Epigenetic age acceleration is associated with occupational exposures, sex, and survival in amyotrophic lateral sclerosisResearch in context

Authors: Yue Zhao, Xiayan Li, Kai Wang, Gayatri Iyer, Stacey A. Sakowski, Lili Zhao, Samuel Teener, Kelly M. Bakulski, John F. Dou, Bryan J. Traynor, Alla Karnovsky, Stuart A. Batterman, Eva L. Feldman, Maureen A. Sartor, Stephen A. Goutman

Source: EBioMedicine, Vol 109, Iss , Pp 105383- (2024)

Subject Terms: Amyotrophic lateral sclerosis (ALS), Epigenetic clock, Occupational risk, Immune cell proportions, Sex, Ageing, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424004195; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/92ff37f3959d477f9169be8c420e4624

Genetic analysis of the X chromosome in people with Lewy body dementia nominates new risk loci

Authors: Ece Bayram, Paolo Reho, Irene Litvan, International LBD Genomics Consortium, Jinhui Ding, J. Raphael Gibbs, Clifton L. Dalgard, Bryan J. Traynor, Sonja W. Scholz, Ruth Chia

Source: npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-9 (2024)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2373-8057

Access URL: https://doaj.org/article/4b0bdd16236c46ffb7fc3ff2e86da758

Differential methylation analysis in neuropathologically confirmed dementia with Lewy bodies

Authors: Paolo Reho, Sara Saez-Atienzar, Paola Ruffo, Sultana Solaiman, Zalak Shah, Ruth Chia, Karri Kaivola, Bryan J. Traynor, Bension S. Tilley, Steve M. Gentleman, Angela K. Hodges, Dag Aarsland, Edwin S. Monuki, Kathy L. Newell, Randy Woltjer, Marilyn S. Albert, Ted M. Dawson, Liana S. Rosenthal, Juan C. Troncoso, Olga Pletnikova, Geidy E. Serrano, Thomas G. Beach, Hariharan P. Easwaran, Sonja W. Scholz

Source: Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/1f5a47a3a95d4835830f83e30874d417

Cognitive determinants of decisional capacity in neurodegenerative disorders

Authors: Makayla Portley, Carolyn Sherer, Tianxia Wu, Jennifer Farren, Laura E. Danielian, Sonja W. Scholz, Bryan J. Traynor, Michael E. Ward, Taryn Haselhuhn, Allison Snyder, Justin Y. Kwan

Source: Annals of Clinical and Translational Neurology, Vol 10, Iss 10, Pp 1816-1823 (2023)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2328-9503

Access URL: https://doaj.org/article/ada1ac69360548858b23f77a82cc0ee4

Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit

Authors: Rita Sattler, Bryan J. Traynor, Janice Robertson, Ludo Van Den Bosch, Sami J. Barmada, Clive N. Svendsen, Matthew D. Disney, Tania F. Gendron, Philip C. Wong, Martin R. Turner, Adam Boxer, Suma Babu, Michael Benatar, Michael Kurnellas, Jonathan D. Rohrer, Christopher J. Donnelly, Lynette M. Bustos, Kendall Van Keuren-Jensen, Penny A. Dacks, Marwan N. Sabbagh, Attendees of the inaugural C9ORF72 FTD/ALS Summit

Source: Neurology and Therapy, Vol 12, Iss 6, Pp 1821-1843 (2023)

Subject Terms: Biomarker, C9ORF72, Dipeptide repeat protein, Gene therapy, Neurofilament, Prevention, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8253; https://doaj.org/toc/2193-6536

Access URL: https://doaj.org/article/29cedee3ed35403a952639263a5b1ede

Combined epigenetic/genetic study identified an ALS age of onset modifier

Authors: Ming Zhang, Zhengrui Xi, Sara Saez-Atienzar, Ruth Chia, Danielle Moreno, Christine Sato, Mahdi Montazer Haghighi, Bryan J. Traynor, Lorne Zinman, Ekaterina Rogaeva

Source: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-9 (2021)

Subject Terms: ALS, Age of onset, Modifier, DNA methylation, CpG-SNPs, Genetic association, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/6c0d2fd2b5314f7f9b0e946d45a59fc7

ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function

Authors: Desiree M. Baron, Adam R. Fenton, Sara Saez-Atienzar, Anthony Giampetruzzi, Aparna Sreeram, Shankaracharya, Pamela J. Keagle, Victoria R. Doocy, Nathan J. Smith, Eric W. Danielson, Megan Andresano, Mary C. McCormack, Jaqueline Garcia, Valérie Bercier, Ludo Van Den Bosch, Jonathan R. Brent, Claudia Fallini, Bryan J. Traynor, Erika L.F. Holzbaur, John E. Landers

