S. mansoni -derived omega-1 prevents OVA-specific allergic airway inflammation via hampering of cDC2 migration.

Authors: Thiago A Patente, Thomas A Gasan, Maaike Scheenstra, Arifa Ozir-Fazalalikhan, Katja Obieglo, Sjoerd Schetters, Stijn Verwaerde, Karl Vergote, Frank Otto, Ruud H P Wilbers, Eline van Bloois, Yolanda van Wijck, Christian Taube, Hamida Hammad, Arjen Schots, Bart Everts, Maria Yazdanbakhsh, Bruno Guigas, Cornelis H Hokke, Hermelijn H Smits

Source: PLoS Pathogens, Vol 20, Iss 8, p e1012457 (2024)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/8e9219acf37049d6b38930cd17cd8862

Extracellular vesicles derived from stressed beta cells mediate monocyte activation and contribute to islet inflammation

Authors: Mette C. Dekkers, Joost M. Lambooij, Xudong Pu, Raphael R. Fagundes, Agustin Enciso-Martinez, Kim Kats, Ben N. G. Giepmans, Bruno Guigas, Arnaud Zaldumbide

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: type 1 diabetes, er stress, extracellular vesicles, monocytes, inflammation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1393248/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/2b3c885eac0a4db1b569f2a73fe0eacb

DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in mice

Authors: Xiaoke Ge, Bram Slütter, Joost M. Lambooij, Enchen Zhou, Zhixiong Ying, Ceren Agirman, Marieke Heijink, Antoine Rimbert, Bruno Guigas, Johan Kuiper, Christoph Müller, Franz Bracher, Martin Giera, Sander Kooijman, Patrick C.N. Rensen, Yanan Wang, Milena Schönke

Source: iScience, Vol 27, Iss 6, Pp 109830- (2024)

Subject Terms: Cardiovascular medicine, Cellular physiology, Molecular genetics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224010526; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/d72d912914924864b6d5ff9166b6b6a7

A polyphenol-rich plant extract prevents hypercholesterolemia and modulates gut microbiota in western diet-fed mice

Authors: Cédric Langhi, Marie Vallier, Auriane Bron, Yolanda F. Otero, Maheva Maura, Florian Le Joubioux, Niek Blomberg, Martin Giera, Bruno Guigas, Thierry Maugard, Benoit Chassaing, Sébastien Peltier, Stéphanie Blanquet-Diot, Jean-Marie Bard, Pascal Sirvent

Source: Frontiers in Cardiovascular Medicine, Vol 11 (2024)

Subject Terms: cholesterol, triglycerides, lipoproteins, intestine, microbiota, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2024.1342388/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/fd059bc1b2854f0aacd7c89732c3df30

Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation

Authors: Enchen Zhou, Xiaoke Ge, Hiroyuki Nakashima, Rumei Li, Hendrik J P van der Zande, Cong Liu, Zhuang Li, Christoph Müller, Franz Bracher, Yassene Mohammed, Jan Freark de Boer, Folkert Kuipers, Bruno Guigas, Christopher K Glass, Patrick C N Rensen, Martin Giera, Yanan Wang

Source: EMBO Molecular Medicine, Vol 15, Iss 8, Pp 1-15 (2023)

Subject Terms: desmosterol, Kupffer cell, liver X receptor, nonalcoholic steatohepatitis, Δ24‐dehydrocholesterol reductase, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/4c911682d99b44c88efeac537e3e77c7

Combined GIP receptor and GLP1 receptor agonism attenuates NAFLD in male APOE∗3-Leiden.CETP miceResearch in context

Authors: Zhixiong Ying, Robin van Eenige, Xiaoke Ge, Christy van Marwijk, Joost M. Lambooij, Bruno Guigas, Martin Giera, Jan Freark de Boer, Tamer Coskun, Hongchang Qu, Yanan Wang, Mariëtte R. Boon, Patrick C.N. Rensen, Sander Kooijman

Source: EBioMedicine, Vol 93, Iss , Pp 104684- (2023)

Subject Terms: Adipose tissue, Bile acid metabolism, Hepatic steatosis, Hepatic inflammation, Glucose metabolism, Lipid metabolism, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423002499; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/d8ae3b6711e4498db0d081190af4e7ce

