Population pharmacokinetics of enrofloxacin and florfenicol in the giant danio (Devario aequipinnatus) following oral administration of both antibiotics and bath administration of enrofloxacin

Authors: Vorbach, Bryan S., Zhou, Jieqiang, Lang, Yinzhi, Bulitta, Jürgen B., Yanong, Roy P.E.

Source: In Aquaculture 30 January 2024 579

Distinguishing Inducible and Non-Inducible Resistance to Colistin in Pseudomonas aeruginosa by Quantitative and Systems Pharmacology Modeling at Low and Standard Inocula

Authors: Bulitta, Jürgen B., Shin, Eunjeong, Bergen, Phillip J., Lang, Yinzhi, Forrest, Alan, Tsuji, Brian T., Moya, Bartolome, Li, Jian, Nation, Roger L., Landersdorfer, Cornelia B.

Source: In Journal of Pharmaceutical Sciences January 2024 113(1):202-213

Research priorities towards precision antibiotic therapy to improve patient care

Authors: Bulman, Zackery P ^*, Wicha, Sebastian G, Nielsen, Elisabet I, Lenhard, Justin R, Nation, Roger L, Theuretzbacher, Ursula, Derendorf, Hartmut, Tängdén, Thomas, Zeitlinger, Markus, Landersdorfer, Cornelia B, Bulitta, Jürgen B, Friberg, Lena E, Li, Jian, Tsuji, Brian T

Source: In The Lancet Microbe October 2022 3(10):e795-e802

Population Pharmacokinetics, Pharmacodynamics and Safety Properties of Trametinib in Dogs With Cancer: A Phase I Dose Escalating Clinical Trial.

Authors: Takada, Marilia, Kitagawa, Keita, Zhang, Yongzhen, Bulitta, Jürgen B., Moirano, Steven, Jones, Abigail, Borgen, Jennifer, Onsager, Ashley, Thaiwong, Tuddow, Vail, David M.

Source: Veterinary & Comparative Oncology; Sep2024, Vol. 22 Issue 3, p410-421, 12p

Subject Terms: RETICULUM cell sarcoma, MONTE Carlo method, ANTINEOPLASTIC agents, MITOGEN-activated protein kinases, PHARMACOKINETICS

First population pharmacokinetic analysis showing increased quinolone metabolite formation and clearance in patients with cystic fibrosis compared to healthy volunteers

Authors: Jiao, Yuanyuan, Kim, Tae Hwan, Tao, Xun, Kinzig, Martina, Landersdorfer, Cornelia B., Drescher, Stefanie K., Sutaria, Dhruvitkumar S., Moya, Bartolome, Holzgrabe, Ulrike, Sörgel, Fritz, Bulitta, Jürgen B.

Source: In European Journal of Pharmaceutical Sciences 15 October 2018 123:416-428

Characterizing the time-course of antihypertensive activity and optimal dose range of fimasartan via mechanism-based population modeling

Authors: Bulitta, Jürgen B., Paik, Soo Heui, Chi, Yong Ha, Kim, Tae Hwan, Shin, Soyoung, Landersdorfer, Cornelia B., Jiao, Yuanyuan, Yadav, Rajbharan, Shin, Beom Soo

Source: In European Journal of Pharmaceutical Sciences 30 September 2017 107:32-44

Central Nervous System Antimicrobial Exposure and Proposed Dosing for Anthrax Meningitis.

Authors: Bradley, John S¹ jsbradley@ucsd.edu, Bulitta, Jürgen B², Cook, Rachel³, Yu, Patricia A⁴, Iwamoto, Chelsea⁵, Hesse, Elisabeth M⁴, Chaney, Danielle⁵, Yu, Yon⁴, Kennedy, Jordan L⁵, Sue, David⁴, Karchmer, Adolf W⁶, Bower, William A⁵ jsbradley@ucsd.edu, Hendricks, Katherine⁵

Source: Clinical Infectious Diseases. 6/15/2024, Vol. 78 Issue 6, p1451-1457. 7p.

