Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer.

Authors: Bharti, Rashmi¹ (AUTHOR), Dey, Goutam¹ (AUTHOR), Khan, Debjit¹ (AUTHOR), Myers, Alex¹ (AUTHOR), Huffman, Olivia G.¹ (AUTHOR), Saygin, Caner^1,2 (AUTHOR), Braley, Chad¹ (AUTHOR), Richards, Elliott^1,3 (AUTHOR), Sangwan, Naseer^1,4,5 (AUTHOR), Willard, Belinda⁶ (AUTHOR), Lathia, Justin D.^1,5 (AUTHOR), Fox, Paul L.^1,5 (AUTHOR), Lin, Feng^5,7 (AUTHOR), Jha, Babal Kant^5,8 (AUTHOR), Brown, J. Mark^5,9 (AUTHOR), Yu, Jennifer S.^5,9 (AUTHOR), Dwidar, Mohammed^1,5,10 (AUTHOR), Joehlin-Price, Amy¹¹ (AUTHOR), Vargas, Roberto^5,12 (AUTHOR), Michener, Chad M.^5,12 (AUTHOR)

Source: Molecular Cancer. 6/10/2024, Vol. 23 Issue 1, p1-23. 23p.

Subject Terms: *CD55 antigen, *OVARIAN cancer, *CISPLATIN, *CANCER stem cells, *CHROMATIN

Clinicopathological and Immunohistochemical Association of CD55 and CD59 in Colorectal Carcinoma: A Cross-sectional Study.

Authors: HAZRA, RATHIN¹ hazra_rathin@rediffmail.com, KHAN, ANANYA², MONDAL, RAJIB KUMAR³, RAKSHIT, SARBARI KAR⁴

Source: Journal of Clinical & Diagnostic Research. May2024, Vol. 18 Issue 5, p6-11. 6p.

Subject Terms: *CD55 antigen, *CD59 antigen, *COLORECTAL cancer, *SURGERY, *CROSS-sectional method

Geographic Terms: KOLKATA (India)

Reviews & Products: SPSS (Computer software)

miR-132-3p regulates antibody-mediated complement-dependent cytotoxicity in colon cancer cells by directly targeting CD55.

Authors: Fan, Yu¹ (AUTHOR), Liao, Juan¹ (AUTHOR), Wang, Yu¹ (AUTHOR), Wang, Zhu¹ (AUTHOR), Zheng, Hong¹ (AUTHOR), Wang, Yanping¹ (AUTHOR) wyanping@scu.edu.cn

Source: Clinical & Experimental Immunology. Jan2023, Vol. 211 Issue 1, p57-67. 11p. 1 Diagram, 1 Chart, 4 Graphs.

Subject Terms: *CD55 antigen, *COLON cancer, *CANCER cells, *GENE expression, *ECULIZUMAB, *DRUG efficacy

Company/Entity: CENTERS for Disease Control & Prevention (U.S.)

In Vitro Investigation of Pulsed Electromagnetic Field Stimulation (PEMF) with MAGCELL ® ARTHRO on the Regulatory Expression of Soluble and Membrane-Bound Complement Factors and Inflammatory Cytokines in Immortalized Synovial Fibroblasts.

Authors: Silawal, Sandeep¹ (AUTHOR) gundula.schulze@pmu.ac.at, Gesslein, Markus² (AUTHOR) markus.gesslein@klinikum-nuernberg.de, Willauschus, Maximilian² (AUTHOR) mp-willauschus@outlook.com, Schulze-Tanzil, Gundula¹ (AUTHOR)

Source: Journal of Personalized Medicine. Jul2024, Vol. 14 Issue 7, p701. 14p.

Subject Terms: *TUMOR necrosis factors, *CD55 antigen, *COMPLEMENT activation, *ELECTROMAGNETIC fields, *CD59 antigen

Complement decay-accelerating factor inhibits inflammation-induced myopia development.

