Molecular design of the γδT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing

Authors: Mallis, Robert J., Duke-Cohan, Jonathan S., Das, Dibyendu Kumar, Akitsu, Aoi, Luoma, Adrienne M., Banik, Debasis, Stephens, Hannah M., Tetteh, Paul W., Castro, Caitlin D., Krahnke, Sophie, Hussey, Rebecca E., Lawney, Brian, Brazin, Kristine N., Reche, Pedro A., Hwang, Wonmuk, Adams, Erin J., Lang, Matthew J., Reinherz, Ellis L.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Jun . 118(26), 1-12.

Access URL: https://www.jstor.org/stable/27040813

Measuring αβ T-Cell Receptor-Mediated Mechanosensing Using Optical Tweezers Combined with Fluorescence Imaging

Authors: Stephens, Hannah M., Brazin, Kristine N., Mallis, Robert J., Feng, Yinnian, Banik, Debasis, Reinherz, Ellis L., Lang, Matthew J.

Source: Methods in molecular biology. 2478:727-753

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630235945&indx=1&recIds=ETOCRN630235945

Biophysical and Structural Features of αβT‐Cell Receptor Mechanosensing: A Paradigmatic Shift in Understanding T‐Cell Activation.

Authors: Mallis, Robert J.^1,2,3,4 (AUTHOR) robert_mallis@hms.harvard.edu, Brazin, Kristine N.^1,2,3 (AUTHOR), Duke‐Cohan, Jonathan S.^1,2,3 (AUTHOR), Akitsu, Aoi^1,2,3 (AUTHOR), Stephens, Hanna M.⁵ (AUTHOR), Chang‐Gonzalez, Ana C.⁶ (AUTHOR), Masi, Daniel J.⁵ (AUTHOR), Kirkpatrick, Evan H.⁵ (AUTHOR), Holliday, Elizabeth L.⁵ (AUTHOR), Feng, Yinnian⁵ (AUTHOR), Zienkiewicz, Katarzyna J.⁵ (AUTHOR), Lee, Jonathan J.^1,2 (AUTHOR), Cinella, Vincenzo^1,2 (AUTHOR), Uberoy, Kaveri I.^1,2 (AUTHOR), Tan, Kemin⁷ (AUTHOR), Wagner, Gerhard⁸ (AUTHOR), Arthanari, Haribabu^8,9 (AUTHOR), Hwang, Wonmuk^6,10,11,12 (AUTHOR), Lang, Matthew J.^5,13 (AUTHOR), Reinherz, Ellis L.^1,2,3 (AUTHOR) ellis_reinherz@dfci.harvard.edu

Source: Immunological Reviews. Jan2025, Vol. 329 Issue 1, p1-28. 28p.

Subject Terms: *T cell receptors, *T cells, *MECHANICAL behavior of materials, *CELLULAR signal transduction, *THERAPEUTICS, *MECHANOTRANSDUCTION (Cytology), *STRUCTURAL dynamics, *IMMUNE recognition

The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations

Authors: Brazin, Kristine N., Mallis, Robert J., Boeszoermenyi, Andras, Feng, Yinnian, Yoshizawa, Akihiro, Reche, Pedro A., Kaur, Pavanjeet, Bi, Kevin, Hussey, Rebecca E., Duke-Cohan, Jonathan S., Song, Likai, Wagner, Gerhard, Arthanari, Haribabu, Lang, Matthew J., Reinherz, Ellis L.

Source: In Immunity 20 November 2018 49(5):829-841

NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology

Authors: Mallis, Robert J., Brazin, Kristine N., Duke-Cohan, Jonathan S., Hwang, Wonmuk, Wang, Jia-huai, Wagner, Gerhard, Arthanari, Haribabu, Lang, Matthew J., Reinherz, Ellis L.

Source: Journal of biomolecular NMR. 73(6-7):319-332

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127705193.0x000001&indx=1&recIds=ETOCvdc_100127705193.0x000001

Mechanosensing drives acuity of αβ T-cell recognition

Authors: Feng, Yinnian, Brazin, Kristine N., Kobayashi, Eiji, Mallis, Robert J., Reinherz, Ellis L., Lang, Matthew J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Sep . 114(39), E8204-E8213.

Access URL: https://www.jstor.org/stable/26488064

Regulation of the Tyrosine Kinase Itk by the Peptidyl-Prolyl Isomerase Cyclophilin A

Authors: Brazin, Kristine N., Mallis, Robert J., Fulton, D. Bruce, Andreotti, Amy H.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2002 Feb . 99(4), 1899-1904.

Access URL: https://www.jstor.org/stable/3057890

Efficient and economic protein labeling for NMR in mammalian expression systems: Application to a preT‐cell and T‐cell receptor protein.

