The pharmacodynamics of minocycline alone and in combination with rifampicin against Staphylococcus aureus studied in an in vitro pharmacokinetic model of infection.

Authors: Noel, A R, Attwood, M, Bowker, K E, MacGowan, A P

Source: Journal of Antimicrobial Chemotherapy (JAC); Jul2021, Vol. 76 Issue 7, p1840-1844, 5p

Subject Terms: RIFAMPIN, STAPHYLOCOCCUS aureus, MINOCYCLINE, PHARMACODYNAMICS, PHARMACOKINETICS, IN vitro studies, MICROCOCCACEAE, METHICILLIN-resistant staphylococcus aureus, ANTIBIOTICS, RESEARCH, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, STAPHYLOCOCCAL diseases, COMPARATIVE studies, MICROBIAL sensitivity tests

In vitro pharmacodynamics of omadacycline against Escherichia coli and Acinetobacter baumannii.

Authors: Noel, A R, Attwood, M, Bowker, K E, MacGowan, A P

Source: Journal of Antimicrobial Chemotherapy (JAC); Mar2021, Vol. 76 Issue 3, p667-670, 4p

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BAL 9141, a new broad-spectrum pyrrolidinone cephalosporin: activity against clinically significant anaerobes in comparison with 10 other antimicrobials.

Authors: Wootton, M., Bowker, K. E., Holt, H. A., MacGowan, A. P.

Source: Journal of Antimicrobial Chemotherapy (JAC); Mar2002, Vol. 49 Issue 3, p535-539, 5p

The activity of vancomycin against heterogeneous vancomycin-intermediate methicillin-resistant Staphylococcus aureus explored using an in vitro pharmacokinetic model.

Authors: Turner, Jonathan, Howe, Robin A., Wootton, Mandy, Bowker, Karen E., Holt, H. Alan, Salisbury, Vyvyan, Bennett, Peter M., Walsh, Timothy R., MacGowan, Alasdair P., Turner, J, Howe, R A, Wootton, M, Bowker, K E, Holt, H A, Salisbury, V, Bennett, P M, Walsh, T R, MacGowan, A P

Source: Journal of Antimicrobial Chemotherapy (JAC); Nov2001, Vol. 48 Issue 5, p727-730, 4p

Use of meropenem 3 g once daily for outpatient treatment of infective exacerbations of bronchiectasis.

Authors: Darley, Elizabeth S. R., Bowker, Karen E., Lovering, Andrew M., Harvey, John E., Macgowan, Alasdair P., Darley, E S, Bowker, K E, Lovering, A M, Harvey, J E, Macgowan, A P

Source: Journal of Antimicrobial Chemotherapy (JAC); Feb2000, Vol. 45 Issue 2, p247-250, 4p

Exploration of the in-vitro pharmacodynamic activity of moxifloxacin for Staphylococcus aureus and Streptococci of lancefield groups A and G.

Authors: MacGowan, Alasdair P., Bowker, Karen E., Wootton, Mandy, Holt, H. Alan, MacGowan, A P, Bowker, K E, Wootton, M, Holt, H A

Source: Journal of Antimicrobial Chemotherapy (JAC); Dec1999, Vol. 44 Issue 6, p761-766, 6p

Comparison of in-vitro pharmacodynamics of once and twice daily ciprofloxacin.

Authors: Bowker, K. E., Wootton, M., Rogers, C. A., Lewis, R., Holt, H. A., MacGowan, A. P.

Source: Journal of Antimicrobial Chemotherapy (JAC); Nov1999, Vol. 44 Issue 5, p661-667, 7p

In-vitro activity of HMR 3647 against Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and beta-haemolytic streptococci.

Authors: Wootton, M., Bowker, K. E., Janowska, A., Holt, H. A., MacGowan, A. P.

Source: Journal of Antimicrobial Chemotherapy (JAC); Oct1999, Vol. 44 Issue 4, p445-453, 9p

Use of a clinical Escherichia coli isolate expressing lux genes to study the antimicrobial pharmacodynamics of moxifloxacin.

