Unbiased kidney-centric molecular categorization of chronic kidney disease as a step towards precision medicine

Authors: Reznichenko, Anna, Nair, Viji, Eddy, Sean, Fermin, Damian, Tomilo, Mark, Slidel, Timothy, Ju, Wenjun, Henry, Ian, Badal, Shawn S., Wesley, Johnna D., Liles, John T., Moosmang, Sven, Williams, Julie M., Quinn, Carol Moreno, Bitzer, Markus, Hodgin, Jeffrey B., Barisoni, Laura, Karihaloo, Anil, Breyer, Matthew D., Duffin, Kevin L., Patel, Uptal D., Magnone, Maria Chiara, Bhat, Ratan, Kretzler, Matthias

Source: In Kidney International June 2024 105(6):1263-1278

Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies

Authors: Wu, Haojia, Gonzalez Villalobos, Romer, Yao, Xiang, Reilly, Dermot, Chen, Tao, Rankin, Matthew, Myshkin, Eugene, Breyer, Matthew D., Humphreys, Benjamin D.

Source: In Cell Metabolism 5 July 2022 34(7):1064-1078

Cyclooxygenase-2 contributes to diabetic nephropathy through glomerular EP4 receptor

Authors: Guan, Yi, Davis, Linda, Breyer, Matthew D., Hao, Chuan-Ming ^*

Source: In Prostaglandins and Other Lipid Mediators April 2022 159

Markers of early progressive renal decline in type 2 diabetes suggest different implications for etiological studies and prognostic tests development

Authors: Nowak, Natalia, Skupien, Jan, Smiles, Adam M., Yamanouchi, Masayuki, Niewczas, Monika A., Galecki, Andrzej T., Duffin, Kevin L., Breyer, Matthew D., Pullen, Nick, Bonventre, Joseph V., Krolewski, Andrzej S.

Source: In Kidney International May 2018 93(5):1198-1206

PKHD1 Protein Encoded by the Gene for Autosomal Recessive Polycystic Kidney Disease Associates with Basal Bodies and Primary Cilia in Renal Epithelial Cells

Authors: Zhang, Ming-Zhi, Mai, Weiyi, Li, Cunxi, Cho, Sae-youll, Hao, Chuanming, Moeckel, Gilbert, Zhao, Runxiang, Kim, Ingyu, Wang, Jikui, Xiong, Huaqi, Wang, Hong, Sato, Yasunori, Wu, Yizhong, Nakanuma, Yasuni, Lilova, Marusia, Pei, York, Harris, Raymond C., Li, Song, Coffey, Robert J., Sun, Le, Wu, Dianqing, Chen, Xing-Zhen, Breyer, Matthew D., Zhao, Zhizhuang Joe, McKanna, James A., Wu, Guanqing, Cohen, Stanley

Source: Proceedings of the National Academy of Sciences of the United States of America, 2004 Feb . 101(8), 2311-2316.

Access URL: https://www.jstor.org/stable/3371288

Improved clinical trial enrollment criterion to identify patients with diabetes at risk of end-stage renal disease

Authors: Yamanouchi, Masayuki, Skupien, Jan, Niewczas, Monika A., Smiles, Adam M., Doria, Alessandro, Stanton, Robert C., Galecki, Andrzej T., Duffin, Kevin L., Pullen, Nick, Breyer, Matthew D., Bonventre, Joseph V., Warram, James H., Krolewski, Andrzej S.

Source: In Kidney International July 2017 92(1):258-266

Alterations in the Regulation of Androgen-Sensitive Cyp 4a Monooxygenases Cause Hypertension

Authors: Holla, Vijaykumar R., Adas, Fadi, Imig, John D., Zhao, Xueying, Price, Edward, Olsen, Nancy, Kovacs, William J., Magnuson, Mark A., Keeney, Diane S., Breyer, Matthew D., Falck, John R., Waterman, Michael R., Capdevila, Jorge H.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2001 Apr . 98(9), 5211-5216.

Access URL: https://www.jstor.org/stable/3055590

Failure of Ductus Arteriosus Closure and Remodeling in Neonatal Mice Deficient in Cyclooxygenase-1 and Cyclooxygenase-2

Authors: Loftin, Charles D., Trivedi, Darshini B., Tiano, Howard F., Clark, James A., Lee, Christopher A., Epstein, Jonathan A., Morham, Scott G., Breyer, Matthew D., Nguyen, MyTrang, Hawkins, Beau M., Goulet, Jennifer L., Smithies, Oliver, Koller, Beverly H., Langenbach, Robert

Source: Proceedings of the National Academy of Sciences of the United States of America, 2001 Jan . 98(3), 1059-1064.

