One size does not fit all: Lysosomes exist in biochemically and functionally distinct states.

Authors: Bussi, Claudio¹ (AUTHOR) claudio.bussi@crick.ac.uk, Gutierrez, Maximiliano G.¹ (AUTHOR) claudio.bussi@crick.ac.uk

Source: PLoS Biology. 3/22/2024, Vol. 22 Issue 3, p1-5. 5p.

Subject Terms: *LYSOSOMES, *HETEROGENEITY

Systemic sterile induced-co-expression of IL-12 and IL-18 drive IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain

Authors: Gaviglio, Emilia A., Peralta Ramos, Javier M., Arroyo, Daniela S., Bussi, Claudio, Iribarren, Pablo, Rodriguez-Galan, Maria C.

Source: In International Immunopharmacology April 2022 105

Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy

Authors: Aitken, Jim, Allen, Zoe, Ambler, Rachel, Ambrose, Karen, Ashton, Emma, Avola, Alida, Balakrishnan, Samutheswari, Barns-Jenkins, Caitlin, Barr, Genevieve, Barrell, Sam, Basu, Souradeep, Beale, Rupert, Beesley, Clare, Bhardwaj, Nisha, Bibi, Shahnaz, Bineva-Todd, Ganka, Biswas, Dhruva, Blackman, Michael J., Bonnet, Dominique, Bowker, Faye, Broncel, Malgorzata, Brooks, Claire, Buck, Michael D., Buckton, Andrew, Budd, Timothy, Burrell, Alana, Busby, Louise, Bussi, Claudio, Butterworth, Simon, Byott, Matthew, Byrne, Fiona, Byrne, Richard, Caidan, Simon, Campbell, Joanna, Canton, Johnathan, Cardoso, Ana, Carter, Nick, Carvalho, Luiz, Carzaniga, Raffaella, Chandler, Natalie, Chen, Qu, Cherepanov, Peter, Churchward, Laura, Clark, Graham, Clayton, Bobbi, Cobolli Gigli, Clementina, Collins, Zena, Cottrell, Sally, Crawford, Margaret, Cubitt, Laura, Cullup, Tom, Davies, Heledd, Davis, Patrick, Davison, Dara, Dearing, Vicky, Debaisieux, Solene, Diaz-Romero, Monica, Dibbs, Alison, Diring, Jessica, Driscoll, Paul C., D'Avola, Annalisa, Earl, Christopher, Edwards, Amelia, Ekin, Chris, Evangelopoulos, Dimitrios, Faraway, Rupert, Fearns, Antony, Ferron, Aaron, Fidanis, Efthymios, Fitz, Dan, Fleming, James, Frampton, Daniel, Frederico, Bruno, Gaiba, Alessandra, Gait, Anthony, Gamblin, Steve, Gärtner, Kathleen, Gaul, Liam, Golding, Helen M., Goldman, Jacki, Goldstone, Robert, Gomez Dominguez, Belen, Gong, Hui, Grant, Paul R., Greco, Maria, Grobler, Mariana, Guedan, Anabel, Gutierrez, Maximiliano G., Hackett, Fiona, Hall, Ross, Halldorsson, Steinar, Harris, Suzanne, Hashim, Sugera, Hatipoglu, Emine, Healy, Lyn, Heaney, Judith, Herbst, Susanne, Hewitt, Graeme, Higgins, Theresa, Hindmarsh, Steve, Hirani, Rajnika, Hope, Joshua, Horton, Elizabeth, Hoskins, Beth, Howell, Michael, Howitt, Louise, Hoyle, Jacqueline, Htun, Mint R., Hubank, Michael, Huerga Encabo, Hector, Hughes, Deborah, Hughes, Jane, Huseynova, Almaz, Hwang, Ming-Shih, Instrell, Rachael, Jackson, Deborah, Jamal-Hanjani, Mariam, Jenkins, Lucy, Jiang, Ming, Johnson, Mark, Jones, Leigh, Kanu, Nnennaya, Kassiotis, George, Kelly, Gavin, Kiely, Louise, Teixeira, Anastacio King Spert, Kirk, Stuart, Kjaer, Svend, Knuepfer, Ellen, Komarov, Nikita, Kotzampaltiris, Paul, Kousis, Konstantinos, Krylova, Tammy, Kucharska, Ania, Labrum, Robyn, Lambe, Catherine, Lappin, Michelle, Lee, Stacey-Ann, Levett, Andrew, Levett, Lisa, Levi, Marcel, Liu, Hon