Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2

Authors: Lucotti, Serena ^{1, 2, ∗}, Ogitani, Yusuke ^{1, 2}, Kenific, Candia M. ^{1, 2}, Geri, Jacob ³, Kim, Young Hun ⁴, Gu, Jinghua ², Balaji, Uthra ², Bojmar, Linda ^{1, 2, 5}, Shaashua, Lee ^{1, 2}, Song, Yi ⁶, Cioffi, Michele ^{1, 2}, Lauritzen, Pernille ^{1, 2}, Joseph, Oveen M. ^{1, 2}, Asao, Tetsuhiko ^{1, 2, 7, 8}, Grandgenett, Paul M. ⁹, Hollingsworth, Michael A. ⁹, Peralta, Christopher ¹⁰, Pagano, Alexandra E. ¹⁰, Molina, Henrik ¹⁰, Lengel, Harry B. ⁷, Dunne, Elizabeth G. ⁷, Jing, Xiaohong ¹¹, Schmitter, Madeleine ¹¹, Borriello, Lucia ^{13, 14}, Miller, Thomas ^{1, 2}, Zhang, Haiying ^{1, 2}, Romin, Yevgeniy ⁴, Manova, Katia ⁴, Paul, Doru ¹⁵, Remmel, H. Lawrence ^{1, 2, 16, 17}, O’Reilly, Eileen M. ¹⁸, Jarnagin, William R. ⁶, Kelsen, David ¹⁸, Castellino, Sharon M. ^{19, 20}, Giulino-Roth, Lisa ²¹, Jones, David R. ⁷, Condeelis, John S. ^{22, 23, 24, 25, 26, 27}, Pascual, Virginia ^{1, 2}, Bussel, James B. ^{2, 21}, Boudreau, Nancy ^{1, 2}, Matei, Irina ^{1, 2}, Entenberg, David ^{23, 24, 25, 26, 27, 28}, Bromberg, Jacqueline F. ^{29, 30, ∗∗}, Simeone, Diane M. ^{12, 31, ∗∗∗}, Lyden, David ^{1, 2, 32, ∗∗∗∗}

Source: In Cell 20 March 2025 188(6):1642-1661

Unexpected diagnosis of WHIM syndrome in refractory autoimmune cytopenia

Authors: Garcia-Carmona, Yolanda, Chavez, Jose, Gernez, Yael, Geyer, Julia T., Bussel, James B., Cunningham-Rundles, Charlotte

Source: In Blood Advances 8 October 2024 8(19):5126-5136

A pilot feasibility trial of daily versus every other day oral iron supplementation in patients with iron deficiency anaemia

Authors: Lin, Yulia, Del Giudice, M. Elisabeth, Kron, Amie, Meirovich, Harley, Sholzberg, Michelle, Swarup, Vidushi, Huang, Mary, Distefano, Lanis, Anani, Waseem Q., Armali, Chantal, Bussel, James B., Callum, Jeannie

Source: British journal of haematology. 201(5):1000-1004

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195100109.0x000001&indx=1&recIds=ETOCvdc_100195100109.0x000001

Maintenence rituximab following induction in autoimmune cytopenias

Authors: Rai, Manoj P., Lee, Eun‐Ju, Bussel, James B.

Source: British journal of haematology. 202(1):153-158

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186093729.0x000001&indx=1&recIds=ETOCvdc_100186093729.0x000001

Overuse of corticosteroids in patients with immune thrombocytopenia (ITP) between 2011 and 2017 in the United States

Authors: Cuker, Adam, Tkacz, Joseph, Manjelievskaia, Janna, Haenig, Jens, Maier, Joan, Bussel, James B

Source: EJHaem. 4(2):350-357

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182871463.0x000001&indx=1&recIds=ETOCvdc_100182871463.0x000001

Should dexamethasone alone or in combination be the initial steroid for adult ITP: Still a relevant question

Authors: Skopec, Barbara, Bussel, James B.

