Analysis of a Case of Brugada Syndrome Through Numerical Simulation of Ventricular Action Potential

Authors: Guidi, Giulia, Bartolucci, Chiara, Frosio, Anthony, Marchese, Procolo, Bucchi, Annalisa, Baruscotti, Mirko, Severi, Stefano

Source: 2020 Computing in Cardiology Computing in Cardiology, 2020. :1-4 Sep, 2020

Relation: 2020 Computing in Cardiology (CinC)

Rate-adapted dynamic-clamp of the funny current in sinoatrial pacemaker cells

Authors: Bartolucci, Chiara, Ravagli, Enrico, Bucchi, Annalisa, Baruscotti, Mirko, DiFrancesco, Dario, Severi, Stefano

Source: 2015 Computing in Cardiology Conference (CinC) Computing in Cardiology Conference (CinC), 2015. :1-4 Sep, 2015

Relation: 2015 Computing in Cardiology Conference (CinC)

Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease

Authors: Boyett, Mark R., Yanni, Joseph, Tellez, James, Bucchi, Annalisa, Mesirca, Pietro, Cai, Xue, Logantha, Sunil Jit R.J., Wilson, Claire, Anderson, Cali, Ariyaratnam, Jonathan, Stuart, Luke, Nakao, Shu, Abd Allah, Eman, Jones, Sandra, Lancaster, Matthew, Stephenson, Robert, Chandler, Natalie, Smith, Matthew, Bussey, Carol, Monfredi, Oliver, Morris, Gwilym, Billeter, Rudi, Mangoni, Matteo E., Zhang, Henggui, Hart, George, D'Souza, Alicia

Source: In Progress in Biophysics and Molecular Biology November 2021 166:61-85

The funny current: Even funnier than 40 years ago. Uncanonical expression and roles of HCN/f channels all over the body

Authors: Benzoni, Patrizia, Bertoli, Giorgia, Giannetti, Federica, Piantoni, Chiara, Milanesi, Raffaella, Pecchiari, Matteo, Barbuti, Andrea, Baruscotti, Mirko, Bucchi, Annalisa

Source: In Progress in Biophysics and Molecular Biology November 2021 166:189-204

A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate

Authors: D’Souza, Alicia, Wang, Yanwen, Anderson, Cali, Bucchi, Annalisa, Baruscotti, Mirko, Olieslagers, Servé, Mesirca, Pietro, Johnsen, Anne Berit, Mastitskaya, Svetlana, Ni, Haibo, Zhang, Yu, Black, Nicholas, Cox, Charlotte, Wegner, Sven, Bano-Otalora, Beatriz, Petit, Cheryl, Gill, Eleanor, Logantha, Sunil Jit R.J., Dobrzynski, Halina, Ashton, Nick, Hart, George, Zhang, Rai, Zhang, Henggui, Cartwright, Elizabeth J., Wisloff, Ulrik, Mangoni, Matteo E., da Costa Martins, Paula A., Piggins, Hugh D., DiFrancesco, Dario, Boyett, Mark R.

Source: In Heart Rhythm May 2021 18(5):801-810

A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate

Authors: D'Souza, Alicia, Wang, Yanwen, Anderson, Cali, Bucchi, Annalisa, Baruscotti, Mirko, Olieslagers, Servé, Mesirca, Pietro, Johnsen, Anne Berit, Mastitskaya, Svetlana, Ni, Haibo, Zhang, Yu, Black, Nicholas, Cox, Charlotte, Wegner, Sven, Bano-Otalora, Beatriz, Petit, Cheryl, Gill, Eleanor, Logantha, Sunil Jit R.J., Dobrzynski, Halina, Ashton, Nick, Hart, George, Zhang, Rai, Zhang, Henggui, Cartwright, Elizabeth J., Wisloff, Ulrik, Mangoni, Matteo E., da Costa Martins, Paula A., Piggins, Hugh D., DiFrancesco, Dario, Boyett, Mark R.

Source: Heart rhythm. 18(5):801-810

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152463746.0x000001&indx=1&recIds=ETOCvdc_100152463746.0x000001

A novel de novo HCN1 loss-of-function mutation in genetic generalized epilepsy causing increased neuronal excitability

Authors: Bonzanni, Mattia, DiFrancesco, Jacopo C., Milanesi, Raffaella, Campostrini, Giulia, Castellotti, Barbara, Bucchi, Annalisa, Baruscotti, Mirko, Ferrarese, Carlo, Franceschetti, Silvana, Canafoglia, Laura, Ragona, Francesca, Freri, Elena, Labate, Angelo, Gambardella, Antonio, Costa, Cinzia, Rivolta, Ilaria, Gellera, Cinzia, Granata, Tiziana, Barbuti, Andrea, DiFrancesco, Dario

Source: In Neurobiology of Disease October 2018 118:55-63

In-vitro studies of the NaV1.5 S805L Brugada mutation: The resting cell voltage is a critical element in determining the pathological or physiological phenotype of the current

Authors: Molla, David, Frosio, Anthony, Bertoli, Giorgia, Piantoni, Chiara, Arici, Martina, Bartolucci, Chiara, Marchese, Procolo, Bazzini, Claudia, Barbuti, Andrea, Rocchetti, Marcella, Severi, Stefano, Bucchi, Annalisa, Baruscotti, Mirko

Source: In Vascular Pharmacology June 2024 155

NOD-1 activation increases the spontaneous activity and the I(f) current of murine sinoatrial node cells