Source: Cell Reports, Vol 39, Iss 1, Pp 110598- (2022)

Subject Terms: CP: Neuroscience, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124722003461; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/41f4ac2c79914783b41ee67f3202e865

Unraveling the complex interplay between genes, environment, and climate in ALS

Authors: Rosario Vasta, Ruth Chia, Bryan J. Traynor, Adriano Chiò

Source: EBioMedicine, Vol 75, Iss , Pp 103795- (2022)

Subject Terms: Amyotrophic lateral sclerosis, Epidemiology, Interactions, Cause, Genetics, Environment, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396421005892; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/e6424701cac7425e82770139b3113a2e

C9orf72 Hexanucleotide Repeat in Huntington-Like Patients: Systematic Review and Meta-Analysis

Authors: Carlos Alva-Diaz, Christoper A. Alarcon-Ruiz, Kevin Pacheco-Barrios, Nicanor Mori, Josmel Pacheco-Mendoza, Bryan J. Traynor, Andrea Rivera-Valdivia, Pongtawat Lertwilaiwittaya, Thomas D. Bird, Mario Cornejo-Olivas

Source: Frontiers in Genetics, Vol 11 (2020)

Subject Terms: C9orf72, Huntington like disorders, systematic review, chorea, prevalence studies, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2020.551780/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/ab9ce89add9f4206b2a0a4c6e8dce082

Age-related penetrance of the C9orf72 repeat expansion

Authors: Natalie A. Murphy, Karissa C. Arthur, Pentti J. Tienari, Henry Houlden, Adriano Chiò, Bryan J. Traynor

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/c16f885d26e849e1b7ccd204b86e2ac3

The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Authors: Yevgeniya A. Abramzon, Pietro Fratta, Bryan J. Traynor, Ruth Chia

Source: Frontiers in Neuroscience, Vol 14 (2020)

Subject Terms: amyotrophic lateral sclerosis, frontotemporal dementia, neurological disorders, neurodegeneration, overlapping genetics, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnins.2020.00042/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/200dcd458ef5465eaf571dbe3b140fab

