Plasma protein signatures reflect systemic immunity and allograft function in kidney transplantation

Authors: Buscher, Konrad, Rixen, Rebecca, Schütz, Paula, Hüchtmann, Birte, Van Marck, Veerle, Heitplatz, Barbara, Jehn, Ulrich, Braun, Daniela A., Gabriëls, Gert, Pavenstädt, Hermann, Reuter, Stefan

Source: In Translational Research December 2023 262:35-43

Data-Driven Kidney Transplant Phenotyping as a Histology-Independent Framework for Biomarker Discovery

Authors: Buscher, Konrad [and others]

Source: Journal of the American Society of Nephrology. 32(8):1933-1945

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190475472.0x000001&indx=1&recIds=ETOCvdc_100190475472.0x000001

Cross-species single-cell RNA sequencing reveals divergent phenotypes and activation states of adaptive immunity in human carotid and experimental murine atherosclerosis.

Authors: Horstmann, Hauke, Michel, Nathaly Anto, Sheng, Xia, Hansen, Sophie, Lindau, Alexandra, Pfeil, Katharina, Fernández, Marbely C, Marchini, Timoteo, Winkels, Holger, Mitre, Lucia Sol, Abogunloko, Tijani, Li, Xiaowei, Mwinyella, Timothy Bon-Nawul, Gissler, Mark Colin, Bugger, Heiko, Heidt, Timo, Buscher, Konrad, Hilgendorf, Ingo, Stachon, Peter, Piepenburg, Sven

Source: Cardiovascular Research; Oct2024, Vol. 120 Issue 14, p1713-1726, 14p

Subject Terms: ATHEROSCLEROTIC plaque, CAROTID endarterectomy, GENETIC models, IMMUNOLOGIC memory, RNA sequencing

Symmetric dimethylarginine in dysfunctional high-density lipoprotein mediates endothelial glycocalyx breakdown in chronic kidney disease

Authors: Hesse, Bettina, Rovas, Alexandros, Buscher, Konrad, Kusche-Vihrog, Kristina, Brand, Marcus, Di Marco, Giovana Seno, Kielstein, Jan T., Pavenstädt, Hermann, Linke, Wolfgang A., Nofer, Jerzy-Roch, Kümpers, Philipp, Lukasz, Alexander

Source: In Kidney International March 2020 97(3):502-515

Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B100–Reactive CD4+ T-Regulatory Cells

Authors: Wolf, Dennis, Gerhardt, Teresa, Winkels, Holger, Michel, Nathaly Anto, Pramod, Akula Bala, Ghosheh, Yanal, Brunel, Simon, Buscher, Konrad, Miller, Jacqueline, McArdle, Sara, Baas, Livia, Kobiyama, Kouji, Vassallo, Melanie, Ehinger, Erik, Dileepan, Thamotharampillai, Ali, Amal, Schell, Maximilian, Mikulski, Zbigniew, Sidler, Daniel, Kimura, Takayuki, Sheng, Xia, Horstmann, Hauke, Hansen, Sophie, Mitre, Lucia Sol, Stachon, Peter, Hilgendorf, Ingo, Gaddis, Dalia E., Hedrick, Catherine, Benedict, Chris A., Peters, Bjoern, Zirlik, Andreas, Sette, Alessandro, Ley, Klaus

Source: Circulation. 142(13):1279-1293

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150444307.0x000001&indx=1&recIds=ETOCvdc_100150444307.0x000001

Classical monocyte transcriptomes reveal significant anti-inflammatory statin effect in women with chronic HIV

Authors: Ehinger, Erik, Ghosheh, Yanal, Pramod, Akula Bala, Lin, Juan, Hanna, David B, Mueller, Karin, Durant, Christopher P, Baas, Livia, Qi, Qibin, Wang, Tao, Buscher, Konrad, Anastos, Kathryn, Lazar, Jason M, Mack, Wendy J, Tien, Phyllis C, Cohen, Mardge H, Ofotokun, Igho, Gange, Stephen, Heath, Sonya L, Hodis, Howard N, Tracy, Russell P, Landay, Alan L, Kaplan, Robert C, Ley, Klaus

Source: Cardiovascular research. 117(4):1166-1177

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130867684.0x000001&indx=1&recIds=ETOCvdc_100130867684.0x000001

Unveiling systemic responses in kidney transplantation: interplay between the allograft transcriptome and serum proteins.

