Establishing RTS,S/AS01 as a benchmark for comparison to next-generation malaria vaccines in a mouse model

Authors: Emily Locke, Yevel Flores-Garcia, Bryan T. Mayer, Randall S. MacGill, Bhavesh Borate, Berenice Salgado-Jimenez, Monica W. Gerber, Shamika Mathis-Torres, Sarah Shapiro, C. Richter King, Fidel Zavala

Source: npj Vaccines, Vol 9, Iss 1, Pp 1-14 (2024)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/cb9a8e98e3904d03ab567757f16ec3bd

High monoclonal neutralization titers reduced breakthrough HIV-1 viral loads in the Antibody Mediated Prevention trials

Authors: Daniel B. Reeves, Bryan T. Mayer, Allan C. deCamp, Yunda Huang, Bo Zhang, Lindsay N. Carpp, Craig A. Magaret, Michal Juraska, Peter B. Gilbert, David C. Montefiori, Katharine J. Bar, E. Fabian Cardozo-Ojeda, Joshua T. Schiffer, Raabya Rossenkhan, Paul Edlefsen, Lynn Morris, Nonhlanhla N. Mkhize, Carolyn Williamson, James I. Mullins, Kelly E. Seaton, Georgia D. Tomaras, Philip Andrew, Nyaradzo Mgodi, Julie E. Ledgerwood, Myron S. Cohen, Lawrence Corey, Logashvari Naidoo, Catherine Orrell, Paul A. Goepfert, Martin Casapia, Magdalena E. Sobieszczyk, Shelly T. Karuna, Srilatha Edupuganti

Source: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/794805ba580c4e44895b377fd359c2eb

A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functions

Authors: Sedem Dankwa, Christina Kosman, Maria Dennis, Elena E. Giorgi, Kenneth Vuong, Ioanna Pahountis, Ashley Garza, Christian Binuya, Janice McCarthy, Bryan T. Mayer, Julia T. Ngo, Chiamaka A. Enemuo, Diane G. Carnathan, Sherry Stanfield-Oakley, Stella J. Berendam, Carolyn Weinbaum, Kathleen Engelman, Diogo M. Magnani, Cliburn Chan, Guido Ferrari, Guido Silvestri, Rama R. Amara, Ann Chahroudi, Sallie R. Permar, Genevieve G. Fouda, Ria Goswami

Source: PLoS ONE, Vol 19, Iss 11 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554116/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/fd221d40992144bb906bb7c974862294

Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV

Authors: Bryan T. Mayer, Lily Zhang, Allan C. deCamp, Chenchen Yu, Alicia Sato, Heather Angier, Kelly E. Seaton, Nicole Yates, Julie E. Ledgerwood, Kenneth Mayer, Marina Caskey, Michel Nussenzweig, Kathryn Stephenson, Boris Julg, Dan H. Barouch, Magdalena E. Sobieszczyk, Srilatha Edupuganti, Colleen F. Kelley, M. Juliana McElrath, Huub C. Gelderblom, Michael Pensiero, Adrian McDermott, Lucio Gama, Richard A. Koup, Peter B. Gilbert, Myron S. Cohen, Lawrence Corey, Ollivier Hyrien, Georgia D. Tomaras, Yunda Huang

Source: Pharmaceutics, Vol 16, Iss 5, p 594 (2024)

Subject Terms: monoclonal antibodies, LS mutation, two-compartment model, population pharmacokinetics modeling, HIV prevention, targeted maximum likelihood estimation (TMLE), Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/5/594; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/34ca5d472d9b40e7a742cd8a83e9c15b

Author Correction: High monoclonal neutralization titers reduced breakthrough HIV-1 viral loads in the Antibody Mediated Prevention trials

Authors: Daniel B. Reeves, Bryan T. Mayer, Allan C. deCamp, Yunda Huang, Bo Zhang, Lindsay N. Carpp, Craig A. Magaret, Michal Juraska, Peter B. Gilbert, David C. Montefiori, Katharine J. Bar, E. Fabian Cardozo-Ojeda, Joshua T. Schiffer, Raabya Rossenkhan, Paul Edlefsen, Lynn Morris, Nonhlanhla N. Mkhize, Carolyn Williamson, James I. Mullins, Kelly E. Seaton, Georgia D. Tomaras, Philip Andrew, Nyaradzo Mgodi, Julie E. Ledgerwood, Myron S. Cohen, Lawrence Corey, Logashvari Naidoo, Catherine Orrell, Paul A. Goepfert, Martin Casapia, Magdalena E. Sobieszczyk, Shelly T. Karuna, Srilatha Edupuganti

Source: Nature Communications, Vol 15, Iss 1, Pp 1-2 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ef191c52261c47488786020343882bd3

mRNA-Based Vaccines Are Highly Immunogenic and Confer Protection in the Gnotobiotic Pig Model of Human Rotavirus Diarrhea

Authors: Casey Hensley, Sandro Roier, Peng Zhou, Sofia Schnur, Charlotte Nyblade, Viviana Parreno, Annie Frazier, Maggie Frazier, Kelsey Kiley, Samantha O’Brien, Yu Liang, Bryan T. Mayer, Ruizhe Wu, Celia Mahoney, Monica M. McNeal, Benjamin Petsch, Susanne Rauch, Lijuan Yuan

Source: Vaccines, Vol 12, Iss 3, p 260 (2024)