Wing, Loughlin, Sam, Lu, Wei-Ting, MacRae, James I., Madoo, Akshay, Marczak, Julie A., Martensson, Mimmi, Martinez, Thomas, Marzook, Bishara, Matthews, John, Matz, Joachim M., McCall, Samuel, McCoy, Laura E., McKay, Fiona, McNamara, Edel C., Minutti, Carlos M., Mistry, Gita, Molina-Arcas, Miriam, Montaner, Beatriz, Montgomery, Kylie, Moore, Catherine, Moore, David, Moraiti, Anastasia, Moreira-Teixeira, Lucia, Mukherjee, Joyita, Naceur-Lombardelli, Cristina, Nelson, Aileen, Nicod, Jerome, Nightingale, Luke, Nofal, Stephanie, Nurse, Paul, Nutan, Savita, Oedekoven, Caroline, O'Garra, Anne, O'Leary, Jean D., Olsen, Jessica, O'Neill, Olga, O'Reilly, Nicola, Suarez, Paula Ordonez, Osborne, Neil, Pabari, Amar, Pajak, Aleksandra, Papayannopoulos, Venizelos, Paraskevopoulou, Stavroula M, Patel, Namita, Patel, Yogen, Paun, Oana, Peat, Nigel, Peces-Barba Castano, Laura, Caballero, Ana Perez, Perez-Lloret, Jimena, Perrault, Magali S., Perrin, Abigail, Poh, Roy, Poirier, Enzo Z., Polke, James M., Pollitt, Marc, Prieto-Godino, Lucia, Proust, Alize, Puvirajasinghe, Clinda, Queval, Christophe, Ramachandran, Vijaya, Ramaprasad, Abhinay, Ratcliffe, Peter, Reed, Laura, Reis e Sousa, Caetano, Richardson, Kayleigh, Ridewood, Sophie, Roberts, Fiona, Roberts, Rowenna, Rodgers, Angela, Romero Clavijo, Pablo, Rosa, Annachiara, Rossi, Alice, Roustan, Chloe, Rowan, Andrew, Sahai, Erik, Sait, Aaron, Sala, Katarzyna, Sanchez, Emilie, Sanderson, Theo, Santucci, Pierre, Sardar, Fatima, Sateriale, Adam, Saunders, Jill A., Sawyer, Chelsea, Schlott, Anja, Schweighoffer, Edina, Segura-Bayona, Sandra, Shah Punatar, Rajvee, Shahmanesh, Maryam, Shaw, Joe, Silva Dos Santos, Mariana, Silvestre, Margaux, Singer, Matthew, Snell, Daniel M., Song, Ok-Ryul, Spyer, Moira J., Steel, Louisa, Strange, Amy, Sullivan, Adrienne E., Tan, Michele S.Y., Tautz-Davis, Zoe H., Taylor, Effie, Taylor, Gunes, Taylor, Harriet B., Taylor-Beadling, Alison, Teixeira Subtil, Fernanda, Terré Torras, Berta, Toolan-Kerr, Patrick, Torelli, Francesca, Toteva, Tea, Treeck, Moritz, Trojer, Hadija, Tsai, Ming-Han C., Turner, James M.A., Turner, Melanie, Ule, Jernej, Ulferts, Rachel, Vanloo, Sharon P., Veeriah, Selvaraju, Venkatesan, Subramanian, Vousden, Karen, Wack, Andreas, Walder, Claire, Walker, Philip A., Wang, Yiran, Ward, Sophia, Wenman, Catharina, Williams, Luke, Williams, Matthew J., Keong Wong, Wai, Wright, Joshua, Wu, Mary, Wynne, Lauren, Xiang, Zheng, Yap, Melvyn, Zagalak, Julian A., Zecchin, Davide, Zillwood, Rachel, Carthiyaniamma, Santhakumari, DeTisi, Jane, Dick, Julie, Hill, Andrea, Kipper, Karin, Kullar, Birinder, Norris, Sarah, Rugg-Gunn, Fergus, Salvatierra, Rebecca, Shaya, Gabriel, Sloan, Astrid, Singh, Priyanka, Varley, James, Whatley, Ben, Balestrini, Simona, Koepp, Matthias J., Gandhi, Sonia, Rickman, Hannah M., Shin, Gee Yen, Houlihan, Catherine F., Anders-Cannon, Jonny, Silvennoinen, Katri, Xiao, Fenglai, Zagaglia, Sara, Hudgell, Kirsty, Ziomek, Mariusz, Haimes, Paul, Sampson, Adam, Parker, Annie, Helen Cross, J., Pardington, Rosemarie, Nastouli, Eleni, Swanton, Charles, Sander, Josemir W., Sisodiya, Sanjay M.

