A Simplified Model of Adenine-Induced Chronic Kidney Disease Using SKH1 Mice.

Authors: French, Benjamin W.¹ (AUTHOR) benjamin.french2@rockets.utoledo.edu, Breidenbach, Joshua D.^1,2 (AUTHOR) joshua.breidenbach@rockets.utoledo.edu, Yassine, Shereen G.^1,3 (AUTHOR) shereen.yassine@rockets.utoledo.edu, Khatib-Shahidi, Bella Z.¹ (AUTHOR) bella.khatibshahidi@rockets.utoledo.edu, Kazmi, Sara¹ (AUTHOR) sara.kazmi@rockets.utoledo.edu, Murphy, Caitlin M.¹ (AUTHOR) caitlin.murphy@rockets.utoledo.edu, Bashir, Humza S.¹ (AUTHOR) humza.bashir@rockets.utoledo.edu, Benson, Evan M.¹ (AUTHOR) evan.benson2@rockets.utoledo.edu, Timalsina, Bivek¹ (AUTHOR) bivek.timalsina@rockets.utoledo.edu, Shrestha, Upasana¹ (AUTHOR) upasana.shrestha@rockets.utoledo.edu, Faleel, Dhilhani¹ (AUTHOR) fmohammedfaleel@mcw.edu, Boyapalli, Satkeerth¹ (AUTHOR) satkeerth.boyapalli@rockets.utoledo.edu, Dube, Prabhatchandra¹ (AUTHOR) prabhatchandra.dube@utoledo.edu, Lad, Apurva¹ (AUTHOR) apurva.lad@utoledo.edu, Syed, Irum⁴ (AUTHOR) irum.syed@rockets.utoledo.edu, Malhotra, Deepak¹ (AUTHOR) deepak.malhotra@utoledo.edu, Gohara, Amira⁵ (AUTHOR) amira.gohara@utoledo.edu, Kennedy, David J.¹ (AUTHOR) david.kennedy@utoledo.edu, Haller, Steven T.¹ (AUTHOR) david.kennedy@utoledo.edu

Source: Cells (2073-4409). Dec2024, Vol. 13 Issue 24, p2117. 13p.

Subject Terms: *RENAL fibrosis, *CHRONIC kidney failure, *LABORATORY mice, *NATURAL immunity, *PROTEINURIA

A systematic scoping review of the neurological effects of COVID-19

Authors: Hogberg, Helena T., Tsaioun, Katya, Breidenbach, Joshua D., Elmore, Bekki, Filipovska, Julija, Garcia-Reyero, Natalia, Hargreaves, Alan J., Joshi, Ojasi, Omeragic, Elma, Plant, Shannon, Ram, Rebecca, Virmani, Ishita, Waspe, Jennifer, Macmillan, Donna S.

Source: In Neurotoxicology July 2024 103:16-26

Aerosolized Harmful Algal Bloom Toxin Microcystin-LR Induces Type 1/Type 17 Inflammation of Murine Airways.

