Somatic loss of ATM is a late event in pancreatic tumorigenesis

Authors: Paranal, Raymond M, Jiang, Zhengdong, Hutchings, Danielle, Kryklyva, Valentyna, Gauthier, Christian, Fujikura, Kohei, Nanda, Neha, Huang, Bo, Skaro, Michael, Wolfgang, Christopher L, He, Jin, Klimstra, David S, Brand, Randall E, Singhi, Aatur D, DeMarzo, Angelo, Zheng, Lei, Goggins, Michael, Brosens, Lodewijk AA, Hruban, Ralph H, Klein, Alison P, Lotan, Tamara, Wood, Laura D, Roberts, Nicholas J

Source: Journal of pathology. 260(4):455-464

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187530395.0x000001&indx=1&recIds=ETOCvdc_100187530395.0x000001

Clinical implications of cell‐of‐origin epigenetic characteristics in non‐functional pancreatic neuroendocrine tumors

Authors: Dreijerink, Koen MA, Hackeng, Wenzel M, Singhi, Aatur D, Heaphy, Christopher M, Brosens, Lodewijk AA

Source: Journal of pathology. 256(2):143-148

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138833026.0x000001&indx=1&recIds=ETOCvdc_100138833026.0x000001

Mismatch repair deficiency in early‐onset duodenal, ampullary, and pancreatic carcinomas is a strong indicator for a hereditary defect

Authors: Kryklyva, Valentyna, Brosens, Lodewijk AA, Marijnissen‐van Zanten, Monica AJ, Ligtenberg, Marjolijn JL, Nagtegaal, Iris D

Source: Journal of pathology.Clinical research. 8(2):181-190

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139989458.0x000001&indx=1&recIds=ETOCvdc_100139989458.0x000001

Clinicopathological and epigenetic differences between primary neuroendocrine tumors and neuroendocrine metastases in the ovary.

Authors: Mulders, Merijn CF, Verschuur, Anna Vera D, de Lussanet de la Sablonière, Quido G, Roes, Eva Maria, Geisenberger, Christoph, Brosens, Lodewijk AA, de Herder, Wouter W, van Velthuysen, Marie‐Louise F, Hofland, Johannes

Source: Journal of Pathology: Clinical Research; Nov2024, Vol. 10 Issue 6, p1-10, 10p

Subject Terms: OVARIAN tumors, NEUROENDOCRINE tumors, DNA methylation, DNA analysis, OLDER patients

Why is pancreatic cancer so deadly? The pathologist's view

Authors: Hruban, Ralph H, Gaida, Matthias M, Thompson, Elizabeth, Hong, Seung‐Mo, Noë, Michaël, Brosens, Lodewijk AA, Jongepier, Martine, Offerhaus, G Johan A, Wood, Laura D

Source: Journal of pathology. 248(2):131-141

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083726343.0x000001&indx=1&recIds=ETOCvdc_100083726343.0x000001

Surgical quality and prospective quality control of the D2-gastrectomy for gastric cancer in the multicenter randomized LOGICA-trial.

Authors: de Jongh, Cas, Triemstra, Lianne, van der Veen, Arjen, Brosens, Lodewijk AA., Nieuwenhuijzen, Grard AP., Stoot, Jan HMB., de Steur, Wobbe O., Ruurda, Jelle P., van Hillegersberg, Richard

Source: European Journal of Surgical Oncology; Oct2023, Vol. 49 Issue 10, pN.PAG-N.PAG, 1p

Subject Terms: STOMACH cancer, QUALITY control, LYMPHADENECTOMY, ONCOLOGIC surgery, NEOADJUVANT chemotherapy, GASTROENTEROSTOMY

Tumour–stroma ratio has poor prognostic value in non-pedunculated T1 colorectal cancer: A multi-centre case-cohort study

Authors: Dang, Hao, van Pelt, Gabi W, Haasnoot, Krijn JC, Backes, Yara, Elias, Sjoerd G, Seerden, Tom CJ, Schwartz, Matthijs P, Spanier, Bernhard WM, de Vos tot Nederveen Cappel, Wouter H, van Bergeijk, Jeroen D, Kessels, Koen, Geesing, Joost MJ, Groen, John N, ter Borg, Frank, Wolfhagen, Frank HJ, Seldenrijk, Cornelis A, Raicu, Mihaela G, Milne, Anya N, van Lent, Anja UG, Brosens, Lodewijk AA, Offerhaus, G Johan A, Siersema, Peter D, Tollenaar, Rob AEM, Hardwick, James CH, Hawinkels, Lukas JAC, Moons, Leon MG, Lacle, Miangela M, Mesker, Wilma E, Boonstra, Jurjen J

Source: United European Gastroenterology Journal; 20240101, Issue: Preprints

Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma.

Authors: Luchini, Claudio, Pea, Antonio, Lionheart, Gemma, Mafficini, Andrea, Nottegar, Alessia, Veronese, Nicola, Chianchiano, Peter, Brosens, Lodewijk AA, Noë, Michaël, Offerhaus, G Johan A, Yonescu, Raluca, Ning, Yi, Malleo, Giuseppe, Riva, Giulio, Piccoli, Paola, Cataldo, Ivana, Capelli, Paola, Zamboni, Giuseppe, Scarpa, Aldo, Wood, Laura D

Source: Journal of Pathology; Oct2017, Vol. 243 Issue 2, p148-154, 7p

Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4.

Authors: Hosoda, Waki, Chianchiano, Peter, Griffin, James F, Pittman, Meredith E, Brosens, Lodewijk AA, Noë, Michaël, Yu, Jun, Shindo, Koji, Suenaga, Masaya, Rezaee, Neda, Yonescu, Raluca, Ning, Yi, Albores‐Saavedra, Jorge, Yoshizawa, Naohiko, Harada, Kenichi, Yoshizawa, Akihiko, Hanada, Keiji, Yonehara, Shuji, Shimizu, Michio, Uehara, Takeshi

Source: Journal of Pathology; May2017, Vol. 242 Issue 1, p16-23, 8p