Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.

Authors: Xiang Wang, Bondar, Vitaliy V., Davis, Oliver B., Maloney, Michael T., Agam, Maayan, Chin, Marcus Y., Cheuk-Nga Ho, Audrey, Ghosh, Rajarshi, Leto, Dara E., Joy, David, Calvert, Meredith E. K., Lewcock, Joseph W., Di Paolo, Gilbert, Thorne, Robert G., Sweeney, Zachary K., Henry, Anastasia G.

Source: eLife; 12/8/2023, p1-24, 24p

Molecular architecture determines brain delivery of a transferrin receptor—targeted lysosomal enzyme

Authors: Arguello, Annie, Mahon, Cathal S., Calvert, Meredith E. K., Chan, Darren, Dugas, Jason C., Pizzo, Michelle E., Thomsen, Elliot R., Chau, Roni, Damo, Lorna A., Duque, Joseph

Source: Journal of experimental medicine. 219(3):E20211057-E20211057

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628810537&indx=1&recIds=ETOCRN628810537

Myosin concentration underlies cell size--dependent scalability of actomyosin ring constriction.

Authors: Calvert, Meredith E. K., Wright, Graham D., Leong, Fong Yew

Source: Journal of Cell Biology; November 28 2011, Vol. 195 Issue 5, p13-1-13-15, 15p

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Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Authors: Kariolis, Mihalis S., Wells, Robert C., Getz, Jennifer A., Kwan, Wanda, Mahon, Cathal S., Tong, Raymond, Kim, Do Jin, Srivastava, Ankita, Bedard, Catherine, Henne, Kirk R., Giese, Tina, Assimon, Victoria A., Chen, Xiaocheng, Zhang, Yin, Solanoy, Hilda, Jenkins, Katherine, Sanchez, Pascal E., Kane, Lesley, Miyamoto, Takashi, Chew, Kylie S., Pizzo, Michelle E., Liang, Nicholas, Calvert, Meredith E. K., DeVos, Sarah L., Baskaran, Sulochanadevi, Hall, Sejal, Sweeney, Zachary K., Thorne, Robert G., Watts, Ryan J., Dennis, Mark S., Silverman, Adam P., Zuchero, Y. Joy Yu

Source: Science Translational Medicine; May 2020, Vol. 12 Issue: 545

SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons.

Authors: Takashi Miyamoto¹, Chaeyoung Kim¹, Chow, Johann¹, Dugas, Jason C.¹, DeGroot, Jack^1,2, Bagdasarian, Alex L.¹, Thottumkara, Arun P.^1,3, Larhammar, Martin^1,4, Calvert, Meredith E. K.¹, Fox, Brian M.¹, Lewcock, Joseph W.¹ lewcock@dnli.com, Kane, Lesley A.¹ kane@dnli.com

Source: Journal of Biological Chemistry. Feb2024, Vol. 300 Issue 2, p1-15. 15p.

Subject Terms: *DORSAL root ganglia, *AXONS, *NEURONS, *HIPPOCAMPUS (Brain), *INTERLEUKIN receptors, *CALPAIN