Authors: Mallis, Robert J., Lee, Jonathan J., Berg, Arjen Van den, Brazin, Kristine N., Viennet, Thibault, Zmuda, Jonathan, Cross, Melissa, Radeva, Denitsa, Rodriguez‐Mias, Ricard, Villén, Judit, Gelev, Vladimir, Reinherz, Ellis L., Arthanari, Haribabu

Source: Protein Science: A Publication of the Protein Society; Apr2024, Vol. 33 Issue 4, p1-17, 17p

Constitutively Oxidized CXXC Motifs within the CD3 Heterodimeric Ectodomains of the T Cell Receptor Complex Enforce the Conformation of Juxtaposed Segments

Authors: Brazin, Kristine N., Mallis, Robert J., Li, Chen, Keskin, Derin B., Arthanari, Haribabu, Gao, Yuanwei, Wu, Shiaw-Lin, Karger, Barry L., Wagner, Gerhard, Reinherz, Ellis L.

Source: In Journal of Biological Chemistry July 2014 289(27):18880-18892

PreTCR Interaction With Self-pMHC: Expanding the Repertoire of Thymocytes During β Selection While Maintaining Developmental Fidelity

Authors: Duke-Cohan, Jonathan S, Akitsu, Aoi, Mallis, Robert J, Brazin, Kristine N, Tan, Kemin, Hwang, Wonmuk, Lang, Matthew J, Reinherz, Ellis L

Source: In Reference Module in Life Sciences 2017

A specific intermolecular association between the regulatory domains of a tec family kinase

Authors: Brazin, Kristine N, Fulton, D.Bruce, Andreotti, Amy H ^*

Source: In Journal of Molecular Biology 2000 302(3):607-623

Structural characterization of a proline-driven conformational switch within the Itk SH2 domain.

Authors: Mallis, Robert J., Brazin, Kristine N., Fulton, D. Bruce, Andreotti, Amy H.

Source: Nature Structural Biology. Dec2002, Vol. 9 Issue 12, p900. 6p.

Subject Terms: *PROTEIN-tyrosine kinases, *IMMUNE response, *T cells, *LIGAND binding (Biochemistry)

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Biophysical Features of the αβTCR Mechanome that Drive High Avidity T-Cell Recognition

Authors: Feng, Yinnian, Brazin, Kristine N., Kobayashi, Eiji, Mallis, Robert J., Reinherz, Ellis L., Lang, Matthew J.

Source: In Biophysical Journal 2 February 2018 114(3) Supplement 1:201a-201a

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Mechanosensing drives acuity of αβ T-cell recognition.

Authors: Yinnian Feng, Brazin, Kristine N., Eiji Kobayashi, Mallis, Robert J., Reinherz, Ellis L., Lang, Matthew J.

Source: Proceedings of the National Academy of Sciences of the United States of America; 9/26/2017, Vol. 114 Issue 39, pE8204-E8213, 10p

Subject Terms: T cell receptors, LYMPHOCYTES, PEPTIDES, ANTIGENS, MOLECULES

Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments.

Authors: Brazin, Kristine N., Mallis, Robert J., Li, Chen, Keskin, Derin B., Arthanari, Haribabu, Gao, Yuanwei, Wu, Shiaw-Lin, Karger, Barry L., Wagner, Gerhard, Reinherz, Ellis L.

Source: In Journal of Biological Chemistry 2 January 2015 290(1):239-239

Structural features of the αβTCR mechanotransduction apparatus that promote pMHC discrimination.

Authors: Brazin, Kristine N., Mallis, Robert J., Das, Dibyendu Kumar, Yinnian Feng, Wonmuk Hwang, Jia-huai Wang, Wagner, Gerhard, Lang, Matthew J., Reinherz, Ellis L., Dushek, Omer, Varma, Rajat

Source: Frontiers in Immunology; Sep2015, p1-13, 13p

Subject Terms: MECHANOTRANSDUCTION (Cytology), T cell receptors, MAJOR histocompatibility complex

Regulation of the tyrosine kinase ltk by the peptidyl-prolyl isomerase cyclophilin A.

Authors: Brazin, Kristine N., Mallis, Robert J., Fulton, D. Bruce, Andreotti, Amy H.

Source: Proceedings of the National Academy of Sciences of the United States of America. 2/19/2002, Vol. 99 Issue 4, p1899. 6p. 13 Diagrams, 9 Graphs.

Subject Terms: *PROTEIN-tyrosine kinases, *CYCLOPHILINS, *NUCLEAR magnetic resonance

Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: Intramolecular contact versus asymmetric homodimerization.

Authors: Laederach, Alain, Cradic, Kendall W., Brazin, Kristine N., Zamoon, Jamillah, Fulton, D. Bruce, Huang, Xin-Yun, Andreotti, Amy H.

Source: Protein Science: A Publication of the Protein Society; 2002, Vol. 11 Issue 1, p36-57, 22p