Authors: Salisbury, V, Pfoestl, A, Wiesinger-Mayr, H, Lewis, R, Bowker, K E, MacGowan, A P

Source: Journal of Antimicrobial Chemotherapy (JAC); Jun1999, Vol. 43 Issue 6, p829-832, 4p

Subject Terms: METABOLISM, ANTIBIOTICS, BACTERIAL growth, BACTERIAL proteins, CYTOLOGY, DOSE-effect relationship in pharmacology, ESCHERICHIA coli, MICROBIAL sensitivity tests, MICROBIOLOGICAL techniques, ORGANIC compounds, OXIDOREDUCTASES, QUINOLINE, QUINOLONE antibacterial agents, PHARMACODYNAMICS

Surveillance of antimicrobial resistance.

Authors: MacGowan, A. P., Bowker, K. E., Bennett, P. M.

Source: Lancet; November 28 1998, Vol. 352 Issue 9142, p1783-1783, 1p

Continuous infusion of beta-lactam antibiotics.

Authors: MacGowan, A P¹ (AUTHOR), Bowker, K E (AUTHOR)

Source: Clinical Pharmacokinetics. 1998, Vol. 35 Issue 5, p391-402. 12p.

The in-vitro activity of trovafloxacin and nine other antimicrobials against 413 anaerobic bacteria.

Authors: Bowker, K. E., Wootton, M., Holt, H. A., Reeves, D. S., MacGowan, A. P.

Source: Journal of Antimicrobial Chemotherapy (JAC); 1996, Vol. 38 Issue 2, p271-281, 11p

Bactericidal activity, post antibiotic effect and modified controlled effective regrowth time of meropenem at high concentrations.

Authors: Bowker, Karen E., Holt, H. Alan, Reeves, David S., MacGowan, Alasdair P., Bowker, K E, Holt, H A, Reeves, D S, MacGowan, A P

Source: Journal of Antimicrobial Chemotherapy (JAC); 1996, Vol. 38 Issue 6, p1055-1060, 6p

A new time-kill method of assessing the relative efficacy of antimicrobial agents alone and in combination developed using a representative beta-lactam, aminoglycoside and fluoroquinolone.

Authors: MacGowan, A. P., Wootton, M., Hedges, A. J., Bowker, K. E., Holt, H. A., Reeves, D. S.

Source: Journal of Antimicrobial Chemotherapy (JAC); 1996, Vol. 38 Issue 2, p193-203, 11p

A critical assessment of the agar dilution chequerboard technique for studying in-vitro antimicrobial interactions using a representative beta-lactam, aminoglycoside and fluoroquinolone.

Authors: Wootton, M., Hedges, A. J., Bowker, K. E., Holt, H. A., Reeves, D. S., MacGowan, A. P.

Source: Journal of Antimicrobial Chemotherapy (JAC); May1995, Vol. 35 Issue 5, p569-576, 8p

The comparative inhibitory and bactericidal activities of meropenem and imipenem against Acinetobacter spp. and Enterobacteriaceae resistant to second generation cephalosporins.

Authors: MacGowan, A. P., Bowker, K. E., Bedford, K. A., Holf, H. A., Reeves, D. S., Hedges, A., Holt, H A

Source: Journal of Antimicrobial Chemotherapy (JAC); Feb1995, Vol. 35 Issue 2, p333-337, 5p

An evaluation of three new immunoassays for determination of serum gentamicin concentrations.

Authors: Holt, H. A., White, L. O., Bedford, K. A., Bowker, K. E., Reeves, D. S., MacGowan, A. P.

Source: Journal of Antimicrobial Chemotherapy (JAC); Nov1994, Vol. 34 Issue 5, p747-754, 8p

Subject Terms: CALIBRATION, DIAGNOSTIC reagents & test kits, DRUG stability, GENTAMICIN, IMMUNOASSAY, RESEARCH evaluation