Spesolimab Reduces Inflammation in Generalized Pustular Psoriasis: Molecular Characterization of Flare Treatment in EFFISAYIL 1

Authors: Farag, Ahmed ¹, Visvanathan, Sudha ^{2, ∗}, Bachelez, Hervé ^{3, 4}, Morita, Akimichi ⁵, Lebwohl, Mark G. ⁶, Barker, Jonathan N. ⁷, Choon, Siew Eng ⁸, Burden, A. David ⁹, Tsai, Tsen-Fang ¹⁰, Leparc, Germán ¹, Delic, Denis ¹, Lang, Benjamin ¹, Thoma, Christian ¹, Krueger, James G. ¹¹

Source: In Journal of Investigative Dermatology March 2025 145(3):573-582

A genome-wide meta-analysis of palmoplantar pustulosis implicates TH2 responses and cigarette smoking in disease pathogenesis

Authors: Abraham, Thamir, Ali, Muhmad, August, Suzannah, Baudry, David, Becher, Gabrielle, Bewley, Anthony, Brown, Victoria, Cornelius, Victoria, Ghaffar, Sharizan, Ingram, John, Kavakleiva, Svetlana, Kelly, Susan, Khorshid, Mohsen, Lachmann, Helen, Ladoyanni, Effie, McAteer, Helen, McKenna, John, Meynell, Freya, Patel, Prakash, Pink, Andrew, Powell, Kingsley, Pushparajah, Angela, Sinclair, Catriona, Wachsmuth, Rachel, Hernandez-Cordero, Ariana, Thomas, Laurent, Smail, Alice, Lim, Zhao Qin, Saklatvala, Jake R., Chung, Raymond, Curtis, Charles J., Baum, Patrick, Visvanathan, Sudha, Burden, A. David, Cooper, Hywel L., Dunnill, Giles, Griffiths, Christopher E.M., Levell, Nick J., Parslew, Richard, Reynolds, Nick J., Wahie, Shyamal, Warren, Richard B., Wright, Andrew, Simpson, Michael, Hveem, Kristian, Barker, Jonathan N., Dand, Nick, Løset, Mari, Smith, Catherine H., Capon, Francesca

Source: In The Journal of Allergy and Clinical Immunology September 2024 154(3):657-665

Psychometric validation of the generalized pustular psoriasis physician global assessment (GPPGA) and generalized pustular psoriasis area and severity index (GPPASI)

Authors: Burden, A. David, Bissonnette, Robert, Lebwohl, Mark G., Gloede, Tristan, Anatchkova, Milena, Budhiarso, Ismail, Hu, Na, Thoma, Christian, Skalicky, Anne M., Bachelez, Hervé

Source: Journal of the European Academy of Dermatology and Venereology. 37(7):1327-1335

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Spesolimab, an interleukin-36 receptor monoclonal antibody, for the treatment of generalized pustular psoriasis

Authors: Burden, A David

Source: Expert review of clinical immunology. 19(5):473-481

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190149770.0x000001&indx=1&recIds=ETOCvdc_100190149770.0x000001

Clinical Characteristics and Outcomes of Generalized Pustular Psoriasis Flares

Authors: Choon, Siew Eng, Lebwohl, Mark G, Turki, Hamida, Zheng, Min, Burden, A. David, Li, Ling, Quaresma, Manuel, Thoma, Christian, Bachelez, Hervé

Source: Dermatology. 239(3):345-354

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Efficacy and safety of subcutaneous spesolimab for the prevention of generalised pustular psoriasis flares (Effisayil 2): an international, multicentre, randomised, placebo-controlled trial

Authors: Morita, Akimichi ^a, Strober, Bruce ^{b, c}, Burden, A David ^d, Choon, Siew Eng ^e, Anadkat, Milan J ^f, Marrakchi, Slaheddine ^g, Tsai, Tsen-Fang ^h, Gordon, Kenneth B ⁱ, Thaçi, Diamant ^j, Zheng, Min ^k, Hu, Na ^l, Haeufel, Thomas ^m, Thoma, Christian ⁿ, Lebwohl, Mark G ^{o, *}

Source: In The Lancet 28 October-3 November 2023 402(10412):1541-1551

Single-cell analysis implicates TH17-to-TH2 cell plasticity in the pathogenesis of palmoplantar pustulosis

Authors: McCluskey, Daniel, Benzian-Olsson, Natashia, Mahil, Satveer K., Hassi, Niina Karoliina, Wohnhaas, Christian T., Burden, A. David, Griffiths, Christopher E.M., Ingram, John R., Levell, Nick J., Parslew, Richard, Pink, Andrew E., Reynolds, Nick J., Warren, Richard B., Visvanathan, Sudha, Baum, Patrick, Barker, Jonathan N., Smith, Catherine H., Capon, Francesca

Source: In The Journal of Allergy and Clinical Immunology October 2022 150(4):882-893

Generalized pustular psoriasis is a disease distinct from psoriasis vulgaris: evidence and expert opinion

Authors: Bachelez, Hervé, Barker, Jonathan, Burden, A. David, Navarini, Alexander A., Krueger, James G.