Source: In Epilepsy & Behavior February 2021 115

The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells

Authors: Omenetti, Sara, Bussi, Claudio, Metidji, Amina, Iseppon, Andrea, Lee, Sunjae, Tolaini, Mauro, Li, Ying, Kelly, Gavin, Chakravarty, Probir, Shoaie, Saeed, Gutierrez, Maximiliano G., Stockinger, Brigitta

Source: In Immunity 16 July 2019 51(1):77-89

Lysosomes drive the piecemeal removal of mitochondrial inner membrane.

Authors: Prashar, Akriti, Bussi, Claudio, Fearns, Antony, Capurro, Mariana I., Gao, Xiaodong, Sesaki, Hiromi, Gutierrez, Maximiliano G., Jones, Nicola L.

Source: Nature; Aug2024, Vol. 632 Issue 8027, p1110-1117, 8p

Autophagy in inflammation, infection, neurodegeneration and cancer

Authors: Arroyo, Daniela S., Gaviglio, Emilia A., Peralta Ramos, Javier M., Bussi, Claudio, Rodriguez-Galan, Maria C., Iribarren, Pablo

Source: In International Immunopharmacology January 2014 18(1):55-65

Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome.

Authors: Lana-Elola, Eva, Aoidi, Rifdat, Llorian, Miriam, Gibbins, Dorota, Buechsenschuetz, Callan, Bussi, Claudio, Flynn, Helen, Gilmore, Tegan, Watson-Scales, Sheona, Haugsten Hansen, Marie, Hayward, Darryl, Song, Ok-Ryul, Brault, Véronique, Herault, Yann, Deau, Emmanuel, Meijer, Laurent, Snijders, Ambrosius P., Gutierrez, Maximiliano G., Fisher, Elizabeth M. C., Tybulewicz, Victor L. J.

Source: Science Translational Medicine; 1/24/2024, Vol. 16 Issue 731, p1-16, 16p

Subject Terms: CONGENITAL heart disease, SERINE/THREONINE kinases, DOWN syndrome, LABORATORY mice, ANIMAL disease models, HEART abnormalities

Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages.

Authors: Pellegrino, Enrica¹, Aylan, Beren¹, Bussi, Claudio¹, Fearns, Antony¹, Bernard, Elliott M.¹, Athanasiadi, Natalia¹, Santucci, Pierre¹, Botella, Laure¹, Gutierrez, Maximiliano G.¹, max.g@crick.ac.uk

Source: Journal of Cell Biology; 12/4/2023, Vol. 222 Issue 12, p1-16, 21p

Stress granules plug and stabilize damaged endolysosomal membranes.

