Remodeling of Mitochondria–Endoplasmic Reticulum Contact Sites Accompanies LUHMES Differentiation.

Authors: Norouzi Esfahani, Emad, Knedlik, Tomas, Shin, Sang Hun, Magalhães Rebelo, Ana Paula, De Mario, Agnese, Vianello, Caterina, Persano, Luca, Rampazzo, Elena, Edomi, Paolo, Bean, Camilla, Brunetti, Dario, Scorrano, Luca, Greco, Samuele, Gerdol, Marco, Giacomello, Marta

Source: Biomolecules (2218-273X); Jan2025, Vol. 15 Issue 1, p126, 17p

Subject Terms: NEURONAL differentiation, PROGENITOR cells, MITOCHONDRIA, SCIENTIFIC community, MORPHOLOGY

Advances in Mitochondria-Targeted Drug Delivery.

Authors: Bottani, Emanuela¹ (AUTHOR) emanuela.bottani@univr.it, Brunetti, Dario^2,3 (AUTHOR) emanuela.bottani@univr.it

Source: Pharmaceutics. Aug2023, Vol. 15 Issue 8, p2089. 5p.

Subject Terms: *CALCIUM-dependent potassium channels, *RECESSIVE genes, *MITOCHONDRIA, *SARCOPENIA, *FRIEDREICH'S ataxia, *ADRENOLEUKODYSTROPHY, *PARKIN (Protein), *PPAR-gamma agonists

Mitochondria in neurogenesis: Implications for mitochondrial diseases

Authors: Brunetti, Dario, Dykstra, Werner, Le, Stephanie, Zink, Annika, Prigione, Alessandro

Source: Stem cells. 39(10):1289-1297

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131150220.0x000001&indx=1&recIds=ETOCvdc_100131150220.0x000001

Complete neural stem cell (NSC) neuronal differentiation requires a branched chain amino acids-induced persistent metabolic shift towards energy metabolism

Authors: Bifari, Francesco ^***, Dolci, Sissi, Bottani, Emanuela, Pino, Annachiara, Di Chio, Marzia, Zorzin, Stefania, Ragni, Maurizio, Zamfir, Raluca Georgiana, Brunetti, Dario, Bardelli, Donatella, Delfino, Pietro, Cattaneo, Maria Grazia, Bordo, Roberta, Tedesco, Laura, Rossi, Fabio, Bossolasco, Patrizia, Corbo, Vincenzo, Fumagalli, Guido, Nisoli, Enzo ^**, Valerio, Alessandra, Decimo, Ilaria ^*

Source: In Pharmacological Research August 2020 158

Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes.

Authors: Giuliani, Maria Elisa, Bigossi, Giorgia, Lai, Giovanni, Marcozzi, Serena, Brunetti, Dario, Malavolta, Marco

Source: Marine Drugs; May2024, Vol. 22 Issue 5, p210, 22p

Cellular senescence and frailty: a comprehensive insight into the causal links.

Authors: Marcozzi, Serena, Bigossi, Giorgia, Giuliani, Maria Elisa, Giacconi, Robertina, Piacenza, Francesco, Cardelli, Maurizio, Brunetti, Dario, Segala, Agnese, Valerio, Alessandra, Nisoli, Enzo, Lattanzio, Fabrizia, Provinciali, Mauro, Malavolta, Marco

Source: GeroScience; Dec2023, Vol. 45 Issue 6, p3267-3305, 39p

Subject Terms: CELLULAR aging, FRAILTY

PPAR-gamma agonist pioglitazone recovers mitochondrial quality control in fibroblasts from PITRM1-deficient patients .

Authors: Di Donfrancesco, Alessia, Berlingieri, Christian, Giacomello, Marta, Frascarelli, Chiara, Magalhaes Rebelo, Ana Paula, Bindoff, Laurence A., Reeval, Segel, Renbaum, Paul, Santorelli, Filippo M., Massaro, Giulia, Viscomi, Carlo, Zeviani, Massimo, Ghezzi, Daniele, Bottani, Emanuela, Brunetti, Dario

Source: Frontiers in Pharmacology; 2023, p1-15, 15p

Subject Terms: FRATAXIN, PEROXISOME proliferator-activated receptors, PPAR-gamma agonists, QUALITY control, MITOCHONDRIA, MITOCHONDRIAL membranes

Comprehensive longitudinal non-invasive quantification of healthspan and frailty in a large cohort (n = 546) of geriatric C57BL/6 J mice.

Authors: Marcozzi, Serena, Bigossi, Giorgia, Giuliani, Maria Elisa, Giacconi, Robertina, Cardelli, Maurizio, Piacenza, Francesco, Orlando, Fiorenza, Segala, Agnese, Valerio, Alessandra, Nisoli, Enzo, Brunetti, Dario, Puca, Annibale, Boschi, Federico, Gaetano, Carlo, Mongelli, Alessia, Lattanzio, Fabrizia, Provinciali, Mauro, Malavolta, Marco

Source: GeroScience; Aug2023, Vol. 45 Issue 4, p2195-2211, 17p

Subject Terms: LABORATORY mice, FRAILTY, ANIMAL health, PHYSICAL mobility, ANIMAL diseases

C19orf12 and FA2H Mutations Are Rare in Italian Patients With Neurodegeneration With Brain Iron Accumulation

