Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stem

Authors: Ataca, Sila ¹, Sangesland, Maya ^{2, 6}, de Paiva Fróes Rocha, Rebeca ^{3, 9}, Torrents de la Peña, Alba ³, Ronsard, Larance ², Boyoglu-Barnum, Seyhan ^{1, 7}, Gillespie, Rebecca A. ¹, Tsybovsky, Yaroslav ⁴, Stephens, Tyler ⁴, Moin, Syed M. ¹, Lederhofer, Julia ¹, Creanga, Adrian ¹, Andrews, Sarah F. ¹, Barnes, Ralston M. ⁵, Rohrer, Daniel ⁵, Lonberg, Nils ⁵, Graham, Barney S. ^{1, 8}, Ward, Andrew B. ³, Lingwood, Daniel ², Kanekiyo, Masaru ^{1, 10, ∗}

Source: In Cell Reports 24 December 2024 43(12)

Antigen spacing on protein nanoparticles influences antibody responses to vaccination

Authors: Ellis, Daniel, Dosey, Annie, Boyoglu-Barnum, Seyhan, Park, Young-Jun, Gillespie, Rebecca, Syeda, Hubza, Hutchinson, Geoffrey B., Tsybovsky, Yaroslav, Murphy, Michael, Pettie, Deleah, Matheson, Nick, Chan, Sidney, Ueda, George, Fallas, Jorge A., Carter, Lauren, Graham, Barney S., Veesler, David, Kanekiyo, Masaru, King, Neil P.

Source: In Cell Reports 26 December 2023 42(12)

Combinatorial immune refocusing within the influenza hemagglutinin RBD improves cross-neutralizing antibody responses

Authors: Dosey, Annie, Ellis, Daniel, Boyoglu-Barnum, Seyhan, Syeda, Hubza, Saunders, Mason, Watson, Michael J., Kraft, John C., Pham, Minh N., Guttman, Miklos, Lee, Kelly K., Kanekiyo, Masaru, King, Neil P.

Source: In Cell Reports 26 December 2023 42(12)

Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses

Authors: Moin, Syed M., Boyington, Jeffrey C., Boyoglu-Barnum, Seyhan, Gillespie, Rebecca A., Cerutti, Gabriele, Cheung, Crystal Sao-Fong, Cagigi, Alberto, Gallagher, John R., Brand, Joshua, Prabhakaran, Madhu, Tsybovsky, Yaroslav, Stephens, Tyler, Fisher, Brian E., Creanga, Adrian, Ataca, Sila, Rawi, Reda, Corbett, Kizzmekia S., Crank, Michelle C., Karlsson Hedestam, Gunilla B., Gorman, Jason, McDermott, Adrian B., Harris, Audray K., Zhou, Tongqing, Kwong, Peter D., Shapiro, Lawrence, Mascola, John R., Graham, Barney S., Kanekiyo, Masaru

Source: In Immunity 13 December 2022 55(12):2405-2418

Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus

Authors: Sangesland, Maya, Torrents de la Peña, Alba, Boyoglu-Barnum, Seyhan, Ronsard, Larance, Mohamed, Faez Amokrane Nait, Moreno, Thalia Bracamonte, Barnes, Ralston M., Rohrer, Daniel, Lonberg, Nils, Ghebremichael, Musie, Kanekiyo, Masaru, Ward, Andrew, Lingwood, Daniel

Source: In Immunity 13 September 2022 55(9):1693-1709

mRNA vaccination in octogenarians 15 and 20 months after recovery from COVID-19 elicits robust immune and antibody responses that include Omicron

Authors: Lee, Hye Kyung, Knabl, Ludwig, Moliva, Juan I., Knabl, Ludwig, Sr., Werner, Anne P., Boyoglu-Barnum, Seyhan, Kapferer, Sebastian, Pateter, Birgit, Walter, Mary, Sullivan, Nancy J., Furth, Priscilla A., Hennighausen, Lothar

Source: In Cell Reports 12 April 2022 39(2)

Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung

Authors: Gagne, Matthew, Corbett, Kizzmekia S., Flynn, Barbara J., Foulds, Kathryn E., Wagner, Danielle A., Andrew, Shayne F., Todd, John-Paul M., Honeycutt, Christopher Cole, McCormick, Lauren, Nurmukhambetova, Saule T., Davis-Gardner, Meredith E., Pessaint, Laurent, Bock, Kevin W., Nagata, Bianca M., Minai, Mahnaz, Werner, Anne P., Moliva, Juan I., Tucker, Courtney, Lorang, Cynthia G., Zhao, Bingchun, McCarthy, Elizabeth, Cook, Anthony, Dodson, Alan, Teng, I-Ting, Mudvari, Prakriti, Roberts-Torres, Jesmine, Laboune, Farida, Wang, Lingshu, Goode, Adrienne, Kar, Swagata, Boyoglu-Barnum, Seyhan, Yang, Eun Sung, Shi, Wei, Ploquin, Aurélie, Doria-Rose, Nicole, Carfi, Andrea, Mascola, John R., Boritz, Eli A., Edwards, Darin K., Andersen, Hanne, Lewis, Mark G., Suthar, Mehul S., Graham, Barney S., Roederer, Mario, Moore, Ian N., Nason, Martha C., Sullivan, Nancy J., Douek, Daniel C., Seder, Robert A.