Source: Expert review of clinical immunology. 18(10):1033-1047

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161574752.0x000001&indx=1&recIds=ETOCvdc_100161574752.0x000001

Quantitative Evaluation of Biologic Therapy Options for Psoriasis: A Systematic Review and Network Meta-Analysis–Correction

Authors: Smith, Catherine H., Mahil, Satveer K., Yiu, Zenas Z.N., Bale, Tracy, Burden, A. David, Coates, Laura C., McGuire, Arlene, Murphy, Ruth, Owen, Caroline M., Parslew, Richard, Uthman, Olalekan A., Woolf, Richard T., Manounah, Lina, Ezejimofor, Martinsixtus C., Exton, Lesley S., Mohd Mustapa, M. Firouz

Source: Journal of investigative dermatology. 141(1):177-181

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133537142.0x000001&indx=1&recIds=ETOCvdc_100133537142.0x000001

Clinical Impact of Antibodies against Ustekinumab in Psoriasis: An Observational, Cross-Sectional, Multicenter Study

Authors: Barker, Jonathan, Benham, Marilyn, Burden, David, Evans, Ian, Griffiths, Christopher, Hussain, Sagair, Kirby, Brian, Lawson, Linda, Mason, Kayleigh, McElhone, Kathleen, Murphy, Ruth, Ormerod, Anthony, Owen, Caroline, Reynolds, Nick, Smith, Catherine, Warren, Richard, Barker, Jonathan N.W.N., Barnes, Michael R., Burden, A. David, DiMeglio, Paola, Emsley, Richard, Evans, Andrea, Griffiths, Christopher E.M., Payne, Katherine, Reynolds, Nick J., Smith, Catherine H., Stocken, Deborah, Warren, Richard B., Loeff, Floris C., Tsakok, Teresa, Dijk, Lisanne, Hart, Margreet H., Duckworth, Michael, Baudry, David, Russell, Alice, Dand, Nick, van Leeuwen, Astrid, de Vries, Annick, Bloem, Karien, Wolbink, Gerrit Jan, Rispens, Theo

Source: In Journal of Investigative Dermatology November 2020 140(11):2129-2137

IL-36 Promotes Systemic IFN-I Responses in Severe Forms of Psoriasis

Authors: Catapano, Marika, Vergnano, Marta, Romano, Marco, Mahil, Satveer K., Choon, Siew-Eng, Burden, A. David, Young, Helen S., Carr, Ian M., Lachmann, Helen J., Lombardi, Giovanna, Smith, Catherine H., Ciccarelli, Francesca D., Barker, Jonathan N., Capon, Francesca

Source: In Journal of Investigative Dermatology April 2020 140(4):816-826

Damaging Alleles Affecting Multiple CARD14 Domains Are Associated with Palmoplantar Pustulosis

Authors: Niaouris, Athanasios, Hernández-Cordero, Ariana, Haddad, Salma, Hassi, Niina Karoliina, Benzian-Olsson, Natashia, Bugarin Diz, Carmen, Burden, A. David, Cooper, Hywel L., Griffiths, Christopher E.M., Parslew, Richard, Pink, Andrew E., Reynolds, Nick J., Wahie, Shyamal, Warren, Richard B., Wright, Andrew, Simpson, Michael, Baum, Patrick, Visvanathan, Sudha, Barker, Jonathan N., Smith, Catherine H., Capon, Francesca

Source: Journal of investigative dermatology. 143(3):504-508.e5

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HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis

Authors: Benham, Marilyn, Hussain, Sagair, Kirby, Brian, Lawson, Linda, McElhone, Kathleen, Ormerod, Anthony, Owen, Caroline, Barnes, Michael R., Di Meglio, Paola, Emsley, Richard, Evans, Andrea, Payne, Katherine, Stocken, Deborah, Dand, Nick, Duckworth, Michael, Baudry, David, Russell, Alice, Curtis, Charles J., Lee, Sang Hyuck, Evans, Ian, Mason, Kayleigh J., Alsharqi, Ali, Becher, Gabrielle, Burden, A. David, Goodwin, Richard G., McKenna, Kevin, Murphy, Ruth, Perera, Gayathri K., Rotarescu, Radu, Wahie, Shyamal, Wright, Andrew, Reynolds, Nick J., Warren, Richard B., Griffiths, Christopher E.M., Smith, Catherine H. ^∗, Simpson, Michael A. ^∗, Barker, Jonathan N. ^∗

