Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers

Authors: Diepstraten, Sarah T., Yuan, Yin, La Marca, John E., Young, Savannah, Chang, Catherine, Whelan, Lauren, Ross, Aisling M., Fischer, Karla C., Pomilio, Giovanna, Morris, Rhiannon, Georgiou, Angela, Litalien, Veronique, Brown, Fiona C., Roberts, Andrew W., Strasser, Andreas, Wei, Andrew H., Kelly, Gemma L.

Source: In Cancer Cell 13 May 2024 42(5):850-868

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia

Authors: Moujalled, Donia M. ^∗, Brown, Fiona C. ^∗, Chua, Chong Chyn, Dengler, Michael A., Pomilio, Giovanna, Anstee, Natasha S., Litalien, Veronique, Thompson, Ella, Morley, Thomas, MacRaild, Sarah, Tiong, Ing S., Morris, Rhiannon, Dun, Karen, Zordan, Adrian, Shah, Jaynish, Banquet, Sebastien, Halilovic, Ensar, Morris, Erick, Herold, Marco J., Lessene, Guillaume, Adams, Jerry M., Huang, David C. S., Roberts, Andrew W., Blombery, Piers, Wei, Andrew H.

Source: In Blood 9 February 2023 141(6):634-644

Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses

Authors: Chan, Kah Lok, Gomez, Juliana, Cardinez, Chelisa, Kumari, Nishi, Sparbier, Christina E., Lam, Enid Y.N., Yeung, Miriam M., Garciaz, Sylvain, Kuzich, James A., Ong, Doen Ming, Brown, Fiona C., Chan, Yih-Chih, Vassiliadis, Dane, Wainwright, Elanor N., Motazedian, Ali, Gillespie, Andrea, Fennell, Katie A., Lai, Junyun, House, Imran G., Macpherson, Laura, Ang, Ching-Seng, Dawson, Sarah-Jane, Beavis, Paul A., Wei, Andrew H., Burr, Marian L., Dawson, Mark A.

Source: In Cancer Cell 10 October 2022 40(10):1190-1206

Acquired BCL2variants associated with venetoclax resistance in acute myeloid leukemia

Authors: Brown, Fiona C., Wang, Xin, Birkinshaw, Richard, Chua, Chong Chyn, Morley, Thomas, Kasapgil, Sila, Pomilio, Giovanna, Blombery, Piers, Huang, David C. S., Czabotar, Peter, Priore, Salvatore F., Yang, Guang, Carroll, Martin, Wei, Andrew H., Perl, Alexander E.

Source: Blood Advances; January 2025, Vol. 9 Issue: 1 p127-131, 5p

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Authors: Thijssen, Rachel ^*, Diepstraten, Sarah T. ^*, Moujalled, Donia ^*, Chew, Edward, Flensburg, Christoffer, Shi, Melissa X., Dengler, Michael A., Litalien, Veronique, MacRaild, Sarah, Chen, Maoshan, Anstee, Natasha S., Reljić, Boris, Gabriel, Sarah S., Djajawi, Tirta M., Riffkin, Chris D., Aubrey, Brandon J., Chang, Catherine, Tai, Lin, Xu, Zhen, Morley, Thomas, Pomilio, Giovanna, Bruedigam, Claudia, Kallies, Axel, Stroud, David A., Bajel, Ashish, Kluck, Ruth M., Lane, Steven W., Schoumacher, Marie, Banquet, Sébastien, Majewski, Ian J., Strasser, Andreas, Roberts, Andrew W., Huang, David C.S. ^****, Brown, Fiona C. ^***, Kelly, Gemma L. ^**, Wei, Andrew H.

Source: In Blood 20 May 2021 137(20):2721-2735

Cellular distribution of IDH mutations in AML during morphologic remission

Authors: Ramanan, Radha, Tiong, Ing Soo, Ivey, Adam, Ong, Doen Ming, Brown, Fiona C., Chua, Chyn, Das, Tongted, Curtis, David J.

Source: Leukemia research. 124

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178571665.0x000001&indx=1&recIds=ETOCvdc_100178571665.0x000001

Acquired BCL2 variants associated with venetoclax resistance in acute myeloid leukemia

Authors: Brown, Fiona C. ^{1, 2, 3}, Wang, Xin ⁴, Birkinshaw, Richard ^{2, 5}, Chua, Chong Chyn ¹, Morley, Thomas ¹, Kasapgil, Sila ^{2, 5}, Pomilio, Giovanna ¹, Blombery, Piers ^{6, 7, 8}, Huang, David C. S. ^{1, 2}, Czabotar, Peter ^{2, 5}, Priore, Salvatore F. ⁹, Yang, Guang ⁹, Carroll, Martin ^{4, 10}, Wei, Andrew H. ^{1, 2, 11, ∗∗}, Perl, Alexander E. ^{4, 10, ∗}

Source: In Blood Advances 14 January 2025 9(1):127-131

Characterization of Tfrc-mutant mice with microcytic phenotypes

Authors: Conway, Ashlee J., Brown, Fiona C., Rank, Gerhard, Kile, Benjamin T., Morton, Craig J., Jane, Stephen M., Curtis, David J.