Authors: Chou, Yung-Lan^1,2 (AUTHOR), Hsu, Yu-An^2,3 (AUTHOR), Lin, Chi-Fong⁴ (AUTHOR), Chen, Chih-Sheng^5,6 (AUTHOR), Tien, Peng-Tai^7,8 (AUTHOR), Wang, Yao-Chien⁹ (AUTHOR), Chang, Ching-Yao¹⁰ (AUTHOR), Lin, En-Shyh¹¹ (AUTHOR), Chen, Jamie Jiin-Yi⁸ (AUTHOR), Wu, Ming-Yen⁸ (AUTHOR), Chuang, Chun-Yu¹ (AUTHOR) cychuang@mx.nthu.edu.tw, Lin, Hui-Ju^1,2,8 (AUTHOR) d2396@mail.cmuh.org.tw, Wan, Lei^1,2,10,12 (AUTHOR) leiwan@cmu.edu.tw

Source: Molecular Immunology. Jul2024, Vol. 171, p47-55. 9p.

Subject Terms: *CD55 antigen, *REFRACTIVE errors, *MYOPIA, *ALLERGIC conjunctivitis, *EYE inflammation

Switching of Receptor Binding Poses between Closely Related Enteroviruses.

Authors: Zhou, Daming^1,2 (AUTHOR), Qin, Ling¹ (AUTHOR), Duyvesteyn, Helen M. E.¹ (AUTHOR), Zhao, Yuguang¹ (AUTHOR), Lin, Tzou-Yien³ (AUTHOR), Fry, Elizabeth E.¹ (AUTHOR), Ren, Jingshan¹ (AUTHOR), Huang, Kuan-Ying A.⁴ (AUTHOR) arthurhuang1726@ntu.edu.tw, Stuart, David I.^1,2,5 (AUTHOR) arthurhuang1726@ntu.edu.tw

Source: Viruses (1999-4915). Dec2022, Vol. 14 Issue 12, p2625. 12p.

Subject Terms: *CD55 antigen, *VACCINE approval, *ECHO viruses, *NEONATAL mortality, *VIRION, *ENTEROVIRUSES

Decay-Accelerating Factor Creates an Organ-Protective Phenotype after Hemorrhage in Conscious Rats.

Authors: Simovic, Milomir O.^1,2 (AUTHOR), Falabella, Michael J.³ (AUTHOR), Le, Tuan D.¹ (AUTHOR), DalleLucca, Jurandir J.⁴ (AUTHOR), Li, Yansong^1,2 (AUTHOR) ysli916@gmail.com

Source: International Journal of Molecular Sciences. Nov2022, Vol. 23 Issue 21, p13563. 17p.

Subject Terms: *CD55 antigen, *SPRAGUE Dawley rats, *COMPLEMENT inhibition, *HEMORRHAGE, *COMPLEMENT activation, *RATS, *SUBLIMINAL perception

Extracellular Vesicles Isolated from Plasma of Multiple Myeloma Patients Treated with Daratumumab Express CD38, PD-L1, and the Complement Inhibitory Proteins CD55 and CD59.

Authors: Brennan, Kieran^1,2 (AUTHOR), Iversen, Katrine F.^3,4 (AUTHOR), Blanco-Fernández, Alfonso⁵ (AUTHOR), Lund, Thomas⁶ (AUTHOR), Plesner, Torben^3,4 (AUTHOR), Mc Gee, Margaret M.^1,2 (AUTHOR) margaret.mcgee@ucd.ie

Source: Cells (2073-4409). Nov2022, Vol. 11 Issue 21, p3365. 19p.

Subject Terms: *CD55 antigen, *CD59 antigen, *PROGRAMMED death-ligand 1, *DARATUMUMAB, *EXTRACELLULAR vesicles, *MULTIPLE myeloma, *PROGRAMMED cell death 1 receptors

Evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy disease: an open-label phase 2 and 3 study.

Authors: Ozen, Ahmet^1,2,3 (AUTHOR), Chongsrisawat, Voranush^4,5 (AUTHOR), Sefer, Asena Pinar^1,2,3 (AUTHOR), Kolukisa, Burcu^1,2,3 (AUTHOR), Jalbert, Jessica J⁶ (AUTHOR), Meagher, Karoline A⁷ (AUTHOR), Brackin, Taylor⁷ (AUTHOR), Feldman, Hagit Baris⁸ (AUTHOR), Baris, Safa^1,2,3 (AUTHOR), Karakoc-Aydiner, Elif^1,2,3 (AUTHOR), Ergelen, Rabia⁹ (AUTHOR), Fuss, Ivan J¹⁰ (AUTHOR), Moorman, Heather¹¹ (AUTHOR), Suratannon, Narissara^5,12 (AUTHOR), Suphapeetiporn, Kanya^13,14 (AUTHOR), Perlee, Lorah⁷ (AUTHOR), Harari, Olivier A^1,7 (AUTHOR) olivier.harari@regeneron.com, Yancopoulos, George D⁷ (AUTHOR), Lenardo, Michael J¹¹ (AUTHOR)

