Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD

Authors: Postma Dirkje S, Slebos Dirk-Jan, Noordhoek Jacobien A, Brandenburg Simone M, Heijink Irene H, van Oosterhout Antoon J

Source: Respiratory Research, Vol 12, Iss 1, p 110 (2011)

Subject Terms: Cigarette smoke, ADAM17, IL-8, TGF-α, TIMP-2, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://respiratory-research.com/content/12/1/110; https://doaj.org/toc/1465-9921

Access URL: https://doaj.org/article/0fb411236409478597433ec335c10484

Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity

Authors: Wang, Boshi, Varela‐Eirin, Marta, Brandenburg, Simone M, Hernandez‐Segura, Alejandra, van Vliet, Thijmen, Jongbloed, Elisabeth M, Wilting, Saskia M, Ohtani, Naoko, Jager, Agnes, Demaria, Marco

Source: EMBO journal. 41(6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144185865.0x000001&indx=1&recIds=ETOCvdc_100144185865.0x000001

Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression

Authors: van Vliet, Thijmen, Varela-Eirin, Marta, Wang, Boshi, Borghesan, Michela, Brandenburg, Simone M., Franzin, Rossana, Evangelou, Konstantinos, Seelen, Marc, Gorgoulis, Vassilis, Demaria, Marco

Source: In Molecular Cell 6 May 2021 81(9):2041-2052

Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression.

Authors: Kohli, Jaskaren, Ge, Chen, Fitsiou, Eleni, Doepner, Miriam, Brandenburg, Simone M., Faller, William J., Ridky, Todd W., Demaria, Marco

Source: Nature Communications; 12/23/2022, Vol. 13 Issue 1, p1-9, 9p

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Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD.

Authors: Ngkelo, Anta, Hoffmann, Roland F., Durham, Andrew L., Marwick, John A., Brandenburg, Simone M., de Bruin, Harold G., Jonker, Marnix R., Rossios, Christos, Tsitsiou, Eleni, Caramori, Gaetano, Contoli, Marco, Casolari, Paolo, Monaco, Francesco, Andò, Filippo, Speciale, Giuseppe, Kilty, Iain, Chung, Kian F., Papi, Alberto, Lindsay, Mark A., ten Hacken, Nick H. T.

Source: American Journal of Physiology: Lung Cellular & Molecular Physiology; 11/15/2015, Vol. 309 Issue 10, pL1112-L1123, 12p

Subject Terms: GLYCOGENOLYSIS, GLYCOSYLTRANSFERASES, LUNGS, RESPIRATORY infections, RESPIRATORY diseases, LUNG diseases, PATHOLOGICAL physiology

Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD.

Authors: Heijink, Irene H., Brandenburg, Simone M., Noordhoek, Jacobien A., Slebos, Dirk-Jan, Postma, Dirkje S., van Oosterhout, Antoon J.

Source: Respiratory Research; Aug2011, Vol. 12 Issue 8, p1-11, 11p, 5 Graphs

Subject Terms: METALLOPROTEINASES, EPITHELIUM, OBSTRUCTIVE lung diseases, CIGARETTE smoke, TRANSFORMING growth factors, DISINTEGRINS, THERAPEUTICS, DISEASE risk factors, PROTEIN metabolism, CELL culture, COMPARATIVE studies, GLYCOPROTEINS, INFLAMMATORY mediators, RESEARCH methodology, MEDICAL cooperation, PROTEINS, RESEARCH, RESPIRATORY mucosa, SMOKE, TOBACCO, PHENOTYPES, EVALUATION research, CHEMICAL inhibitors