Dendritic cell–intrinsic LKB1-AMPK/SIK signaling controls metabolic homeostasis by limiting the hepatic Th17 response during obesity

Authors: Hendrik J.P. vanderZande, Eline C. Brombacher, Joost M. Lambooij, Leonard R. Pelgrom, Anna Zawistowska-Deniziak, Thiago A. Patente, Graham A. Heieis, Frank Otto, Arifa Ozir-Fazalalikhan, Maria Yazdanbakhsh, Bart Everts, Bruno Guigas

Source: JCI Insight, Vol 8, Iss 11 (2023)

Subject Terms: Immunology, Metabolism, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/a2a53ade54994d4e8b65b8433ec93d8d

Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis

Authors: Pascale Gluais‐Dagorn, Marc Foretz, Gregory R. Steinberg, Battsetseg Batchuluun, Anna Zawistowska‐Deniziak, Joost M. Lambooij, Bruno Guigas, David Carling, Pierre‐Axel Monternier, David E. Moller, Sebastien Bolze, Sophie Hallakou‐Bozec

Source: Hepatology Communications, Vol 6, Iss 1, Pp 101-119 (2022)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/2471-254X

Access URL: https://doaj.org/article/2df65d317e994c11bf3fa834d69f136d

FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis

Authors: Cong Liu, Milena Schönke, Borah Spoorenberg, Joost M Lambooij, Hendrik JP van der Zande, Enchen Zhou, Maarten E Tushuizen, Anne-Christine Andreasson, Andrew Park, Stephanie Oldham, Martin Uhrbom, Ingela Ahlstedt, Yasuhiro Ikeda, Kristina Wallenius, Xiao-Rong Peng, Bruno Guigas, Mariëtte R Boon, Yanan Wang, Patrick CN Rensen

Source: eLife, Vol 12 (2023)

Subject Terms: fibroblast growth factor 21, steatohepatitis, lipid/scar-associated macrophages, liver-adipose tissue crosstalk, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/83075; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/10b3762987d94deeac6dedce6336b7ac

ER stress promotes mitochondrial DNA mediated type-1 interferon response in beta-cells and interleukin-8 driven neutrophil chemotaxis

Authors: Saurabh Vig, Joost M. Lambooij, Mette C. Dekkers, Frank Otto, Françoise Carlotti, Bruno Guigas, Arnaud Zaldumbide

Source: Frontiers in Endocrinology, Vol 13 (2022)

Subject Terms: type 1 diabetes, ER stress, mitochondria, innate immunity, neutrophils, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2022.991632/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/61cf86ab88874b8c93ca856edcc182d2

Fasciola hepatica Fatty Acid Binding Protein 1 Modulates T cell Polarization by Promoting Dendritic Cell Thrombospondin-1 Secretion Without Affecting Metabolic Homeostasis in Obese Mice

Authors: Anna Zawistowska-Deniziak, Joost M. Lambooij, Alicja Kalinowska, Thiago A. Patente, Maciej Łapiński, Hendrik J. P. van der Zande, Katarzyna Basałaj, Clarize M. de Korne, Mathilde A. M. Chayé, Thomas A. Gasan, Luke J. Norbury, Martin Giera, Arnaud Zaldumbide, Hermelijn H. Smits, Bruno Guigas

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: helminths, liver fluke, dendritic cells, Th2, Th1, TSP-1, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.884663/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/7c070fb103e2496b99a4b157b84ffcc5

Editorial: Immune Regulation of Metabolic Homeostasis

Authors: Bruno Guigas, Tony Jourdan, Rinke Stienstra

Source: Frontiers in Endocrinology, Vol 13 (2022)

Subject Terms: immunometabolism, obesity, type 2 diabetes, NASH, macrophages, dendritic cells, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2022.929460/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/e678667d85134da5bea64f5a7985f4bf

The Mannose Receptor: From Endocytic Receptor and Biomarker to Regulator of (Meta)Inflammation

Authors: Hendrik J. P. van der Zande, Dominik Nitsche, Laura Schlautmann, Bruno Guigas, Sven Burgdorf

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: mannose receptor, sMR, metaflammation, macrophage, biomarker, immunometabolism, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.765034/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0830c0f3b2d24aed98d26c111c13277a