Authors: Panteghini, Celeste, Zorzi, Giovanna, Venco, Paola, Dusi, Sabrina, Reale, Chiara, Brunetti, Dario, Chiapparini, Luisa, Zibordi, Federica, Siegel, Brigitte, Garavaglia, Barbara, Simonati, Alessandro, Bertini, Enrico, Nardocci, Nardo, Tiranti, Valeria

Source: In Seminars in Pediatric Neurology June 2012 19(2):75-81

Comprehensive longitudinal non-invasive quantification of healthspan and frailty in a large cohort (n= 546) of geriatric C57BL/6 J mice

Authors: Marcozzi, Serena, Bigossi, Giorgia, Giuliani, Maria Elisa, Giacconi, Robertina, Cardelli, Maurizio, Piacenza, Francesco, Orlando, Fiorenza, Segala, Agnese, Valerio, Alessandra, Nisoli, Enzo, Brunetti, Dario, Puca, Annibale, Boschi, Federico, Gaetano, Carlo, Mongelli, Alessia, Lattanzio, Fabrizia, Provinciali, Mauro, Malavolta, Marco

Source: GeroScience; August 2023, Vol. 45 Issue: 4 p2195-2211, 17p

Generation of two human iPSC lines, HMGUi004-A and FINCBi004-A, from fibroblasts of MPAN patients carrying pathogenic recessive mutations in the gene C19orf12

Authors: Zanuttigh, Enrica, Rusha, Ejona, Peron, Camille, Brunetti, Dario, Zorzi, Giovanna, Pertek, Anna, Nteli, Polyxeni, Winkelmann, Juliane, Tiranti, Valeria, Iuso, Arcangela

Source: In Stem Cell Research October 2023 72

Comparative aspects of somatic cell nuclear transfer with conventional and zona-free method in cattle, horse, pig and sheep

Authors: Lagutina, Irina, Lazzari, Giovanna, Duchi, Roberto, Turini, Paola, Tessaro, Irene, Brunetti, Dario, Colleoni, Silvia, Crotti, Gabriella, Galli, Cesare

Source: In Theriogenology 2007 67(1):90-98

Correction to: Fetal and obstetrics manifestations of mitochondrial diseases.

Authors: Adelizzi, Alessia, Giri, Anastasia, Di Donfrancesco, Alessia, Boito, Simona, Prigione, Alessandro, Bottani, Emanuela, Bollati, Valentina, Tiranti, Valeria, Persico, Nicola, Brunetti, Dario

Source: Journal of Translational Medicine; 12/5/2024, Vol. 22 Issue 1, p1-1, 1p

Subject Terms: PERSONAL names, MITOCHONDRIA, OBSTETRICS

Gene Therapy for Mitochondrial Diseases: Current Status and Future Perspective.

Authors: Di Donfrancesco, Alessia, Massaro, Giulia, Di Meo, Ivano, Tiranti, Valeria, Bottani, Emanuela, Brunetti, Dario

Source: Pharmaceutics; Jun2022, Vol. 14 Issue 6, p1287-N.PAG, 30p

Subject Terms: GENE therapy, MITOCHONDRIAL DNA, EXPRESSIVE arts therapy, MITOCHONDRIA, ART therapy, TRANSGENE expression

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Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.

Authors: Inak, Gizem, Rybak-Wolf, Agnieszka, Lisowski, Pawel, Pentimalli, Tancredi M., Jüttner, René, Glažar, Petar, Uppal, Karan, Bottani, Emanuela, Brunetti, Dario, Secker, Christopher, Zink, Annika, Meierhofer, David, Henke, Marie-Thérèse, Dey, Monishita, Ciptasari, Ummi, Mlody, Barbara, Hahn, Tobias, Berruezo-Llacuna, Maria, Karaiskos, Nikos, Di Virgilio, Michela

Source: Nature Communications; 3/26/2021, Vol. 12 Issue 1, p1-22, 22p

Subject Terms: PLURIPOTENT stem cells, INDUCED pluripotent stem cells, MORPHOGENESIS

Targeting Multiple Mitochondrial Processes by a Metabolic Modulator Prevents Sarcopenia and Cognitive Decline in SAMP8 Mice.

Authors: Brunetti, Dario, Bottani, Emanuela, Segala, Agnese, Marchet, Silvia, Rossi, Fabio, Orlando, Fiorenza, Malavolta, Marco, Carruba, Michele O., Lamperti, Costanza, Provinciali, Mauro, Nisoli, Enzo, Valerio, Alessandra

Source: Frontiers in Pharmacology; 7/31/2020, Vol. 11, pN.PAG-N.PAG, 16p

Subject Terms: PEROXISOME proliferator-activated receptors, PLANT mitochondria, KREBS cycle, AMYLOID beta-protein precursor, ESSENTIAL amino acids, ELEMENTAL diet, MICE

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Mitochondrial PITRM1peptidase loss-of-function in childhood cerebellar atrophy

Authors: Langer, Yeshaya, Aran, Adi, Gulsuner, Suleyman, Abu Libdeh, Bassam, Renbaum, Paul, Brunetti, Dario, Teixeira, Pedro-Filipe, Walsh, Tom, Zeligson, Sharon, Ruotolo, Roberta, Beeri, Rachel, Dweikat, Imad, Shahrour, Maher, Weinberg-Shukron, Ariella, Zahdeh, Fouad, Baruffini, Enrico, Glaser, Elzbieta, King, Mary-Claire, Levy-Lahad, Ephrat, Zeviani, Massimo, Segel, Reeval

Source: Journal of Medical Genetics (JMG); 2018, Vol. 55 Issue: 9 p599-606, 8p