Authors: Bussi, Claudio, Mangiarotti, Agustín, Vanhille-Campos, Christian, Aylan, Beren, Pellegrino, Enrica, Athanasiadi, Natalia, Fearns, Antony, Rodgers, Angela, Franzmann, Titus M., Šarić, Anđela, Dimova, Rumiana, Gutierrez, Maximiliano G.

Source: Nature; Nov2023, Vol. 623 Issue 7989, p1062-1069, 8p

Effects of rapamycin in combination with fludarabine on primary chronic lymphocytic leukemia cells.

Authors: Rodriguez, Cecilia M.^1,2, Bussi, Claudio², Arroyo, Daniela S.^1,2, Sastre, Dario¹, Heller, Viviana¹, Stanganelli, Carmen³, Slavutsky, Irma⁴, Iribarren, Pablo² piribarr@fcq.unc.edu.ar

Source: Leukemia & Lymphoma. May2019, Vol. 60 Issue 5, p1299-1303. 5p.

Subject Terms: *CHRONIC lymphocytic leukemia, *BONE marrow cells, *BCL-2 proteins, *B cell receptors, *CELLS

Biomolecular condensates interacting with membranes: Wetting, remodeling, and damage stabilization

Authors: Mangiarotti, Agustín, Bussi, Claudio, Siri, Macarena, Tam, Nicky W., Malacrida, Leonel S., Gutierrez, Maximiliano G., Dimova, Rumiana

Source: In Biophysical Journal 8 February 2024 123(3) Supplement 1:310a-310a

Increased Expression of Autophagy Protein LC3 in Two Patients With Progressing Chronic Lymphocytic Leukemia.

Authors: Arroyo, Daniela S., Rodriguez, Cecilia M., Bussi, Claudio, Manzone-Rodriguez, Clarisa, Sastre, Darío, Heller, Viviana, Stanganelli, Carmen, Slavutsky, Irma, Iribarren, Pablo

Source: Frontiers in Endocrinology; 7/22/2020, Vol. 11, p1-6, 6p

Subject Terms: CHRONIC lymphocytic leukemia, PROTEIN expression, CHRONIC leukemia, LYMPHOID tissue, B cells, BONE marrow

Biocompatible Magnetic Micro‐ and Nanodevices: Fabrication of FePt Nanopropellers and Cell Transfection.

Authors: Kadiri, Vincent Mauricio, Bussi, Claudio, Holle, Andrew W., Son, Kwanghyo, Kwon, Hyunah, Schütz, Gisela, Gutierrez, Maximiliano G., Fischer, Peer