Authors: Breidenbach, Joshua D.^1,2,3 (AUTHOR) irum.syed@rockets.utoledo.edu, French, Benjamin W.¹ (AUTHOR) benjamin.french2@rockets.utoledo.edu, Stanoszek, Lauren M.⁴ (AUTHOR) lauren.stanoszek@utoledo.edu, Lavik, John-Paul⁵ (AUTHOR), Maddipati, Krishna Rao⁶ (AUTHOR) maddipati@wayne.edu, Premathilaka, Sanduni H.⁷ (AUTHOR) meegahamadiththegedara.premathilaka@rockets.utoledo.edu, Baliu-Rodriguez, David⁷ (AUTHOR) baliurodrigu1@llnl.gov, Timalsina, Bivek^1,2 (AUTHOR) bivek.timalsina@rockets.utoledo.edu, Aradhyula, Vaishnavi¹ (AUTHOR) vaishnavi.aradhyula@rockets.utoledo.edu, Patel, Shivani C.¹ (AUTHOR) shivani.patel8@rockets.utoledo.edu, Lad, Apurva¹ (AUTHOR) apurva.lad@utoledo.edu, Syed, Irum² (AUTHOR), Kleinhenz, Andrew L.¹ (AUTHOR) andrew.kleinhenz@utoledo.edu, Blomquist, Thomas M.⁴ (AUTHOR) thomas.blomquist@utoledo.edu, Gohara, Amira⁴ (AUTHOR) amira.gohara@utoledo.edu, Dube, Prabhatchandra¹ (AUTHOR) prabhatchandra.dube@utoledo.edu, Zhang, Shungang¹ (AUTHOR) shungang.zhang@rockets.utoledo.edu, Faleel, Dhilhani¹ (AUTHOR) fathimadhilhani.mohammedfaleel@rockets.utoledo.edu, Khalaf, Fatimah K.⁸ (AUTHOR) kareem.khalaf@rockets.utoledo.edu, Isailovic, Dragan⁷ (AUTHOR) dragan.isailovic@utoledo.edu

Source: Toxins. Nov2024, Vol. 16 Issue 11, p470. 15p.

Subject Terms: *ALGAL blooms, *ALGAL toxins, *BODIES of water, *CYANOBACTERIAL toxins, *INTERLEUKINS

Microcystin-LR aerosol induces inflammatory responses in healthy human primary airway epithelium

Authors: Breidenbach, Joshua D., French, Benjamin W., Gordon, Tamiya T., Kleinhenz, Andrew L., Khalaf, Fatimah K., Willey, James C., Hammersley, Jeffrey R., Mark Wooten, R., Crawford, Erin L., Modyanov, Nikolai N., Malhotra, Deepak, Teeguarden, Justin G., Haller, Steven T., Kennedy, David J.

Source: In Environment International November 2022 169

Acute Exposure to Aerosolized Nanoplastics Modulates Redox-Linked Immune Responses in Human Airway Epithelium.

Authors: Breidenbach, Joshua D., French, Benjamin W., Shrestha, Upasana, Adya, Zaneh K., Wooten, R. Mark, Fribley, Andrew M., Malhotra, Deepak, Haller, Steven T., Kennedy, David J.

Source: Antioxidants; Apr2025, Vol. 14 Issue 4, p424, 14p

Assessment of diagnostic biomarkers of liver injury in the setting of microcystin-LR (MC-LR) hepatotoxicity

Authors: Su, Robin C., Lad, Apurva, Breidenbach, Joshua D., Kleinhenz, Andrew L., Modyanov, Nikolai, Malhotra, Deepak, Haller, Steven T., Kennedy, David J.

Source: In Chemosphere October 2020 257

The Addition of Transcriptomics to the Bead-Enabled Accelerated Monophasic Multi-Omics Method: A Step toward Universal Sample Preparation.

Authors: Breidenbach, Joshua D.¹ (AUTHOR), Rivera, Emilio S.¹ (AUTHOR), Harvey, Tara¹ (AUTHOR), Mikolitis, Abigale S.¹ (AUTHOR), Tseng, Chi Yen¹ (AUTHOR), Sanders, Claire K.² (AUTHOR), Solomon, Emilia¹ (AUTHOR), Gleasner, Cheryl D.³ (AUTHOR), Thornhill, M. Grace¹ (AUTHOR), Luchini, Kes A.¹ (AUTHOR), McBride, Ethan M.¹ (AUTHOR), Blackwell, Brett R.¹ (AUTHOR), LeBrun, Erick S.¹ (AUTHOR), Mach, Phillip M.¹ (AUTHOR), Glaros, Trevor G.¹ (AUTHOR) tglaros@lanl.gov

Source: Analytical Chemistry. 11/19/2024, Vol. 96 Issue 46, p18343-18348. 6p.

Feature-agnostic metabolomics for determining effective subcytotoxic doses of common pesticides in human cells.

