Physiological shedding and C-terminal proteolytic processing of TMEM106B

Authors: Held, Sebastian ¹, Erck, Christian ^{2, 3}, Kemppainen, Susanna ⁴, Bleibaum, Florian ¹, Giridhar, Neha Jadhav ⁵, Feederle, Regina ^{6, 7, 8}, Krenner, Claudia ⁹, Juopperi, Sini-Pauliina ⁴, Calliari, Anna ¹⁰, Mentrup, Torben ¹¹, Schröder, Bernd ¹¹, Dickson, Dennis W. ^{10, 12}, Rauramaa, Tuomas ^{13, 14}, Petrucelli, Leonard ^{10, 12}, Prudencio, Mercedes ^{10, 12}, Hiltunen, Mikko ⁴, Lüningschrör, Patrick ⁵, Capell, Anja ^{8, 9}, Damme, Markus ^{1, 15, ∗}

Source: In Cell Reports 28 January 2025 44(1)

HDGFL2 cryptic protein: a portal to detection and diagnosis in neurodegenerative disease.

Authors: Albagli, Ellen A.¹ (AUTHOR), Calliari, Anna¹ (AUTHOR), Gendron, Tania F.^1,2 (AUTHOR) gendron.tania@mayo.edu, Zhang, Yong-Jie^1,2 (AUTHOR) zhang.yongjie@mayo.edu

Source: Molecular Neurodegeneration. 10/25/2024, Vol. 19 Issue 1, p1-4. 4p.

Subject Terms: *ALZHEIMER'S disease, *CYTOSKELETAL proteins, *RNA-binding proteins, *LEWY body dementia, *DNA-binding proteins, *AMYOTROPHIC lateral sclerosis, *IMMUNOASSAY, *RNA splicing

HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases.

Authors: Calliari, Anna¹ (AUTHOR), Daughrity, Lillian M.¹ (AUTHOR), Albagli, Ellen A.¹ (AUTHOR), Castellanos Otero, Paula¹ (AUTHOR), Yue, Mei¹ (AUTHOR), Jansen-West, Karen¹ (AUTHOR), Islam, Naeyma N.¹ (AUTHOR), Caulfield, Thomas¹ (AUTHOR), Rawlinson, Bailey¹ (AUTHOR), DeTure, Michael^1,2 (AUTHOR), Cook, Casey^1,2 (AUTHOR), Graff-Radford, Neill R.³ (AUTHOR), Day, Gregory S.³ (AUTHOR), Boeve, Bradley F.⁴ (AUTHOR), Knopman, David S.⁴ (AUTHOR), Petersen, Ronald C.⁴ (AUTHOR), Josephs, Keith A.⁴ (AUTHOR), Oskarsson, Björn³ (AUTHOR), Gitler, Aaron D.⁵ (AUTHOR), Dickson, Dennis W.^1,2 (AUTHOR)

Source: Molecular Neurodegeneration. 7/27/2024, Vol. 19 Issue 1, p1-5. 5p.

Subject Terms: *NEURODEGENERATION, *PATHOLOGY, *DNA-binding proteins, *PROTEINS, *TAR

Correction: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases.

Authors: Calliari, Anna¹ (AUTHOR), Daughrity, Lillian M.¹ (AUTHOR), Albagli, Ellen A.¹ (AUTHOR), Castellanos Otero, Paula¹ (AUTHOR), Yue, Mei¹ (AUTHOR), Jansen-West, Karen¹ (AUTHOR), Islam, Naeyma N.¹ (AUTHOR), Caulfield, Thomas¹ (AUTHOR), Rawlinson, Bailey¹ (AUTHOR), DeTure, Michael^1,2 (AUTHOR), Cook, Casey^1,2 (AUTHOR), Graff-Radford, Neill R.³ (AUTHOR), Day, Gregory S.³ (AUTHOR), Boeve, Bradley F.⁴ (AUTHOR), Knopman, David S.⁴ (AUTHOR), Petersen, Ronald C.⁴ (AUTHOR), Josephs, Keith A.⁴ (AUTHOR), Oskarsson, Björn³ (AUTHOR), Gitler, Aaron D.⁵ (AUTHOR), Dickson, Dennis W.^1,2 (AUTHOR)

Source: Molecular Neurodegeneration. 7/27/2024, Vol. 19 Issue 1, p1-2. 2p.

Subject Terms: *NEURODEGENERATION, *PATHOLOGY, *PROTEINS, *STATISTICAL significance

TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia.

Authors: Marks, Jordan D., Ayuso, Virginia Estades, Carlomagno, Yari, Yue, Mei, Todd, Tiffany W., Hao, Ying, Li, Ziyi, McEachin, Zachary T., Shantaraman, Anantharaman, Duong, Duc M., Daughrity, Lillian M., Jansen-West, Karen, Shao, Wei, Calliari, Anna, Bejarano, Jesus Gonzalez, DeTure, Michael, Rawlinson, Bailey, Casey, Monica Castanedes, Lilley, Meredith T., Donahue, Megan H.

Source: Science Translational Medicine; 1/17/2024, Vol. 16 Issue 730, p1-14, 14p

Subject Terms: FRONTOTEMPORAL dementia, POSTMORTEM changes, FRONTOTEMPORAL lobar degeneration, MEMBRANE proteins, GENETIC variation, HAPLOTYPES, DELAYED onset of disease