Effective targeting of PDGFRA-altered high-grade glioma with avapritinib

Authors: Mayr, Lisa ^{1, 2, 41}, Neyazi, Sina ^{1, 41}, Schwark, Kallen ^{3, 41}, Trissal, Maria ^{1, 41}, Beck, Alexander ⁴, Labelle, Jenna ¹, Eder, Sebastian K. ^{1, 5}, Weiler-Wichtl, Liesa ², Marques, Joana G. ¹, de Biagi-Junior, Carlos A.O. ¹, Lo Cascio, Costanza ¹, Chapman, Owen ⁶, Sridhar, Sunita ⁶, Kenkre, Rishaan ⁶, Dutta, Aditi ⁶, Wang, Shanqing ⁶, Wang, Jessica ⁶, Hack, Olivia ¹, Nascimento, Andrezza ¹, Nguyen, Cuong M. ¹, Castellani, Sophia ¹, Rozowsky, Jacob S. ¹, Groves, Andrew ¹, Panditharatna, Eshini ¹, Cruzeiro, Gustavo Alencastro Veiga ¹, Haase, Rebecca D. ¹, Tabatabai, Kuscha ¹, Madlener, Sibylle ², Wadden, Jack ³, Adam, Tiffany ³, Kong, Seongbae ³, Miclea, Madeline ³, Patel, Tirth ³, Bruckner, Katharina ^{2, 7}, Senfter, Daniel ², Lämmerer, Anna ^{2, 8, 9}, Supko, Jeffrey ¹⁰, Guntner, Armin S. ¹¹, Palova, Hana ¹², Neradil, Jakub ^{13, 14}, Stepien, Natalia ², Lötsch-Gojo, Daniela ⁷, Berger, Walter ^{8, 9}, Leiss, Ulrike ², Rosenmayr, Verena ², Dorfer, Christian ⁷, Dieckmann, Karin ¹⁵, Peyrl, Andreas ², Azizi, Amedeo A. ², Baumgartner, Alicia ^{1, 2}, Slaby, Ondrej ^{12, 16}, Pokorna, Petra ¹², Clark, Louise M. ¹⁷, Cameron, Amy ¹⁷, Nguyen, Quang-De ¹⁷, Wakimoto, Hiroaki ¹⁸, Dubois, Frank ¹, Greenwald, Noah F. ^{19, 20}, Bandopadhayay, Pratiti ¹, Beroukhim, Rameen ^{19, 21}, Ligon, Keith ¹, Kramm, Christof ²², Bronsema, Annika ²³, Bailey, Simon ^{24, 25}, Stucklin, Ana Guerreiro ²⁶, Mueller, Sabine ²⁷, Skrypek, Mary ²⁸, Martinez, Nina ²⁹, Bowers, Daniel C. ³⁰, Jones, David T.W. ^{31, 32}, Jones, Chris ³³, Jäger, Natalie ³⁴, Sterba, Jaroslav ³⁵, Müllauer, Leonhard ³⁶, Haberler, Christine ³⁷, Kumar-Sinha, Chandan ³⁸, Chinnaiyan, Arul ³⁸, Mody, Rajen ³, Chavez, Lukas ⁶, Furtner, Julia ^{39, 40}, Koschmann, Carl ^{3, 41, ∗}, Gojo, Johannes ^{2, 41, ∗∗}, Filbin, Mariella G. ^{1, 19, 41, 42, ∗∗∗}

Source: In Cancer Cell February 2025

Osteonecrosis in children with acute lymphoblastic leukemia at initial diagnosis and prior to any chemotherapy

Authors: Krull, Kathinka, Kunstreich, Marina, Bronsema, Annika, Bleckmann, Kirsten, Classen, Carl-Friedrich, Erdlenbruch, Bernhard, Jorch, Norbert, Kolb, Reinhard, Leipold, Alfred, Moser, Olga, Prokop, Aram, Scheurlen, Wolfram, Steinbach, Daniel, Klasen-Sansone, Janina, Klee, Dirk, Escherich, Gabriele, Moericke, Anja, Schrappe, Martin, Borkhardt, Arndt, Kuhlen, Michaela

Source: Leukemia & lymphoma. 60(1):78-84

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097915739.0x000001&indx=1&recIds=ETOCvdc_100097915739.0x000001

ALK inhibition as a salvage therapy for a relapsed unclassifiable sarcomatous CNS tumor with EML4/ALK fusion in an infant

Authors: Holsten, Till, Bronsema, Annika, Sturm, Dominik, Sahm, Felix, Rutkowski, Stefan, Schüller, Ulrich, Wößmann, Wilhelm, Kordes, Uwe R.

