Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice

Authors: Ma, Xiaoye ^a, Prokopenko, Dmitry ^b, Wang, Ni ^a, Aikawa, Tomonori ^a, Choi, Younjung ^b, Zhang, Can ^b, Lei, Dan ^b, Ren, Yingxue ^c, Kawatani, Keiji ^a, Starling, Skylar C. ^a, Perkerson, Ralph B. ^a, Roy, Bhaskar ^a, Quintero, Astrid C. ^a, Parsons, Tammee M. ^a, Pan, Yining ^d, Li, Zonghua ^a, Wang, Minghui ^e, Bao, Hanmei ^f, Han, Xianlin ^f, Bu, Guojun ^{a, g}, Tanzi, Rudolph E. ^{b, ⁎}, Kanekiyo, Takahisa ^{a, ⁎}

Source: In Neurobiology of Disease March 2025 206

Amyloid pathology and cognitive impairment in hAβ-KI and APPSAA-KI mouse models of Alzheimer's disease

Authors: Lu, Wenyan, Shue, Francis, Kurti, Aishe, Jeevaratnam, Suren, Macyczko, Jesse R., Roy, Bhaskar, Izhar, Taha, Wang, Ni, Bu, Guojun, Kanekiyo, Takahisa, Li, Yonghe

Source: In Neurobiology of Aging January 2025 145:13-23

Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy

Authors: Chadarevian, Jean Paul, Hasselmann, Jonathan, Lahian, Alina, Capocchi, Joia K., Escobar, Adrian, Lim, Tau En, Le, Lauren, Tu, Christina, Nguyen, Jasmine, Kiani Shabestari, Sepideh, Carlen-Jones, William, Gandhi, Sunil, Bu, Guojun, Hume, David A., Pridans, Clare, Wszolek, Zbigniew K., Spitale, Robert C., Davtyan, Hayk, Blurton-Jones, Mathew

Source: In Neuron 21 August 2024 112(16):2686-2707

Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer's disease model by restoring BDNF signaling

Authors: Wang, Wanbing, Li, Yanzhong, Ma, Fangling, Sheng, Xuan, Chen, Kai, Zhuo, Rengong, Wang, Chen, Zheng, Honghua, Zhang, Yun-wu, Bu, Guojun, Chen, Xiao-Fen, Zhong, Li

Source: Brain behavior and immunity. 113:275-288

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Pushing the boundaries of brain organoids to study Alzheimer's disease

Authors: Cerneckis, Jonas, Bu, Guojun, Shi, Yanhong

Source: Trends in molecular medicine. 29(8):659-672

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194265972.0x000001&indx=1&recIds=ETOCvdc_100194265972.0x000001

APOE and immunity: Research highlights

Authors: Kloske, Courtney M., Barnum, Christopher J., Batista, Andre F., Bradshaw, Elizabeth M., Brickman, Adam M., Bu, Guojun, Dennison, Jessica, Gearon, Mary D., Goate, Alison M., Haass, Christian, Heneka, Michael T., Hu, William T., Huggins, Lenique K. L., Jones, Nahdia S., Koldamova, Radosveta, Lemere, Cynthia A., Liddelow, Shane A., Marcora, Edoardo, Marsh, Samuel E., Nielsen, Henrietta M., Petersen, Kellen K., Petersen, Melissa, Piña‐Escudero, Stefanie D., Qiu, Wei Qiao, Quiroz, Yakeel T., Reiman, Eric, Sexton, Claire, Tansey, Malú Gámez, TCW, Julia, Teunissen, Charlotte E., Tijms, Betty M., Kant, Rik, Wallings, Rebecca, Weninger, Stacie C., Wharton, Whitney, Wilcock, Donna M., Wishard, Tyler James, Worley, Susan L, Zetterberg, Henrik, Carrillo, Maria C.

Source: Alzheimer's & dementia. 19(6):2677-2696

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185026382.0x000001&indx=1&recIds=ETOCvdc_100185026382.0x000001

APOE2 Exacerbates TDP‐43 Related Toxicity in the Absence of Alzheimer Pathology

Authors: Meneses, Axel D., Koga, Shunsuke, Li, Zonghua, O'Leary, Justin, Li, Fuyao, Chen, Kai, Murakami, Aya, Qiao, Wenhui, Kurti, Aishe, Heckman, Michael G., White, Launia, Xie, Manling, Chen, Yixing, Finch, Nicole A., Lim, Melina J., Delenclos, Marion, DeTure, Michael A., Linares, Cynthia, Martin, Nicholas B., Ikezu, Tadafumi C., Blitterswijk, Marka M., Wu, Long‐Jun, McLean, Pamela J., Rademakers, Rosa, Ross, Owen A., Dickson, Dennis W., Bu, Guojun, Zhao, Na

Source: Annals of neurology. 93(4):830-843

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178572469.0x000001&indx=1&recIds=ETOCvdc_100178572469.0x000001

