Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies

Authors: Adams, Mark J., Streit, Fabian, Meng, Xiangrui, Awasthi, Swapnil, Adey, Brett N., Choi, Karmel W., Chundru, V. Kartik, Coleman, Jonathan R.I., Ferwerda, Bart, Foo, Jerome C., Gerring, Zachary F., Giannakopoulou, Olga, Gupta, Priya, Hall, Alisha S.M., Harder, Arvid, Howard, David M., Hübel, Christopher, Kwong, Alex S.F., Levey, Daniel F., Mitchell, Brittany L., Ni, Guiyan, Ota, Vanessa K., Pain, Oliver, Pathak, Gita A., Schulte, Eva C., Shen, Xueyi, Thorp, Jackson G., Walker, Alicia, Yao, Shuyang, Zeng, Jian, Zvrskovec, Johan, Aarsland, Dag, Actkins, Ky'Era V., Adli, Mazda, Agerbo, Esben, Aichholzer, Mareike, Aiello, Allison, Air, Tracy M., Als, Thomas D., Andersson, Evelyn, Andlauer, Till F.M., Arolt, Volker, Ask, Helga, Bäckman, Julia, Badola, Sunita, Ballard, Clive, Banasik, Karina, Bass, Nicholas J., Beekman, Aartjan T.F., Belangero, Sintia, Bigdeli, Tim B., Binder, Elisabeth B., Bjerkeset, Ottar, Bjornsdottir, Gyda, Børte, Sigrid, Bränn, Emma, Braun, Alice, Brodersen, Thorsten, Brückl, Tanja M., Brunak, Søren, Bruun, Mie T., Burmeister, Margit, Buspavanich, Pichit, Bybjerg-Grauholm, Jonas, Byrne, Enda M., Cai, Jianwen, Campbell, Archie, Campbell, Megan L., Campos, Adrian I., Castelao, Enrique, Cervilla, Jorge, Chaumette, Boris, Chen, Chia-Yen, Chen, Hsi-Chung, Chen, Zhengming, Cichon, Sven, Colodro-Conde, Lucía, Corbett, Anne, Corfield, Elizabeth C., Couvy-Duchesne, Baptiste, Craddock, Nick, Dannlowski, Udo, Davies, Gail, de Geus, E.J.C., Deary, Ian J., Degenhardt, Franziska, Dehghan, Abbas, DePaulo, J. Raymond, Deuschle, Michael, Didriksen, Maria, Dinh, Khoa Manh, Direk, Nese, Djurovic, Srdjan, Docherty, Anna R., Domschke, Katharina, Dowsett, Joseph, Drange, Ole Kristian, Dunn, Erin C., Eaton, William, Einarsson, Gudmundur, Eley, Thalia C., Elsheikh, Samar S.M., Engelmann, Jan, Benros, Michael E., Erikstrup, Christian, Escott-Price, Valentina, Fabbri, Chiara, Fang, Yu, Finer, Sarah, Frank, Josef, Free, Robert C., Gallo, Linda, Gao, He, Gill, Michael, Gilles, Maria, Goes, Fernando S., Gordon, Scott Douglas, Grove, Jakob, Gudbjartsson, Daniel F., Gutierrez, Blanca, Hahn, Tim, Hall, Lynsey S., Hansen, Thomas F., Haraldsson, Magnus, Hartman, Catharina A., Havdahl, Alexandra, Hayward, Caroline, Heilmann-Heimbach, Stefanie, Herms, Stefan, Hickie, Ian B., Hjalgrim, Henrik, Hjerling-Leffler, Jens, Hoffmann, Per, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Hougaard, David M., Hovatta, Iiris, Huang, Qin Qin, Hucks, Donald, Huider, Floris, Hunt, Karen A., Ialongo, Nicholas S., Ising, Marcus, Isometsä, Erkki, Jansen, Rick, Jiang, Yunxuan, Jones, Ian, Jones, Lisa A., Jonsson, Lina, Kanai, Masahiro, Karlsson, Robert, Kasper, Siegfried, Kendler, Kenneth S., Kessler, Ronald C., Kloiber, Stefan, Knowles, James A., Koen, Nastassja, Kraft, Julia, Kranzler, Henry R., Krebs, Kristi, Kallak, Theodora Kunovac, Kutalik, Zoltán, Lahtela, Elisa, Lake, Marilyn, Larsen, Margit Hørup, Lenze, Eric J., Lewins, Melissa, Lewis, Glyn, Li, Liming, Lin, Bochao Danae, Lin, Kuang, Lind, Penelope A., Liu, Yu-Li, MacIntyre, Donald J., MacKinnon, Dean F., Maher, Brion S., Maier, Wolfgang, Marshe, Victoria S., Martinez-Levy, Gabriela A., Matsuda, Koichi, Mbarek, Hamdi, McGuffin, Peter, Medland, Sarah E., Meinert, Susanne, Mikkelsen, Christina, Mikkelsen, Susan, Milaneschi, Yuri, Millwood, Iona Y., Molina, Esther, Mondimore, Francis M., Mortensen, Preben Bo, Mulsant, Benoit