Source: Pediatric blood & cancer. 69(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154072053.0x000001&indx=1&recIds=ETOCvdc_100154072053.0x000001

Comprehensive Analysis of Hypermutation in Human Cancer

Authors: Campbell, Brittany B., Light, Nicholas, Fabrizio, David, Zatzman, Matthew, Fuligni, Fabio, de Borja, Richard, Davidson, Scott, Edwards, Melissa, Elvin, Julia A., Hodel, Karl P., Zahurancik, Walter J., Suo, Zucai, Lipman, Tatiana, Wimmer, Katharina, Kratz, Christian P., Bowers, Daniel C., Laetsch, Theodore W., Dunn, Gavin P., Johanns, Tanner M., Grimmer, Matthew R., Smirnov, Ivan V., Larouche, Valérie, Samuel, David, Bronsema, Annika, Osborn, Michael, Stearns, Duncan, Raman, Pichai, Cole, Kristina A., Storm, Phillip B., Yalon, Michal, Opocher, Enrico, Mason, Gary, Thomas, Gregory A., Sabel, Magnus, George, Ben, Ziegler, David S., Lindhorst, Scott, Issai, Vanan Magimairajan, Constantini, Shlomi, Toledano, Helen, Elhasid, Ronit, Farah, Roula, Dvir, Rina, Dirks, Peter, Huang, Annie, Galati, Melissa A., Chung, Jiil, Ramaswamy, Vijay, Irwin, Meredith S., Aronson, Melyssa, Durno, Carol, Taylor, Michael D., Rechavi, Gideon, Maris, John M., Bouffet, Eric, Hawkins, Cynthia, Costello, Joseph F., Meyn, M. Stephen, Pursell, Zachary F., Malkin, David, Tabori, Uri, Shlien, Adam

Source: In Cell 16 November 2017 171(5):1042-1056

Looking back: Identifying supportive care and unmet needs of parents of children receiving specialist paediatric palliative care from the bereavement perspective.

Authors: Bronsema, Annika¹ a.bronsema@uke.de, Theißen, Tabea², Oechsle, Karin², Wikert, Julia^2,3, Escherich, Gabriele¹, Rutkowski, Stefan¹, Bokemeyer, Carsten², Ullrich, Anneke²

Source: BMC Palliative Care. 5/25/2022, Vol. 21, p1-18. 18p.

Subject Terms: *RESEARCH, *SOCIAL support, *HEALTH services accessibility, *CHILDREN'S hospitals, *PEDIATRICS, *HEALTH status indicators, *COMPARATIVE studies, *TUMORS in children, *CHILDREN'S health, *DESCRIPTIVE statistics, *NEEDS assessment, *DEATH, *PALLIATIVE treatment, *PARENTS, *BEREAVEMENT, *MEDICAL needs assessment

RARE-17. SURVIVAL BENEFIT FOR INDIVIDUALS WITH CONSTITUTIONAL MISMATCH REPAIR DEFICIENCY SYNDROME AND BRAIN TUMORS WHO UNDERGO SURVEILLANCE PROTOCOL. A REPORT FROM THE INTERNATIONAL REPLICATION REPAIR CONSORTIUM

Authors: Ercan, Ayse Bahar, Durno, Carol, Bianchi, Vanessa J, Edwards, Melissa, Aronson, Melyssa, Bouffet, Eric, Al-Battashi, Abeer, Alharbi, Musa, Basel, Donald, Bedgood, Raymond, Bendel, Anne, Blumenthal, Deborah T, Bornhorst, Miriam, Bronsema, Annika, Cairney, Elizabeth, Carroll, Sara, Chamdin, Aghiad, Chiaravalli, Stefano, Constantini, Shlomi, Das, Anirban, Dvir, Rina, Farah, Roula, Foulkes, William, Frenkel, Zehavit, Gardner, Sharon, Ghalibafian, Mithra, Gilpin, Cathy, Goudie, Catherine, Hamid, Syed Ahmer, Hansford, Jordan, Harlos, Craig, Hijiya, Nobuko, Hsu, Saunders, Kamihara, Junne, Knipstein, Jeffrey, Koschmann, Carl, Larouche, Valerie, Lassaletta, Alvaro, Lindhorst, Scott, Ling, Simon, Link, Michael, De Mola, Rebecca Loret, Luiten, Rebecca, Lurye, Michal, Maciaszek, Jamie, Magimairajan, Vanan, Maher, Ossama, Massimino, Maura, Mushtaq, Naureen, Newmark, Monica, Nicholas, Garth, Nichols, Kim, Nicolaides, Theodore, Opocher, Enrico, Osborn, Michael, Oshrine, Benjamin, Pearlman, Rachel, Pettee, Daniel, Rapp, Jan, Rashid, Mohsin, Reddy, Alyssa, Reichman, Lara, Remke, Marc, Robbins, Gabriel, Sabel, Magnus, Samuel, David, Scheers, Isabelle, Sen, Santanu, Stearns, Duncan, Sumerauer, David, Swallow, Carol, Taylor, Leslie, Toledano, Helen, Tomboc, Patrick, Van Damme, An, Winer, Ira, Yalon, Michal, Yen, Lee Yi, Zapotocky, Michal, Azad, Vahid Fallah, Zelcer, Shayna, Ziegler, David, Zimmerman, Stefanie, Tabori, Uri

Source: Neuro-oncology. 22(Supplement 3):iii445-iii446

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112165243.0x000001&indx=1&recIds=ETOCvdc_100112165243.0x000001

Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling.

