leslie R. Sedgeman, Lei Cai, Joseph D. Layne, Zhen Wang, Calvin Pan, Richard Lee, Ryan E. Temel, Aldons J. Lusis

Source: Frontiers in Medicine, Vol 8 (2021)

Subject Terms: microbiome, primate, lipids, high-fat diet, bile acids, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2021.646710/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/4e2cf84c24634462855dfffa9e348351

Identification of the Transcription Factor ATF3 as a Direct and Indirect Regulator of the LDLR

Authors: Sabine Bauer, Jana Eigenmann, Yuqi Zhao, Julia Fleig, Johann S. Hawe, Calvin Pan, Dario Bongiovanni, Simon Wengert, Angela Ma, Aldons J. Lusis, Jason C. Kovacic, Johan L. M. Björkegren, Lars Maegdefessel, Heribert Schunkert, Moritz von Scheidt

Source: Metabolites, Vol 12, Iss 9, p 840 (2022)

Subject Terms: ATF3, atherosclerosis, cardiovascular disease, coronary artery disease, gene expression, inflammation, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/12/9/840; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/efe6562806804c91a3b74dc0b85090ca

Machine Learning Reveals Time-Varying Microbial Predictors with Complex Effects on Glucose Regulation

Authors: Oliver Aasmets, Kreete Lüll, Jennifer M. Lang, Calvin Pan, Johanna Kuusisto, Krista Fischer, Markku Laakso, Aldons J. Lusis, Elin Org

Source: mSystems, Vol 6, Iss 1 (2021)

Subject Terms: T2D, gut microbiome, machine learning, prediction analysis, type 2 diabetes, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5077

Access URL: https://doaj.org/article/f257e30117d14b4c92887fd9da5785fa

Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2–induced systemic toxicity

Authors: Shen Li, Feiyang Ma, Tomohiro Yokota, Gustavo Garcia Jr., Amelia Palermo, Yijie Wang, Colin Farrell, Yu-Chen Wang, Rimao Wu, Zhiqiang Zhou, Calvin Pan, Marco Morselli, Michael A. Teitell, Sergey Ryazantsev, Gregory A. Fishbein, Johanna ten Hoeve, Valerie A. Arboleda, Joshua Bloom, Barbara Dillon, Matteo Pellegrini, Aldons J. Lusis, Thomas G. Graeber, Vaithilingaraja Arumugaswami, Arjun Deb

Source: JCI Insight, Vol 6, Iss 2 (2021)

Subject Terms: COVID-19, Metabolism, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/5eccd2b0db0941ecae1137cd886d2357

Genetic control of the mouse HDL proteome defines HDL traits, function, and heterogeneity[S]

Authors: Nathalie Pamir, Calvin Pan, Deanna L. Plubell, Patrick M. Hutchins, Chongren Tang, Jake Wimberger, Angela Irwin, Thomas Q. de Aguiar Vallim, Jay W. Heinecke, Aldons J. Lusis

Source: Journal of Lipid Research, Vol 60, Iss 3, Pp 594-608 (2019)

Subject Terms: high density lipoprotein, single nucleotide polymorphism, sterol efflux, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520326213; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/7c54341009d446dd8d852ced69ab68d9

Natriuretic Peptide Receptor 2 Locus Contributes to Carotid Remodeling

Authors: Vyacheslav A. Korshunov, Elaine M. Smolock, Mary E. Wines‐Samuelson, Abrar Faiyaz, Deanne M. Mickelsen, Breandan Quinn, Calvin Pan, George J. Dugbartey, Chen Yan, Marvin M. Doyley, Aldons J. Lusis, Bradford C. Berk

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 10 (2020)

Subject Terms: carotid artery, genome‐wide association, inbred mice, Npr2, vascular remodeling, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/26da8cbb24ac4d5c835b7e9142e7bc5a