Potential outcome simulation for efficient head-to-head comparison of adaptive dose-finding designs

Authors: Sweeting, Michael, Slade, Daniel, Jackson, Dan, Brock, Kristian

Subject Terms: Statistics - Computation, Statistics - Methodology

Access URL: http://arxiv.org/abs/2402.15460

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A Bayesian method for safety signal detection in ongoing blinded randomised controlled trials

Authors: Brock, Kristian, Chen, Chen, Ho, Shuyen, Fuller, Greg, Woolfolk, Jared, McShea, Cindy, Penard, Nils

Source: Pharmaceutical statistics. 22(2):378-395

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177746238.0x000001&indx=1&recIds=ETOCvdc_100177746238.0x000001

trialr: Bayesian Clinical Trial Designs in R and Stan

Authors: Brock, Kristian

Subject Terms: Statistics - Computation, Statistics - Applications, Statistics - Methodology, 97K80

Access URL: http://arxiv.org/abs/1907.00161

Implementing the time-to-event continual reassessment method in the presence of partial orders in a phase I head and neck cancer trial.

Authors: Patel, Amit¹ (AUTHOR) a.patel.13@bham.ac.uk, Brock, Kristian¹ (AUTHOR), Slade, Daniel^1,2 (AUTHOR), Gaunt, Claire¹ (AUTHOR), Kong, Anthony³ (AUTHOR), Mehanna, Hisham^1,4 (AUTHOR), Billingham, Lucinda¹ (AUTHOR), Gaunt, Piers¹ (AUTHOR)

Source: BMC Medical Research Methodology. 1/13/2024, Vol. 24 Issue 1, p1-12. 12p.

Subject Terms: *HEAD & neck cancer, *SQUAMOUS cell carcinoma, *DATABASES

Quality-of-life outcomes in older patients with early-stage rectal cancer receiving organ-preserving treatment with hypofractionated short-course radiotherapy followed by transanal endoscopic microsurgery (TREC): non-randomised registry of patients unsuitable for total mesorectal excision

Authors: Beveridge, Alan, Levy, Bruce, Handley, Kelly, Brown, Gina, Antonio, Peter, Vince, Alex, Hilken, Nick, Sidile, Chakanaka, Wilcockson, Adrian, Peto, Richard, Crosby, Tom, Moran, Brendan, Olliff, Julie, Ashok, Katti, Slawik, Simone, Smethurst, Andrew, Sripadam, Rajaram, Tagore, Veena, Terlizzo, Monica, Philip, Bearn, Davies, Robert, Dodd, Susan, Essapen, Sharadah, Nisar, Pasha, Stewart, Alexandra, Trickett, Jonathan, Ashish, Bansal, Billings, Peter, Chandran, Palanichamy, Corr, Conor, Favill, Edward, Gollins, Simon, Marsh, Peter, Maw, Andrew, Neupane, Rakha, Rajagopal, Ramesh, Cooper, Rachel, Griffith, John, Hatfield, Paul, Lowe, Andy, Ostrowski, Julian, Robinson, Jonathan, Simpson, Rhian, Adams, Richard, Bleehen, Robert, Davies, Michael, Morgan, Meleri, Boone, Darren, Lacey, Nicola, Seddon, Ian, Sizer, Bruce, Stunell, Helen, Wu, Shaobin, Hadaki, Maher, Blunt, Dominic, Cleator, Susan, Darzi, Ara, Goldin, Robert, Ziprin, Paul, Dobson, Mike, Pitt, Mark, Susnerwala, Shabbir, Williamson, Deborah, Howarth, Georgina, Lee, Stephen, Wright, Paul, Hoare, Tim, Horgan, Alan, McDonald, Fiona, Needham, Stephanie, Scott, John, Simmons, Timothy, Biswas, Debashis, Hernon, James, Kapur, Gaurav, Kapur, Sandeep, Sington, James, Speakman, Christopher, Stebbings, William, Williams, Stuart, Adusumalli, Madhavi, Agarwal, Anil, Borowski, David, Garg, Dharmendra, Gill, Talvinder, Hegab, Mohammed, Hobday, Catherine, Rao, Veena, Shrimankar, Jyotsna, Tabaqchali, Mohamed, Wilson, David, Jones, Oliver, Mortensen, Neil, Slater, Andrew, Szuts, Aron, Wang, Lai, Warren, Bryan, Weaver, Andrew, Ahmad, Mukhtar, Alexander, Julian, Flubacher, Maxine, Tarver, David, Baluch, Suhail, Beable, Richard, Cowlishaw, David, Higginson, Antony, Vogiatzis, Prokopios, Cruickshank, Neil, Joy, Howard, Peake, David, Zanetto, Ulises, Saunders, Mark, Sun-Myint, Arthur, Teo, Mark, Allan, Arthur, Geh, Ian, Glaholm, John, Goldstein, Mark, Hejmadi, Rahul, Langman, Gerald, Morton, Dion, Nelson, Cyril, Tattersall, Deborah, Falk, Stephen, Longman, Robert, Roach, Huw, Shabbir, Jamshed, Shelley-Fraser, Golda, Thomas, Michael, Cripps, Neil, Haba, Yasser, Harris, Guy, Hookway, Max, Simson, Jay, Skull, Angela, Umar, Tijani, Gilbert, Alexandra ^{*, *}, Homer, Victoria ^*, Brock, Kristian, Korsgen, Stephan, Hill, James, Hainsworth, Paul, Tutton, Matthew, Khan, Jim, Steward, Mark, Cunningham, Christopher, Kaur, Manjinder, Magill, Laura, Russell, Ann, Quirke, Philip, West, Nicholas P, Sebag-Montefiore, David, Bach, Simon P