Subject Terms: rotavirus, mRNA vaccine, gnotobiotic pigs, P2-VP8*, diarrhea, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/12/3/260; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/cb5a7873ad0641e491f027758ab5b5e0

Slight reduction in SARS-CoV-2 exposure viral load due to masking results in a significant reduction in transmission with widespread implementation

Authors: Ashish Goyal, Daniel B. Reeves, Niket Thakkar, Mike Famulare, E. Fabián Cardozo-Ojeda, Bryan T. Mayer, Joshua T. Schiffer

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/11d149a0abe748048ab4459d08ac25d7

Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein

Authors: Rama Raghunandan, Bryan T. Mayer, Yevel Flores-Garcia, Monica W. Gerber, Raphael Gottardo, Hugo Jhun, Sonia M. Herrera, Daniel W. Perez-Ramos, Emily Locke, C. Richter King, Fidel Zavala

Source: Malaria Journal, Vol 19, Iss 1, Pp 1-15 (2020)

Subject Terms: Malaria, Transgenic parasite, Bioluminescence, Monoclonal antibodies, Functional activity, Circumsporozoite protein (CSP), Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12936-020-03181-0; https://doaj.org/toc/1475-2875

Access URL: https://doaj.org/article/4b5eb85f1d8e48149087791ff171d018

Viral diversity is an obligate consideration in CRISPR/Cas9 designs for targeting the HIV reservoir

Authors: Pavitra Roychoudhury, Harshana De Silva Feelixge, Daniel Reeves, Bryan T. Mayer, Daniel Stone, Joshua T. Schiffer, Keith R. Jerome

Source: BMC Biology, Vol 16, Iss 1, Pp 1-13 (2018)

Subject Terms: CRISPR/Cas9, Gene therapy, Endonucleases, Gene editing, HIV, Latent reservoir, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12915-018-0544-1; https://doaj.org/toc/1741-7007

Access URL: https://doaj.org/article/712df32c53994199b41d718103d4859e

Estimating the Risk of Human Herpesvirus 6 and Cytomegalovirus Transmission to Ugandan Infants from Viral Shedding in Saliva by Household Contacts

Authors: Bryan T. Mayer, Elizabeth M. Krantz, Anna Wald, Lawrence Corey, Corey Casper, Soren Gantt, Joshua T. Schiffer

Source: Viruses, Vol 12, Iss 2, p 171 (2020)

Subject Terms: hhv-6, cmv, virology, transmission, epidemiology, biostatistics, viral excretion, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/12/2/171; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/0d4b83c486214e1aaa661b175960964d

A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functions.

Authors: Sedem Dankwa, Christina Kosman, Maria Dennis, Elena E Giorgi, Kenneth Vuong, Ioanna Pahountis, Ashley Garza, Christian Binuya, Janice McCarthy, Bryan T Mayer, Julia T Ngo, Chiamaka A Enemuo, Diane G Carnathan, Sherry Stanfield-Oakley, Stella J Berendam, Carolyn Weinbaum, Kathleen Engelman, Diogo M Magnani, Cliburn Chan, Guido Ferrari, Guido Silvestri, Rama R Amara, Ann Chahroudi, Sallie R Permar, Genevieve G Fouda, Ria Goswami

Source: PLoS ONE, Vol 19, Iss 11, p e0312411 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/67249a617a5941c98087a2a5528cf93f

Optimizing clinical dosing of combination broadly neutralizing antibodies for HIV prevention.

Authors: Bryan T Mayer, Allan C deCamp, Yunda Huang, Joshua T Schiffer, Raphael Gottardo, Peter B Gilbert, Daniel B Reeves

Source: PLoS Computational Biology, Vol 18, Iss 4, p e1010003 (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/b20d108e19284c90906534360439205e

Viral load and contact heterogeneity predict SARS-CoV-2 transmission and super-spreading events

Authors: Ashish Goyal, Daniel B Reeves, E Fabian Cardozo-Ojeda, Joshua T Schiffer, Bryan T Mayer

Source: eLife, Vol 10 (2021)

Subject Terms: SARS-CoV-2, epidemiology, mathematical modeling, viral dynamics, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/63537; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/008fe4290c394c67af594a260723aec4

Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation

Authors: E Fabian Cardozo-Ojeda, Elizabeth R Duke, Christopher W Peterson, Daniel B Reeves, Bryan T Mayer, Hans-Peter Kiem, Joshua T Schiffer

Source: eLife, Vol 10 (2021)

Subject Terms: mathematical modeling, HIV cure, pigtailed macaque, hematopoietic ΔCCR5 stem cells, autologous transplantation, nonlinear mixed-effects, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/57646; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/e4fa43b65ac8466fba011375655a9c96

Mathematical modeling to reveal breakthrough mechanisms in the HIV Antibody Mediated Prevention (AMP) trials.

Authors: Daniel B Reeves, Yunda Huang, Elizabeth R Duke, Bryan T Mayer, E Fabian Cardozo-Ojeda, Florencia A Boshier, David A Swan, Morgane Rolland, Merlin L Robb, John R Mascola, Myron S Cohen, Lawrence Corey, Peter B Gilbert, Joshua T Schiffer

Source: PLoS Computational Biology, Vol 16, Iss 2, p e1007626 (2020)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/b57609ab3ca948799af4d9654506360b