H., Naamanka, Joonas, Najman, Jake M., Nauck, Matthias, Nenadić, Igor, Nielsen, Kasper R., Nolt, Ilja M., Nordentoft, Merete, Nöthen, Markus M., Nyegaard, Mette, O'Donovan, Michael C., Oddsson, Asmundur, Oliveira, Adrielle M., Olsen, Catherine M., Oskarsson, Hogni, Ostrowski, Sisse Rye, Owen, Michael J., Packer, Richard, Palviainen, Teemu, Pan, Pedro M., Pato, Carlos N., Pato, Michele T., Pedersen, Nancy L., Pedersen, Ole Birger, Peyrot, Wouter J., Potash, James B., Preisig, Martin, Preuss, Michael H., Quiroz, Jorge A., Renteria, Miguel E., Reynolds III, Charles F., Rice, John P., Sakaue, Saori, Santoro, Marcos L., Schoevers, Robert A., Schork, Andrew, Schulze, Thomas G., Send, Tabea S., Shi, Jianxin, Sigurdsson, Engilbert, Singh, Kritika, Sinnamon, Grant C.B., Sirignano, Lea, Smeland, Olav B., Smith, Daniel J., Sofer, Tamar, Sørensen, Erik, Srinivasan, Sundararajan, Stefansson, Hreinn, Stefansson, Kari, Straub, Peter, Su, Mei-Hsin, Tadic, André, Teismann, Henning, Teumer, Alexander, Thapar, Anita, Thomson, Pippa A., Thørner, Lise Wegner, Topaloudi, Apostolia, Tsai, Shih-Jen, Tzoulaki, Ioanna, Uhl, George, Uitterlinden, André G., Ullum, Henrik, Umbricht, Daniel, Ursano, Robert J., Van der Auwera, Sandra, van Hemert, Albert M., Veluchamy, Abirami, Viktorin, Alexander, Völzke, Henry, Walters, G. Bragi, Wang, Xiaotong, Wani, Agaz, Weissman, Myrna M., Wellmann, Jürgen, Whiteman, David C., Wildman, Derek, Willemsen, Gonneke, Williams, Alexander T., Winsvold, Bendik S., Witt, Stephanie H., Xiong, Ying, Zillich, Lea, Zwart, John-Anker, Twenty-Three and Me Research Team, China Kadoorie Biobank Collaborative Group, Estonian Biobank Research Team, Genes & Health Research Team, HUNT All-In Psychiatry, The BioBank Japan Project, VA Million Veteran Program, Andreassen, Ole A., Baune, Bernhard T., Berger, Klaus, Boomsma, Dorret I., Børglum, Anders D., Breen, Gerome, Cai, Na, Coon, Hilary, Copeland, William E., Creese, Byron, Cruz-Fuentes, Carlos S., Czamara, Darina, Davis, Lea K., Derks, Eske M., Domenici, Enrico, Elliott, Paul, Forstner, Andreas J., Gawlik, Micha, Gelernter, Joel, Grabe, Hans J., Hamilton, Steven P., Hveem, Kristian, John, Catherine, Kaprio, Jaakko, Kircher, Tilo, Krebs, Marie-Odile, Kuo, Po-Hsiu, Landén, Mikael, Lehto, Kelli, Levinson, Douglas F., Li, Qingqin S., Lieb, Klaus, Loos, Ruth J.F., Lu, Yi, Lucae, Susanne, Luykx, Jurjen J., Maes, Hermine H.M., Magnusson, Patrik K., Martin, Hilary C., Martin, Nicholas G., McQuillin, Andrew, Middeldorp, Christel M., Milani, Lili, Mors, Ole, Müller, Daniel J., Müller-Myhsok, Bertram, Okada, Yukinori, Oldehinkel, Albertine J., Paciga, Sara A., Palmer, Colin N.A., Paschou, Peristera, Penninx, Brenda W.J.H., Perlis, Roy H., Peterson, Roseann E., Pistis, Giorgio, Polimanti, Renato, Porteous, David J., Posthuma, Danielle, Rabinowitz, Jill A., Reichborn-Kjennerud, Ted, Reif, Andreas, Rice, Frances, Ricken, Roland, Rietschel, Marcella, Rivera, Margarita, Rück, Christian, Salum, Giovanni A., Schaefer, Catherine, Sen, Srijan, Serretti, Alessandro, Skalkidou, Alkistis, Smoller, Jordan W., Stein, Dan J., Stein, Frederike, Stein, Murray B., Sullivan, Patrick F., Tesli, Martin, Thorgeirsson, Thorgeir E., Tiemeier, Henning, Timpson, Nicholas J., Uddin, Monica, Uher, Rudolf, van Heel, David A., Verweij, Karin J.H., Walters, Robin G., Wassertheil-Smoller, Sylvia, Wendland, Jens R., Werge, Thomas, Zwinderman, Aeilko H., Kuchenbaecker, Karoline, Wray, Naomi R., Ripke, Stephan, Lewis, Cathryn M., McIntosh, Andrew M.