Authors: Rivera, Emilio S, LeBrun, Erick S, Breidenbach, Joshua D, Solomon, Emilia, Sanders, Claire K, Harvey, Tara, Tseng, Chi Yen, Thornhill, M Grace, Blackwell, Brett R, McBride, Ethan M, Luchini, Kes A, Alvarez, Marc, Williams, Robert F, Norris, Jeremy L, Mach, Phillip M, Glaros, Trevor G

Source: Toxicological Sciences; Nov2024, Vol. 202 Issue 1, p85-95, 11p

Subject Terms: PHENOMENOLOGICAL biology, MOLECULAR biology, CARBARYL, PESTICIDES, RESEARCH personnel, METABOLOMICS

Transcriptomic Analysis of Arachidonic Acid Pathway Genes Provides Mechanistic Insight into Multi-Organ Inflammatory and Vascular Diseases.

Authors: Aradhyula, Vaishnavi¹ (AUTHOR) vaishnavi.aradhyula@rockets.utoledo.edu, Breidenbach, Joshua D.^1,2 (AUTHOR), Khatib-Shahidi, Bella Z.¹ (AUTHOR), Slogar, Julia N.¹ (AUTHOR), Eyong, Sonia A.¹ (AUTHOR), Faleel, Dhilhani¹ (AUTHOR), Dube, Prabhatchandra¹ (AUTHOR), Gupta, Rajesh¹ (AUTHOR), Khouri, Samer J.¹ (AUTHOR), Haller, Steven T.¹ (AUTHOR), Kennedy, David J.¹ (AUTHOR) vaishnavi.aradhyula@rockets.utoledo.edu

Source: Genes. Jul2024, Vol. 15 Issue 7, p954. 25p.

Subject Terms: *GENE expression, *INFLAMMATORY mediators, *ARACHIDONIC acid, *VASCULAR remodeling, *CYTOCHROME P-450

As We Drink and Breathe: Adverse Health Effects of Microcystins and Other Harmful Algal Bloom Toxins in the Liver, Gut, Lungs and Beyond.

Authors: Lad, Apurva¹ (AUTHOR) apurva.lad@rockets.utoledo.edu, Breidenbach, Joshua D.¹ (AUTHOR) joshua.breidenbach@rockets.utoledo.edu, Su, Robin C.¹ (AUTHOR) robin.su@rockets.utoledo.edu, Murray, Jordan¹ (AUTHOR) jordan.murray@rockets.utoledo.edu, Kuang, Rebecca¹ (AUTHOR) rebecca.kuang@rockets.utoledo.edu, Mascarenhas, Alison¹ (AUTHOR) alison.mascarenhas@rockets.utoledo.edu, Najjar, John¹ (AUTHOR) john.najjar@rockets.utoledo.edu, Patel, Shivani¹ (AUTHOR) shivani.patel8@rockets.utoledo.edu, Hegde, Prajwal¹ (AUTHOR) prajwal.hegde@rockets.utoledo.edu, Youssef, Mirella¹ (AUTHOR) mirella.youssef@osumc.edu, Breuler, Jason¹ (AUTHOR) jason.breuler@rockets.utoledo.edu, Kleinhenz, Andrew L.¹ (AUTHOR) andrew.kleinhenz@utoledo.edu, Ault, Andrew P.² (AUTHOR) aulta@umich.edu, Westrick, Judy A.³ (AUTHOR) judy.westrick@wayne.edu, Modyanov, Nikolai N.¹ (AUTHOR) nikolai.modyanov@utoledo.edu, Kennedy, David J.¹ (AUTHOR) david.kennedy@utoledo.edu, Haller, Steven T.¹ (AUTHOR) david.kennedy@utoledo.edu

Source: Life (2075-1729). Mar2022, Vol. 12 Issue 3, p418-N.PAG. 17p.

Subject Terms: *ALGAL toxins, *ALGAL blooms, *MICROCYSTINS, *LUNGS, *EXANTHEMA, *ANIMAL health, *DRINKING water, *FEED additives

Novel Model of Oxalate Diet-Induced Chronic Kidney Disease in Dahl-Salt-Sensitive Rats.