Source: Lancet. Feb2024, Vol. 403 Issue 10427, p645-656. 12p.

Subject Terms: Protein-losing enteropathy, CD55 antigen, Patient safety, Complement inhibition, Serum albumin, Facial pain

Geographic Terms: Turkey

EBV-induced upregulation of CD55 reduces the efficacy of cetuximab treatment in nasopharyngeal carcinoma.

Authors: Zhu, Qian^1,2 (AUTHOR), Duan, Xiao-Bing³ (AUTHOR), Hu, Hao⁴ (AUTHOR), You, Rui⁵ (AUTHOR), Xia, Tian-Liang^1,6 (AUTHOR), Yu, Tao^1,6 (AUTHOR), Xiang, Tong⁶ (AUTHOR) xiangtong@sysucc.org.cn, Chen, Ming-Yuan⁵ (AUTHOR) chmingy@mail.sysu.edu.cn

Source: Journal of Translational Medicine. 12/18/2024, Vol. 22 Issue 1, p1-15. 15p.

Subject Terms: *ANTIBODY-dependent cell cytotoxicity, *MEMBRANE proteins, *CD55 antigen, *PROTEIN overexpression, *MEDICAL sciences

Complement regulatory proteins in hepatitis-induced thrombocytopenia.

Authors: Aziz, Shereen P.¹ (AUTHOR) sanymn@yahoo.com, Sayed, Sherif A.¹ (AUTHOR), Mohamed, Nermeen G.¹ (AUTHOR), Ali, Amal H.² (AUTHOR), Elsharkawy, Ramy³ (AUTHOR), Hefny, Hesham M.¹ (AUTHOR)

Source: Egyptian Journal of Haematology. Oct-Dec2024, Vol. 49 Issue 4, p431-437. 7p.

Subject Terms: *CHRONIC hepatitis C, *CHRONIC active hepatitis, *CD55 antigen, *HEPATITIS C virus, *HEPATITIS B virus

Establishment of a Panel of Human Cell Lines to Identify Cellular Receptors Used by Enteroviruses to Infect Cells.

Authors: Sosnovtseva, Anastasiia O., Le, Thi Hoa, Karpov, Dmitry S., Vorobyev, Pavel O., Gumennaya, Yana D., Alekseeva, Olga N., Chumakov, Peter M., Lipatova, Anastasia V.

Source: International Journal of Molecular Sciences; Feb2025, Vol. 26 Issue 3, p923, 12p

Subject Terms: ONCOLYTIC virotherapy, CELL receptors, VIRAL genes, ENTEROVIRUSES, CD55 antigen

In situ tumor cell engineering reverses immune escape to enhance immunotherapy effect.

Authors: Liu, Shujun, Yuan, Shijun, Liu, Meichen, Liu, Jinhu, Fu, Shunli, Gao, Tong, Liang, Shuang, Huang, Xinyan, Zhang, Xinke, Liu, Yongjun, Zhang, Zipeng, Zhang, Na

Source: Acta Pharmaceutica Sinica B; Jan2025, Vol. 15 Issue 1, p627-641, 15p

Subject Terms: CELLULAR recognition, DRUG delivery systems, CD55 antigen, CELL surface antigens, B cells, DRUG formularies

In situ tumor cell engineering reverses immune escape to enhance immunotherapy effect

Authors: Shujun Liu, Shijun Yuan, Meichen Liu, Jinhu Liu, Shunli Fu, Tong Gao, Shuang Liang, Xinyan Huang, Xinke Zhang, Yongjun Liu, Zipeng Zhang, Na Zhang

Source: Acta Pharmaceutica Sinica B, Vol 15, Iss 1, Pp 627-641 (2025)

Subject Terms: Tumor engineering, MHC-I, T cell recognition, CD55, ICOSL+ B cell, Immunotherapy, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383524003496; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/b5c630633f1840628dba0ec117f7faf0

Exosomes mediate Coxsackievirus B3 transmission and expand the viral tropism.

