CD70 CAR T cells secreting an anti-CD33/anti-CD3 dual-targeting antibody overcome antigen heterogeneity in AML

Authors: Silva, Harrison J. ¹, Martin, Grace ¹, Birocchi, Filippo ¹, Wehrli, Marc ¹, Kann, Michael C. ¹, Supper, Valentina ¹, Parker, Aiyana ¹, Graham, Charlotte ¹, Bratt, Alexandra ¹, Bouffard, Amanda ¹, Donner, Hannah ¹, Escobar, Giulia ¹, Takei, Hana ¹, Armstrong, Alexander ¹, Goncalves, Sadie ¹, Berger, Trisha R. ¹, Choi, Bryan D. ^{2, 3, 4}, Maus, Marcela V. ^{1, 2, 3}, Leick, Mark B. ^{1, 2, 3, ∗}

Source: In Blood 13 February 2025 145(7):720-731

Phase 1 study of CAR-37 T cells in patients with relapsed or refractory CD37+ lymphoid malignancies

Authors: Frigault, Matthew J., Graham, Charlotte E., Berger, Trisha R., Ritchey, Julie, Horick, Nora K., El-Jawahri, Areej, Scarfò, Irene, Schmidts, Andrea, Haradhvala, Nicholas J., Wehrli, Marc, Lee, Won-Ho, Parker, Aiyana L., Wiggin, Hadley R., Bouffard, Amanda, Dey, Aonkon, Leick, Mark B., Katsis, Katelin, Elder, Eva L., Dolaher, Maria A., Cook, Daniella T., Chekmasova, Alena A., Huang, Lu, Nikiforow, Sarah, Daley, Heather, Ritz, Jerome, Armant, Myriam, Preffer, Fred, DiPersio, John F., Nardi, Valentina, Chen, Yi-Bin, Gallagher, Kathleen M. E., Maus, Marcela V.

Source: In Blood 12 September 2024 144(11):1153-1167

Genetic retargeting of E3 ligases to enhance CAR T cell therapy

Authors: Lane, Isabel C., Kembuan, Gabriele, Carreiro, Jeannie, Kann, Michael C., Lin, William, Bouffard, Amanda A., Kreuzer, Johannes, Morris, Robert, Schneider, Emily M., Kim, Joanna Y., Zou, Charles, Salas-Benito, Diego, Gasser, Jessica A., Leick, Mark B., Słabicki, Mikołaj, Haas, Wilhelm, Maus, Marcela V., Jan, Max

Source: In Cell Chemical Biology 15 February 2024 31(2):338-348

Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia

Authors: Leick, Mark B., Silva, Harrison, Scarfò, Irene, Larson, Rebecca, Choi, Bryan D., Bouffard, Amanda A., Gallagher, Kathleen, Schmidts, Andrea, Bailey, Stefanie R., Kann, Michael C., Jan, Max, Wehrli, Marc, Grauwet, Korneel, Horick, Nora, Frigault, Matthew J., Maus, Marcela V.

Source: In Cancer Cell 9 May 2022 40(5):494-508

Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma

Authors: Schmidts, Andrea, Ormhøj, Maria, Choi, Bryan D., Taylor, Allison O., Bouffard, Amanda A., Scarfò, Irene, Larson, Rebecca C., Frigault, Matthew J., Gallagher, Kathleen, Castano, Ana P., Riley, Lauren S., Cabral, Maria L., Boroughs, Angela C., Velasco Cárdenas, Rubí M.-H., Schamel, Wolfgang, Zhou, Jing, Mackay, Sean, Tai, Yu-Tzu, Anderson, Kenneth C., Maus, Marcela V.

Source: In Blood Advances 12 November 2019 3(21):3248-3260

Anti-CD37 chimeric antigen receptor T cells are active against B- and T-cell lymphomas

Authors: Scarfò, Irene, Ormhøj, Maria, Frigault, Matthew J., Castano, Ana P., Lorrey, Selena, Bouffard, Amanda A., van Scoyk, Alexandria, Rodig, Scott J., Shay, Alexandra J., Aster, Jon C., Preffer, Frederic I., Weinstock, David M., Maus, Marcela V.