Source: In Cell 6 January 2022 185(1):113-130

COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge

Authors: DiPiazza, Anthony T., Leist, Sarah R., Abiona, Olubukola M., Moliva, Juan I., Werner, Anne, Minai, Mahnaz, Nagata, Bianca M., Bock, Kevin W., Phung, Emily, Schäfer, Alexandra, Dinnon, Kenneth H., III, Chang, Lauren A., Loomis, Rebecca J., Boyoglu-Barnum, Seyhan, Alvarado, Gabriela S., Sullivan, Nancy J., Edwards, Darin K., Morabito, Kaitlyn M., Mascola, John R., Carfi, Andrea, Corbett, Kizzmekia S., Moore, Ian N., Baric, Ralph S., Graham, Barney S., Ruckwardt, Tracy J.

Source: In Immunity 10 August 2021 54(8):1869-1882

Germline-Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response against Influenza Virus

Authors: Sangesland, Maya, Ronsard, Larance, Kazer, Samuel W., Bals, Julia, Boyoglu-Barnum, Seyhan, Yousif, Ashraf S., Barnes, Ralston, Feldman, Jared, Quirindongo-Crespo, Maricel, McTamney, Patrick M., Rohrer, Daniel, Lonberg, Nils, Chackerian, Bryce, Graham, Barney S., Kanekiyo, Masaru, Shalek, Alex K., Lingwood, Daniel

Source: In Immunity 15 October 2019 51(4):735-749

Designed nanoparticles elicit cross-reactive antibody responses to conserved influenza virus hemagglutinin stem epitopes.

Authors: McCraw, Dustin M.¹, Myers, Mallory L.¹, Gulati, Neetu M.¹, Prabhakaran, Madhu², Brand, Joshua², Andrews, Sarah², Gallagher, John R.¹, Maldonado-Puga, Samantha¹, Kim, Alexander J.¹, Torian, Udana¹, Syeda, Hubza², Boyoglu-Barnum, Seyhan², Kanekiyo, Masaru², McDermott, Adrian B.², Harris, Audray K.¹, harrisau@mail.nih.gov

Source: PLoS Pathogens; 8/28/2023, Vol. 19 Issue 8, p1-37, 37p

An anti-G protein monoclonal antibody treats RSV disease more effectively than an anti-F monoclonal antibody in BALB/c mice

Authors: Boyoglu-Barnum, Seyhan, Todd, Sean O., Chirkova, Tatiana, Barnum, Thomas R., Gaston, Kelsey A., Haynes, Lia M., Tripp, Ralph A., Moore, Martin L., Anderson, Larry J.

Source: In Virology September 2015 483:117-125

Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera.

Authors: Hutchinson, Geoffrey B., Abiona, Olubukola M., Ziwawo, Cynthia T., Werner, Anne P., Ellis, Daniel, Tsybovsky, Yaroslav, Leist, Sarah R., Palandjian, Charis, West, Ande, Fritch, Ethan J., Wang, Nianshuang, Wrapp, Daniel, Boyoglu-Barnum, Seyhan, Ueda, George, Baker, David, Kanekiyo, Masaru, McLellan, Jason S., Baric, Ralph S., King, Neil P., Graham, Barney S.

Source: Nature Communications; 10/4/2023, Vol. 14 Issue 1, p1-11, 11p

Subject Terms: CORONAVIRUSES, ANTIBODY formation, IMMUNOGLOBULINS, NANOPARTICLES, COVID-19, SARS virus, VIRUS-like particles, MONOCLONAL antibodies

Impact of adjuvant: Trivalent vaccine with quadrivalent-like protection against heterologous Yamagata-lineage influenza B virus.

Authors: Myers, Mallory L., Gallagher, John R., Woolfork, De'Marcus D., Stradtmann-Carvalho, Regan K., Maldonado-Puga, Samantha, Bock, Kevin W., Boyoglu-Barnum, Seyhan, Syeda, Hubza, Creanga, Adrian, Alves, Derron A., Masaru Kanekiyo, Harris, Audray K.