Novel genetic loci associated with hippocampal volume

Authors: Derrek P. Hibar, Hieab H. H. Adams, Neda Jahanshad, Ganesh Chauhan, Jason L. Stein, Edith Hofer, Miguel E. Renteria, Joshua C. Bis, Alejandro Arias-Vasquez, M. Kamran Ikram, Sylvane Desrivières, Meike W. Vernooij, Lucija Abramovic, Saud Alhusaini, Najaf Amin, Micael Andersson, Konstantinos Arfanakis, Benjamin S. Aribisala, Nicola J. Armstrong, Lavinia Athanasiu, Tomas Axelsson, Ashley H. Beecham, Alexa Beiser, Manon Bernard, Susan H. Blanton, Marc M. Bohlken, Marco P. Boks, Janita Bralten, Adam M. Brickman, Owen Carmichael, M. Mallar Chakravarty, Qiang Chen, Christopher R. K. Ching, Vincent Chouraki, Gabriel Cuellar-Partida, Fabrice Crivello, Anouk Den Braber, Nhat Trung Doan, Stefan Ehrlich, Sudheer Giddaluru, Aaron L. Goldman, Rebecca F. Gottesman, Oliver Grimm, Michael E. Griswold, Tulio Guadalupe, Boris A. Gutman, Johanna Hass, Unn K. Haukvik, David Hoehn, Avram J. Holmes, Martine Hoogman, Deborah Janowitz, Tianye Jia, Kjetil N. Jørgensen, Nazanin Karbalai, Dalia Kasperaviciute, Sungeun Kim, Marieke Klein, Bernd Kraemer, Phil H. Lee, David C. M. Liewald, Lorna M. Lopez, Michelle Luciano, Christine Macare, Andre F. Marquand, Mar Matarin, Karen A. Mather, Manuel Mattheisen, David R. McKay, Yuri Milaneschi, Susana Muñoz Maniega, Kwangsik Nho, Allison C. Nugent, Paul Nyquist, Loes M. Olde Loohuis, Jaap Oosterlaan, Martina Papmeyer, Lukas Pirpamer, Benno Pütz, Adaikalavan Ramasamy, Jennifer S. Richards, Shannon L. Risacher, Roberto Roiz-Santiañez, Nanda Rommelse, Stefan Ropele, Emma J. Rose, Natalie A. Royle, Tatjana Rundek, Philipp G. Sämann, Arvin Saremi, Claudia L. Satizabal, Lianne Schmaal, Andrew J. Schork, Li Shen, Jean Shin, Elena Shumskaya, Albert V. Smith, Emma Sprooten, Lachlan T. Strike, Alexander Teumer, Diana Tordesillas-Gutierrez, Roberto Toro, Daniah Trabzuni, Stella Trompet, Dhananjay Vaidya, Jeroen Van der Grond, Sven J. Van der Lee, Dennis Van der Meer, Marjolein M. J. Van Donkelaar, Kristel R. Van Eijk, Theo G. M. Van Erp, Daan Van Rooij, Esther Walton, Lars T. Westlye, Christopher D. Whelan, Beverly G. Windham, Anderson M. Winkler, Katharina Wittfeld, Girma Woldehawariat, Christiane Wolf, Thomas Wolfers, Lisa R. Yanek, Jingyun Yang, Alex Zijdenbos, Marcel P. Zwiers, Ingrid Agartz, Laura Almasy, David Ames, Philippe Amouyel, Ole A. Andreassen, Sampath Arepalli, Amelia A. Assareh, Sandra Barral, Mark E. Bastin, Diane M. Becker, James T. Becker, David A. Bennett, John Blangero, Hans van Bokhoven, Dorret I. Boomsma, Henry Brodaty, Rachel M. Brouwer, Han G. Brunner, Randy L. Buckner, Jan K. Buitelaar, Kazima B. Bulayeva, Wiepke Cahn, Vince D. Calhoun, Dara M. Cannon, Gianpiero L. Cavalleri, Ching-Yu Cheng, Sven Cichon, Mark R. Cookson, Aiden Corvin, Benedicto Crespo-Facorro, Joanne E. Curran, Michael Czisch, Anders M. Dale, Gareth E. Davies, Anton J. M. De Craen, Eco J. C. De Geus, Philip L. De Jager, Greig I. De Zubicaray, Ian J. Deary, Stéphanie Debette, Charles DeCarli, Norman Delanty, Chantal Depondt, Anita DeStefano, Allissa Dillman, Srdjan Djurovic, Gary Donohoe, Wayne C. Drevets, Ravi Duggirala, Thomas D. Dyer, Christian Enzinger, Susanne Erk, Thomas Espeseth, Iryna O. Fedko, Guillén Fernández, Luigi Ferrucci, Simon E. Fisher, Debra A. Fleischman, Ian Ford, Myriam Fornage, Tatiana M. Foroud, Peter T. Fox, Clyde Francks, Masaki Fukunaga, J. Raphael Gibbs, David C. Glahn, Randy L. Gollub, Harald H. H. Göring, Robert C. Green, Oliver Gruber, Vilmundur Gudnason, Sebastian Guelfi, Asta K. Håberg, Narelle K. Hansell, John Hardy, Catharina A. Hartman, Ryota Hashimoto, Katrin Hegenscheid, Andreas Heinz, Stephanie Le Hellard, Dena G. Hernandez, Dirk J. Heslenfeld, Beng-Choon Ho, Pieter J. Hoekstra, Wolfgang Hoffmann, Albert Hofman, Florian Holsboer, Georg Homuth, Norbert Hosten, Jouke-Jan Hottenga, Matthew Huentelman, Hilleke E. Hulshoff Pol, Masashi Ikeda, Clifford R. Jack Jr, Mark Jenkinson, Robert Johnson, Erik G. Jönsson, J. Wouter Jukema, René S. Kahn, Ryota Kanai, Iwona Kloszewska, David S. Knopman, Peter Kochunov, John B. Kwok, Stephen M. Lawrie, Hervé Lemaître, Xinmin Liu, Dan L. Longo, Oscar L. Lopez, Simon Lovestone, Oliver Martinez, Jean-Luc Martinot, Venkata S. Mattay, Colm McDonald, Andrew M. McIntosh, Francis J. McMahon, Katie L. McMahon, Patrizia Mecocci, Ingrid Melle, Andreas Meyer-Lindenberg, Sebastian Mohnke, Grant W. Montgomery, Derek W. Morris, Thomas H. Mosley, Thomas W. Mühleisen, Bertram Müller-Myhsok, Michael A. Nalls, Matthias Nauck, Thomas E. Nichols, Wiro J. Niessen, Markus M. Nöthen, Lars Nyberg, Kazutaka Ohi, Rene L. Olvera, Roel A. Ophoff, Massimo Pandolfo, Tomas Paus, Zdenka Pausova, Brenda W. J. H. Penninx, G. Bruce Pike, Steven G. Potkin, Bruce M. Psaty, Simone Reppermund, Marcella Rietschel, Joshua L. Roffman, Nina Romanczuk-Seiferth, Jerome I. Rotter, Mina Ryten, Ralph L. Sacco, Perminder S. Sachdev, Andrew J. Saykin, Reinhold Schmidt, Helena Schmidt, Peter R. Schofield, Sigurdur Sigursson, Andrew Simmons, Andrew Singleton, Sanjay M. Sisodiya, Colin Smith, Jordan W. Smoller, Hilkka Soininen, Vidar M. Steen, David J. Stott, Jessika E. Sussmann, Anbupalam Thalamuthu, Arthur W. Toga, Bryan J. Traynor, Juan Troncoso, Magda Tsolaki, Christophe Tzourio, Andre G. Uitterlinden, Maria C. Valdés Hernández, Marcel Van der Brug, Aad van der Lugt, Nic J. A. van der Wee, Neeltje E. M. Van Haren, Dennis van ’t Ent, Marie-Jose Van Tol, Badri N. Vardarajan, Bruno Vellas, Dick J. Veltman, Henry Völzke, Henrik Walter, Joanna M. Wardlaw, Thomas H. Wassink, Michael E. Weale, Daniel R. Weinberger, Michael W. Weiner, Wei Wen, Eric Westman, Tonya White, Tien Y. Wong, Clinton B. Wright, Ronald H. Zielke, Alan B. Zonderman, Nicholas G. Martin, Cornelia M. Van Duijn, Margaret J. Wright, W. T. Longstreth, Gunter Schumann, Hans J. Grabe, Barbara Franke, Lenore J. Launer, Sarah E. Medland, Sudha Seshadri, Paul M. Thompson, M. Arfan Ikram