Source: In Blood 4 October 2018 132(14):1495-1506

Phase 1 study of CAR-37 T cells in patients with relapsed or refractory CD37+lymphoid malignancies

Authors: Frigault, Matthew J., Graham, Charlotte E., Berger, Trisha R., Ritchey, Julie, Horick, Nora K., El-Jawahri, Areej, Scarfò, Irene, Schmidts, Andrea, Haradhvala, Nicholas J., Wehrli, Marc, Lee, Won-Ho, Parker, Aiyana L., Wiggin, Hadley R., Bouffard, Amanda, Dey, Aonkon, Leick, Mark B., Katsis, Katelin, Elder, Eva L., Dolaher, Maria A., Cook, Daniella T., Chekmasova, Alena A., Huang, Lu, Nikiforow, Sarah, Daley, Heather, Ritz, Jerome, Armant, Myriam, Preffer, Fred, DiPersio, John F., Nardi, Valentina, Chen, Yi-Bin, Gallagher, Kathleen M. E., Maus, Marcela V.

Source: Blood; September 2024, Vol. 144 Issue: 11 p1153-1167, 15p

Comparative analysis of Bcl-2 family protein overexpression in CAR T cells alone and in combination with BH3 mimetics.

Authors: Korell, Felix, Olson, Michael L., Salas-Benito, Diego, Leick, Mark B., Larson, Rebecca C., Bouffard, Amanda, Silva, Harrison, Gasparetto, Alessandro, Berger, Trisha R., Kann, Michael C., Mergen, Markus, Kienka, Tamina, Wehrli, Marc, Haradhvala, Nicholas J., Bailey, Stefanie R., Letai, Anthony, Maus, Marcela V.

Source: Science Translational Medicine; 6/5/2024, Vol. 16 Issue 750, p1-17, 17p

Subject Terms: BCL-2 proteins, PROTEIN overexpression, T cells, CHIMERIC antigen receptors, CANCER cells

Anti-TACI single and dual-targeting CAR T cells overcome BCMA antigen loss in multiple myeloma.

Authors: Larson, Rebecca C., Kann, Michael C., Graham, Charlotte, Mount, Christopher W., Castano, Ana P., Lee, Won-Ho, Bouffard, Amanda A., Takei, Hana N., Almazan, Antonio J., Scarfó, Irene, Berger, Trisha R., Schmidts, Andrea, Frigault, Matthew J., Gallagher, Kathleen M. E., Maus, Marcela V.

Source: Nature Communications; 11/18/2023, Vol. 14 Issue 1, p1-15, 15p

Subject Terms: MULTIPLE myeloma, T cells, GENE expression, T cell receptors, CHIMERIC antigen receptors, ANTIGENS, BASAL ganglia

CRISPR-Cas9 disruption of PD-1 enhances activity of universal EGFRvIII CAR T cells in a preclinical model of human glioblastoma

Authors: Choi, Bryan D., Yu, Xiaoling, Castano, Ana P., Darr, Henia, Henderson, Daniel B., Bouffard, Amanda A., Larson, Rebecca C., Scarfò, Irene, Bailey, Stefanie R., Gerhard, Genevieve M., Frigault, Matthew J., Leick, Mark B., Schmidts, Andrea, Sagert, Jason G., Curry, William T., Carter, Bob S., Maus, Marcela V.

Source: Journal for immunotherapy of cancer. 7(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130994246.0x000001&indx=1&recIds=ETOCvdc_100130994246.0x000001

Tandem chimeric antigen receptor (CAR) T cells targeting EGFRvIII and IL-13Rα2 are effective against heterogeneous glioblastoma.

Authors: Schmidts, Andrea, Srivastava, Ambike A, Ramapriyan, Rishab, Bailey, Stefanie R, Bouffard, Amanda A, Cahill, Daniel P, Carter, Bob S, Curry, William T, Dunn, Gavin P, Frigault, Matthew J, Gerstner, Elizabeth R, Ghannam, Jack Y, Kann, Michael C, Larson, Rebecca C, Leick, Mark B, Nahed, Brian V, Richardson, Leland G, Scarfò, Irene, Sun, Jing, Wakimoto, Hiroaki

Source: Neuro-Oncology Advances; 2023, Vol. 5 Issue 1, p1-11, 11p

A Lenalidomide-Inducible Suicide Switch for Gene- and Cell-Based Therapy

Authors: Lin, William, Sarkar, Ditsa, Kim, Joanna Y, Knudsen, Nelson H, Lane, Isabel C, Cheng, Andi, Kembaun, Gabriele, Kienka, Tamina, Carreiro, Jeannie, Bouffard, Amanda A, Maus, Marcela V, Manguso, Robert T, Jan, Max

Source: In Blood 2 November 2023 142 Supplement 1:4825-4825

Chemical genetic control of cytokine signaling in CAR-T cells using lenalidomide-controlled membrane-bound degradable IL-7

Authors: Kann, Michael C., Schneider, Emily M., Almazan, Antonio J., Lane, Isabel C., Bouffard, Amanda A., Supper, Valentina M., Takei, Hana N., Tepper, Alexander, Leick, Mark B., Larson, Rebecca C., Ebert, Benjamin L., Maus, Marcela V., Jan, Max

Source: Leukemia; 20230101, Issue: Preprints p1-11, 11p

CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours.

