Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity

Authors: Ahmed E. I. Hamouda, Jessica Filtjens, Elisabeth Brabants, Daliya Kancheva, Ayla Debraekeleer, Jan Brughmans, Lotte Jacobs, Pauline M. R. Bardet, Elisabeth Knetemann, Pierre Lefesvre, Lize Allonsius, Mark Gontsarik, Ismael Varela, Marian Crabbé, Emile J. Clappaert, Federica Cappellesso, Aarushi A. Caro, Alícia Gordún Peiró, Luna Fredericq, Eva Hadadi, Mariona Estapé Senti, Raymond Schiffelers, Leo A. van Grunsven, Frank Aboubakar Nana, Bruno G. De Geest, Sofie Deschoemaeker, Stefaan De Koker, Florence Lambolez, Damya Laoui

Source: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5d3d46521d37404983a65684b85cc442

A preclinical platform for assessing long-term drug efficacy exploiting mechanically tunable scaffolds colonized by a three-dimensional tumor microenvironment

Authors: Elly De Vlieghere, Koen Van de Vijver, Eva Blondeel, Nathan Carpentier, Rouba Ghobeira, Jarne Pauwels, Sebastian Riemann, Manon Minsart, Charlotte Fieuws, Johanna Mestach, Ans Baeyens, Nathalie De Geyter, Charlotte Debbaut, Hannelore Denys, Benedicte Descamps, Kathleen Claes, Anne Vral, Jo Van Dorpe, Kris Gevaert, Bruno G. De Geest, Wim Ceelen, Sandra Van Vlierberghe, Olivier De Wever

Source: Biomaterials Research, Vol 27, Iss 1, Pp 1-18 (2023)

Subject Terms: 3D cancer model, Long-term, Drug evaluation, Pre-clinical, Micro-environment, Stiffness, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/2055-7124

Access URL: https://doaj.org/article/3e5a307685aa4c44b056bfedd46942cf

Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in quadrivalent influenza vaccine vaccinated mice

Authors: Sonia Jangra, Alexander Lamoot, Gagandeep Singh, Gabriel Laghlali, Yong Chen, Tingting Ye, Adolfo García-Sastre, Bruno G. De Geest, Michael Schotsaert

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: influenza vaccine, QIV, adjuvant, lipid nanoparticles, ionizable lipids, antibody class switching, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1370564/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/ec458a7862724502a5cded87814e573f

Impact of the polymer backbone chemistry on interactions of amino-acid-derived zwitterionic polymers with cells

Authors: Meike N. Leiske, Bruno G. De Geest, Richard Hoogenboom

Source: Bioactive Materials, Vol 24, Iss , Pp 524-534 (2023)

Subject Terms: Amino-acid-functionalised polymer, Zwitterionic polymer, Cell-specific polymer, Cancer-targeting, RAFT-Polymerisation, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2452199X23000051; https://doaj.org/toc/2452-199X

Access URL: https://doaj.org/article/984a404ccac145739fb6fdadb6eb662d

Influenza breakthrough infection in vaccinated mice is characterized by non-pathological lung eosinophilia

Authors: Lauren A. Chang, Angela Choi, Raveen Rathnasinghe, Prajakta Warang, Moataz Noureddine, Sonia Jangra, Yong Chen, Bruno G. De Geest, Michael Schotsaert

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: eosinophils - immunology, influenza, breakthrough infection, eosinophils subtypes, influenza vaccination, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1217181/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f7543b749d5d433c9261b41937fc7018

Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera

Authors: Raveen Rathnasinghe, Sonia Jangra, Chengjin Ye, Anastasija Cupic, Gagandeep Singh, Carles Martínez-Romero, Lubbertus C. F. Mulder, Thomas Kehrer, Soner Yildiz, Angela Choi, Stephen T. Yeung, Ignacio Mena, Virginia Gillespie, Jana De Vrieze, Sadaf Aslam, Daniel Stadlbauer, David A. Meekins, Chester D. McDowell, Velmurugan Balaraman, Michael J. Corley, Juergen A. Richt, Bruno G. De Geest, Lisa Miorin, PVI study group, Florian Krammer, Luis Martinez-Sobrido, Viviana Simon, Adolfo García-Sastre, Michael Schotsaert

Source: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/12c6e893f2b043239df7246c95215cf6

RIG-I and TLR-7/8 agonists as combination adjuvant shapes unique antibody and cellular vaccine responses to seasonal influenza vaccine

Authors: Sonia Jangra, Gabriel Laghlali, Angela Choi, Raveen Rathnasinghe, Yong Chen, Soner Yildiz, Lynda Coughlan, Adolfo García-Sastre, Bruno G. De Geest, Michael Schotsaert