Source: In Blood Advances 14 August 2018 2(15):1914-1922

Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia

Authors: So, Joan, Lewis, Alexander C, Smith, Lorey K, Stanley, Kym, Franich, Rheana, Yoannidis, David, Pijpers, Lizzy, Dominguez, Pilar, Hogg, Simon J, Vervoort, Stephin J, Brown, Fiona C, Johnstone, Ricky W, McDonald, Gabrielle, Ulanet, Danielle B, Murtie, Josh, Gruber, Emily, Kats, Lev M

Source: EMBO molecular medicine. 14(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154878976.0x000001&indx=1&recIds=ETOCvdc_100154878976.0x000001

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model

Authors: Brown, Fiona C., Conway, Ashlee J., Cerruti, Loretta, Collinge, Janelle E., McLean, Catriona, Wiley, James S., Kile, Ben T., Jane, Stephen M. ^*, Curtis, David J. ^*

Source: In Blood 24 December 2015 126(26):2863-2870

Author Correction: KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria

Authors: Hortle, Elinor, Starrs, Lora, Brown, Fiona C., Jane, Stephen M., Curtis, David J., McMorran, Brendan J., Foote, Simon J., Burgio, Gaetan

Source: Scientific reports. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161827681.0x000001&indx=1&recIds=ETOCvdc_100161827681.0x000001

ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level

Authors: Brown, Fiona C., Scott, Nicholas, Rank, Gerhard, Collinge, Janelle E., Vadolas, Jim, Vickaryous, Nicola, Whitelaw, Nadia, Whitelaw, Emma, Kile, Benjamin T., Jane, Stephen M., Curtis, David J.

Source: In Blood Cells, Molecules and Diseases February 2013 50(2):86-92

KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria

Authors: Hortle, Elinor, Starrs, Lora, Brown, Fiona C., Jane, Stephen M., Curtis, David J., McMorran, Brendan J., Foote, Simon J., Burgio, Gaetan

Source: Scientific reports. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161828729.0x000001&indx=1&recIds=ETOCvdc_100161828729.0x000001

BAX Mutated Clonal Hematopoiesis Arises Following Treatment with the BCL2 Inhibitor Class of Therapeutics across a Range of Hematological and Non-Hematological Neoplasms

Authors: Tiong, Ing Soo, Nguyen, Tamia, Teh, Charis, Chua, Chong Chyn, Ftouni, Sarah, Lew, Thomas E, Brown, Fiona C., Moujalled, Donia, Muttiah, Christine, Gray, Daniel, Anderson, Mary Ann, Thompson, Philip A., Tam, Constantine S., Seymour, John F., Dawson, Sarah-Jane, Wei, Andrew H., Lindeman, Geoffrey, Blombery, Piers

Source: In Blood 2 November 2023 142 Supplement 1:2688-2688

Direct, Potent, and TP53-Independent Activity of Sting Agonists Against Acute Myeloid Leukaemia Enhances Venetoclax Efficacy In Vivo

Authors: Yuan, Yin, Diepstraten, Sarah T, Brown, Fiona C., Litalien, Veronique, Strasser, Andreas, Kelly, Gemma L, Roberts, Andrew W., Wei, Andrew H.

Source: In Blood 2 November 2023 142 Supplement 1:4163-4163

Venetoclax Has Potent Efficacy in NPM1 mutated AML with Acquired Resistance Associated with Either Perturbed Pro-Survival Signalling or NPM1 wild-Type Populations

Authors: Chua, Chong Chyn, Anstee, Natasha, Flensburg, Christoffer, Teh, Charis, Ivey, Adam, Amin, Noorul, Thijssen, Rachel, Bohlander, Stefan K., Kakadia, Purvi M., Xu, Zhen, Fong, Chun Yew, Ting, Stephen, Loo, Sun, Tiong, Ing Soo, Gray, Daniel, Fleming, Shaun, Davidson, Nadia, Roberts, Andrew W., Majewski, Ian, Wei, Andrew H., Brown, Fiona C.

Source: In Blood 2 November 2023 142 Supplement 1:423-423

The AP-1/ETS Transcription Factor Network Regulates Stem Cell Quiescence and Chemotherapy Resistance in Acute Myeloid Leukemia

Authors: Takao, Sumiko ^*, Morell, Victor ^*, Brown, Fiona C. ^*, Koche, Richard ^*, Kentsis, Alex

Source: In Blood 15 November 2022 140 Supplement 1:8682-8683

Pharmacological Reduction of Mitochondrial Iron in AML Triggers a BAX/BAK Dependent Non-Canonical Cell Death Synergistic with Venetoclax

Authors: Garciaz, Sylvain, Müller, Sebastian, Guirguis, Andrew, Brown, Fiona C., Chan, Yih-Chih, Poplineau, Mathilde, Tran, Kevin, Chan, Kah-Lok, MacPherson, Laura, Liddicoat, Brian, Lam, Enid Y.N., Cañeque, Tatiana, Burr, Marian L., Litalien, Veronique, Pomilio, Giovanna, Duprez, Estelle, Huang, David C.S., Dawson, Sarah-Jane, Ramm, Georg, Cox, Andrew G., Brown, Kristin K., Wei, Andrew H., McArthur, Kate, Rodriguez, Raphael, Dawson, Mark A.

Source: In Blood 23 November 2021 138 Supplement 1:267-267

Chemotherapy and Venetoclax in Elderly Acute Myeloid Leukemia Trial (CAVEAT): A Phase Ib Dose-Escalation Study of Venetoclax Combined With Modified Intensive Chemotherapy.

Authors: Chua, Chong Chyn, Roberts, Andrew W., Reynolds, John, Fong, Chun Yew, Ting, Stephen B., Salmon, Jessica M., MacRaild, Sarah, Ivey, Adam, Tiong, Ing Soo, Fleming, Shaun, Brown, Fiona C., Loo, Sun, Majewski, Ian J., Bohlander, Stefan K., Wei, Andrew H.

Source: Journal of Clinical Oncology; 10/20/2020, Vol. 38 Issue 30, p3506-3517, 13p

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