Authors: Larson, Rebecca C., Kann, Michael C., Bailey, Stefanie R., Haradhvala, Nicholas J., Llopis, Paula Montero, Bouffard, Amanda A., Scarfó, Irene, Leick, Mark B., Grauwet, Korneel, Berger, Trisha R., Stewart, Kai, Anekal, Praju Vikas, Jan, Max, Joung, Julia, Schmidts, Andrea, Ouspenskaia, Tamara, Law, Travis, Regev, Aviv, Getz, Gad, Maus, Marcela V.

Source: Nature; 4/21/2022, Vol. 604 Issue 7906, p563-570, 8p

Blocking IFNγ in CAR-T Reduces Checkpoint Inhibitors and Cell-Mediated Toxicity without Compromising Therapeutic Efficacy in CD19 +malignancies

Authors: Bailey, Stefanie R., Vatsa, Sonika, Larson, Rebecca, Bouffard, Amanda A, Scarfò, Irene, Gallagher, Kathleen M.E., Frigault, Matthew J., Maus, Marcela V.

Source: In Blood 23 November 2021 138 Supplement 1:1723-1723

Rational Chemical and Genetic Modifications Enhance Avidity and Function of CD70-Directed CAR-T-Cells for Myeloid Leukemia

Authors: Leick, Mark B., Silva, Harrison, Scarfò, Irene, Larson, Rebecca, Choi, Bryan D., Bouffard, Amanda A, Gallagher, Kathleen M.E., Schmidts, Andrea, Bailey, Stefanie R., Kann, Michael C., Jan, Max, Wehrli, Marc, Grauwet, Korneel, Frigault, Matthew J., Maus, Marcela V.

Source: In Blood 23 November 2021 138 Supplement 1:405-405

Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide.

Authors: Jan, Max, Scarfò, Irene, Larson, Rebecca C., Walker, Amanda, Schmidts, Andrea, Guirguis, Andrew A., Gasser, Jessica A., Słabicki, Mikołaj, Bouffard, Amanda A., Castano, Ana P., Kann, Michael C., Cabral, Maria L., Tepper, Alexander, Grinshpun, Daniel E., Sperling, Adam S., Kyung, Taeyoon, Sievers, Quinlan L., Birnbaum, Michael E., Maus, Marcela V., Ebert, Benjamin L.

Source: Science Translational Medicine; 1/6/2021, Vol. 13 Issue 575, p1-13, 13p

Subject Terms: CHIMERIC antigen receptors, UBIQUITIN ligases, T cells, ZINC-finger proteins, CD19 antigen, HEMATOLOGIC malignancies

CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity.

Authors: Choi, Bryan D., Yu, Xiaoling, Castano, Ana P., Bouffard, Amanda A., Schmidts, Andrea, Larson, Rebecca C., Bailey, Stefanie R., Boroughs, Angela C., Frigault, Matthew J., Leick, Mark B., Scarfò, Irene, Cetrulo, Curtis L., Demehri, Shadmehr, Nahed, Brian V., Cahill, Daniel P., Wakimoto, Hiroaki, Curry, William T., Carter, Bob S., Maus, Marcela V.

Source: Nature Biotechnology; Sep2019, Vol. 37 Issue 9, p1049-1058, 10p, 6 Graphs

Use of CD70 Targeted Chimeric Antigen Receptor (CAR) T Cells for the Treatment of Acute Myeloid Leukemia (AML)

Authors: Leick, Mark ^*, Scarfò, Irene, Choi, Bryan D. ^*, Larson, Rebecca, Bouffard, Amanda A ^*, Castano, Ana ^*, Cabral, Maria L. ^*, Schmidts, Andrea ^*, Frigault, Matthew J. ^*, Maus, Marcela V.

Source: In Blood 13 November 2019 134 Supplement 1:4443-4443

Exploiting the Zinc Finger Degrome Targeted By Lenalidomide to Engineer Reversible Off-Switch Degradable Chimeric Antigen Receptors

Authors: Jan, Max, Castano, Ana ^*, Walker, Amanda, Guirguis, Andrew A, Gasser, Jessica A ^*, Bouffard, Amanda A ^*, Slabicki, Mikolaj ^*, Tepper, Alexander ^*, Grinshpun, Daniel E ^*, Kyung, Taeyoon ^*, Sievers, Quinlan, Birnbaum, Michael E ^*, Maus, Marcela V ^*, Ebert, Benjamin L.

Source: In Blood 13 November 2019 134 Supplement 1:866-866