Elevated levels of cyclophilin A secreted in milk during bovine mastitis.

Authors: Takanashi, Satoru^1,2 (AUTHOR), Yoshimura, Kozue^1,2 (AUTHOR), Endo, Yuma^1,2 (AUTHOR), Urakawa, Megumi^1,2 (AUTHOR), Sato, Hidetoshi³ (AUTHOR), Zhuang, Tao^1,2 (AUTHOR), Hayashi, Tomohito⁴ (AUTHOR), Kiku, Yoshio⁴ (AUTHOR), Nagasawa, Yuya⁴ (AUTHOR), Kitazawa, Haruki^1,5 (AUTHOR), Rose, Michael T.⁶ (AUTHOR), Uemoto, Yoshinobu⁷ (AUTHOR), Watanabe, Kouichi^1,2 (AUTHOR), Nochi, Tomonori^1,2 (AUTHOR), Aso, Hisashi^1,2,8 (AUTHOR) hisashi.aso.a6@tohoku.ac.jp

Source: Journal of Dairy Science. Jan2025, Vol. 108 Issue 1, p835-844. 10p.

Subject Terms: Lactation, Cyclophilins, Carrier proteins, Milk yield, Mastitis, Mammary glands, Bovine mastitis

Cyclosporin A-Based PROTACs Can Deplete Abundant Cellular Cyclophilin A without Suppressing T Cell Activation.

Authors: Hilbig, Katharina¹ (AUTHOR) hilbig@mpi-cbg.de, Towers, Russell² (AUTHOR) russell.towers@ukdd.de, Schmitz, Marc^3,4 (AUTHOR) marc.schmitz@tu-dresden.de, Bornhäuser, Martin^2,3,4,5 (AUTHOR) martin.bornhaeuser@ukdd.de, Lennig, Petra¹ (AUTHOR) petralennig@gmx.de, Zhang, Yixin^1,6 (AUTHOR) yixin.zhang1@tu-dresden.de

Source: Molecules. Jun2024, Vol. 29 Issue 12, p2779. 15p.

Subject Terms: *CYCLOPHILINS, *CYCLOSPORINE, *T cells, *HIV, *TREATMENT effectiveness

Cyclophilin D knockout significantly prevents HCC development in a streptozotocin-induced mouse model of diabetes-linked NASH.

Authors: Stauffer, Winston T.¹ (AUTHOR), Bobardt, Michael¹ (AUTHOR), Ure, Daren R.² (AUTHOR), Foster, Robert T.² (AUTHOR), Gallay, Philippe¹ (AUTHOR) gallay@scripps.edu

Source: PLoS ONE. 4/4/2024, Vol. 19 Issue 4, p1-15. 15p.

Subject Terms: *CYCLOPHILINS, *STREPTOZOTOCIN, *NON-alcoholic fatty liver disease, *HIGH cholesterol diet, *LABORATORY mice, *ISOMERASES, *PANCREATIC enzymes

Inhibitors of Cyclophilin A: Current and Anticipated Pharmaceutical Agents for Inflammatory Diseases and Cancers.

Authors: Zhao, Xuemei¹ (AUTHOR) zhaoxm@sdfmu.edu.cn, Zhao, Xin¹ (AUTHOR) 18363429604@163.com, Di, Weihua¹ (AUTHOR), Wang, Chang^1,2 (AUTHOR) zhaoxm@sdfmu.edu.cn

Source: Molecules. Mar2024, Vol. 29 Issue 6, p1235. 24p.

Subject Terms: *CYCLOPHILINS, *CYCLOSPORINE, *PEPTIDES, *SMALL molecules, *IMMUNOLOGIC diseases

Mice lacking cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model.

Authors: Stauffer, Winston T.¹ (AUTHOR), Goodman, Asha Z.¹ (AUTHOR), Bobardt, Michael¹ (AUTHOR), Ure, Daren R.² (AUTHOR), Foster, Robert T.² (AUTHOR), Gallay, Philippe¹ (AUTHOR) gallay@scripps.edu

Source: PLoS ONE. 3/1/2024, Vol. 19 Issue 2, p1-16. 16p.

Subject Terms: *CYCLOPHILINS, *CARBON tetrachloride, *HIGH cholesterol diet, *HEPATIC fibrosis, *STAINS & staining (Microscopy), *MICE, *ISOMERASES

Cyclophilin A: An Independent Prognostic Factor for Survival in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab and Chemotherapy.