Subject Terms: *CIPROFLOXACIN, *PENICILLIN G, *RESEARCH funding, *ANTHRAX meningitis, *CENTRAL nervous system, *AMPICILLIN, *DOXYCYCLINE, *DESCRIPTIVE statistics, *ANTI-infective agents, *DOSE-effect relationship in pharmacology, *SIMULATION methods in education, *QUINOLONE antibacterial agents, *VANCOMYCIN, *CLINDAMYCIN, *AMIKACIN, *CILASTATIN, *MINOCYCLINE, *LINEZOLID, *CEREBROSPINAL fluid, *MEROPENEM, *PENICILLIN

Population data analysis of dissolution time profiles: Assessment of physicochemical properties of the drug, drug particles and the pharmaceutical formulation

Authors: Horkovics-Kovats, Stefan, Brunovský, Pavel, Pichler, Arthur, Bulitta, Jürgen B.

Source: In European Journal of Pharmaceutical Sciences 12 October 2015 78:245-254

Next generation antibiotic combinations to combat pan-drug resistant Klebsiella pneumoniae.

Authors: Kaur, Jan Naseer, Singh, Navaldeep, Smith, Nicholas M., Klem, Jack F., Cha, Raymond, Lang, Yinzhi, Chen, Liang, Kreiswirth, Barry, Holden, Patricia N., Bulitta, Jürgen B., Tsuji, Brian T.

Source: Scientific Reports; 2/7/2024, Vol. 14 Issue 1, p1-9, 9p

PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin

Authors: Ryan, Gemma M., Kaminskas, Lisa M., Bulitta, Jürgen B., McIntosh, Michelle P., Owen, David J., Porter, Christopher J.H.

Source: In Journal of Controlled Release 28 November 2013 172(1):128-136

The Impact of Lymphatic Transport on the Systemic Disposition of Lipophilic Drugs

Authors: Caliph, Suzanne M., Cao, Enyuan, Bulitta, Jürgen B., Hu, Luojuan, Han, Sifei, Porter, Christopher J.H., Trevaskis, Natalie L. ^*

Source: In Journal of Pharmaceutical Sciences July 2013 102(7):2395-2408

Central and peripheral lung deposition of fluticasone propionate dry powder inhaler formulations in humans characterized by population pharmacokinetics.

Authors: Drescher, Stefanie K., Jiao, Yuanyuan, Chen, Mong-Jen, Kurumaddali, Abhinav, Shao, Jie, Amini, Elham, Hochhaus, Günther, Bulitta, Jürgen B.

Source: Pharmaceutical Research; May2023, Vol. 40 Issue 5, p1177-1191, 15p

Subject Terms: FLUTICASONE propionate, PHARMACOKINETICS, INHALERS, MUCOCILIARY system, LUNGS, POWDERS

Postexposure Prophylaxis and Treatment of Bacillus anthracis Infections: A Systematic Review and Meta-analyses of Animal Models, 1947–2019.

Authors: Kennedy, Jordan L¹ kua9@cdc.gov, Bulitta, Jürgen B², Chatham-Stephens, Kevin³, Person, Marissa K¹, Cook, Rachel⁴, Mongkolrattanothai, Thitipong⁴, Shin, Eunjeong², Yu, Patricia⁵, Negron, Maria E¹, Bower, William A¹, Hendricks, Katherine¹

Source: Clinical Infectious Diseases. 2022 Supplement, Vol. 75, pS379-S391. 13p.

Subject Terms: *BIOLOGICAL models, *ANTHRAX, *META-analysis, *CIPROFLOXACIN, *SYSTEMATIC reviews, *ANTI-infective agents, *FLUOROQUINOLONES, *TETRACYCLINES, *BACILLUS (Bacteria), *DRUG resistance, *DOXYCYCLINE, *QUINOLONE antibacterial agents

Systematic Evaluation of the Effect of Formulation Variables on In Vitro Performance of Mometasone Furoate Suspension-Metered Dose Inhalers.

Authors: Bachhav, Sagar S., Sheth, Poonam, Sandell, Dennis, Svensson, Mårten, Bhagwat, Sharvari, Conti, Denise S., Oguntimein, Oluwamurewa, Dhapare, Sneha, Saluja, Bhawana, Winner, Lawrence, Bulitta, Jürgen B., Hochhaus, Guenther

Source: AAPS Journal; Feb2022, Vol. 24 Issue 1, p1-19, 19p

Aminoglycoside-resistance gene signatures are predictive of aminoglycoside MICs for carbapenem-resistant Klebsiella pneumoniae.