Source: Advanced Materials; 6/26/2020, Vol. 32 Issue 25, p1-9, 9p

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Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors: Aitken, Jim, Allen, Zoe, Ambler, Rachel, Ambrose, Karen, Ashton, Emma, Avola, Alida, Balakrishnan, Samutheswari, Barns-Jenkins, Caitlin, Barr, Genevieve, Barrell, Sam, Basu, Souradeep, Beale, Rupert, Beesley, Clare, Bhardwaj, Nisha, Bibi, Shahnaz, Bineva-Todd, Ganka, Biswas, Dhruva, Blackman, Michael J, Bonnet, Dominique, Bowker, Faye, Broncel, Malgorzata, Brooks, Claire, Buck, Michael D, Buckton, Andrew, Budd, Timothy, Burrell, Alana, Busby, Louise, Bussi, Claudio, Butterworth, Simon, Byrne, Fiona, Byrne, Richard, Caidan, Simon, Campbell, Joanna, Canton, Johnathan, Cardoso, Ana, Carter, Nick, Carvalho, Luiz, Carzaniga, Raffaella, Chandler, Natalie, Chen, Qu, Cherepanov, Peter, Churchward, Laura, Clark, Graham, Clayton, Bobbi, Cobolli Gigli, Clementina, Collins, Zena, Cottrell, Sally, Crawford, Margaret, Cubitt, Laura, Cullup, Tom, Davies, Heledd, Davis, Patrick, Davison, Dara, D'Avola, Annalisa, Dearing, Vicky, Debaisieux, Solene, Diaz-Romero, Monica, Dibbs, Alison, Diring, Jessica, Driscoll, Paul C, Earl, Christopher, Edwards, Amelia, Ekin, Chris, Evangelopoulos, Dimitrios, Faraway, Rupert, Fearns, Antony, Ferron, Aaron, Fidanis, Efthymios, Fitz, Dan, Fleming, James, Frederico, Bruno, Gaiba, Alessandra, Gait, Anthony, Gamblin, Steve, Gandhi, Sonia, Gaul, Liam, Golding, Helen M, Goldman, Jacki, Goldstone, Robert, Gomez Dominguez, Belen, Gong, Hui, Grant, Paul R, Greco, Maria, Grobler, Mariana, Guedan, Anabel, Gutierrez, Maximiliano G, Hackett, Fiona, Hall, Ross, Halldorsson, Steinar, Harris, Suzanne, Hashim, Sugera, Healy, Lyn, Heaney, Judith, Herbst, Susanne, Hewitt, Graeme, Higgins, Theresa, Hindmarsh, Steve, Hirani, Rajnika, Hope, Joshua, Horton, Elizabeth, Hoskins, Beth, Houlihan, Catherine F, Howell, Michael, Howitt, Louise, Hoyle, Jacqueline, Htun, Mint R, Hubank, Michael, Huerga Encabo, Hector, Hughes, Deborah, Hughes, Jane, Huseynova, Almaz, Hwang, Ming-Shih, Instrell, Rachael, Jackson, Deborah, Jamal-Hanjani, Mariam, Jenkins, Lucy, Jiang, Ming, Johnson, Mark, Jones, Leigh, Kanu, Nnennaya, Kassiotis, George, Kiely, Louise, King Spert Teixeira, Anastacio, Kirk, Stuart, Kjaer, Svend, Knuepfer, Ellen, Komarov, Nikita, Kotzampaltiris, Paul, Kousis, Konstantinos, Krylova, Tammy, Kucharska, Ania, Labrum, Robyn, Lambe, Catherine, Lappin, Michelle, Lee, Stacey-Ann, Levett, Andrew, Levett, Lisa, Levi, Marcel, Liu, Hon-Wing, Loughlin, Sam, Lu, Wei-Ting, MacRae, James I, Madoo, Akshay, Marczak, Julie A, Martensson, Mimmi, Martinez, Thomas, Marzook, Bishara, Matthews, John, Matz, Joachim M, McCall, Samuel, McCoy, Laura E, McKay, Fiona, McNamara, Edel C, Minutti, Carlos M, Mistry, Gita, Molina-Arcas, Miriam, Montaner, Beatriz, Montgomery, Kylie, Moore, Catherine, Moore, David, Moraiti, Anastasia, Moreira-Teixeira, Lucia, Mukherjee, Joyita, Naceur-Lombardelli, Cristina, Nastouli, Eleni, Nelson, Aileen, Nicod, Jerome, Nightingale, Luke, Nofal, Stephanie, Nurse, Paul, Nutan, Savita, Oedekoven, Caroline, O'Garra, Anne, O'Leary, Jean