Authors: Kresbach, Catena^1,2 (AUTHOR), Bronsema, Annika¹ (AUTHOR), Guerreiro, Helena³ (AUTHOR), Rutkowski, Stefan¹ (AUTHOR), Schüller, Ulrich^1,2,4 (AUTHOR), Winkler, Beate¹ (AUTHOR) b.winkler@uke.de

Source: Child's Nervous System. Feb2022, Vol. 38 Issue 2, p479-483. 5p.

Subject Terms: *VALPROIC acid, *BRAIN tumors, *VINBLASTINE, *METHYLATION, *GLIOBLASTOMA multiforme, *TEENAGERS

IMMU-18. FAVORABLE OUTCOME IN REPLICATION REPAIR DEFICIENT HYPERMUTANT BRAIN TUMORS TO IMMUNE CHECKPOINT INHIBITION: AN INTERNATIONAL RRD CONSORTIUM REGISTRY STUDY

Authors: Bouffet, Eric, Sudhaman, Sumedha, Chung, Jiil, Kelly, Jacalyn, Coblentz, Ailish, Edwards, Melissa, Lipman, Tatiana, Zhang, Cindy, Ercan, Ayse Bahar, Sambira, Lauren, Bendel, Anne, Bielack, Stefan, Koustenis, Elisabeth, Blumenthal, Deborah, Bowers, Daniel, Broniscer, Alberto, Bronsema, Annika, Carroll, Sara, Chiaravalli, Stefano, Cole, Kristina, Constantini, Shlomi, De Mola, Rebecca Loret, Dunn, Gavin, Fröjd, Charlotta, Gass, David, Gauvain, Karen, George, Ben, Hijiya, Nobuko, Hoffman, Lindsey, Knipstein, Jeffrey, Laetsch, Ted, Larouche, Valérie, Lassaletta, Alvaro, Lindhorst, Scott, Lossos, Alexander, Luna-Fineman, Sandra, Magimairajan, Vanan, Mason, Gary, Mason, Warren, Massimino, Maura, Mordechai, Oz, Opocher, Enrico, Oren, Michal, Osborn, Michael, Reddy, Alyssa, Remke, Mark, Roy, Sumita, Sabel, Magnus, Samuel, David, Schneider, Kami, Sen, Santanu, Stearns, Duncan, Sumerauer, David, Thomas, Gregory, Tomboc, Patrick, Van Damme, An, Wierman, Margaret, Winer, Ira, Yen, Lee Yi, Zapotocky, Michal, Ziegler, David, Zimmermann, Stefanie, Dvir, Rina, Rechavi, Gidi, Durno, Carol, Aronson, Melyssa, Taylor, Michael, Dirks, Peter, Pugh, Trevor, Shlien, Adam, Hawkins, Cynthia, Morgenstern, Daniel, Tabori, Uri

Source: Neuro-oncology. 22(Supplement 3):iii363-iii363

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112160275.0x000001&indx=1&recIds=ETOCvdc_100112160275.0x000001

Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance.

Authors: Durno, Carol, Ercan, Ayse Bahar, Bianchi, Vanessa, Edwards, Melissa, Aronson, Melyssa, Galati, Melissa, Atenafu, Eshetu G, Abebe-Campino, Gadi, Al-Battashi, Abeer, Alharbi, Musa, Azad, Vahid Fallah, Baris, Hagit N, Basel, Donald, Bedgood, Raymond, Bendel, Anne, Ben-Shachar, Shay, Blumenthal, Deborah T, Blundell, Maude, Bornhorst, Miriam, Bronsema, Annika

Source: Journal of Clinical Oncology; 9/1/2021, Vol. 39 Issue 25, p2779-2790, 12p

Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency

Authors: Das, Anirban, Sudhaman, Sumedha, Morgenstern, Daniel, Coblentz, Ailish, Chung, Jiil, Stone, Simone C., Alsafwani, Noor, Liu, Zhihui Amy, Karsaneh, Ola Abu Al, Soleimani, Shirin, Ladany, Hagay, Chen, David, Zatzman, Matthew, Cabric, Vanja, Nobre, Liana, Bianchi, Vanessa, Edwards, Melissa, C, Lauren, Nahum, Sambira, Ercan, Ayse B., Nabbi, Arash, Constantini, Shlomi, Dvir, Rina, Yalon-Oren, Michal, Campino, Gadi Abebe, Caspi, Shani, Larouche, Valerie, Reddy, Alyssa, Osborn, Michael, Mason, Gary, Lindhorst, Scott, Bronsema, Annika, Magimairajan, Vanan, Opocher, Enrico, De Mola, Rebecca Loret, Sabel, Magnus, Frojd, Charlotta, Sumerauer, David, Samuel, David, Cole, Kristina, Chiaravalli, Stefano, Massimino, Maura, Tomboc, Patrick, Ziegler, David S., George, Ben, Van Damme, An, Hijiya, Nobuko, Gass, David, McGee, Rose B., Mordechai, Oz, Bowers, Daniel C., Laetsch, Theodore W., Lossos, Alexander, Blumenthal, Deborah T., Sarosiek, Tomasz, Yen, Lee Yi, Knipstein, Jeffrey, Bendel, Anne, Hoffman, Lindsey M., Luna-Fineman, Sandra, Zimmermann, Stefanie, Scheers, Isabelle, Nichols, Kim E., Zapotocky, Michal, Hansford, Jordan R., Maris, John M., Dirks, Peter, Taylor, Michael D., Kulkarni, Abhaya V., Shroff, Manohar, Tsang, Derek S., Villani, Anita, Xu, Wei, Aronson, Melyssa, Durno, Carol, Shlien, Adam, Malkin, David, Getz, Gad, Maruvka, Yosef E., Ohashi, Pamela S., Hawkins, Cynthia, Pugh, Trevor J., Bouffet, Eric, Tabori, Uri

Source: Nature Medicine; 20220101, Issue: Preprints p1-11, 11p

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Immune Check Point Inhibitor Treatment for Young Patients with Hypermutant Cancers

Authors: Durno, Carol A., Aronson, Melyssa, Edwards, Melissa, Ling, Simon, Larouche, Valérie, Bronsema, Annika, Osborn, Michael, Stearns, Duncan, Cole, Kristina, Oren, Michal, Opocher, Enrico, Mason, Gary E., Thomas, Gregory, Sabel, Magnus, George, Ben, Ziegler, David, Lindhorst, Scott, Magimairajan, Vanan, Laperriere, Normand, Samuel, David, Bouffet, Eric, Tabori, Uri

Source: Gastroenterology. 152(5):S141-S141

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100054022213.0x000001&indx=1&recIds=ETOCvdc_100054022213.0x000001

649 - Immune Check Point Inhibitor Treatment for Young Patients with Hypermutant Cancers

Authors: Durno, Carol A., Aronson, Melyssa, Edwards, Melissa, Ling, Simon, Larouche, Valérie, Bronsema, Annika, Osborn, Michael, Stearns, Duncan, Cole, Kristina, Oren, Michal, Opocher, Enrico, Mason, Gary E., Thomas, Gregory, Sabel, Magnus, George, Ben, Ziegler, David, Lindhorst, Scott, Magimairajan, Vanan, Laperriere, Normand, Samuel, David, Bouffet, Eric, Tabori, Uri

Source: In Gastroenterology April 2017 152(5) Supplement 1:S141-S141

IMMU-20. IMMUNE AND TUMOR BIOMARKERS OF OUTCOME IN REPLICATION REPAIR DEFICIENT BRAIN TUMORS TREATED WITH IMMUNE CHECKPOINT INHIBITORS: UPDATES FROM THE INTERNATIONAL REPLICATION REPAIR DEFICIENCY CONSORTIUM.

Authors: Bouffet, Eric, Sudhaman, Sumedha, Chung, Jiil, Campbell, Brittany, Kelly, Jacalyn, Coblentz, Ailish, Edwards, Melissa, Lipman, Tatiana, Zhang, Cindy, Ercan, Ayse Bahar, Sambira, Lauren, Bendel, Anne, Bielack, Stefan, Koustenis, Elisabeth, Blumenthal, Deborah, Bowers, Daniel, Nichols, Kim, Bronsema, Annika, Carroll, Sara, Chiaravalli, Stefano

Source: Neuro-Oncology; 2019 Supplement, Vol. 21, pii96-ii97, 2p

Analyse und Bewertung potenziell spezifischer Promotoren auf ihre Eignung zur Anwendung in einem gentherapeutischen Ansatz bei der Behandlung des Osteosarkoms

Contributors: Bronsema, Annika Eva Charlotte

Availability: http://data.europeana.eu/aggregation/europeana/2048441/item_OLXLRRSU2OBBQLPJFWDSSFC3EN3KFUFJ