Source: British journal of haematology. 200(1):15-22

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182461617.0x000001&indx=1&recIds=ETOCvdc_100182461617.0x000001

Romiplostim use in pregnant women with immune thrombocytopenia

Authors: Bussel, James B., Cooper, Nichola, Lawrence, Tatiana, Michel, Marc, Vander Haar, Emilie, Wang, Kejia, Wang, Hongmei, Saad, Hossam

Source: American journal of hematology. 98(1):31-40

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169845422.0x000001&indx=1&recIds=ETOCvdc_100169845422.0x000001

Efficacy and safety of the neonatal Fc receptor inhibitor efgartigimod in adults with primary immune thrombocytopenia (ADVANCE IV): a multicentre, randomised, placebo-controlled, phase 3 trial

Authors: Fillitz, Michael, Knoebl, Paul, Meers, Stef, Amine, Ismail Mohamad, Gumulec, Jaromir, Hlusi, Antonin, Mayer, Jiri, Quittet, Philippe, Viallard, Jean-Francois, Betaneli, Magdana, Datikashvili-David, Irine, Iosava, Genadi, Makhaldiani, Levan, Rejto, Laszlo, Sharashenidze, Nino, Groepper, Stefanie, Röth, Alexander, Hamed, Aryan, Illes, Arpad, Carpenedo, Monica, Artoni, Andrea, Bocchia, Monica, Gamberi, Barbara, Borchiellini, Alessandra, Oliva, Esther Natalie, Patriarca, Andrea, Tomassetti, Simona, Miyakawa, Yoshitaka, Ando, Kiyoshi, Handa, Hiroshi, Katsutani, Shinya, Nishiwaki, Kaichi, Ito, Shoko, Ito, Tomoki, de Boer, Fransien, Jansen, A.J. Gerard, Ciepluch, Hanna, Fornagiel, Szymon, Grosicki, Sebastian, Soroka-Wojtaszko, Maria, Trelinski, Jacek, Bakirov, Bulat, Borisenkova, Elena, Volodicheva, Elena, Shatokhin, Yuri, Proydakov, Andrey, Alonso, Maria Aranzazu, Mingot-Castellano, María Eva, Sanchez-Gonzalez, Blanca, Valcarcel Ferreiras, David, Ayli, Meltem, Hacibekiroglu, Tuba, Demir, Ahmet Muzaffer, Nalçaci, Meliha, Sonmez, Mehmet, Tombak, Anil, Toprak, Selami Kocak, Turgut, Burhan, Vural, Filiz, Yagci, Munci, Altuntas, Fevzi, Turgut, Mehmet, Kaya, Emin, Romanyuk, Nataliya, McDonald, Vickie, Kazmi, Syed Rashid Saeed, Broome, Catherine, Cataland, Spero, Doshi, Ketan, Lentz, Steven R., Boxer, Michael, Rosenberg, Richard, Broome, Catherine M ^*, Kuter, David J, Al-Samkari, Hanny, Bussel, James B, Godar, Marie, Ayguasanosa, Jaume, De Beuf, Kristof, Rodeghiero, Francesco, Michel, Marc, Newland, Adrian

Source: In The Lancet 4-10 November 2023 402(10413):1648-1659

The role of CD8+ T-cell clones in immune thrombocytopenia

Authors: Malik, Amna, Sayed, Anwar A., Han, Panpan, Tan, Michelle M. H., Watt, Eleanor, Constantinescu-Bercu, Adela, Cocker, Alexander T. H., Khoder, Ahmad, Saputil, Rocel C., Thorley, Emma, Teklemichael, Ariam, Ding, Yunchuan, Hart, Alice C. J., Zhang, Haiyu, Mitchell, Wayne A., Imami, Nesrina, Crawley, James T. B., Salles-Crawley, Isabelle I., Bussel, James B., Zehnder, James L., Adams, Stuart, Zhang, Bing M., Cooper, Nichola

Source: In Blood 18 May 2023 141(20):2417-2429

Longitudinal study of 2 patients with cyclic thrombocytopenia, STAT3 and MPL mutations

Authors: Zhang, Haiyu, Chien, May, Hou, Yu, Shomali, William, Brar, Rondeep S., Ho, Chandler, Han, Panpan, Xu, Danfei, Zhang, Bing M., Guo, Xiangqian, Tolentino, Lorna L., Wu, Nancy C., Tsai, Albert G., Jin, Jing, Witteles, Wesley H., Chen, Zhenping, Abidi, Parveen, Jangam, Diwash, Krieger, Madison S., Craig, Morgan, Bussel, James B., Gotlib, Jason R., Zehnder, James L. ^∗

Source: In Blood Advances 10 January 2023 7(1):190-194

The role of genetics in refractory immune thrombocytopenia

Authors: Zehnder, James L., Bussel, James B., Cooper, Nichola

Source: British journal of haematology. 203(1):62-64

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195599016.0x000001&indx=1&recIds=ETOCvdc_100195599016.0x000001

Plasma gastric biomarker evaluation with avatrombopag dosing in patients with chronic immune thrombocytopenia in phase 3 trials

Authors: Bussel, James B., Tarantino, Michael D., Lee, Eun‐Ju, Jamieson, Brian D.