Authors: Buscher, Konrad, Rixen, Rebecca, Schütz, Paula, Van Marck, Veerle, Heitplatz, Barbara, Gabriels, Gert, Jehn, Ulrich, Braun, Daniela Anne, Pavenstädt, Hermann, Reuter, Stefan

Source: Frontiers in Immunology; 2024, p1-9, 9p

Subject Terms: BLOOD proteins, GENE regulatory networks, KIDNEY transplantation, SYSTEMS biology, GENE expression

Migratory and Dancing Macrophage Subsets in Atherosclerotic Lesions

Authors: McArdle, Sara, Buscher, Konrad, Ghosheh, Yanal, Pramod, Akula Bala, Miller, Jacqueline, Winkels, Holger, Wolf, Dennis, Ley, Klaus

Source: Circulation research. 125(12):1038-1051

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100093825439.0x000001&indx=1&recIds=ETOCvdc_100093825439.0x000001

Inflammatory Pathways Regulated by Tumor Necrosis Receptor–Associated Factor 1 Protect From Metabolic Consequences in Diet-Induced Obesity

Authors: Anto Michel, Nathaly, Colberg, Christian, Buscher, Konrad, Sommer, Björn, Pramod, Akula Bala, Ehinger, Erik, Dufner, Bianca, Hoppe, Natalie, Pfeiffer, Katharina, Marchini, Timoteo, Willecke, Florian, Stachon, Peter, Hilgendorf, Ingo, Heidt, Timo, von zur Muhlen, Constantin, von Elverfeldt, Dominik, Pfeifer, Dietmar, Schüle, Roland, Kintscher, Ulrich, Brachs, Sebastian, Ley, Klaus, Bode, Christoph, Zirlik, Andreas, Wolf, Dennis

Source: Circulation research. 122(5):693-700

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100055622026.0x000001&indx=1&recIds=ETOCvdc_100055622026.0x000001

A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense

Authors: Wolf, Dennis, Anto-Michel, Nathaly, Blankenbach, Hermann, Wiedemann, Ansgar, Buscher, Konrad, Hohmann, Jan, Lim, Bock, Bäuml, Marina, Marki, Alex, Mauler, Maximilian, Duerschmied, Daniel, Fan, Zhichao, Winkels, Holger, Sidler, Daniel, Diehl, Philipp, Zajonc, Dirk, Hilgendorf, Ingo, Stachon, Peter, Marchini, Timoteo, Willecke, Florian, Schell, Maximilian, Sommer, Björn, von zur Muhlen, Constantin, Reinöhl, Jochen, Gerhardt, Teresa, Plow, Edward, Yakubenko, Valentin, Libby, Peter, Bode, Christoph, Ley, Klaus, Peter, Karlheinz, Zirlik, Andreas

Source: Nature communications. 9(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112260474.0x000001&indx=1&recIds=ETOCvdc_100112260474.0x000001

Rolling neutrophils form tethers and slings under physiologic conditions in vivo

Authors: Marki, Alex, Buscher, Konrad, Mikulski, Zbigniew, Pries, Axel, Ley, Klaus

Source: Journal of leukocyte biology. 103(1):67-70

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083213107.0x000001&indx=1&recIds=ETOCvdc_100083213107.0x000001

Structural requirements of mono- and multivalent L-selectin blocking aptamers for enhanced receptor inhibition in vitro and in vivo

Authors: Riese, Sebastian B., Buscher, Konrad, Enders, Sven, Kuehne, Christian, Tauber, Rudolf, Dernedde, Jens

Source: In Nanomedicine: Nanotechnology, Biology, and Medicine May 2016 12(4):901-908

Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration

Authors: Song, Jian, Zhang, Xueli, Buscher, Konrad, Wang, Ying, Wang, Huiyu, Di Russo, Jacopo, Li, Lixia, Lütke-Enking, Stefan, Zarbock, Alexander, Stadtmann, Anika, Striewski, Paul, Wirth, Benedikt, Kuzmanov, Ivan, Wiendl, Heinz, Schulte, Dörte, Vestweber, Dietmar, Sorokin, Lydia

Source: Cell reports. 18(5):1256-1269

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100062383351.0x000001&indx=1&recIds=ETOCvdc_100062383351.0x000001

Endothelial Protective Monocyte Patrolling in Large Arteries Intensified by Western Diet and Atherosclerosis

Authors: Quintar, Amado, McArdle, Sara, Wolf, Dennis, Marki, Alex, Ehinger, Erik, Vassallo, Melanie, Miller, Jacqueline, Mikulski, Zbigniew, Ley, Klaus, Buscher, Konrad

Source: Circulation research. 120(11):1789-1799

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100049615392.0x000001&indx=1&recIds=ETOCvdc_100049615392.0x000001

l-Selectin – A dynamic regulator of leukocyte migration

Authors: Wedepohl, Stefanie, Beceren-Braun, Figen, Riese, Sebastian, Buscher, Konrad, Enders, Sven, Bernhard, Gesche, Kilian, Karin, Blanchard, Véronique, Dernedde, Jens, Tauber, Rudolf

Source: In European Journal of Cell Biology April 2012 91(4):257-264

Microvillus positioning of L-selectin and CD44 and its impact on leukocyte adhesion

Authors: Buscher, Konrad-Robert

Availability: http://data.europeana.eu/aggregation/europeana/2048441/item_TMFPCL4MYGJVKILVYQQHUXXOV7P2CYSX

WED-126 Biglycan as a biomarker in acute-on-chronic liver failure (ACLF)

Authors: Schulz, Martin, Roth, Esther, Zeng-Brouwers, Jinyang, Buscher, Konrad, Schierwagen, Robert, Joseph Brol, Maximilian, Erhard Uschner, Frank, Klein, Sabine, Zeuzem, Stefan, Peiffer, Kai-Henrik, Trebicka, Jonel, Schaefer, Liliana

Source: In Journal of Hepatology June 2024 80 Supplement 1:S198-S199

THU-083 Acute kidney injury (AKI) severity in critically-ill patients with decompensated liver cirrhosis and acute-on-chronic liver failure (ACLF)

Authors: Schulz, Martin, Wolters, Lena, Jurr, Helen, Gu, Wenyi, Brol, Maximilian Joseph, Uschner, Frank Erhard, Tischendorf, Michael, Buscher, Konrad, Zarbock, Alexander, Schierwagen, Robert, Klein, Sabine, Zeuzem, Stefan, Peiffer, Kai-Henrik, Trebicka, Jonel

Source: In Journal of Hepatology June 2024 80 Supplement 1:S169-S170

The Transmembrane Domains of L-selectin and CD44 Regulate Receptor Cell Surface Positioning and Leukocyte Adhesion under Flow

Authors: Buscher, Konrad, Riese, Sebastian B., Shakibaei, Mehdi, Reich, Christian, Dernedde, Jens, Tauber, Rudolf, Ley, Klaus

Source: In Journal of Biological Chemistry 30 April 2010 285(18):13490-13497

Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE study.

Authors: Rovas, Alexandros, Buscher, Konrad, Osiaevi, Irina, Drost, Carolin Christina, Sackarnd, Jan, Tepasse, Phil-Robin, Fobker, Manfred, Kühn, Joachim, Braune, Stephan, Göbel, Ulrich, Thölking, Gerold, Gröschel, Andreas, Rossaint, Jan, Vink, Hans, Lukasz, Alexander, Pavenstädt, Hermann, Kümpers, Philipp

Source: Angiogenesis; Nov2022, Vol. 25 Issue 4, p503-515, 13p

Subject Terms: SEPSIS, COVID-19, PROTEOMICS, BLOOD proteins, BIOMARKERS