A reference human induced pluripotent stem cell line for large-scale collaborative studies

Authors: Pantazis, Caroline B., Yang, Andrian, Lara, Erika, McDonough, Justin A., Blauwendraat, Cornelis, Peng, Lirong, Oguro, Hideyuki, Kanaujiya, Jitendra, Zou, Jizhong, Sebesta, David, Pratt, Gretchen, Cross, Erin, Blockwick, Jeffrey, Buxton, Philip, Kinner-Bibeau, Lauren, Medura, Constance, Tompkins, Christopher, Hughes, Stephen, Santiana, Marianita, Faghri, Faraz, Nalls, Mike A., Vitale, Daniel, Ballard, Shannon, Qi, Yue A., Ramos, Daniel M., Anderson, Kailyn M., Stadler, Julia, Narayan, Priyanka, Papademetriou, Jason, Reilly, Luke, Nelson, Matthew P., Aggarwal, Sanya, Rosen, Leah U., Kirwan, Peter, Pisupati, Venkat, Coon, Steven L., Scholz, Sonja W., Priebe, Theresa, Öttl, Miriam, Dong, Jian, Meijer, Marieke, Janssen, Lara J.M., Lourenco, Vanessa S., van der Kant, Rik, Crusius, Dennis, Paquet, Dominik, Raulin, Ana-Caroline, Bu, Guojun, Held, Aaron, Wainger, Brian J., Gabriele, Rebecca M.C., Casey, Jackie M., Wray, Selina, Abu-Bonsrah, Dad, Parish, Clare L., Beccari, Melinda S., Cleveland, Don W., Li, Emmy, Rose, Indigo V.L., Kampmann, Martin, Calatayud Aristoy, Carles, Verstreken, Patrik, Heinrich, Laurin, Chen, Max Y., Schüle, Birgitt, Dou, Dan, Holzbaur, Erika L.F., Zanellati, Maria Clara, Basundra, Richa, Deshmukh, Mohanish, Cohen, Sarah, Khanna, Richa, Raman, Malavika, Nevin, Zachary S., Matia, Madeline, Van Lent, Jonas, Timmerman, Vincent, Conklin, Bruce R., Johnson Chase, Katherine, Zhang, Ke, Funes, Salome, Bosco, Daryl A., Erlebach, Lena, Welzer, Marc, Kronenberg-Versteeg, Deborah, Lyu, Guochang, Arenas, Ernest, Coccia, Elena, Sarrafha, Lily, Ahfeldt, Tim, Marioni, John C., Skarnes, William C., Cookson, Mark R., Ward, Michael E., Merkle, Florian T.

Source: In Cell Stem Cell 1 December 2022 29(12):1685-1702

ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias

Authors: Martens, Yuka A., Zhao, Na, Liu, Chia-Chen, Kanekiyo, Takahisa, Yang, Austin J., Goate, Alison M., Holtzman, David M., Bu, Guojun

Source: Neuron. 110(8):1304-1317

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186671704.0x000001&indx=1&recIds=ETOCvdc_100186671704.0x000001

ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease

Authors: Li, Yonghe, Macyczko, Jesse R., Liu, Chia-Chen, Bu, Guojun

Source: NEUROBIOLOGY OF AGING. 115:20-28

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163407198.0x000001&indx=1&recIds=ETOCvdc_100163407198.0x000001

Lipoproteins in the Central Nervous System: From Biology to Pathobiology

Authors: Raulin, Ana-Caroline, Martens, Yuka A., Bu, Guojun

Source: Annual review of biochemistry. 91:731-759

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629986118&indx=1&recIds=ETOCRN629986118

Associations of amyloid and neurodegeneration plasma biomarkers with comorbidities

Authors: Syrjanen, Jeremy A., Campbell, Michelle R., Algeciras‐Schimnich, Alicia, Vemuri, Prashanthi, Graff‐Radford, Jonathan, Machulda, Mary M., Bu, Guojun, Knopman, David S., Jack, Clifford R., Petersen, Ronald C., Mielke, Michelle M.

Source: Alzheimer's & dementia. 18(6):1128-1140

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100151699222.0x000001&indx=1&recIds=ETOCvdc_100151699222.0x000001

Clinicopathologic Factors Associated With Reversion to Normal Cognition in Patients With Mild Cognitive Impairment

Authors: Li, Zonghua, Heckman, Michael G., Kanekiyo, Takahisa, Martens, Yuka A., Day, Gregory S., Vassilaki, Maria, Liu, Chia-Chen, Bennett, David A., Petersen, Ronald C., Zhao, Na, Bu, Guojun

Source: Neurology. 98(20):e2036-e2045

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150829090.0x000001&indx=1&recIds=ETOCvdc_100150829090.0x000001

Effect of Osteoporosis on Adjacent Segmental Degeneration After Posterior Lumbar Interbody Fusion Under Whole Body Vibration