Authors: Moisuc, Diana Cornelia¹ (AUTHOR) cornelia-diana-i-miron@d.umfiasi.ro, Constantinescu, Daniela^1,2 (AUTHOR) d.constantinescu@umfiasi.ro, Marinca, Mihai Vasile^3,4 (AUTHOR) mihai.marinca@umfiasi.ro, Gafton, Bogdan^3,4 (AUTHOR) bogdan.gafton@umfiasi.ro, Pavel-Tanasa, Mariana^1,2 (AUTHOR) mariana.pavel-tanasa@umfiasi.ro, Cianga, Petru^1,2 (AUTHOR) mariana.pavel-tanasa@umfiasi.ro

Source: Cancers. Jan2024, Vol. 16 Issue 2, p385. 18p.

Subject Terms: *CYCLOPHILINS, *CANCER chemotherapy, *MULTIVARIATE analysis, *METASTASIS, *COLORECTAL cancer, *CANCER patients, *ENZYME-linked immunosorbent assay, *KAPLAN-Meier estimator, *RESEARCH funding, *BEVACIZUMAB, *TUMOR markers, *PROGRESSION-free survival, *LONGITUDINAL method, *OVERALL survival, *PROPORTIONAL hazards models

Passage of the HIV capsid cracks the nuclear pore.

Authors: Kreysing, Jan Philipp^1,2, Heidari, Maziar^1,3, Zila, Vojtech^1,4, Cruz-León, Sergio³, Obarska-Kosinska, Agnieszka¹, Laketa, Vibor^4,5, Rohleder, Lara⁴, Welsch, Sonja⁶, Köfinger, Jürgen³, Turoňová, Beata¹, Hummer, Gerhard^1,3,7, gerhard.hummer@biophys.mpg.de, Kräusslich, Hans-Georg^1,4,5, hans-georg.kraeusslich@med.uni-heidelberg.de, Beck, Martin^1,8, martin.beck@biophys.mpg.de

Source: Cell; Feb2025, Vol. 188 Issue 4, p930-994, 65p

Metastatic Colorectal Cancer 2.0.

Authors: Passardi, Alessandro¹ (AUTHOR) alessandro.passardi@irst.emr.it, Marisi, Giorgia² (AUTHOR) giorgia.marisi@irst.emr.it, Ulivi, Paola² (AUTHOR)

Source: Cancers. Jun2024, Vol. 16 Issue 12, p2190. 3p.

Subject Terms: *CYCLOPHILINS, *DRUG resistance in cancer cells, *CANCER invasiveness, *ABLATION techniques, *CANCER patient medical care, *IMMUNOTHERAPY, *COLORECTAL cancer, *METASTASIS, *COMBINED modality therapy, *DISEASE susceptibility, *HEPATECTOMY, *SURVIVAL analysis (Biometry), *GENETIC testing, *COLECTOMY, *DISEASE complications

Characterization and regulation of salt upregulated cyclophilin from a halotolerant strain of Penicillium oxalicum.

Authors: Singh, Mangaljeet¹ (AUTHOR), Singh, Harpreet² (AUTHOR), Kaur, Kirandeep¹ (AUTHOR), Shubhankar, Shubhankar¹ (AUTHOR), Singh, Supreet¹ (AUTHOR), Kaur, Amarjeet³ (AUTHOR), Singh, Prabhjeet¹ (AUTHOR) singhprabhjeet62@gmail.com

Source: Scientific Reports. 11/18/2023, Vol. 13 Issue 1, p1-15. 15p.

Subject Terms: *CYCLOPHILINS, *ISOMERASES, *AMINO acid residues, *PENICILLIUM, *ESCHERICHIA coli, *GENE expression

Cyclophilin E (CypE) Functions as a Positive Regulator in Osteoblast Differentiation by Regulating the Transcriptional Activity of Runx2.

Authors: Piao, Meiyu¹ (AUTHOR) my101park@gmail.com, Lee, Sung Ho¹ (AUTHOR) puzim23@gmail.com, Li, Yuankuan¹ (AUTHOR) lyk208943@jnu.ac.kr, Choi, Joong-Kook² (AUTHOR) jkchoi@chungbuk.ac.kr, Yeo, Chang-Yeol³ (AUTHOR) cyeo@ewha.ac.kr, Lee, Kwang Youl¹ (AUTHOR) cyeo@ewha.ac.kr

Source: Cells (2073-4409). Nov2023, Vol. 12 Issue 21, p2549. 14p.

Subject Terms: *CYCLOPHILINS, *ISOMERASES, *CELLULAR signal transduction, *ISOMERIZATION

The Cyclophilin Inhibitor Rencofilstat Decreases HCV-Induced Hepatocellular Carcinoma Independently of Its Antiviral Activity.