Source: In The Journal of Allergy and Clinical Immunology June 2019 143(6):2120-2130

Secukinumab for moderate-to-severe palmoplantar pustular psoriasis: Results of the 2PRECISE study

Authors: Mrowietz, Ulrich, Bachelez, Hervé, Burden, A. David, Rissler, Michael, Sieder, Christian, Orsenigo, Roberto, Chaouche-Teyara, Kamel

Source: In Journal of the American Academy of Dermatology May 2019 80(5):1344-1352

Loss-of-Function Myeloperoxidase Mutations Are Associated with Increased Neutrophil Counts and Pustular Skin Disease

Authors: Vergnano, Marta, Mockenhaupt, Maja, Benzian-Olsson, Natashia, Paulmann, Maren, Grys, Katarzyna, Mahil, Satveer K., Chaloner, Charlotte, Barbosa, Ines A., August, Suzannah, Burden, A. David, Choon, Siew-Eng, Cooper, Hywel, Navarini, Alex A., Reynolds, Nick J., Wahie, Shyamal, Warren, Richard B., Wright, Andrew, Huffmeier, Ulrike, Baum, Patrick, Visvanathan, Sudha, Barker, Jonathan N., Smith, Catherine H., Capon, Francesca

Source: American journal of human genetics. 107(3):539-543

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136697704.0x000001&indx=1&recIds=ETOCvdc_100136697704.0x000001

Clinical Impact of Antibodies against Ustekinumab in Psoriasis: An Observational, Cross-Sectional, Multicenter Study

Authors: Loeff, Floris C., Tsakok, Teresa, Dijk, Lisanne, Hart, Margreet H., Duckworth, Michael, Baudry, David, Russell, Alice, Dand, Nick, van Leeuwen, Astrid, Griffiths, Christopher E.M., Reynolds, Nick J., Barker, Jonathan, Burden, A. David, Warren, Richard B., de Vries, Annick, Bloem, Karien, Wolbink, Gerrit Jan, Smith, Catherine H., Rispens, Theo

Source: Journal of investigative dermatology. 140(11):2129-2137

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136164216.0x000001&indx=1&recIds=ETOCvdc_100136164216.0x000001

Clinical and genetic differences between pustular psoriasis subtypes

Authors: Twelves, Sophie, Mostafa, Alshimaa, Dand, Nick, Burri, Elias, Farkas, Katalin, Wilson, Rosemary, Cooper, Hywel L., Irvine, Alan D., Oon, Hazel H., Kingo, Külli, Köks, Sulev, Mrowietz, Ulrich, Puig, Luis, Reynolds, Nick, Tan, Eugene Sern-Ting, Tanew, Adrian, Torz, Kaspar, Trattner, Hannes, Valentine, Mark, Wahie, Shyamal, Warren, Richard B., Wright, Andrew, Bata-Csörgő, Zsuzsa, Szell, Marta, Griffiths, Christopher E.M., Burden, A. David, Choon, Siew-Eng, Smith, Catherine H., Barker, Jonathan N. ^∗, Navarini, Alexander A. ^∗, Capon, Francesca ^∗

Source: In The Journal of Allergy and Clinical Immunology March 2019 143(3):1021-1026

Defining the Therapeutic Range for Adalimumab and Predicting Response in Psoriasis: A Multicenter Prospective Observational Cohort Study

Authors: Wilkinson, Nina, Tsakok, Teresa, Dand, Nick, Bloem, Karien, Duckworth, Michael, Baudry, David, Pushpa-Rajah, Angela, Griffiths, Christopher E.M., Reynolds, Nick J., Barker, Jonathan, Warren, Richard B., Burden, A. David, Rispens, Theo, Stocken, Deborah, Smith, Catherine

Source: In Journal of Investigative Dermatology January 2019 139(1):115-123

Efficacy and safety of secukinumab in moderate to severe palmoplantar pustular psoriasis over 148 weeks: Extension of the 2PRECISE study

Authors: Mrowietz, Ulrich, Bachelez, Hervé, Burden, Arthur David, Rissler, Michael, Sieder, Christian, Orsenigo, Roberto, Jagiello, Piotr

Source: Journal of the American Academy of Dermatology. 84(2):552-554

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123885486.0x000001&indx=1&recIds=ETOCvdc_100123885486.0x000001

MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2

Alternate Title: MicroRNA regulation of ACKR2 expression (English)

Authors: Shams, Kave, Kurowska-Stolarska, Mariola, Schütte, Fabian, Burden, A. David ^**, McKimmie, Clive S., Graham, Gerard J.

Source: In Journal of Biological Chemistry 23 February 2018 293(8):3003-3012