The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTD

Authors: Fang He, Brittany N. Flores, Amy Krans, Michelle Frazer, Sam Natla, Sarjina Niraula, Olamide Adefioye, Sami J. Barmada, Peter K. Todd

Source: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-17 (2020)

Subject Terms: C9ORF72, Amyotrophic lateral sclerosis, Dipeptide repeat proteins (DPRs), Repeat-associated non-AUG translation (RAN), Carboxyl terminus, Drosophila, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40478-020-01002-8; https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/dd210e22a9564bf18e7a0e23570b79f3

RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response

Authors: Katelyn M. Green, M. Rebecca Glineburg, Michael G. Kearse, Brittany N. Flores, Alexander E. Linsalata, Stephen J. Fedak, Aaron C. Goldstrohm, Sami J. Barmada, Peter K. Todd

Source: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/265548349b414438ad9f9384c10a2220

Exome Sequence Analysis Suggests that Genetic Burden Contributes to Phenotypic Variability and Complex Neuropathy

Authors: Claudia Gonzaga-Jauregui, Tamar Harel, Tomasz Gambin, Maria Kousi, Laurie B. Griffin, Ludmila Francescatto, Burcak Ozes, Ender Karaca, Shalini N. Jhangiani, Matthew N. Bainbridge, Kim S. Lawson, Davut Pehlivan, Yuji Okamoto, Marjorie Withers, Pedro Mancias, Anne Slavotinek, Pamela J. Reitnauer, Meryem T. Goksungur, Michael Shy, Thomas O. Crawford, Michel Koenig, Jason Willer, Brittany N. Flores, Igor Pediaditrakis, Onder Us, Wojciech Wiszniewski, Yesim Parman, Anthony Antonellis, Donna M. Muzny, Nicholas Katsanis, Esra Battaloglu, Eric Boerwinkle, Richard A. Gibbs, James R. Lupski

Source: Cell Reports, Vol 12, Iss 7, Pp 1169-1183 (2015)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124715007639; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/b23784000fc94e8fa5337756d5dd9e52

Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity.

Authors: Brittany N Flores, Mark E Dulchavsky, Amy Krans, Michael R Sawaya, Henry L Paulson, Peter K Todd, Sami J Barmada, Magdalena I Ivanova

Source: PLoS ONE, Vol 11, Iss 10, p e0165084 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5077081?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/fe73098c17dd4b6d8f8a53920cde6af8