Authors: Huang, Yanqin, Rana, Amisha P., Wenzler, Eric, Ozer, Egon A., Krapp, Fiorella, Bulitta, Jürgen B., Hauser, Alan R., Bulman, Zackery P.

Source: Journal of Antimicrobial Chemotherapy (JAC); Feb2022, Vol. 77 Issue 2, p356-363, 8p

Subject Terms: CARBAPENEM-resistant bacteria, KLEBSIELLA pneumoniae, AMIKACIN, CARBAPENEMS, PRINCIPAL components analysis, GENES, TOBRAMYCIN, KLEBSIELLA, RESEARCH, RESEARCH methodology, AMINOGLYCOSIDES, EVALUATION research, HYDROLASES, COMPARATIVE studies, RESEARCH funding, ANTIBIOTICS, MICROBIAL sensitivity tests, PHARMACODYNAMICS

CDC Guidelines for the Prevention and Treatment of Anthrax, 2023.

Authors: Bower, William A., Yon Yu, Person, Marissa K., Parker, Corinne M., Kennedy, Jordan L., Sue, David, Hesse, Elisabeth M., Cook, Rachel, Bradley, John, Bulitta, Jürgen B., Karchmer, Adolf W., Ward, Robert M., Godfred Cato, Shana, Chatham Stephens, Kevin, Hendricks, Katherine A.

Source: MMWR Recommendations & Reports; 11/17/2023, Vol. 72 Issue 6, p1-46, 46p

Subject Terms: ANTIBIOTICS, ANTHRAX prevention, ANTHRAX meningitis, BIOTERRORISM, DRUG efficacy, ANTHRAX, ANTHRAX vaccines, BACILLUS (Bacteria), MEDICAL protocols, DRUG resistance in microorganisms, RESOURCE-limited settings, ANTITOXINS, PHARMACODYNAMICS, THERAPEUTICS

Company/Entity: CENTERS for Disease Control & Prevention (U.S.)

Evaluation of Meropenem‐Ciprofloxacin Combination Dosage Regimens for the Pharmacokinetics of Critically Ill Patients With Augmented Renal Clearance.

Authors: Agyeman, Akosua A., Rogers, Kate E., Tait, Jessica R., Bergen, Phillip J., Kirkpatrick, Carl M., Wallis, Steven C., Bulitta, Jürgen B., Paterson, David L., Lipman, Jeffrey, Nation, Roger L., Roberts, Jason A., Landersdorfer, Cornelia B.

Source: Clinical Pharmacology & Therapeutics; Apr2021, Vol. 109 Issue 4, p1104-1115, 12p

Subject Terms: MEROPENEM, CRITICALLY ill, MONTE Carlo method, PHARMACOKINETICS, DRUG dosage, BACTERIAL population

Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii

Authors: Rao, Gauri G. ^*, Ly, Neang S., Diep, John, Forrest, Alan, Bulitta, Jürgen B., Holden, Patricia N., Nation, Roger L., Li, Jian, Tsuji, Brian T. ^**

Source: In International Journal of Antimicrobial Agents September 2016 48(3):331-336

Determining the optimal dosing of a novel combination regimen of ceftazidime/avibactam with aztreonam against NDM-1-producing Enterobacteriaceae using a hollow-fibre infection model.

Authors: Lodise, Thomas P, Smith, Nicolas M, O'Donnell, Nick, Eakin, Ann E, Holden, Patricia N, Boissonneault, Katie Rose, Zhou, Jieqiang, Tao, Xun, Bulitta, Jürgen B, Fowler, Vance G, Chambers, Henry F, Bonomo, Robert A, Tsuji, Brian T

Source: Journal of Antimicrobial Chemotherapy (JAC); Sep2020, Vol. 75 Issue 9, p2622-2632, 11p

Subject Terms: CEFTAZIDIME, ESCHERICHIA coli, RESEARCH, COMBINATION drug therapy, RESEARCH evaluation, RESEARCH methodology, ORGANIC compounds, MEDICAL cooperation, EVALUATION research, ENTEROBACTERIACEAE, HYDROLASES, COMPARATIVE studies, RESEARCH funding, AZTREONAM, ANTIBIOTICS, LONGITUDINAL method, MICROBIAL sensitivity tests, PHARMACODYNAMICS

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