Protein structure prediction provides comparable performance to crystallographic structures in docking-based virtual screening

Authors: Du, H., Brender, J. R., Zhang, J., Zhang, Y.

Source: METHODS -LONDON THEN SAN DIEGO- A COMPANION TO METHODS IN ENZYMOLOGY-. 71:77-84

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GLASS: a comprehensive database for experimentally validated GPCR-ligand associations

Authors: Chan, W. K., Zhang, H., Yang, J., Brender, J. R., Hur, J., Özgür, A., Zhang, Y.

Source: BIOINFORMATICS -OXFORD-. 31(18):3035-3042

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Cations as Switches of Amyloid-Mediated Membrane Disruption Mechanisms: Calcium and IAPP

Authors: Sciacca, M. F., Milardi, D., Messina, G. M., Marletta, G., Brender, J. R., Ramamoorthy, A., La Rosa, C.

Source: BIOPHYSICAL JOURNAL. 104(1):173-184

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Does cholesterol suppress the antimicrobial peptide induced disruption of lipid raft containing membranes?

Authors: McHenry, A. J., Sciacca, M. F., Brender, J. R., Ramamoorthy, A.

Source: BIOCHIMICA ET BIOPHYSICA ACTA. 1818(12):3019-3024

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Two-Step Mechanism of Membrane Disruption by Ab through Membrane Fragmentation and Pore Formation

Authors: Sciacca, M. F., Kotler, S. A., Brender, J. R., Chen, J., Lee, D. k., Ramamoorthy, A.

Source: BIOPHYSICAL JOURNAL. 103(4):702-710

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NMR Characterization of Monomeric and Oligomeric Conformations of Human Calcitonin and Its Interaction with EGCG

Authors: Huang, R., Vivekanandan, S., Brender, J. R., Abe, Y., Naito, A., Ramamoorthy, A.

Source: JOURNAL OF MOLECULAR BIOLOGY. 416(1):108-120

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Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment

Authors: Nanga, R. P., Brender, J. R., Vivekanandan, S., Ramamoorthy, A.

Source: BIOCHIMICA ET BIOPHYSICA ACTA. 1808(10):2337-2342

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A partially folded structure of amyloid-beta(1-40) in an aqueous environment

Authors: Vivekanandan, S., Brender, J. R., Lee, S. Y., Ramamoorthy, A.

Source: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 411(2):312-316

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Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins

Authors: Yoo, S. I., Yang, M., Brender, J. R., Subramanian, V., Sun, K., Joo, N. E., Jeong, S. H., Ramamoorthy, A., Kotov, N. A.

Source: ANGEWANDTE CHEMIE -INTERNATIONAL EDITION IN ENGLISH-. 50(22):5110-5115

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A Two-Site Mechanism for the Inhibition of IAPP Amyloidogenesis by Zinc

Authors: Salamekh, S., Brender, J. R., Hyung, S. J., Nanga, R. P., Vivekanandan, S., Ruotolo, B. T., Ramamoorthy, A.

Source: JOURNAL OF MOLECULAR BIOLOGY. 410(2):294-306

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The amyloidogenic SEVI precursor, PAP248-286, is highly unfolded in solution despite an underlying helical tendency

Authors: Brender, J. R., Nanga, R. P., Popovych, N., Soong, R., Macdonald, P. M., Ramamoorthy, A.

Source: BIOCHIMICA ET BIOPHYSICA ACTA. 1808(4):1161-1169

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Absorbance-based assay for membrane disruption by antimicrobial peptides and synthetic copolymers using pyrroloquinoline quinone-loaded liposomes

Authors: Zimmerman, L. B., Worley, B. V., Palermo, E. F., Brender, J. R., Lee, K. D., Kuroda, K., Ramamoorthy, A., Meyerhoff, M. E.

Source: ANALYTICAL BIOCHEMISTRY. 411(2):194-199

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Biphasic Effects of Insulin on Islet Amyloid Polypeptide Membrane Disruption

Authors: Brender, J. R., Lee, E. L., Hartman, K., Wong, P. T., Ramamoorthy, A., Steel, D. G., Gafni, A.

Source: BIOPHYSICAL JOURNAL. 100(3):685-692

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Membrane fragmentation by an amyloidogenic fragment of human Islet Amyloid Polypeptide detected by solid-state NMR spectroscopy of membrane nanotubes

Authors: Brender, J. R., Dürr, U. H., Heyl, D., Budarapu, M. B., Ramamoorthy, A.

Source: BIOCHIMICA ET BIOPHYSICA ACTA. 1768(9):2026-2029

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Conformational Dynamics of the Isoalloxazine in Substrate-Free p-Hydroxybenzoate Hydroxylase: Single-Molecule Studies

Authors: Brender, J. R., Dertouzos, J., Ballou, D. P., Massey, V., Palfey, B. A., Entsch, B., Steel, D. G., Gafni, A.

Source: JOURNAL- AMERICAN CHEMICAL SOCIETY. 127(51):18171-18178

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Functional dynamics in the active site of the ribonuclease binase

Authors: Wang, L., Pang, Y., Holder, T., Brender, J. R., Kurochkin, A. V., Zuiderweg, E. R. P.

Source: PROCEEDINGS- NATIONAL ACADEMY OF SCIENCES USA. 98(14):7684-7689

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Orientation of Amide-Nitrogen-15 Chemical Shift Tensors in Peptides: A Quantum Chemical Study

Authors: Brender, J. R., Taylor, D. M., Ramamoorthy, A.

Source: JOURNAL- AMERICAN CHEMICAL SOCIETY. 123(5):914-922

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Molecular Basis of the Interaction Between Zinc and the Amyloidogenic Islet Amyloid Polypeptide

Authors: Salamekh, S., Brender, J. R., Nanga, R. P., Hyung, S., Hartman, K., Ruotolo, B. T., Ramamoorthy, A.

Source: BIOPHYSICAL JOURNAL. 100(3):540a-541a

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High-resolution Structures of Membrane-Bound IAPP Reveal Functional Implications of the Toxicity of Prefibrillar States of Amyloidogenic Proteins

Authors: Nanga, R. P., Brender, J. R., Hartman, K., Ramamoorthy, A.

Source: BIOPHYSICAL JOURNAL. 96(3):92a-93a

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Pores Versus Fibrils: Calcium Ions Regulate Different IAPP-Mediated Membrane Damage Mechanisms

Authors: Sciacca, M. F., Milardi, D., Messina, G. M., Marletta, G., Brender, J. R., Ramamoorthy, A., La Rosa, C.

Source: BIOPHYSICAL JOURNAL. 104(2):395a-395a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN326203967&indx=1&recIds=ETOCRN326203967