Platelet Acetyl-CoA Carboxylase Phosphorylation

Authors: Shakeel Kautbally, MD, Sophie Lepropre, PhD, Marie-Blanche Onselaer, PhD, Astrid Le Rigoleur, MD, Audrey Ginion, MS, Christophe De Meester de Ravenstein, PhD, Jerome Ambroise, PhD, Karim Z. Boudjeltia, PhD, Marie Octave, MS, Odile Wéra, MS, Alexandre Hego, BSc, Joël Pincemail, PhD, Jean-Paul Cheramy-Bien, Thierry Huby, PhD, Martin Giera, PhD, Bernhard Gerber, MD, PhD, Anne-Catherine Pouleur, MD, PhD, Bruno Guigas, PhD, Jean-Louis Vanoverschelde, MD, PhD, Joelle Kefer, MD, PhD, Luc Bertrand, PhD, Cécile Oury, PhD, Sandrine Horman, PhD, Christophe Beauloye, MD, PhD

Source: JACC: Basic to Translational Science, Vol 4, Iss 5, Pp 596-610 (2019)

Subject Terms: Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2452302X19301780; https://doaj.org/toc/2452-302X

Access URL: https://doaj.org/article/a0b12aa846a24ab19eb1da72ee5b48e2

Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes

Authors: Sanne G. S. Verberk, Hendrik J. P. van der Zande, Jeroen Baardman, Kyra E. de Goede, Karl J. Harber, Eelco D. Keuning, Joost M. Lambooij, Frank Otto, Anna Zawistowska-Deniziak, Helga E. de Vries, Menno P. J. de Winther, Bruno Guigas, Jan Van den Bossche

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: obesity, peritonitis, macrophage, immunometabolism, inflammation, ATP citrate lyase, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.669920/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/eedffe2b80ad4e5590a19202f028c287

Endoplasmic Reticulum-Mitochondria Crosstalk and Beta-Cell Destruction in Type 1 Diabetes

Authors: Saurabh Vig, Joost M. Lambooij, Arnaud Zaldumbide, Bruno Guigas

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: endoplasmic reticulum, ER stress, mitochondria, Type 1 diabetes (T1D), beta-cell, inflammation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.669492/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/be4f9a58b9cb459b9b8091ee7379af06

Schistosoma haematobium infection is associated with lower serum cholesterol levels and improved lipid profile in overweight/obese individuals.

Authors: Jeannot F Zinsou, Jacqueline J Janse, Yabo Y Honpkehedji, Jean Claude Dejon-Agobé, Noemí García-Tardón, Pytsje T Hoekstra, Marguerite Massinga-Loembe, Paul L A M Corstjens, Govert J van Dam, Martin Giera, Peter G Kremsner, Maria Yazdanbakhsh, Ayola A Adegnika, Bruno Guigas

Source: PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008464 (2020)

Subject Terms: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735

Access URL: https://doaj.org/article/3b352b556cda437eb34237fc11eb817d

Impact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet

Authors: Dicky L. Tahapary, Karin de Ruiter, Farid Kurniawan, Yenny Djuardi, Yanan Wang, Siti M. E. Nurdin, Elisa Iskandar, Dominggus Minggu, Em Yunir, Bruno Guigas, Taniawati Supali, Patrick C. N. Rensen, Erliyani Sartono, Pradana Soewondo, Dante S. Harbuwono, Johannes W. A. Smit, Maria Yazdanbakhsh

Source: Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/f0aadfa327ef4384bf168fe6d66930fd

Role of Mitochondria in the Mechanism(s) of Action of Metformin

Authors: Guillaume Vial, Dominique Detaille, Bruno Guigas

Source: Frontiers in Endocrinology, Vol 10 (2019)

Subject Terms: biguanides, respiratory-chain complex 1, bioenergetics, AMPK, cancer, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fendo.2019.00294/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/b84c6052c9c7485eac26bc003986dffd

Dietary yeast-derived mannan oligosaccharides have immune-modulatory properties but do not improve high fat diet-induced obesity and glucose intolerance.

Authors: Lisa R Hoving, Hendrik J P van der Zande, Amanda Pronk, Bruno Guigas, Ko Willems van Dijk, Vanessa van Harmelen

Source: PLoS ONE, Vol 13, Iss 5, p e0196165 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5933760?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f3d05831d6684760ae13f3237078d424