Authors: Dube, Prabhatchandra, Aradhyula, Vaishnavi, Lad, Apurva, Khalaf, Fatimah K., Breidenbach, Joshua D., Kashaboina, Eshita, Gorthi, Snigdha, Varatharajan, Shangari, Stevens, Travis W., Connolly, Jacob A., Soehnlen, Sophia M., Sood, Ambika, Marellapudi, Amulya, Ranabothu, Meghana, Kleinhenz, Andrew L., Domenig, Oliver, Dworkin, Lance D., Malhotra, Deepak, Haller, Steven T., Kennedy, David J.

Source: International Journal of Molecular Sciences; Jun2023, Vol. 24 Issue 12, p10062, 14p

Subject Terms: CALCIUM oxalate, CHRONIC kidney failure, OXALATES, RAT diseases, LIQUID chromatography-mass spectrometry, KIDNEY cortex, CYSTATIN C, METABOLOMICS

Cardioprotective Role for Paraoxonase-1 in Chronic Kidney Disease.

Authors: Dube, Prabhatchandra, Khalaf, Fatimah K., DeRiso, Armelle, Mohammed, Chrysan J., Connolly, Jacob A., Battepati, Dhanushya, Lad, Apurva, Breidenbach, Joshua D., Kleinhenz, Andrew L., Khatib-Shahidi, Bella, Patel, Mitra, Tassavvor, Iman, Gohara, Amira F., Malhotra, Deepak, Morgan, Eric E., Haller, Steven T., Kennedy, David J.

Source: Biomedicines; Sep2022, Vol. 10 Issue 9, p2301-2301, 14p

Subject Terms: CHRONIC kidney failure, LEFT ventricular hypertrophy, HIGH-salt diet, CARDIAC hypertrophy, HYDROLASES

GeneToList: A Web Application to Assist with Gene Identifiers for the Non-Bioinformatics-Savvy Scientist.

Authors: Breidenbach, Joshua D.¹ (AUTHOR) eugene.f.begue@gmail.com, Begue III, E. Francis¹ (AUTHOR), Kennedy, David J.¹ (AUTHOR), Haller, Steven T.¹ (AUTHOR)

Source: Biology (2079-7737). Aug2022, Vol. 11 Issue 8, pN.PAG-N.PAG. 5p.

Subject Terms: *WEB-based user interfaces, *GENE conversion, *SCIENTIFIC communication, *DNA microarrays, *GERMPLASM, *BIOINFORMATICS software, *GENES

Antioxidant Therapy Significantly Attenuates Hepatotoxicity following Low Dose Exposure to Microcystin-LR in a Murine Model of Diet-Induced Non-Alcoholic Fatty Liver Disease.

Authors: Lad, Apurva, Hunyadi, Jonathan, Connolly, Jacob, Breidenbach, Joshua D., Khalaf, Fatimah K., Dube, Prabhatchandra, Zhang, Shungang, Kleinhenz, Andrew L., Baliu-Rodriguez, David, Isailovic, Dragan, Hinds Jr., Terry D., Gatto-Weis, Cara, Stanoszek, Lauren M., Blomquist, Thomas M., Malhotra, Deepak, Haller, Steven T., Kennedy, David J.

Source: Antioxidants; Aug2022, Vol. 11 Issue 8, pN.PAG-N.PAG, 21p

Subject Terms: NON-alcoholic fatty liver disease, CYANOBACTERIAL toxins, LIVER histology, LEPTIN receptors, EXPOSURE dose, HEPATOTOXICOLOGY, WEIGHT loss, XENOBIOTICS

Paraoxonase-1 Regulation of Renal Inflammation and Fibrosis in Chronic Kidney Disease.

