Anti–Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct–Ligated Mice

Authors: Gee, Lucy M.V., Barron-Millar, Ben, Leslie, Jack, Richardson, Claire, Zaki, Marco Y.W., Luli, Saimir, Burgoyne, Rachel A., Cameron, Rainie I.T., Smith, Graham R., Brain, John G., Innes, Barbara, Jopson, Laura, Dyson, Jessica K., McKay, Katherine R.C., Pechlivanis, Alexandros, Holmes, Elaine, Berlinguer-Palmini, Rolando, Victorelli, Stella, Mells, George F., Sandford, Richard N., Palmer, Jeremy, Kirby, John A., Kiourtis, Christos, Mokochinski, Joao, Hall, Zoe, Bird, Thomas G., Borthwick, Lee A., Morris, Christopher M., Hanson, Peter S., Jurk, Diana, Stoll, Elizabeth A., LeBeau, Fiona E.N., Jones, David E.J., Oakley, Fiona

Source: American journal of pathology. 193(1):11-26

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Pharmacological characterisation of GSK3335103, an oral αvβ6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic disease

Authors: Wilkinson, Alex L., John, Alison E., Barrett, John W., Gower, E., Morrison, Valerie S., Man, Yim, Pun, K. Tao, Roper, James A., Luckett, Jeni C., Borthwick, Lee A., Barksby, Ben S., Burgoyne, Rachel A., Barnes, Rory, Fisher, Andrew J., Procopiou, Panayiotis A., Hatley, Richard J.D., Barrett, Tim N., Marshall, Richard P., Macdonald, Simon J.F., Jenkins, R. Gisli, Slack, Robert J.

Source: In European Journal of Pharmacology 15 December 2021 913

A Mammalian Target of Rapamycin‐Perilipin 3 (mTORC1‐Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis

Authors: Garcia‐Macia, Marina, Santos‐Ledo, Adrián, Leslie, Jack, Paish, Hannah L., Collins, Amy L., Scott, Rebecca S., Watson, Abigail, Burgoyne, Rachel A., White, Steve, French, Jeremy, Hammond, John, Borthwick, Lee A., Mann, Jelena, Bolaños, Juan P., Korolchuk, Viktor I., Oakley, Fiona, Mann, Derek A.

Source: Hepatology. 74(6):3441-3459

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C-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis

Authors: Leslie, Jack, Macia, Marina García, Luli, Saimir, Worrell, Julie C., Reilly, William J., Paish, Hannah L., Knox, Amber, Barksby, Ben S., Gee, Lucy M., Zaki, Marco Y. W., Collins, Amy L., Burgoyne, Rachel A., Cameron, Rainie, Bragg, Charlotte, Xu, Xin, Chung, Git W., Brown, Colin D. A., Blanchard, Andrew D., Nanthakumar, Carmel B., Karsdal, Morten, Robinson, Stuart M., Manas, Derek M., Sen, Gourab, French, Jeremy, White, Steven A., Murphy, Sandra, Trost, Matthias, Zakrzewski, Johannes L., Klein, Ulf, Schwabe, Robert F., Mederacke, Ingmar, Nixon, Colin, Bird, Tom, Teuwen, Laure-Anne, Schoonjans, Luc, Carmeliet, Peter, Mann, Jelena, Fisher, Andrew J., Sheerin, Neil S., Borthwick, Lee A., Mann, Derek A., Oakley, Fiona

Source: Nature metabolism. 2(11):1350-1367

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Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

Authors: John, Alison E., Graves, Rebecca H., Pun, K. Tao, Vitulli, Giovanni, Forty, Ellen J., Mercer, Paul F., Morrell, Josie L., Barrett, John W., Rogers, Rebecca F., Hafeji, Maryam, Bibby, Lloyd I., Gower, Elaine, Morrison, Valerie S., Man, Yim, Roper, James A., Luckett, Jeni C., Borthwick, Lee A., Barksby, Ben S., Burgoyne, Rachel A., Barnes, Rory, Le, Joelle, Flint, David J., Pyne, Susan, Habgood, Anthony, Organ, Louise A., Joseph, Chitra, Edwards-Pritchard, Rochelle C., Maher, Toby M., Fisher, Andrew J., Gudmann, Natasja Stæhr, Leeming, Diana J., Chambers, Rachel C., Lukey, Pauline T., Marshall, Richard P., Macdonald, Simon J. F., Jenkins, R. Gisli, Slack, Robert J.

Source: Nature communications. 11(1)

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Author Correction: c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis

Authors: Leslie, Jack, Macia, Marina García, Luli, Saimir, Worrell, Julie C., Reilly, William J., Paish, Hannah L., Knox, Amber, Barksby, Ben S., Gee, Lucy M., Zaki, Marco Y. W., Collins, Amy L., Burgoyne, Rachel A., Cameron, Rainie, Bragg, Charlotte, Xu, Xin, Chung, Git W., Brown, Colin D. A., Blanchard, Andrew D., Nanthakumar, Carmel B., Karsdal, Morten, Robinson, Stuart M., Manas, Derek M., Sen, Gourab, French, Jeremy, White, Steven A., Murphy, Sandra, Trost, Matthias, Zakrzewski, Johannes L., Klein, Ulf, Schwabe, Robert F., Mederacke, Ingmar, Nixon, Colin, Bird, Tom, Teuwen, Laure-Anne, Schoonjans, Luc, Carmeliet, Peter, Mann, Jelena, Fisher, Andrew J., Sheerin, Neil S., Borthwick, Lee A., Mann, Derek A., Oakley, Fiona

Source: Nature metabolism. 3(1):118-119

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Obeticholic acid but not bezafibrate treatment improves cholestasis-induced cognitive decline

Authors: Gee, Lucy, Burgoyne, Rachel, Lebeau, Fiona, Jones, David, Oakley, Fiona

Source: Journal of hepatology. 73(S1):S198-S198

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THU118 - Obeticholic acid but not bezafibrate treatment improves cholestasis-induced cognitive decline

Authors: Gee, Lucy, Burgoyne, Rachel, Lebeau, Fiona, Jones, David, Oakley, Fiona

Source: In Journal of Hepatology August 2020 73 Supplement 1:S198-S198

The Role of the Interleukin 1 Family in Lung Disease

Authors: Reilly, William J., Burgoyne, Rachel A., Borthwick, Lee A.

Source: In Reference Module in Biomedical Research 2015

The Role of Epithelial Damage in the Pulmonary Immune Response.

Authors: Burgoyne, Rachel Ann¹ (AUTHOR) Rachel.Burgoyne@newcastle.ac.uk, Fisher, Andrew John^2,3 (AUTHOR) A.J.Fisher@newcastle.ac.uk, Borthwick, Lee Anthony^1,4 (AUTHOR) Lee.Borthwick@newcastle.ac.uk

Source: Cells (2073-4409). Oct2021, Vol. 10 Issue 10, p2763-2763. 1p.

Subject Terms: *WOUND healing, *OBSTRUCTIVE lung diseases, *IDIOPATHIC pulmonary fibrosis, *IMMUNE response, *COVID-19, *CELLULAR aging, *LUNGS