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: influenza vaccine, adjuvant, ADCC, T cell, antibody class switching, HA stalk, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.974016/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/8948680f21d34497a5a69b874b6560f4

Recombinant DnaK Orally Administered Protects Axenic European Sea Bass Against Vibriosis

Authors: Eamy Nursaliza Yaacob, Parisa Norouzitallab, Bruno G. De Geest, Aline Bajek, Kristof Dierckens, Peter Bossier, Daisy Vanrompay

Source: Frontiers in Immunology, Vol 10 (2020)

Subject Terms: gnotobiotic, European sea bass larvae, bacterial HSP70, DnaK, immunity, vibriosis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.03162/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0b489d768fb541a0b51f0ee0adee3927

Transient Multivalent Nanobody Targeting to CD206-Expressing Cells via PH-Degradable Nanogels

Authors: Maximilian Scherger, Evangelia Bolli, Ana Rita Pombo Antunes, Sana Arnouk, Judith Stickdorn, Alexandra Van Driessche, Hansjörg Schild, Stephan Grabbe, Bruno G. De Geest, Jo A. Van Ginderachter, Lutz Nuhn

Source: Cells, Vol 9, Iss 10, p 2222 (2020)

Subject Terms: nanogel, nanobody, targeting, RAFT polymerization, click chemistry, CD206, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/10/2222; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/da8008b0c0bf450e8efd7d18830ad2da

Feasibility of Mechanical Extrusion to Coat Nanoparticles with Extracellular Vesicle Membranes

Authors: Jan Van Deun, Quentin Roux, Sarah Deville, Thibaut Van Acker, Pekka Rappu, Ilkka Miinalainen, Jyrki Heino, Frank Vanhaecke, Bruno G. De Geest, Olivier De Wever, An Hendrix

Source: Cells, Vol 9, Iss 8, p 1797 (2020)

Subject Terms: extracellular vesicle, exosome, microvesicle, biomimetics, gold nanoparticle, functionalization, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/8/1797; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/7954e922a9234bacbf83d6b8935b1207

Fusing Antigens and Adjuvants into Traceless Nanogels

Authors: Bruno G. De Geest

Source: ACS Central Science, Vol 6, Iss 3, Pp 342-343 (2020)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2374-7951

Access URL: https://doaj.org/article/2f32539b1f2e4fe794166535345cd4a1

Biocatalytically Active Thin Films via Self-Assembly of 2-Deoxy-D-ribose-5-phosphate Aldolase-Poly(N-isopropylacrylamide) Conjugates.

Authors: Shuhao Zhang, Carolin Bisterfeld, Julia Bramski, Nane Vanparijs, Bruno G. De Geest, Jörg Pietruszka, Alexander Böker, Stefan Reinicke

Source: Bioconjugate Chemistry; 1/17/2018, Vol. 29 Issue 1, p104-116, 13p

Designing polymeric particles for antigen delivery.

Authors: Stefaan De Koker, Bart N. Lambrecht, Monique A. Willart, Yvette van Kooyk, Johan Grooten, Chris Vervaet, Jean Paul Remon, Bruno G. De Geest

Source: Chemical Society Reviews; Dec2010, Vol. 40 Issue 1, p320-339, 20p

Subject Terms: ANTIGENS, POLYMERIZATION, DENDRITIC cells, IMMUNOLOGY, IMMUNE response, VACCINES

Multifunctional Layer-by-Layer Coating of Digitally Encoded Microparticles.

Authors: Stefaan Derveaux¹, Bruno G. De Geest¹, Chris Roelant¹, Kevin Braeckmans¹, Jo Demeester¹, Stefaan C. De Smedt¹

Source: Langmuir. Sep2007, Vol. 23 Issue 20, p10272-10279. 8p.

Subject Terms: *DIAGNOSIS, *BAR codes, *COATING processes, *SURFACES (Technology)

Release mechanisms for polyelectrolyte capsules.

Authors: Bruno G. De Geest¹, Niek N. Sanders¹, Gleb B. Sukhorukov², Joseph Demeester¹, Stefaan C. De Smedt¹

Source: Chemical Society Reviews. Mar2007, Vol. 36 Issue 4, p636-649. 14p.

Subject Terms: *POLYELECTROLYTES, *ELECTROLYTE solutions, *MACROMOLECULES, *PHARMACEUTICAL encapsulation

Ultrasound stimulated release and catalysis using polyelectrolyte multilayer capsules.

Authors: Andre G. Skirtach, Bruno G. De Geest, Arif Mamedov, Alexei A. Antipov, Nicholas A. Kotov, Gleb B. Sukhorukov

Source: Journal of Materials Chemistry; Mar2007, Vol. 17 Issue 11, p1050-1054, 5p