The neglected burden of chronic hypoxia on the resistance of glioblastoma multiforme to first-line therapies.

Authors: Bou-Gharios, Jolie^1,2 (AUTHOR), Noël, Georges^1,2,3 (AUTHOR), Burckel, Hélène^1,2 (AUTHOR) h.burckel@icans.eu

Source: BMC Biology. 11/28/2024, Vol. 22 Issue 1, p1-15. 15p.

Subject Terms: *GLIOBLASTOMA multiforme, *BRAIN tumors, *TEMOZOLOMIDE, *CELLULAR signal transduction, *HYPOXEMIA

Tumor reirradiation: Issues, challenges and perspectives for radiobiology

Alternate Title: Réirradiation des tumeurs : enjeux, défis et perspectives de la radiobiologie (French)

Authors: Noël, Georges, Bou-Gharios, Jolie, Burckel, Hélène

Source: In Cancer / Radiothérapie October 2024 28(5):493-502

Role of autophagy in modulating tumor cell radiosensitivity: Exploring pharmacological interventions for glioblastoma multiforme treatment

Alternate Title: Rôle de l’autophagie dans la modulation de la radiosensibilité des cellules tumorales : exploration des interventions pharmacologiques pour le traitement du glioblastome multiforme (French)

Authors: Bischoff, Pierre, Bou-Gharios, Jolie, Noël, Georges, Burckel, Hélène

Source: In Cancer / Radiothérapie October 2024 28(5):416-423

Inclusion of Nitrofurantoin into the Realm of Cancer Chemotherapy via Biology-Oriented Synthesis and Drug Repurposing

Authors: Elzahhar, Perihan A., Nematalla, Hisham A., Al-Koussa, Houssam, Abrahamian, Carla, El-Yazbi, Amira F., Bodgi, Larry, Bou-Gharios, Jolie, Azzi, Joyce, Al Choboq, Joelle, Labib, Hala F.

Source: Journal of medicinal chemistry. 66(7):4565-4587

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632396622&indx=1&recIds=ETOCRN632396622

Radiosensitizing Effect of Curcumin on Human Bladder Cancer Cell Lines: Impact on DNA Repair Mechanisms

Authors: Azzi, Joyce, Waked, Anthony, Bou-Gharios, Jolie, Al Choboq, Joelle, Geara, Fady, Bodgi, Larry, Maalouf, Mira

Source: Nutrition and cancer. 74(6):2207-2221

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178746574.0x000001&indx=1&recIds=ETOCvdc_100178746574.0x000001

Distinct immune responses to proton and photon radiotherapy: implications for anti-PD-L1 combination therapy in colorectal cancer.

Authors: Burckel, Hélène, Nicol, Anaïs, Mura, Carole, Rousseau, Marc, Bou-Gharios, Jolie, Froidurot, Lisa, Richard, Corentin, Morgand, Véronique, Laurent, Pierre-Antoine, Limagne, Emeric, Boidot, Romain, Noël, Georges, Mirjolet, Céline

Source: Journal of Translational Medicine; 3/25/2025, Vol. 23 Issue 1, p1-12, 12p

Spacer engineering in nanoparticle–peptide conjugates boosts targeting specificity for tumor-associated antigens.

Authors: Ramírez, María de los Angeles, Bou-Gharios, Jolie, Freis, Barbara, Draussin, Julien, Cheignon, Clémence, Charbonniεave;re, Loic J., Laurent, Sophie, Gevart, Thomas, Gasser, Adeline, Jung, Sebastian, Rossetti, Fabien, Tillement, Olivier, Noel, Georges, Pivot, Xavier, Detappe, Alexandre, Bégin-Colin, Sylvie, Harlepp, Sébastien

Source: Nanoscale; 3/7/2025, Vol. 17 Issue 9, p5021-5032, 12p

The potential use of tideglusib as an adjuvant radio-therapeutic treatment for glioblastoma multiforme cancer stem-like cells

Authors: Bou-Gharios, Jolie, Assi, Sahar, Bahmad, Hisham F., Kharroubi, Hussein, Araji, Tarek, Chalhoub, Reda M., Ballout, Farah, Harati, Hayat, Fares, Youssef, Abou-Kheir, Wassim

Source: Pharmacological reports. 73(1):227-239

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194108204.0x000001&indx=1&recIds=ETOCvdc_100194108204.0x000001

Tideglusib attenuates growth of neuroblastoma cancer stem/progenitor cells in vitro and in vivo by specifically targeting GSK-3β

Authors: Bahmad, Hisham F., Chalhoub, Reda M., Harati, Hayat, Bou-Gharios, Jolie, Assi, Sahar, Ballout, Farah, Monzer, Alissar, Msheik, Hiba, Araji, Tarek, Elajami, Mohamad K., Ghanem, Paola, Chamaa, Farah, Kadara, Humam, Abou-Antoun, Tamara, Daoud, Georges, Fares, Youssef, Abou-Kheir, Wassim

Source: Pharmacological reports. 73(1):211-226

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194108364.0x000001&indx=1&recIds=ETOCvdc_100194108364.0x000001

Impaired DNA Double-Strand Break Repair in Irradiated Sheep Lung Fibroblasts: Late Effects of Previous Irradiation of the Spinal Thecal Sac.

Authors: Youssef, Bassem, Feghaly, Charbel, Al Choboq, Joelle, Bou-Gharios, Jolie, Challita, Rafka, Azzi, Joyce, Bou Hadir, Hanine, Abi Antoun, Fabienne, Araji, Tarek, Taddei, Phillip J., Geara, Fady, Sfeir, Pierre, Jurjus, Abdo, Abou-Kheir, Wassim, Bodgi, Larry

Source: Cancers; Sep2024, Vol. 16 Issue 17, p2968, 17p

Subject Terms: BIOPSY, COLONY-forming units assay, RESEARCH funding, DNA, SPINAL tumors, FLUORESCENT antibody technique, FIBROBLASTS, CELL lines, ANIMAL experimentation, SHEEP, DNA repair, CELL nuclei, RADIATION doses, BRAIN tumors, BIOMARKERS

Preclinical and clinical advances to overcome hypoxia in glioblastoma multiforme.