Source: Frontiers in Immunology; 2023, p1-14, 14p

Subject Terms: COMBINED vaccines, INFLUENZA B virus, INFLUENZA vaccines, INFLUENZA viruses, VACCINE development

Geographic Terms: VICTORIA

Impact of adjuvant: Trivalent vaccine with quadrivalent-like protection against heterologous Yamagata-lineage influenza B virus.

Authors: Myers, Mallory L., Gallagher, John R., Woolfork, De'Marcus D., Stradtmann-Carvalho, Regan K., Maldonado-Puga, Samantha, Bock, Kevin W., Boyoglu-Barnum, Seyhan, Syeda, Hubza, Creanga, Adrian, Alves, Derron A., Kanekiyo, Masaru, Harris, Audray K.

Source: Frontiers in Immunology; 9/30/2022, Vol. 13, p1-14, 14p

Subject Terms: COMBINED vaccines, INFLUENZA B virus, INFLUENZA vaccines, TECHNOLOGICAL innovations, VACCINE development

Geographic Terms: VICTORIA

Protective role of Indoleamine 2,3 dioxygenase in Respiratory Syncytial Virus associated immune response in airway epithelial cells

Authors: Rajan, Devi, Chinnadurai, Raghavan, O'Keefe, Evan L., Boyoglu-Barnum, Seyhan, Todd, Sean O., Hartert, Tina V., Galipeau, Jacques, Anderson, Larry J.

Source: In Virology December 2017 512:144-150

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness.

Authors: Corbett, Kizzmekia S., Edwards, Darin K., Leist, Sarah R., Abiona, Olubukola M., Boyoglu-Barnum, Seyhan, Gillespie, Rebecca A., Himansu, Sunny, Schäfer, Alexandra, Ziwawo, Cynthia T., DiPiazza, Anthony T., Dinnon, Kenneth H., Elbashir, Sayda M., Shaw, Christine A., Woods, Angela, Fritch, Ethan J., Martinez, David R., Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Hutchinson, Geoffrey B.

Source: Nature; 10/22/2020, Vol. 586 Issue 7830, p567-571, 5p

Microscopic Studies of Various Sizes of Gold Nanoparticles and Their Cellular Localizations.

Authors: Boyoglu, Cemil¹, Qingwen He², Willing, Gerold², Boyoglu-Barnum, Seyhan¹, Dennis, Vida A.¹, Pillai, Shreekumar¹, Singh, Shree R.¹, ssingh@alasu.edu

Source: ISRN Nanotechnology; 2013, p1-13, 13p

Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses.

Authors: Boyoglu-Barnum, Seyhan, Hutchinson, Geoffrey B., Boyington, Jeffrey C., Moin, Syed M., Gillespie, Rebecca A., Tsybovsky, Yaroslav, Stephens, Tyler, Vaile, John R., Lederhofer, Julia, Corbett, Kizzmekia S., Fisher, Brian E., Yassine, Hadi M., Andrews, Sarah F., Crank, Michelle C., McDermott, Adrian B., Mascola, John R., Graham, Barney S., Kanekiyo, Masaru

Source: Nature Communications; 2/7/2020, Vol. 11 Issue 1, p1-12, 12p

Subject Terms: ANTIBODY formation, INFLUENZA, INFLUENZA A virus, H7N9 subtype, VIRUS diseases, INFLUENZA A virus, H5N1 subtype, H1N1 influenza, BIODEGRADABLE nanoparticles

Geographic Terms: NEW Caledonia

Biology of Infection and Disease Pathogenesis to Guide RSV Vaccine Development.

Authors: Boyoglu-Barnum, Seyhan, Chirkova, Tatiana, Anderson, Larry J.

Source: Frontiers in Immunology; 7/25/2019, p1-10, 10p

Subject Terms: INFLUENZA, H7N9 Influenza, RESPIRATORY diseases, VACCINES, AIDS vaccines, INFLUENZA vaccines, RESPIRATORY syncytial virus

Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine.

Authors: Kai Wu¹, Werner, Anne P.², Edwards, Darin K.¹, darin.edwards@modernatx.com, Wu, Kai³, Koch, Matthew³, Choi, Angela³, Narayanan, Elisabeth³, Stewart-Jones, Guillaume B E³, Colpitts, Tonya³, Bennett, Hamilton³, Boyoglu-Barnum, Seyhan⁴, Shi, Wei⁴, Moliva, Juan I⁴, Sullivan, Nancy J⁴, Graham, Barney S⁴, Carfi, Andrea³, Corbett, Kizzmekia S⁴, Seder, Robert A⁴

Source: New England Journal of Medicine; 4/15/2021, Vol. 384 Issue 15, p1468-1470, 3p