Source: In Cell 6 February 2025 188(3):640-652

Dissecting depression symptoms: Multi-omics clustering uncovers immune-related subgroups and cell-type specific dysregulation

Authors: Hagenberg, Jonas ^{a, b, c}, Brückl, Tanja M. ^a, Erhart, Mira ^{a, b}, Kopf-Beck, Johannes ^{a, d}, Ködel, Maik ^a, Rehawi, Ghalia ^{a, c}, Röh-Karamihalev, Simone ^a, Sauer, Susann ^a, Yusupov, Natan ^{a, b}, Rex-Haffner, Monika ^a, Spoormaker, Victor I. ^a, Sämann, Philipp ^a, Binder, Elisabeth ^{a, e}, Knauer-Arloth, Janine ^{a, c, ⁎}

Source: In Brain Behavior and Immunity January 2025 123:353-369

Data-Driven Pupil Response Profiles as Transdiagnostic Readouts for the Detection of Neurocognitive Functioning in Affective and Anxiety Disorders

Authors: Binder, Elisabeth B., Erhardt, Angelika, Lucae, Susanne, Grandi, Norma C., Namendorf, Tamara, Elbau, Immanuel, Leuchs, Laura, Schilbach, Leonhard, Ilić-Ćoćić, Sanja, Ziebula, Julius, Mücke-Heim, Iven-Alex von, Kim, Yeho, Pape, Julius, Fietz, Julia, Pöhlchen, Dorothee, Brückl, Tanja M., Brem, Anna-Katharine, Padberg, Frank, Czisch, Michael, Sämann, Philipp G., Spoormaker, Victor I.