Source: In The Lancet Healthy Longevity December 2022 3(12):e825-e838

A Critical Investigation of Cerebellar Associative Learning in Isolated Dystonia

Authors: Sadnicka, Anna, Rocchi, Lorenzo, Latorre, Anna, Antelmi, Elena, Teo, James, Pareés, Isabel, Hoffland, Britt S., Brock, Kristian, Kornysheva, Katja, Edwards, Mark J., Bhatia, Kailash P., Rothwell, John C.

Source: Movement disorders. 37(6):1187-1192

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187525086.0x000001&indx=1&recIds=ETOCvdc_100187525086.0x000001

Ponatinib with fludarabine, cytarabine, idarubicin, and granulocyte colony-stimulating factor chemotherapy for patients with blast-phase chronic myeloid leukaemia (MATCHPOINT): a single-arm, multicentre, phase 1/2 trial

Authors: Copland, Mhairi, Slade, Daniel, McIlroy, Graham, Horne, Gillian, Byrne, Jenny L, Rothwell, Kate, Brock, Kristian, De Lavallade, Hugues, Craddock, Charles, Clark, Richard E, Smith, Matthew L, Fletcher, Rachel, Bishop, Rebecca, Milojkovic, Dragana, Yap, Christina

Source: Lancet.Haematology. 9(2):e121-e132

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183249037.0x000001&indx=1&recIds=ETOCvdc_100183249037.0x000001

Association of Amount of Weight Lost After Bariatric Surgery With Intracranial Pressure in Women With Idiopathic Intracranial Hypertension

Authors: Mollan, Susan P., Mitchell, James L., Yiangou, Andreas, Ottridge, Ryan S., Alimajstorovic, Zerin, Cartwright, David M., Hickman, Simon J., Markey, Keira A., Singhal, Rishi, Tahrani, Abd A., Frew, Emma, Brock, Kristian, Sinclair, Alexandra Jean

Source: Neurology. 99(11):e1090-e1099

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172936367.0x000001&indx=1&recIds=ETOCvdc_100172936367.0x000001

WFS1-Associated Optic Neuropathy: Genotype-Phenotype Correlations and Disease Progression

Authors: Majander, Anna, Jurkute, Neringa, Burté, Florence, Brock, Kristian, João, Catarina, Huang, Houbin, Neveu, Magella M., Chan, Choi Mun, Duncan, Holly J., Kelly, Simon, Burkitt-Wright, Emma, Khoyratty, Fadil, Lai, Yoon Tse, Subash, Mala, Chinnery, Patrick F., Bitner-Glindzicz, Maria, Arno, Gavin, Webster, Andrew R., Moore, Anthony T., Michaelides, Michel, Stockman, Andrew, Robson, Anthony G., Yu-Wai-Man, Patrick

Source: American journal of ophthalmology. 241:9-27

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169062626.0x000001&indx=1&recIds=ETOCvdc_100169062626.0x000001

Radical surgery versus organ preservation via short-course radiotherapy followed by transanal endoscopic microsurgery for early-stage rectal cancer (TREC): a randomised, open-label feasibility study

