AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells

Authors: Cahuzac, Kaitlyn M., Lubin, Abigail, Bosch, Kaitlyn, Stokes, Nicole, Shoenfeld, Sarah Mense, Zhou, Royce, Lemon, Haddy, Asara, John, Parsons, Ramon E.

Source: In Cell Reports 30 May 2023 42(5)

High-fructose corn syrup enhances intestinal tumor growth in mice

Authors: Goncalves, Marcus D., Lu, Changyuan, Tutnauer, Jordan, Hartman, Travis E., Hwang, Seo-Kyoung, Murphy, Charles J, Pauli, Chantal, Morris, Roxanne, Taylor, Sam, Bosch, Kaitlyn, Yang, Sukjin, Wang, Yumei, Van Riper, Justin, Lekaye, H Carl, Roper, Jatin, Kim, Young, Chen, Qiuying, Gross, Steven S., Rhee, Kyu Y., Cantley, Lewis C., Yun, Jihye

Source: Science, 2019 Mar . 363(6433), 1345-1349.

Access URL: https://www.jstor.org/stable/26630609

Deletion of the gene Pip4k2c , a novel phosphatidylinositol kinase, results in hyperactivation of the immune system

Authors: Shim, Hyeseok, Wu, Chuan, Ramsamooj, Shivan, Bosch, Kaitlyn N., Chen, Zuojia, Emerling, Brooke M., Yun, Jihye, Liu, Hui, Choo-Wing, Rayman, Yang, Zhiwei, Wulf, Gerburg M., Kuchroo, Vijay Kumar, Cantley, Lewis C.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2016 Jul 01. 113(27), 7596-7601.

Access URL: https://www.jstor.org/stable/26470732

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

Authors: Yun, Jihye, Mullarky, Edouard, Lu, Changyuan, Bosch, Kaitlyn N., Kavalier, Adam, Rivera, Keith, Roper, Jatin, Chio, Iok In Christine, Giannopoulou, Eugenia G., Rago, Carlo, Muley, Ashlesha, Asara, John M., Paik, Jihye, Elemento, Olivier, Chen, Zhengming, Pappin, Darryl J., Dow, Lukas E., Papadopoulos, Nickolas, Gross, Steven S., Cantley, Lewis C.

Source: Science, 2015 Dec 01. 350(6266), 1391-1396.

Access URL: http://www.jstor.org/stable/24740895

A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma.

Authors: Zhou, Royce W., Xu, Jia, Martin, Tiphaine C., Zachem, Alexis L., He, John, Ozturk, Sait, Demircioglu, Deniz, Bansal, Ankita, Trotta, Andrew P., Giotti, Bruno, Gryder, Berkley, Shen, Yao, Wu, Xuewei, Carcamo, Saul, Bosch, Kaitlyn, Hopkins, Benjamin, Tsankov, Alexander, Steinhagen, Randolph, Jones, Drew R., Asara, John

Source: Nature Communications; 10/17/2022, Vol. 13 Issue 1, p1-17, 17p

Subject Terms: COLORECTAL cancer, TUMOR microenvironment, PENTOSE phosphate pathway, CANCER cells, EPITHELIAL cells

Author Correction: A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma.

Authors: Zhou, Royce W., Xu, Jia, Martin, Tiphaine C., Zachem, Alexis L., He, John, Ozturk, Sait, Demircioglu, Deniz, Bansal, Ankita, Trotta, Andrew P., Giotti, Bruno, Gryder, Berkley, Shen, Yao, Wu, Xuewei, Carcamo, Saul, Bosch, Kaitlyn, Hopkins, Benjamin, Tsankov, Alexander, Steinhagen, Randolph, Jones, Drew R., Asara, John

Source: Nature Communications; 4/6/2023, Vol. 14 Issue 1, p1-1, 1p

Subject Terms: COLORECTAL cancer, TUMOR microenvironment

Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system.

Authors: Hyeseok Shim, Chuan Wu, Ramsamooj, Shivan, Bosch, Kaitlyn N., Zuojia Chen, Emerling, Brooke M., Jihye Yun, Hui Liu, Rayman Choo-Wing, Zhiwei Yang, Wulf, Gerburg M., Kuchroo, Vijay Kumar, Cantley, Lewis C.

Source: Proceedings of the National Academy of Sciences of the United States of America; 7/5/2016, Vol. 113 Issue 27, p7596-7601, 6p

Subject Terms: DELETION mutation, PHOSPHATIDYLINOSITOL 3-kinases, IMMUNE system, METABOLIC regulation, GERM cells, CYTOKINES, T cells

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