Source: In Biological Psychiatry: Cognitive Neuroscience and Neuroimaging June 2024 9(6):580-587

Multimodal predictions of treatment outcome in major depression: A comparison of data-driven predictors with importance ratings by clinicians

Authors: Rost, Nicolas, Dwyer, Dominic B., Gaffron, Swetlana, Rechberger, Simon, Maier, Dieter, Binder, Elisabeth B., Brückl, Tanja M.

Source: Journal of affective disorders. 327:330-339

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187669760.0x000001&indx=1&recIds=ETOCvdc_100187669760.0x000001

Early adversity as the prototype gene × environment interaction in mental disorders?

Authors: Martins, Jade, Yusupov, Natan, Binder, Elisabeth B., Brückl, Tanja M., Czamara, Darina

Source: In Pharmacology, Biochemistry and Behavior April 2022 215

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Imagery of negative interpersonal experiences influence the neural mechanisms of social interaction

Authors: Brandi, Marie-Luise, Lahnakoski, Juha M., Kopf-Beck, Johannes, Nolte, Tobias, Brückl, Tanja M., Schilbach, Leonhard

Source: In Neuropsychologia 17 September 2021 160

No robust differences in fear conditioning between patients with fear-related disorders and healthy controls

Authors: Binder, Elisabeth B., Czisch, Michael, Erhardt, Angelika, Grandi, Norma C., Ilic-Cocic, Sanja, Lucae, Susanne, Sämann, Philipp, Tontsch, Alina, Pöhlchen, Dorothee, Leuchs, Laura, Binder, Florian P., Blaskovich, Borbala, Nantawisarakul, Taechawidd, Topalidis, Pavlos, Brückl, Tanja M., Norrholm, Seth D., Jovanovic, Tanja, Spoormaker, Victor I.

Source: In Behaviour Research and Therapy June 2020 129

Creating sparser prediction models of treatment outcome in depression: a proof-of-concept study using simultaneous feature selection and hyperparameter tuning.

Authors: Rost, Nicolas^1,2 (AUTHOR) nicolas_rost@psych.mpg.de, Brückl, Tanja M.¹ (AUTHOR), Koutsouleris, Nikolaos^3,4,5 (AUTHOR), Binder, Elisabeth B.¹ (AUTHOR), Müller-Myhsok, Bertram^1,6 (AUTHOR)

Source: BMC Medical Informatics & Decision Making. 7/14/2022, Vol. 22 Issue 1, p1-13. 13p.

Subject Terms: *FEATURE selection, *TREATMENT effectiveness, *PREDICTION models, *MENTAL depression, *CLASSIFICATION algorithms

Free-viewing gaze patterns reveal a mood-congruency bias in MDD during an affective fMRI/eye-tracking task.

Authors: Sun, Rui, Fietz, Julia, Erhart, Mira, Poehlchen, Dorothee, Henco, Lara, Brückl, Tanja M., Binder, Elisabeth B., Erhardt, Angelika, Lucae, Susanne, Grandi, Norma C., Namendorf, Tamara, Elbau, Immanuel, Leuchs, Laura, Brem, Anna Katharine, Schilbach, Leonhard, Ilić-Ćoćić, Sanja, Ziebula, Julius, von Mücke-Heim, Iven-Alex, Kim, Yeho, Pape, Julius

Source: European Archives of Psychiatry & Clinical Neuroscience; Apr2024, Vol. 274 Issue 3, p559-571, 13p

Subject Terms: ATTENTIONAL bias, MENTAL depression, GAZE, AFFECT (Psychology), FACE perception, PATHOLOGICAL psychology

Geographic Terms: MUNICH (Germany)

The biological classification of mental disorders (BeCOME) study: a protocol for an observational deep-phenotyping study for the identification of biological subtypes.

