Assessment of tuberculosis drug efficacy using preclinical animal models and in vitro predictive techniques

Authors: Hazem F. M. Abdelaal, Bryan J. Berube, Brendan K. Podell, Matthew H. Harband, Hadley E. Gary, Martin Perez-Jaimes, David F. Ackart, Valerie A. Reese, Sasha E. Larsen, Tiffany Pecor, David Z. Wilkins, Tanya Parish, Sara E. Maloney-Norcross, Jeffrey B. Mecham, Anthony J. Hickey, Susan L. Baldwin, Rhea N. Coler

Source: npj Antimicrobials and Resistance, Vol 2, Iss 1, Pp 1-12 (2024)

Subject Terms: Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2731-8745

Access URL: https://doaj.org/article/37a123bccd994fedbe8d2a140b3ba2a3

The DosR regulon of Mycobacterium avium and adaptation to hypoxia

Authors: Juan M. Belardinelli, Charlotte Avanzi, Kelsey E. Martin, Ha Lam, Marte S. Dragset, William H. Wheat, Brendan K. Podell, Mercedes Gonzalez-Juarrero, Mary Jackson

Source: Frontiers in Cellular and Infection Microbiology, Vol 15 (2025)

Subject Terms: Mycobacterium avium, nontuberculous mycobacteria, DosRS, biofilm, hypoxia, virulence, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2025.1545856/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/2b48d4671f7f407e9888f615992ced75

ELISA-R: an R-based method for robust ELISA data analysis

Authors: Taru S. Dutt, John S. Spencer, Burton R. Karger, Amy Fox, Andres Obregon-Henao, Brendan K. Podell, G. Brooke Anderson, Marcela Henao-Tamayo

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: ELISA, Mycobacterium tuberculosis, Mycobacterium leprae, antibodies, data analysis, curve-fitting, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1427526/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e541c6d127904cffbb00ec9adaec42d7

Heterogeneity in immune cell composition is associated with Mycobacterium tuberculosis replication at the granuloma level

Authors: Sarah K. Cooper, David Forrest Ackart, Faye Lanni, Marcela Henao-Tamayo, G. Brooke Anderson, Brendan K. Podell

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: Mycobacterium, tuberculosis, granuloma, immunohistochemistry (IHC), in situ hybridization (ISH), image analysis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1427472/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/d3abf1a56ca54c45854449446b7414b0

Protective interplay: Mycobacterium tuberculosis diminishes SARS-CoV-2 severity through innate immune priming

Authors: Brittany D. Williams, Debora Ferede, Hazem F. M. Abdelaal, Bryan J. Berube, Brendan K. Podell, Sasha E. Larsen, Susan L. Baldwin, Rhea N. Coler

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: SARS-CoV-2, Mycobacterium tuberculosis, tuberculosis, co-infection, COVID-19, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1424374/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/aff08b3a575940cbbf9ef16b41cab381

Gliosis, misfolded protein aggregation, and neuronal loss in a guinea pig model of pulmonary tuberculosis

Authors: Amanda S. Latham, Charlize E. Geer, David F. Ackart, Isla K. Anderson, Kaley M. Vittoria, Brendan K. Podell, Randall J. Basaraba, Julie A. Moreno

Source: Frontiers in Neuroscience, Vol 17 (2023)

Subject Terms: tuberculosis, neuroinflammation, glia, infection, neurodegeneration, tau, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2023.1157652/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/0dc3cb2aa699433f855868582cd2883e

Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens

Authors: Nicholas D. Walter, Sarah E. M. Born, Gregory T. Robertson, Matthew Reichlen, Christian Dide-Agossou, Victoria A. Ektnitphong, Karen Rossmassler, Michelle E. Ramey, Allison A. Bauman, Victor Ozols, Shelby C. Bearrows, Gary Schoolnik, Gregory Dolganov, Benjamin Garcia, Emmanuel Musisi, William Worodria, Laurence Huang, J. Lucian Davis, Nhung V. Nguyen, Hung V. Nguyen, Anh T. V. Nguyen, Ha Phan, Carol Wilusz, Brendan K. Podell, N’ Dira Sanoussi, Bouke C. de Jong, Corinne S. Merle, Dissou Affolabi, Helen McIlleron, Maria Garcia-Cremades, Ekaterina Maidji, Franceen Eshun-Wilson, Brandon Aguilar-Rodriguez, Dhuvarakesh Karthikeyan, Khisimuzi Mdluli, Cathy Bansbach, Anne J. Lenaerts, Radojka M. Savic, Payam Nahid, Joshua J. Vásquez, Martin I. Voskuil

Source: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e0c6c2c659ca434dbad834a1759cfbb7

Subunit vaccine protects against a clinical isolate of Mycobacterium avium in wild type and immunocompromised mouse models

Authors: Sasha E. Larsen, Valerie A. Reese, Tiffany Pecor, Bryan J. Berube, Sarah K. Cooper, Guy Brewer, Diane Ordway, Marcela Henao-Tamayo, Brendan K. Podell, Susan L. Baldwin, Rhea N. Coler

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/927dd0386d3f47ee8d7c92fa46bca032

Therapeutic efficacy against Mycobacterium tuberculosis using ID93 and liposomal adjuvant formulations

Authors: Susan L. Baldwin, Valerie A. Reese, Sasha E. Larsen, Tiffany Pecor, Bryan P. Brown, Brian Granger, Brendan K. Podell, Christopher B. Fox, Steven G. Reed, Rhea N. Coler

Source: Frontiers in Microbiology, Vol 13 (2022)