Authors: Khalaf, Fatimah K., Mohammed, Chrysan J., Dube, Prabhatchandra, Connolly, Jacob A., Lad, Apurva, Ashraf, Usman M., Breidenbach, Joshua D., Su, Robin C., Kleinhenz, Andrew L., Malhotra, Deepak, Gohara, Amira F., Haller, Steven T., Kennedy, David J.

Source: Antioxidants; May2022, Vol. 11 Issue 5, p900, 15p

Subject Terms: RENAL fibrosis, CHRONIC kidney failure, HIGH-salt diet, HIGH density lipoproteins, HYDROLASES

Renal Fibrosis Is Significantly Attenuated Following Targeted Disruption of in Experimental Renal Ischemia.

Authors: Zhang, Shungang, Breidenbach, Joshua D., Khalaf, Fatimah K., Dube, Prabhatchandra R., Mohammed, Chrysan J., Lad, Apurva, Stepkowski, Stanislaw, Hinds, Terry D., Kumarasamy, Sivarajan, Kleinhenz, Andrew, Jiang Tian, Malhotra, Deepak, Kennedy, David J., Cooper, Christopher J., Haller, Steven T., Tian, Jiang

Source: Journal of the American Heart Association; 4/9/2020, Vol. 9 Issue 7, p1-15, 26p

Hyperglycemia induces key genetic and phenotypic changes in human liver epithelial HepG2 cells which parallel the Lepr^db/J mouse model of non-alcoholic fatty liver disease (NAFLD).

Authors: Su, Robin C., Lad, Apurva, Breidenbach, Joshua D., Blomquist, Thomas M., Gunning, William T., Dube, Prabhatchandra, Kleinhenz, Andrew L., Malhotra, Deepak, Haller, Steven T., Kennedy, David J.

Source: PLoS ONE; 12/5/2019, Vol. 14 Issue 12, p1-17, 17p

Subject Terms: FATTY liver, GLYCEMIC index, ALKALINE phosphatase, EPITHELIAL cells, HYPERGLYCEMIA

Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in murine heart allograft rejection.

Authors: Khattar, Mithun, Baum, Caitlin E., Schroder, Paul, Breidenbach, Joshua D., Haller, Steven T., Chen, Wenhao, Stepkowski, Stanislaw

Source: PLoS ONE; 11/22/2019, Vol. 14 Issue 11, p1-12, 12p

Subject Terms: INTERLEUKIN-21, HEART transplantation, SKIN grafting, MAJOR histocompatibility complex, GRAFT rejection, CHIMERIC proteins

Microcystin-LR (MC-LR) Triggers Inflammatory Responses in Macrophages.

Authors: Su, Robin C.¹ (AUTHOR) Robin.Su@rockets.utoledo.edu, Breidenbach, Joshua D.¹ (AUTHOR) Joshua.Breidenbach@rockets.utoledo.edu, Alganem, Khaled² (AUTHOR) Khaled.Alganem@rockets.utoledo.edu, Khalaf, Fatimah K.¹ (AUTHOR) Kareem.Khalaf@rockets.utoledo.edu, French, Benjamin W.¹ (AUTHOR) Benjamin.French2@rockets.utoledo.edu, Dube, Prabhatchandra¹ (AUTHOR) prabhatchandra.dube@utoledo.edu, Malhotra, Deepak¹ (AUTHOR) Deepak.Malhotra@utoledo.edu, McCullumsmith, Robert^2,3 (AUTHOR) Robert.McCullumsmith@utoledo.edu, Presloid, John B.⁴ (AUTHOR) john.presloid@utoledo.edu, Wooten, R. Mark⁴ (AUTHOR) r.mark.wooten@utoledo.edu, Kennedy, David J.¹ (AUTHOR) David.Kennedy@utoledo.edu, Haller, Steven T.¹ (AUTHOR) David.Kennedy@utoledo.edu

Source: International Journal of Molecular Sciences. Sep2021, Vol. 22 Issue 18, p9939. 1p.

Subject Terms: *INFLAMMATION, *MACROPHAGES, *DRUG target, *MACROPHAGE activation, *INFLAMMATORY bowel diseases

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