Authors: Stauffer, Winston¹ (AUTHOR) wstauffer@scripps.edu, Bobardt, Michael¹ (AUTHOR) mbobardt@scripps.edu, Ure, Daren² (AUTHOR) dure@hepionpharma.com, Foster, Robert² (AUTHOR) rfoster@hepionpharma.com, Gallay, Philippe¹ (AUTHOR) gallay@scripps.edu

Source: Viruses (1999-4915). Oct2023, Vol. 15 Issue 10, p2099. 14p.

Subject Terms: *HEPATOCELLULAR carcinoma, *CYCLOPHILINS, *CYCLOSPORINE

Structure/epitope analysis and IgE binding activities of three cyclophilin family proteins from Dermatophagoides pteronyssinus.

Authors: Li, Yuwei^1,2,3 (AUTHOR), Sun, Xizhuo² (AUTHOR), Yang, Liteng^1,2 (AUTHOR) yang20002003@126.com

Source: Scientific Reports. 8/21/2023, Vol. 13 Issue 1, p1-10. 10p.

Subject Terms: *DERMATOPHAGOIDES pteronyssinus, *CYCLOPHILINS, *BLOOD proteins, *IMMUNOGLOBULIN E, *PROTEINS, *CELL physiology

Trypanosoma cruzi Secreted Cyclophilin Tc CyP19 as an Early Marker for Trypanocidal Treatment Efficiency.

Authors: Perrone, Alina E.¹ (AUTHOR) alinaperrone@yahoo.com.ar, Pinillo, Mariana¹ (AUTHOR) marianapinillo2017@gmail.com, Rial, Marcela S.¹ (AUTHOR) marcelarial2@hotmail.com, Fernández, Marisa¹ (AUTHOR) marisa.fernandez@gmail.com, Milduberger, Natalia¹ (AUTHOR) nmilduberger@gmail.com, González, Carolina¹ (AUTHOR) caro.gonzalez327@gmail.com, Bustos, Patricia L.^1,2 (AUTHOR) pato54mar@yahoo.com.ar, Fichera, Laura E.^1,2 (AUTHOR) lfichera@yahoo.com, Laucella, Susana A.^1,2 (AUTHOR) slaucella@yahoo.com, Albareda, María Cecilia^1,2 (AUTHOR) mcalbareda@gmail.com, Bua, Jacqueline^1,2 (AUTHOR) jbua@anlis.gob.ar

Source: International Journal of Molecular Sciences. Aug2023, Vol. 24 Issue 15, p11875. 13p.

Subject Terms: *TRYPANOSOMA cruzi, *CYCLOPHILINS, *CHAGAS' disease, *PROTEIN folding

Cyclophilin D in Mitochondrial Dysfunction: A Key Player in Neurodegeneration?

Authors: Coluccino, Gabriele¹ (AUTHOR) gabriele.coluccino@uniud.it, Muraca, Valentina Pia¹ (AUTHOR), Corazza, Alessandra¹ (AUTHOR), Lippe, Giovanna¹ (AUTHOR) gabriele.coluccino@uniud.it

Source: Biomolecules (2218-273X). Aug2023, Vol. 13 Issue 8, p1265. 29p.

Subject Terms: *PARKINSON'S disease, *CYCLOPHILINS, *ALZHEIMER'S disease, *EXTRACELLULAR matrix proteins, *ISOMERASES, *NEURODEGENERATION

Cyclophilin A as a Pro-Inflammatory Factor Exhibits Embryotoxic and Teratogenic Effects during Fetal Organogenesis.

Authors: Kalinina, Anastasiia¹ (AUTHOR) tgorkova70@gmail.com, Semenova, Maria² (AUTHOR), Bruter, Alexandra^1,3 (AUTHOR) trukhanova80@gmail.com, Varlamova, Ekaterina³ (AUTHOR), Kubekina, Marina³ (AUTHOR), Pavlenko, Natalia³ (AUTHOR), Silaeva, Yulia⁴ (AUTHOR) yulya.silaeva@gmail.com, Deikin, Alexey⁵ (AUTHOR), Antoshina, Elena¹ (AUTHOR), Gorkova, Tatyana¹ (AUTHOR), Trukhanova, Lubov¹ (AUTHOR), Salmina, Alla⁶ (AUTHOR) allasalmina@mail.ru, Novikova, Svetlana⁶ (AUTHOR) levik_82@mail.ru, Voronkov, Dmitry⁶ (AUTHOR), Kazansky, Dmitry¹ (AUTHOR), Khromykh, Ludmila¹ (AUTHOR) lkhromykh@list.ru

Source: International Journal of Molecular Sciences. Jul2023, Vol. 24 Issue 14, p11279. 16p.