Authors: Brückl, Tanja M.¹ (AUTHOR) brueckl@psych.mpg.de, Spoormaker, Victor I.¹ (AUTHOR), Sämann, Philipp G.² (AUTHOR), Brem, Anna-Katharine^2,3 (AUTHOR), Henco, Lara⁴ (AUTHOR), Czamara, Darina¹ (AUTHOR), Elbau, Immanuel¹ (AUTHOR), Grandi, Norma C.¹ (AUTHOR), Jollans, Lee¹ (AUTHOR), Kühnel, Anne^1,5 (AUTHOR), Leuchs, Laura¹ (AUTHOR), Pöhlchen, Dorothee^1,5 (AUTHOR), Schneider, Maximilian² (AUTHOR), Tontsch, Alina¹ (AUTHOR), Keck, Martin E.² (AUTHOR), Schilbach, Leonhard⁴ (AUTHOR), Czisch, Michael² (AUTHOR), Lucae, Susanne² (AUTHOR), Erhardt, Angelika¹ (AUTHOR), Binder, Elisabeth B.^1,6 (AUTHOR)

Source: BMC Psychiatry. 5/11/2020, Vol. 20 Issue 1, p1-25. 25p. 2 Diagrams, 4 Charts.

Subject Terms: *CLASSIFICATION of mental disorders, *BIOLOGICAL classification, *MENTAL illness, *BIOLOGICAL psychiatry, *GEOGRAPHICAL perception, *FEAR

No robust differences in fear conditioning between patients with fear-related disorders and healthy controls

Authors: Pöhlchen, Dorothee, Leuchs, Laura, Binder, Florian P., Blaskovich, Borbala, Nantawisarakul, Taechawidd, Topalidis, Pavlos, Brückl, Tanja M., Norrholm, Seth D., Jovanovic, Tanja, Spoormaker, Victor I.

Source: Behaviour research and therapy. 129

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116026312.0x000001&indx=1&recIds=ETOCvdc_100116026312.0x000001

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Childhood Separation Anxiety and the Risk of Subsequent Psychopathology : Results from a Community Study

Authors: Brückl, Tanja M., Wittchen, Hans-Ulrich, Höfler, Michael, Pfister, Hildegard, Schneider, Silvia, Lieb, Roselind

Source: Psychotherapy and Psychosomatics, 2007 Jan 01. 76(1), 47-56.

Access URL: https://www.jstor.org/stable/48510982

Predicting treatment outcome in depression: an introduction into current concepts and challenges.

Authors: Rost, Nicolas, Binder, Elisabeth B., Brückl, Tanja M.

Source: European Archives of Psychiatry & Clinical Neuroscience; Feb2023, Vol. 273 Issue 1, p113-127, 15p, 1 Diagram, 2 Charts

Subject Terms: CLINICAL decision support systems, TREATMENT effectiveness, PSYCHIATRIC research, MENTAL depression, PREDICTION models

Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks

Authors: Thoeringer, Christoph K., Binder, Elisabeth B., Salyakina, Daria, Erhardt, Angelika, Ising, Marcus, Unschuld, Paul G., Kern, Nikola, Lucae, Susanne, Brueckl, Tanja M., Mueller, Marianne B., Fuchs, Brigitte, Puetz, Benno, Lieb, Roselind, Uhr, Manfred, Holsboer, Florian, Mueller-Myhsok, Bertram, Keck, Martin E.

Source: In Journal of Psychiatric Research 2007 41(7):579-584

179. Transdiagnostic Evaluation of Epigenetic Age Acceleration and Burden of Psychiatric Disorders

Authors: Yusupov, Natan, Dieckmann, Linda, Erhart, Mira, Sauer, Susann, Rex-Haffner, Monika, Kopf-Beck, Johannes, Brückl, Tanja M., Czamara, Darina, Binder, Elisabeth

Source: In Biological Psychiatry 1 May 2023 93(9) Supplement:S166-S166

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