D, Olsen, Jessica, O'Neill, Olga, Ordonez Suarez, Paula, O'Reilly, Nicola, Osborne, Neil, Pabari, Amar, Pajak, Aleksandra, Papayannopoulos, Venizelos, Patel, Namita, Patel, Yogen, Paun, Oana, Peat, Nigel, Peces-Barba Castano, Laura, Perez Caballero, Ana, Perez-Lloret, Jimena, Perrault, Magali S, Perrin, Abigail, Poh, Roy, Poirier, Enzo Z, Polke, James M, Pollitt, Marc, Prieto-Godino, Lucia, Proust, Alize, Shah Punatar, Rajvee, Puvirajasinghe, Clinda, Queval, Christophe, Ramachandran, Vijaya, Ramaprasad, Abhinay, Ratcliffe, Peter, Reed, Laura, Reis e Sousa, Caetano, Richardson, Kayleigh, Ridewood, Sophie, Roberts, Rowenna, Rodgers, Angela, Romero Clavijo, Pablo, Rosa, Annachiara, Rossi, Alice, Roustan, Chloe, Rowan, Andrew, Sahai, Erik, Sait, Aaron, Sala, Katarzyna, Sanderson, Theo, Santucci, Pierre, Sardar, Fatima, Sateriale, Adam, Saunders, Jill A, Sawyer, Chelsea, Schlott, Anja, Schweighoffer, Edina, Segura-Bayona, Sandra, Shaw, Joe, Shin, Gee Yen, Silva Dos Santos, Mariana, Silvestre, Margaux, Singer, Matthew, Snell, Daniel M, Song, Ok-Ryul, Spyer, Moira J, Steel, Louisa, Strange, Amy, Sullivan, Adrienne E, Swanton, Charles, Tan, Michele SY, Tautz-Davis, Zoe H, Taylor, Effie, Taylor, Gunes, Taylor, Harriet B, Taylor-Beadling, Alison, Teixeira Subtil, Fernanda, Terré Torras, Berta, Toolan-Kerr, Patrick, Torelli, Francesca, Toteva, Tea, Treeck, Moritz, Trojer, Hadija, Tsai, Ming-Han C, Turner, James MA, Turner, Melanie, Ule, Jernej, Ulferts, Rachel, Vanloo, Sharon P, Veeriah, Selvaraju, Venkatesan, Subramanian, Vousden, Karen, Wack, Andreas, Walder, Claire, Walker, Philip A, Wang, Yiran, Ward, Sophia, Wenman, Catharina, Wiliams, Luke, Williams, Matthew J, Wong, Wai Keong, Wright, Joshua, Wu, Mary, Wynne, Lauren, Xiang, Zheng, Yap, Melvyn, Zagalak, Julian A, Zecchin, Davide, Zillwood, Rachel, Matthews, Rebecca, Severn, Abigail, Adam, Sajida, Enfield, Louise, McBride, Angela, Gärtner, Kathleen, Edwards, Sarah, Lorencatto, Fabiana, Michie, Susan, Manley, Ed, Shahmanesh, Maryam, Lukha, Hinal, Prymas, Paulina, McBain, Hazel, Shortman, Robert, Wood, Leigh, Davies, Claudia, Williams, Bethany, Ng, Kevin W, Cornish, Georgina H, Faulkner, Nikhil, Riddell, Andrew, Hobson, Philip, Agua-Doce, Ana, Bartolovic, Kerol, Russell, Emma, Carr, Lotte, Sanchez, Emilie, Frampton, Daniel, Byott, Matthew, Paraskevopoulou, Stavroula M, Crayton, Elise, Meyer, Carly, Vora, Nina, Gkouleli, Triantafylia, Stoltenberg, Andrea, Ranieri, Veronica, Byrne, Tom, Lewer, Dan, Hayward, Andrew, Gilson, Richard, Kelly, Gavin, Roberts, Fiona, Hatipoglu, Emine, Byrne, Thomas

Source: In The Lancet 25-31 July 2020 396(10246):e6-e7

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Mycobacterium tuberculosis infection of host cells in space and time.

Authors: Bussi, Claudio¹ (AUTHOR), Gutierrez, Maximiliano G¹ (AUTHOR) max.g@crick.ac.uk

Source: FEMS Microbiology Reviews. Jul2019, Vol. 43 Issue 4, p341-361. 21p. 8 Diagrams.

Subject Terms: *MYCOBACTERIUM tuberculosis, *MYCOBACTERIAL diseases, *HUMAN biology, *SPACETIME, *EUKARYOTIC cells, *TUBERCULOSIS in cattle

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