Subject Terms: adjuvant, tuberculosis, immunotherapy, QS-21, glucopyranosyl lipid adjuvant, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2022.935444/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/699e1361e91840d39815fe328c717453

Preparation Strategies of the Anti-Mycobacterial Drug Bedaquiline for Intrapulmonary Routes of Administration

Authors: Sara E. Maloney, Ian E. Stewart, Brendan K. Podell, Hadley E. Gary, Jeffrey B. Mecham, Bryan J. Berube, Susan L. Baldwin, Rhea N. Coler, Anthony J. Hickey

Source: Pharmaceuticals, Vol 16, Iss 5, p 729 (2023)

Subject Terms: bedaquiline, tuberculosis, inhalation therapy, spray drying, dry powder inhaler, excipient, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/5/729; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/fb1e73021b01468fbe479f08053d7b07

A model of type 2 diabetes in the guinea pig using sequential diet-induced glucose intolerance and streptozotocin treatment

Authors: Brendan K. Podell, David F. Ackart, Michael A. Richardson, James E. DiLisio, Bruce Pulford, Randall J. Basaraba

Source: Disease Models & Mechanisms, Vol 10, Iss 2, Pp 151-162 (2017)

Subject Terms: Animal model, Insulin-independent diabetes, Guinea pig, Glucose intolerance, Streptozotocin, Type 2 diabetes, Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/10/2/151; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/70216dc32b294770a9becb5408d2cc50

Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection

Authors: Molly Butler, Nunya Chotiwan, Connie D. Brewster, James E. DiLisio, David F. Ackart, Brendan K. Podell, Randall J. Basaraba, Rushika Perera, Sandra L. Quackenbush, Joel Rovnak

Source: Viruses, Vol 12, Iss 6, p 654 (2020)

Subject Terms: dengue virus, CDK8, CDK19, hexokinase, LC3, Senexin, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/12/6/654; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/0707cd3260064beea66db7467adc8929

Enhanced Anti-Mycobacterium tuberculosis Immunity over Time with Combined Drug and Immunotherapy Treatment

Authors: Sasha E. Larsen, Susan L. Baldwin, Mark T. Orr, Valerie A. Reese, Tiffany Pecor, Brian Granger, Natasha Dubois Cauwelaert, Brendan K. Podell, Rhea N. Coler

Source: Vaccines, Vol 6, Iss 2, p 30 (2018)

Subject Terms: therapeutic vaccine, Mycobacterium tuberculosis, tuberculosis, immunotherapy, adjuvant, GLA-SE, ID93, Medicine

File Description: electronic resource

Relation: http://www.mdpi.com/2076-393X/6/2/30; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/1bd3c591d0f5443787e2a0d1fccfca66

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Immune cell infiltration and modulation of the blood-brain barrier in a guinea pig model of tuberculosis: Observations without evidence of bacterial dissemination to the brain.

Authors: Amanda S Latham, Charlize E Geer, David F Ackart, Kristin N Weninger, Chase C Gross, Brendan K Podell, Randall J Basaraba, Julie A Moreno

Source: PLoS ONE, Vol 19, Iss 12, p e0307577 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/4ef52534dc624e00820372ec48e97214

A Whole Virion Vaccine for COVID-19 Produced via a Novel Inactivation Method and Preliminary Demonstration of Efficacy in an Animal Challenge Model

Authors: Izabela K Ragan, Lindsay M Hartson, Taru S Dutt, Andres Obregon-Henao, Rachel M Maison, Paul Gordy, Amy Fox, Burton R Karger, Shaun T Cross, Marylee L Kapuscinski, Sarah K Cooper, Brendan K Podell, Mark D Stenglein, Richard A Bowen, Marcela Henao-Tamayo, Raymond P Goodrich

Source: Vaccines, Vol 9, Iss 4, p 340 (2021)

Subject Terms: SARS-CoV-2, vaccination, hamster, inactivated virus vaccine, riboflavin, UV light, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/9/4/340; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/ae2134d385154377817932c1e948a491

High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types

Authors: Landry Blanc, Isaac B Daudelin, Brendan K Podell, Pei-Yu Chen, Matthew Zimmerman, Amanda J Martinot, Rada M Savic, Brendan Prideaux, Véronique Dartois

Source: eLife, Vol 7 (2018)

Subject Terms: tuberculosis, drug distribution, fluoroquinolones, rabbit model, MALDI mass spectrometry imaging, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/41115; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/cbca0d4970894efa84dfd916ff209774

Standardized guinea pig model for Q fever vaccine reactogenicity.

Authors: Laurie A Baeten, Brendan K Podell, Ann E Sluder, Anja Garritsen, Richard A Bowen, Mark C Poznansky

Source: PLoS ONE, Vol 13, Iss 10, p e0205882 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC6185858?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/db26f937517549f8824e279869b89ea7

2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability.

Authors: Albert B Jeon, Andrés Obregón-Henao, David F Ackart, Brendan K Podell, Juan M Belardinelli, Mary Jackson, Tuan V Nguyen, Meghan S Blackledge, Roberta J Melander, Christian Melander, Benjamin K Johnson, Robert B Abramovitch, Randall J Basaraba

Source: PLoS ONE, Vol 12, Iss 7, p e0180925 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5547695?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/13b71f62b38642b8ae75712bb88ac78d

Non-diabetic hyperglycemia exacerbates disease severity in Mycobacterium tuberculosis infected guinea pigs.

Authors: Brendan K Podell, David F Ackart, Natalie M Kirk, Sarah P Eck, Christopher Bell, Randall J Basaraba

Source: PLoS ONE, Vol 7, Iss 10, p e46824 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3464230?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/25adbd799c8a441c983c046e41a137eb