Authors: Zhang, Renwen, Zhang, Chenchen, Shu, Xinnong, Yuan, Xin, Li, Yixuan, Chen, Qian, Huang, Honghao, Zeng, Qiuhong, Bu, Guojun, Li, Ruihui, Li, Shuyu, Chang, Minmin, Tang, Shujie

Source: In World Neurosurgery August 2021 152:e700-e707

Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples

Authors: Watzlawik, Jens O., Hou, Xu, Fricova, Dominika, Ramnarine, Chloe, Barodia, Sandeep K., Gendron, Tania F., Heckman, Michael G., DeTure, Michael, Siuda, Joanna, Wszolek, Zbigniew K., Scherzer, Clemens R., Ross, Owen A., Bu, Guojun, Dickson, Dennis W., Goldberg, Matthew S., Fiesel, Fabienne C., Springer, Wolfdieter

Source: Autophagy. 17(9):2613-2628

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138420048.0x000001&indx=1&recIds=ETOCvdc_100138420048.0x000001

Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology

Authors: Hou, Xu, Watzlawik, Jens O., Cook, Casey, Liu, Chia‐Chen, Kang, Silvia S., Lin, Wen‐Lang, DeTure, Michael, Heckman, Michael G., Diehl, Nancy N., Al‐Shaikh, Fadi S. Hanna, Walton, Ronald L., Ross, Owen A., Melrose, Heather L., Ertekin‐Taner, Nilüfer, Bu, Guojun, Petrucelli, Leonard, Fryer, John D., Murray, Melissa E., Dickson, Dennis W., Fiesel, Fabienne C., Springer, Wolfdieter

Source: Alzheimer's & dementia. 17(3):417-430

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121639067.0x000001&indx=1&recIds=ETOCvdc_100121639067.0x000001

The UFMylation pathway is impaired in Alzheimer's disease.

Authors: Yan, Tingxiang, Heckman, Michael G., Craver, Emily C., Liu, Chia-Chen, Rawlinson, Bailey D., Wang, Xue, Murray, Melissa E., Dickson, Dennis W., Ertekin-Taner, Nilufer, Lou, Zhenkun, Bu, Guojun, Springer, Wolfdieter, Fiesel, Fabienne C.

Source: Molecular Neurodegeneration; 12/18/2024, Vol. 19 Issue 1, p1-17, 17p

Subject Terms: DNA repair, UNFOLDED protein response, ALZHEIMER'S disease, NEUROFIBRILLARY tangles, BIOMARKERS

Alzheimer’s Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways

Authors: Zhao, Na, Ren, Yingxue, Yamazaki, Yu, Qiao, Wenhui, Li, Fuyao, Felton, Lindsey M., Mahmoudiandehkordi, Siamak, Kueider-Paisley, Alexandra, Sonoustoun, Berkiye, Arnold, Matthias, Shue, Francis, Zheng, Jiaying, Attrebi, Olivia N., Martens, Yuka A., Li, Zonghua, Bastea, Ligia, Meneses, Axel D., Chen, Kai, Thompson, J. Will, St John-Williams, Lisa, Tachibana, Masaya, Aikawa, Tomonori, Oue, Hiroshi, Job, Lucy, Yamazaki, Akari, Liu, Chia-Chen, Storz, Peter, Asmann, Yan W., Ertekin-Taner, Nilüfer, Kanekiyo, Takahisa, Kaddurah-Daouk, Rima, Bu, Guojun

Source: In Neuron 3 June 2020 106(5):727-742

Cyclin-Dependent Kinase 5–Dependent BAG3 Degradation Modulates Synaptic Protein Turnover

Authors: Zhou, Jiechao, Chow, Hei-Man, Liu, Yan, Wu, Di, Shi, Meng, Li, Jieyin, Wen, Lei, Gao, Yuehong, Chen, Guimiao, Zhuang, Kai, Lin, Hui, Zhang, Guanyun, Xie, Wenting, Li, Huifang, Leng, Lige, Wang, Mengdan, Zheng, Naizhen, Sun, Hao, Zhao, Yingjun, Zhang, Yunwu, Xue, Maoqiang, Huang, Timothy Y., Bu, Guojun, Xu, Huaxi, Yuan, Zengqiang, Herrup, Karl, Zhang, Jie

Source: In Biological Psychiatry 15 April 2020 87(8):756-769

TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration

Authors: Zhong, Li, Sheng, Xuan, Wang, Wanbing, Li, Yanzhong, Zhuo, Rengong, Wang, Kai, Zhang, Lianshuai, Hu, Dan-Dan, Hong, Yujuan, Chen, Linting, Rao, Hengjun, Li, Tingting, Chen, Muyang, Lin, Zhihao, Zhang, Yun-wu, Wang, Xin, Yan, Xiao-Xin, Chen, Xiaochun, Bu, Guojun, Chen, Xiao-Fen

Source: Immunity. 56(8):1794-1808.e8

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195176610.0x000001&indx=1&recIds=ETOCvdc_100195176610.0x000001