Authors: Brown, Gina, Antonio, Peter, Vince, Alex, Hilken, Nick, Sidile, Chakanaka, Wilcockson, Adrian, Peto, Richard, Crosby, Tom, Moran, Brendan, Olliff, Julie, Ashok, Katti, Slawik, Simone, Smethurst, Andrew, Sripadam, Rajaram, Tagore, Veena, Terlizzo, Monica, Philip, Bearn, Davies, Robert, Dodd, Susan, Essapen, Sharadah, Nisar, Pasha, Stewart, Alexandra, Trickett, Jonathan, Ashish, Bansal, Billings, Peter, Chandran, Palanichamy, Corr, Conor, Favill, Edward, Gollins, Simon, Marsh, Peter, Maw, Andrew, Neupane, Rakha, Rajagopal, Ramesh, Cooper, Rachel, Griffith, John, Hatfield, Paul, Lowe, Andy, Ostrowski, Julian, Robinson, Jonathan, Simpson, Rhian, Adams, Richard, Bleehen, Robert, Davies, Michael, Morgan, Meleri, Boone, Darren, Lacey, Nicola, Seddon, Ian, Sizer, Bruce, Stunell, Helen, Wu, Shaobin, Hadaki, Maher, Blunt, Dominic, Cleator, Susan, Darzi, Ara, Goldin, Robert, Ziprin, Paul, Dobson, Mike, Pitt, Mark, Susnerwala, Shabbir, Williamson, Deborah, Howarth, Georgina, Lee, Stephen, Wright, Paul, Hoare, Tim, Horgan, Alan, McDonald, Fiona, Needham, Stephanie, Scott, John, Simmons, Timothy, Biswas, Debashis, Hernon, James, Kapur, Gaurav, Kapur, Sandeep, Sington, James, Speakman, Christopher, Stebbings, William, Williams, Stuart, Adusumalli, Madhavi, Agarwal, Anil, Borowski, David, Garg, Dharmendra, Gill, Talvinder, Hegab, Mohammed, Hobday, Catherine, Rao, Veena, Shrimankar, Jyotsna, Tabaqchali, Mohamed, Wilson, David, Jones, Oliver, Mortensen, Neil, Slater, Andrew, Szuts, Aron, Wang, Lai, Warren, Bryan, Weaver, Andrew, Ahmad, Mukhtar, Alexander, Julian, Flubacher, Maxine, Tarver, David, Baluch, Suhail, Beable, Richard, Cowlishaw, David, Higginson, Antony, Vogiatzis, Prokopios, Cruickshank, Neil, Joy, Howard, Peake, David, Zanetto, Ulises, Saunders, Mark, Sun-Myint, Arthur, Teo, Mark, Allan, Arthur, Geh, Ian, Glaholm, John, Goldstein, Mark, Hejmadi, Rahul, Langman, Gerald, Morton, Dion, Nelson, Cyril, Tattersall, Deborah, Falk, Stephen, Longman, Robert, Roach, Huw, Shabbir, Jamshed, Shelley-Fraser, Golda, Thomas, Michael, Cripps, Neil, Haba, Yasser, Harris, Guy, Hookway, Max, Simson, Jay, Skull, Angela, Umar, Tijani, Bach, Simon P ^*, Gilbert, Alexandra, Brock, Kristian, Korsgen, Stephan, Hill, James, Hainsworth, Paul, Tutton, Matthew G, Khan, Jim, Steward, Mark, Cunningham, Christopher, Levy, Bruce, Beveridge, Alan, Handley, Kelly, Kaur, Manjinder, Marchevsky, Natalie, Magill, Laura, Russell, Ann, Quirke, Philip, West, Nicholas P, Sebag-Montefiore, David

Source: In The Lancet Gastroenterology & Hepatology February 2021 6(2):92-105

Radical surgery versus organ preservation via short-course radiotherapy followed by transanal endoscopic microsurgery for early-stage rectal cancer (TREC): a randomised, open-label feasibility study

Authors: Bach, Simon P, Gilbert, Alexandra, Brock, Kristian, Korsgen, Stephan, Geh, Ian, Hill, James, Gill, Talvinder, Hainsworth, Paul, Tutton, Matthew G, Khan, Jim, Robinson, Jonathan, Steward, Mark, Cunningham, Christopher, Levy, Bruce, Beveridge, Alan, Handley, Kelly, Kaur, Manjinder, Marchevsky, Natalie, Magill, Laura, Russell, Ann, Quirke, Philip, West, Nicholas P, Sebag-Montefiore, David