Source: British journal of haematology. 202(4):890-892

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191749743.0x000001&indx=1&recIds=ETOCvdc_100191749743.0x000001

Common‐sense combination therapy in refractory immune thrombocytopaenia

Authors: Al‐Samkari, Hanny, Bussel, James B.

Source: British journal of haematology. 202(4):728-730

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191749805.0x000001&indx=1&recIds=ETOCvdc_100191749805.0x000001

A phase 3, randomized, double‐blind, active‐controlled trial evaluating efficacy and safety of avatrombopag versus eltrombopag in ITP

Authors: Tarantino, Michael D., Bussel, James B., Lee, Eun‐Ju, Jamieson, Brian D.

Source: British journal of haematology. 202(4):897-899

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191749764.0x000001&indx=1&recIds=ETOCvdc_100191749764.0x000001

Treatment of immune thrombocytopenia with eltrombopag in patients who had and who had not received prior rituximab: post‐hoc analysis of the EXTEND study

Authors: Meyer, Oliver, Wong, Raymond S. M., Khelif, Abderrahim, Stankovic, Miona, Maier, Joan, Saleh, Mansoor N., Bussel, James B.

Source: British journal of haematology. 196(2):448-452

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138896745.0x000001&indx=1&recIds=ETOCvdc_100138896745.0x000001

SARS-CoV-2 vaccination and ITP in patients with de novo or preexisting ITP

Authors: Lee, Eun-Ju, Beltrami-Moreira, Marina, Al-Samkari, Hanny, Cuker, Adam, DiRaimo, Jennifer, Gernsheimer, Terry, Kruse, Alexandra, Kessler, Craig, Kruse, Caroline, Leavitt, Andrew D., Lee, Alfred I., Liebman, Howard A., Newland, Adrian C., Ray, Ashley E., Tarantino, Michael D., Thachil, Jecko, Kuter, David J., Cines, Douglas B., Bussel, James B.

Source: Blood. 139(10):1564-1574

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183246548.0x000001&indx=1&recIds=ETOCvdc_100183246548.0x000001

Inhibition of FcRn with rozanolixizumab in adults with immune thrombocytopenia: Two randomised, double‐blind, placebo‐controlled phase 3 studies and their open‐label extension.

Authors: Cooper, Nichola¹ (AUTHOR) n.cooper@imperial.ac.uk, Bussel, James B.² (AUTHOR), Kaźmierczak, Maciej³ (AUTHOR), Miyakawa, Yoshitaka⁴ (AUTHOR), Cluck, Sarah⁵ (AUTHOR), Lledó García, Rocío⁵ (AUTHOR), Haier, Birgit⁶ (AUTHOR), Lavrov, Andreea⁶ (AUTHOR), Singh, Puneet⁵ (AUTHOR), Snipes, Rose⁷ (AUTHOR), Kuter, David J.⁸ (AUTHOR)

Source: British Journal of Haematology. Feb2025, Vol. 206 Issue 2, p675-688. 14p.

Subject Terms: *IDIOPATHIC thrombocytopenic purpura, *MONOCLONAL antibodies, *CLINICAL trials, *BLOOD platelet activation, *FC receptors, *PATIENT safety

Complement activation negatively affects the platelet response to thrombopoietin receptor agonists in patients with immune thrombocytopenia: a prospective cohort study.

Authors: Åkesson, Alexander¹ alexander.akesson@med.lu.se, Bussel, James B.², Martin, Myriam¹, Blom, Anna M.¹, Klintman, Jenny¹, Ghanima, Waleed³, Zetterberg, Eva¹, Garabet, Lamya^3,4

Source: Platelets. Dec2023, Vol. 34 Issue 1, p1-9. 9p.

Subject Terms: *THROMBOPOIETIN receptor agonists, *IDIOPATHIC thrombocytopenic purpura, *COMPLEMENT activation, *BLOOD platelets, *PLATELET count

New developments in fetal and neonatal alloimmune thrombocytopenia

Authors: Bussel, James B., Vander Haar, Emilie L., Berkowitz, Richard L.

Source: In American Journal of Obstetrics and Gynecology August 2021 225(2):120-127

Clinical outcomes in eight patients with immune thrombocytopenia each treated with the three approved thrombopoietin receptor agonists

Authors: Lee, Eun‐Ju, Seshadri, Madhav, Bussel, James B.

Source: American journal of hematology. 96(10):E373-E376

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140901257.0x000001&indx=1&recIds=ETOCvdc_100140901257.0x000001