Access URL: https://www.jstor.org/stable/3054821

Novel avenues for drug discovery in diabetic kidney disease

Authors: Breyer, Matthew D., Kretzler, Matthias

Source: Expert opinion on drug discovery. 13(1):65-74

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100102908747.0x000001&indx=1&recIds=ETOCvdc_100102908747.0x000001

Developing Treatments for Chronic Kidney Disease in the 21st Century

Authors: Breyer, Matthew D., Susztak, Katalin

Source: In Seminars in Nephrology November 2016 36(6):436-447

Tackling AKI

Authors: Rana, Rajashree, Breyer, Matthew D.

Source: Journal of the American Society of Nephrology. 34(6):935-935

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632479527&indx=1&recIds=ETOCRN632479527

Generation and Activity of a Humanized Monoclonal Antibody That Selectively Neutralizes the Epidermal Growth Factor Receptor Ligands Transforming Growth Factor-α and Epiregulin

Authors: Beidler, Catherine B., Petrovan, Ramona J., Conner, Elaine M., Boyles, Jeffrey S., Yang, Derek D., Harlan, Shannon M., Chu, Shaoyou, Ellis, Bernice, Datta-Mannan, Amita, Johnson, Robert L., Stauber, Anja, Witcher, Derrick R., Breyer, Matthew D., Heuer, Josef G. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics May 2014 349(2):330-343

Prostacyclin Mitigates Renal Fibrosis by Activating Fibroblast Prostaglandin I2Receptor

Authors: Li, Jing, Guan, Yi, Xu, Yunyu, Cao, Yingxue, Xie, Qionghong, Harris, Raymond C., Breyer, Matthew D., Lu, Limin, Hao, Chuan-Ming

Source: Journal of the American Society of Nephrology; February 2024, Vol. 35 Issue: 2 p149-165, 17p

SOD1, but not SOD3, deficiency accelerates diabetic renal injury in C57BL/6-Ins2Akita diabetic mice

Authors: Fujita, Hiroki, Fujishima, Hiromi, Takahashi, Keiko, Sato, Takehiro, Shimizu, Tatsunori, Morii, Tsukasa, Shimizu, Takahiko, Shirasawa, Takuji, Qi, Zhonghua, Breyer, Matthew D., Harris, Raymond C., Yamada, Yuichiro, Takahashi, Takamune

Source: In Metabolism December 2012 61(12):1714-1724

Drug Discovery for Diabetic Nephropathy: Trying the Leap From Mouse to Man

Authors: Breyer, Matthew D.

Source: In Seminars in Nephrology September 2012 32(5):445-451

Improving productivity of modern-day drug discovery

Authors: Breyer, Matthew D

Source: Expert opinion on drug discovery. 9(2):115-118

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100102984550.0x000001&indx=1&recIds=ETOCvdc_100102984550.0x000001

Effects of global or targeted deletion of the EP4 receptor on the response of osteoblasts to prostaglandin in vitro and on bone histomorphometry in aged mice

Authors: Gao, Qi, Zhan, Peili, Alander, Cynthia B., Kream, Barbara E., Hao, Chuanming, Breyer, Matthew D., Pilbeam, Carol C., Raisz, Lawrence G. ^⁎

Source: In Bone July 2009 45(1):98-103

Macrophage EP4 Deficiency Increases Apoptosis and Suppresses Early Atherosclerosis

Authors: Babaev, Vladimir R., Chew, Joshua D., Ding, Lei, Davis, Sarah, Breyer, Matthew D., Breyer, Richard M., Oates, John A., Fazio, Sergio, Linton, MacRae F.

Source: In Cell Metabolism 6 December 2008 8(6):492-501

Mouse EP3 α, β, and γ Receptor Variants Reduce Tumor Cell Proliferation and Tumorigenesis in Vivo

Authors: Macias-Perez, Ines M., Zent, Roy, Carmosino, Monica, Breyer, Matthew D., Breyer, Richard M., Pozzi, Ambra

Source: In Journal of Biological Chemistry 2 May 2008 283(18):12538-12545

AKR1A1 and Kidney Disease: Promise and Perils of the Multiverse.

Authors: Breyer, Matthew D.¹ (AUTHOR) mbreyer@its.jnj.com

Source: Diabetes. Jul2024, Vol. 73 Issue 7, p1046-1047. 2p.

Subject Terms: *KIDNEY diseases, *GENE expression, *GENETIC variation, *LOCUS (Genetics), *KIDNEY cortex