Authors: Fu, Yuxuan¹, Xiong, Sidong¹, sdxiong@suda.edu.cn

Source: PLoS Pathogens; 1/12/2023, Vol. 18 Issue 1, p1-29, 29p

Complement Decay-Accelerating Factor is a modulator of influenza A virus lung immunopathology.

Authors: Santos, Nuno Brito¹ (AUTHOR), Vaz da Silva, Zoé Enderlin¹ (AUTHOR), Gomes, Catarina^2,3 (AUTHOR), Reis, Celso A.^2,3,4,5 (AUTHOR), Amorim, Maria João¹ (AUTHOR) mjamorim@igc.gulbenkian.pt

Source: PLoS Pathogens. 7/1/2021, Vol. 17 Issue 7, p1-34. 34p.

Subject Terms: *CD55 antigen, *INFLUENZA A virus, *INFLUENZA viruses, *IMMUNOPATHOLOGY, *COMPLEMENT activation, *HEMAGGLUTININ, *INFLUENZA

A Histological Analysis and Detection of Complement Regulatory Protein CD55 in SARS-CoV-2 Infected Lungs.

Authors: Silawal, Sandeep¹ (AUTHOR) clemens.goegele@pmu.ac.at, Gögele, Clemens¹ (AUTHOR) c.werner@pmu.ac.at, Pelikan, Petr² (AUTHOR) petr.pelikan@klinikum-nuernberg.de, Werner, Christian¹ (AUTHOR) gundula.schulze@pmu.ac.at, Levidou, Georgia² (AUTHOR) georgia.levidou@klinikum-nuernberg.de, Mahato, Raman³ (AUTHOR) raman.mahato@klinikumevb.de, Schulze-Tanzil, Gundula¹ (AUTHOR)

Source: Life (2075-1729). Sep2024, Vol. 14 Issue 9, p1058. 11p.

Subject Terms: *ADULT respiratory distress syndrome, *LUNGS, *CD55 antigen, *LUNG diseases, *COMPLEMENT activation, *CELL anatomy

Exercise training upregulates CD55 to suppress complement-mediated synaptic phagocytosis in Parkinson’s disease

Authors: Hongkai Yao, Weifang Tong, Yunping Song, Ruoyu Li, Xuerui Xiang, Wen Cheng, Yunjiao Zhou, Yijing He, Yi Yang, Yunxi Liu, Siguang Li, Lingjing Jin

Source: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)

Subject Terms: Parkinson’s disease, Microglia, Proteomics and RNA-seq analysis, Complement pathway, Synapses, CD55, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/3d44f0e51fd843db87f90dda4d717ec5

Single-cell RNA sequencing identifies inherent abnormalities of adipose-derived stem cells from nonlesional sites of patients with localized scleroderma

Authors: Xuanyu Liu, Zhujun Li, Hayson Chenyu Wang, Meng Yuan, Jie Chen, Jiuzuo Huang, Nanze Yu, Zhou Zhou, Xiao Long

Source: Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-22 (2024)

Subject Terms: Localized scleroderma, Adipose-derived stem cells, Stromal vascular fraction, CD55, Single-cell RNA sequencing, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1689-1392

Access URL: https://doaj.org/article/d6c9da29630d40cb81ca94db5e393547

Complement-Mediated Two-Step NETosis: Serum-Induced Complement Activation and Calcium Influx Generate NADPH Oxidase-Dependent NETs in Serum-Free Conditions.

Authors: Maqsood, Maria, Suntharalingham, Samuel, Khan, Meraj, Ortiz-Sandoval, Carolina G., Feitz, Wouter J. C., Palaniyar, Nades, Licht, Christoph

Source: International Journal of Molecular Sciences; Sep2024, Vol. 25 Issue 17, p9625, 18p

Subject Terms: COMPLEMENT activation, NATURAL immunity, REACTIVE oxygen species, ENDOTHELIAL cells, CD55 antigen, NEUTROPHILS