Subject Terms: *CYCLOPHILINS, *PREGNANCY complications, *MORPHOGENESIS, *BONE growth, *EMBRYOLOGY, *FETAL brain, *FETUS

Cyclophilin A Isomerisation of Septin 2 Mediates Abscission during Cytokinesis.

Authors: Gorry, Rebecca L.¹ (AUTHOR) k.brennan@ucd.ie, Brennan, Kieran¹ (AUTHOR), Lavin, Paul T. M.¹ (AUTHOR), Mazurski, Tayler¹ (AUTHOR), Mary, Charline² (AUTHOR), Matallanas, David³ (AUTHOR), Guichou, Jean-François² (AUTHOR), Mc Gee, Margaret M.¹ (AUTHOR) margaret.mcgee@ucd.ie

Source: International Journal of Molecular Sciences. Jul2023, Vol. 24 Issue 13, p11084. 18p.

Subject Terms: *CYCLOPHILINS, *CYTOKINESIS, *ISOMERIZATION, *G proteins, *ISOMERASES, *CELL division

Microplitis bicoloratus Bracovirus Promotes Cyclophilin D-Acetylation at Lysine 125 That Correlates with Apoptosis during Insect Immunosuppression.

Authors: Yu, Dan^1,2 (AUTHOR) 20210172@ynu.edu.cn, Zhang, Pan¹ (AUTHOR) yndxxb@ynu.edu.cn, Xu, Cuixian^1,3 (AUTHOR) xucuixian@mail.xingaojiao.com, Hu, Yan¹ (AUTHOR) huyan@walvax.com, Liang, Yaping¹ (AUTHOR) liangyaping@mail.ynu.edu.cn, Li, Ming¹ (AUTHOR) leeming@ynu.edu.cn

Source: Viruses (1999-4915). Jul2023, Vol. 15 Issue 7, p1491. 16p.

Subject Terms: *CYCLOPHILINS, *CHIMERIC proteins, *IMMUNOSUPPRESSION, *LYSINE, *APOPTOSIS

The adenine nucleotide translocase family underlies cardiac ischemia-reperfusion injury through the mitochondrial permeability pore independently of cyclophilin D.

Authors: Patel, Pooja¹, Mendoza, Arielys, Ramirez, Daniel¹, Robichaux, Dexter¹, Molkentin, Jeffery D.², Karch, Jason^1,3 ason.karch@bcm.edu

Source: Science Advances. 12/13/2024, Vol. 10 Issue 50, p1-10. 10p.

Subject Terms: *CYCLOPHILINS, *HEART injuries, *REPERFUSION injury, *ADENINE, *MITOCHONDRIA, *REPERFUSION

Cyclophilin D plays a critical role in the survival of senescent cells.

Authors: Protasoni, Margherita^1,2 (AUTHOR), López-Polo, Vanessa¹ (AUTHOR), Stephan-Otto Attolini, Camille¹ (AUTHOR), Brandariz, Julian³ (AUTHOR), Herranz, Nicolas^3,4 (AUTHOR), Mateo, Joaquin^3,5 (AUTHOR), Ruiz, Sergio⁶ (AUTHOR), Fernandez-Capetillo, Oscar^7,8 (AUTHOR), Kovatcheva, Marta^1,9 (AUTHOR) marta.kovatcheva@ifom.eu, Serrano, Manuel^1,2 (AUTHOR) mserrano@altoslabs.com

Source: EMBO Journal. Dec2024, Vol. 43 Issue 23, p5972-6000. 29p.

Subject Terms: *CYCLOPHILINS, *MITOCHONDRIAL proteins, *CYCLOSPORINE, *MATRIX effect, *CELL survival, *CALCIUM channels, *PLANT mitochondria

Personal essay of a rookie's journey with Bill Pak and his legacy: tales and perspectives on PI-PLC, NorpA and cyclophilin, NinaA - William L. Pak, PhD., 1932–2023: in memoriam.

Authors: Ferreira, Paulo A.¹ (AUTHOR) paulo.ferreira@duke.edu

Source: Journal of Neurogenetics. Dec2024, Vol. 38 Issue 4, p165-174. 10p.

Subject Terms: *PHOSPHOLIPASE C, *CYCLOPHILINS, *DROSOPHILA melanogaster, *FRUIT flies, *NEUROGENETICS