Source: Lancet.Gastroenterology & hepatology. 6(2):92-105

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183244076.0x000001&indx=1&recIds=ETOCvdc_100183244076.0x000001

Pembrolizumab in patients with non-small-cell lung cancer of performance status 2 (PePS2): a single arm, phase 2 trial

Authors: Middleton, Gary ^*, Brock, Kristian, Savage, Joshua, Mant, Rhys, Summers, Yvonne, Connibear, John, Shah, Riyaz, Ottensmeier, Christian, Shaw, Paul, Lee, Siow-Ming, Popat, Sanjay, Barrie, Colin, Barone, Gloria, Billingham, Lucinda

Source: In The Lancet Respiratory Medicine September 2020 8(9):895-904

CSTI-300 (SMP-100); a Novel 5-HT3 Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome

Authors: Roberts, Alexander, Grafton, Gillian, Powell, Andrew D., Brock, Kristian, Chen, Chunlin, Xie, Dejian, Huang, Jinkun, Liu, Shuang, Cooper, Alison J., Brady, Catherine A., Qureshi, Omar, Stamataki, Zania, Manning, David D., Moore, Nicholas A., Sargent, Bruce J., Guzzo, Peter R., Barnes, Nicholas M. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics April 2020 373(1):122-134

Bayesian statistical methods and their application to resuscitation trials

Authors: Gates, Simon, Brock, Kristian, Ryan, Elizabeth G.

Source: In Resuscitation April 2020 149:60-64

A low molecular weight dextran sulphate, ILB^®, for the treatment of amyotrophic lateral sclerosis (ALS): An open-label, single-arm, single-centre, phase II trial.

Authors: Srinivasan, Venkataramanan, Homer, Victoria, Barton, Darren, Clutterbuck-James, Abigail, Jenkins, Siân, Potter, Claire, Brock, Kristian, Logan, Ann, Smith, Donna, Bruce, Lars, Nagy, Zsuzsanna, Bach, Simon P.

Source: PLoS ONE; 7/11/2024, Vol. 19 Issue 7, p1-24, 24p

Subject Terms: AMYOTROPHIC lateral sclerosis, MOTOR neuron diseases, CLINICAL trial registries, TERMINATION of treatment, DEXTRAN, MOLECULAR weights

How to design a dose-finding study using the continual reassessment method

Authors: Wheeler, Graham, Mander, Adrian, Bedding, Alun, Brock, Kristian, Cornelius, Victoria, Grieve, Andrew, Jaki, Thomas, Love, Sharon, Odondi, Lang'o, Weir, Christopher, Yap, Christina, Bond, Simon

Source: BMC medical research methodology. 19(1):1-15

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185481660.0x000001&indx=1&recIds=ETOCvdc_100185481660.0x000001

Ibrutinib Plus Venetoclax in Relapsed/Refractory Chronic Lymphocytic Leukemia: The CLARITY Study

Authors: Hillmen, Peter, Rawstron, Andy C., Brock, Kristian

Source: Journal of clinical oncology. 37(30):2722-2729

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN621757809&indx=1&recIds=ETOCRN621757809

Effect of glucagon like peptide-1 receptor agonist exenatide, used as an intracranial pressure lowering agent, on cognition in Idiopathic Intracranial Hypertension

Authors: Grech, Olivia, Mitchell, James L., Lyons, Hannah S., Yiangou, Andreas, Thaller, Mark, Tsermoulas, Georgios, Brock, Kristian, Mollan, Susan P., Sinclair, Alexandra J.

Source: Eye; May 2024, Vol. 38 Issue: 7 p1374-1379, 6p

Is more better? An analysis of toxicity and response outcomes from dose-finding clinical trials in cancer.

Authors: Brock, Kristian¹ (AUTHOR) k.brock@bham.ac.uk, Homer, Victoria¹ (AUTHOR), Soul, Gurjinder² (AUTHOR), Potter, Claire¹ (AUTHOR), Chiuzan, Cody³ (AUTHOR), Lee, Shing³ (AUTHOR)

Source: BMC Cancer. 7/5/2021, Vol. 21 Issue 1, p1-18. 18p.

Subject Terms: *CLINICAL trials, *TREATMENT effectiveness, *NONLINEAR regression, *THERAPEUTICS, *CANCER treatment