Authors: Bou-Gharios, Jolie, Noël, Georges, Burckel, Hélène

Source: Cell Death & Disease; Jul2024, Vol. 15 Issue 7, p1-12, 12p

Effect of bisphosphonates and statins on the in vitro radiosensitivity of breast cancer cell lines.

Authors: Bodgi, Larry, Bou-Gharios, Jolie, Azzi, Joyce, Challita, Rafka, Feghaly, Charbel, Baalbaki, Khanom, Kharroubi, Hussein, Chhade, Fatima, Geara, Fady, Abou-Kheir, Wassim, Ayoub, Zeina

Source: Pharmacological Reports; Feb2024, Vol. 76 Issue 1, p171-184, 14p

Stereotactic Radiation Therapy of Single Brain Metastases: A Literature Review of Dosimetric Studies.

Authors: Chambrelant, Isabelle, Jarnet, Delphine, Bou-Gharios, Jolie, Le Fèvre, Clara, Kuntz, Laure, Antoni, Delphine, Jenny, Catherine, Noël, Georges

Source: Cancers; Aug2023, Vol. 15 Issue 15, p3937, 15p

Subject Terms: COMPUTERS in medicine, SYSTEMATIC reviews, METASTASIS, TREATMENT duration, BRAIN tumors, RADIATION doses, RADIOSURGERY, MEDLINE, RADIATION injuries, RADIOTHERAPY, RADIATION dosimetry

Radiation Treatment Timing and Dose Delivery: Effects on Bladder Cancer Cells in 3D in Vitro Culture.

Authors: Bodgi, Larry, Al-Choboq, Joelle, Araji, Tarek, Bou-Gharios, Jolie, Azzi, Joyce, Challita, Rafka, Feghaly, Charbel, Bahmad, Hisham F., Eid, Toufic, Geara, Fady, Zeidan, Youssef H., Abou-Kheir, Wassim

Source: Radiation; Dec2022, Vol. 2 Issue 4, p318-337, 20p

Correction to: The potential use of tideglusib as an adjuvant radio-therapeutic treatment for glioblastoma multiforme cancer stem-like cells

Authors: Bou-Gharios, Jolie, Assi, Sahar, Bahmad, Hisham F., Kharroubi, Hussein, Araji, Tarek, Chalhoub, Reda M., Ballout, Farah, Harati, Hayat, Fares, Youssef, Abou-Kheir, Wassim

Source: Pharmacological reports. 73(1):316-316

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194108076.0x000001&indx=1&recIds=ETOCvdc_100194108076.0x000001

The potential use of tideglusib as an adjuvant radio-therapeutic treatment for glioblastoma multiforme cancer stem-like cells.

Authors: Bou-Gharios, Jolie, Assi, Sahar, Bahmad, Hisham F., Kharroubi, Hussein, Araji, Tarek, Chalhoub, Reda M., Ballout, Farah, Harati, Hayat, Fares, Youssef, Abou-Kheir, Wassim

Source: Pharmacological Reports; 2021, Vol. 73 Issue 1, p227-239, 13p

Tideglusib attenuates growth of neuroblastoma cancer stem/progenitor cells in vitro and in vivo by specifically targeting GSK-3β.

Authors: Bahmad, Hisham F., Chalhoub, Reda M., Harati, Hayat, Bou-Gharios, Jolie, Assi, Sahar, Ballout, Farah, Monzer, Alissar, Msheik, Hiba, Araji, Tarek, Elajami, Mohamad K., Ghanem, Paola, Chamaa, Farah, Kadara, Humam, Abou-Antoun, Tamara, Daoud, Georges, Fares, Youssef, Abou-Kheir, Wassim

Source: Pharmacological Reports; 2021, Vol. 73 Issue 1, p211-226, 16p

Drug repurposing towards targeting cancer stem cells in pediatric brain tumors.

Authors: Bahmad, Hisham F., Elajami, Mohamad K., El Zarif, Talal, Bou-Gharios, Jolie, Abou-Antoun, Tamara, Abou-Kheir, Wassim

Source: Cancer & Metastasis Reviews; Mar2020, Vol. 39 Issue 1, p127-148, 22p

Assessing Radiosensitivity of Bladder Cancer in vitro : A 2D vs. 3D Approach.

Authors: Bodgi, Larry, Bahmad, Hisham F., Araji, Tarek, Al Choboq, Joelle, Bou-Gharios, Jolie, Cheaito, Katia, Zeidan, Youssef H., Eid, Toufic, Geara, Fady, Abou-Kheir, Wassim

Source: Frontiers in Oncology; 3/19/2019, pN.PAG-N.PAG, 11p

Subject Terms: BLADDER cancer, RADIOTHERAPY, CANCER stem cells, CELL lines, CYSTECTOMY

Correction to: The potential use of tideglusib as an adjuvant radio-therapeutic treatment for glioblastoma multiforme cancer stem-like cells.

Authors: Bou-Gharios, Jolie, Assi, Sahar, Bahmad, Hisham F., Kharroubi, Hussein, Araji, Tarek, Chalhoub, Reda M., Ballout, Farah, Harati, Hayat, Fares, Youssef, Abou-Kheir, Wassim

Source: Pharmacological Reports; 2021, Vol. 73 Issue 1, p316-316, 1p