Authors: Canzolino, Serena, Bertoli, Giorgia, Bakhouba, Samira, Molla, David, Benzoni, Patrizia, Barbuti, Andrea, Baruscotti, Mirko, Fernández-Velasco, Maria, Bucchi, Annalisa

Source: In Vascular Pharmacology June 2024 155

A gain of function mutation in PITX2c gene linked to atrial fibrillation alters mitochondrial function and membrane excitability

Authors: Benzoni, Patrizia, Da Dalt, Lorenzo, Cospito, Alessandro, Popolizio, Vera, Giannetti, Federica, Ruberti, Cristina, Baruscotti, Mirko, Bucchi, Annalisa, Norata, Giuseppe Danilo, Barbuti, Andrea

Source: In Vascular Pharmacology June 2024 155

Caveolin-3 and Caveolin-1 Interaction Decreases Channel Dysfunction Due to Caveolin-3 Mutations.

Authors: Benzoni, Patrizia, Gazzerro, Elisabetta, Fiorillo, Chiara, Baratto, Serena, Bartolucci, Chiara, Severi, Stefano, Milanesi, Raffaella, Lippi, Melania, Langione, Marianna, Murano, Carmen, Meoni, Clarissa, Popolizio, Vera, Cospito, Alessandro, Baruscotti, Mirko, Bucchi, Annalisa, Barbuti, Andrea

Source: International Journal of Molecular Sciences; Jan2024, Vol. 25 Issue 2, p980, 18p

Subject Terms: CAVEOLINS, HEART, ION channels, CHO cell, MUSCULAR dystrophy, CAVEOLAE, HETEROZYGOSITY, HEART diseases

PITX2 gain-of-function mutation associated with atrial fibrillation alters mitochondrial activity in human iPSC atrial-like cardiomyocytes.

Authors: Benzoni, Patrizia, Da Dalt, Lorenzo, Elia, Noemi, Popolizio, Vera, Cospito, Alessandro, Giannetti, Federica, Dell'Era, Patrizia, Olesen, Morten S., Bucchi, Annalisa, Baruscotti, Mirko, Norata, Giuseppe Danilo, Barbuti, Andrea

Source: Frontiers in Physiology; 2023, p01-11, 11p

Subject Terms: GAIN-of-function mutations, ATRIAL fibrillation, MITOCHONDRIA, MELAS syndrome, ARRHYTHMIA, ENERGY consumption, TRANSCRIPTION factors

Lack of the transcription factor Nfix causes tachycardia in mice sinus node and rats neonatal cardiomyocytes.

Authors: Landi, Sara, Giannetti, Federica, Benzoni, Patrizia, Campostrini, Giulia, Rossi, Giuliana, Piantoni, Chiara, Bertoli, Giorgia, Bonfanti, Chiara, Carnevali, Luca, Bucchi, Annalisa, Baruscotti, Mirko, Careccia, Giorgia, Messina, Graziella, Barbuti, Andrea

Source: Acta Physiologica; Oct2023, Vol. 239 Issue 2, p1-13, 13p, 1 Color Photograph, 1 Diagram, 6 Charts, 5 Graphs

Subject Terms: SINOATRIAL node, TRANSCRIPTION factors, TACHYCARDIA, MICE, HEART beat

Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4

Authors: Baruscotti, Mirko, Bucchi, Annalisa, Viscomi, Carlo, Mandelli, Giacomo, Consalez, Giacomo, Gnecchi-Rusconi, Tomaso, Montano, Nicola, Casali, Karina Rabello, Micheloni, Stefano, Barbuti, Andrea, DiFrancesco, Dario, Catterall, William A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2011 Jan . 108(4), 1705-1710.

Access URL: https://www.jstor.org/stable/41001924

F/HCN channels: From a tiny current controlling cardiac pacemaking to a pleiotropic current all over the body

Authors: Bucchi, Annalisa, Baruscotti, Mirko, Barbuti, Andrea

Source: Progress in biophysics and molecular biology. 166:1-2

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150024095.0x000001&indx=1&recIds=ETOCvdc_100150024095.0x000001

The cardiac pacemaker current

Authors: Baruscotti, Mirko, Barbuti, Andrea, Bucchi, Annalisa

Source: In Journal of Molecular and Cellular Cardiology 2010 48(1):55-64

HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with If blockade

Authors: Plotnikov, Alexei N., Bucchi, Annalisa, Shlapakova, Iryna, Danilo, Peter, Jr., Brink, Peter R., Robinson, Richard B., Cohen, Ira S., Rosen, Michael R.

Source: In Heart Rhythm February 2008 5(2):282-288

Heart rate reduction via selective ‘funny’ channel blockers

Authors: Bucchi, Annalisa, Barbuti, Andrea, Baruscotti, Mirko, DiFrancesco, Dario

Source: In Current Opinion in Pharmacology 2007 7(2):208-213

Modulation of rate by autonomic agonists in SAN cells involves changes in diastolic depolarization and the pacemaker current

Authors: Bucchi, Annalisa, Baruscotti, Mirko, Robinson, Richard B., DiFrancesco, Dario

Source: In Journal of Molecular and Cellular Cardiology 2007 43(1):39-48

Regulation of Gating and Rundown of HCN Hyperpolarization-activated Channels by Exogenous and Endogenous PIP2.

Authors: Pian, Phillip, Bucchi, Annalisa, Robinson, Richard B.

Source: Journal of General Physiology; November 2006, Vol. 128 Issue 5, p593-604, 12p