Source: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/769accb8151a4aceadb44ac82c3f59e0

Projected increase in amyotrophic lateral sclerosis from 2015 to 2040

Authors: Karissa C. Arthur, Andrea Calvo, T. Ryan Price, Joshua T. Geiger, Adriano Chiò, Bryan J. Traynor

Source: Nature Communications, Vol 7, Iss 1, Pp 1-6 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/599811c1630441adaaf2c53d9fa853e3

Longitudinal imaging in C9orf72 mutation carriers: Relationship to phenotype

Authors: Mary Kay Floeter, Devin Bageac, Laura E. Danielian, Laura E. Braun, Bryan J. Traynor, Justin Y. Kwan

Source: NeuroImage: Clinical, Vol 12, Iss C, Pp 1035-1043 (2016)

Subject Terms: C9orf72, Amyotrophic lateral sclerosis, Frontotemporal dementia, Diffusion tensor imaging, Cortical thickness, Ventricular volume, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213158216301954; https://doaj.org/toc/2213-1582

Access URL: https://doaj.org/article/f88d19c05b074be7991ae3920933395d

Clinical Characteristics of C9ORF72-Linked Frontotemporal Lobar Degeneration

Authors: Anna-Lotta Kaivorinne, Michaela K. Bode, Liisa Paavola, Hannu Tuominen, Mika Kallio, Alan E. Renton, Bryan J. Traynor, Virpi Moilanen, Anne M. Remes

Source: Dementia and Geriatric Cognitive Disorders Extra, Vol 3, Iss 1, Pp 251-262 (2013)

Subject Terms: Association study, Clinical features, Frontotemporal dementia, Frontotemporal lobar degeneration, Genetics, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: http://www.karger.com/Article/FullText/351859; https://doaj.org/toc/1664-5464

Access URL: https://doaj.org/article/e967a863b9224a4e9375cf8ea7440259

Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain

Authors: Dena G. Hernandez, Mike A. Nalls, Matthew Moore, Sean Chong, Allissa Dillman, Daniah Trabzuni, J. Raphael Gibbs, Mina Ryten, Sampath Arepalli, Michael E. Weale, Alan B. Zonderman, Juan Troncoso, Richard O'Brien, Robert Walker, Colin Smith, Stefania Bandinelli, Bryan J. Traynor, John Hardy, Andrew B. Singleton, Mark R. Cookson

Source: Neurobiology of Disease, Vol 47, Iss 1, Pp 20-28 (2012)

Subject Terms: eQTL, GWAS, Brain, Blood, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996112000915; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/c1a531d7f42944b19e51399ccc0f58f8

G507D mutation in FUS gene causes familial amyotrophic lateral sclerosis with a specific genotype-phenotype correlation

Authors: Ilaria, Martinelli, Elisabetta, Zucchi, Viviana, Pensato, Cinzia, Gellera, Bryan J, Traynor, Giulia, Gianferrari, Adriano, Chiò, Jessica, Mandrioli

Source: NEUROBIOLOGY OF AGING. 118:124-128

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168507621.0x000001&indx=1&recIds=ETOCvdc_100168507621.0x000001

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.