Exploring the contribution of the dopaminergic and noradrenergic systems in the antidepressant-like action of 1-(2-(4-(4-ethylphenyl)-1H-1,2,3-triazol-1-yl)phenyl)ethanone in mice

Authors: Presa, Marcelo Heinemann ^a, da Rocha, Marcia Juciele ^a, Ledebuhr, Kauane Nayara Bahr ^a, Zuge, Narryman Pinto ^a, Goulart, Taís Barcelos ^b, Alves, Diego ^b, Bortolatto, Cristiani Folharini ^{a, ⁎, 1}, Brüning, César Augusto ^{a, ⁎, 2}

Source: In Behavioural Brain Research 5 March 2025 480

Dopaminergic receptors involvement in the antidepressant-like effect of N-(3-((3-(trifluoromethyl)phenyl)selanyl)prop-2-yn-1-yl) benzamide in mice

Authors: Pires, Camila Simões ^a, da Rocha, Marcia Juciele ^a, Presa, Marcelo Heinemann ^a, Zuge, Narryman Pinto ^a, Besckow, Evelyn Mianes ^a, Ledebuhr, Kauane Nayara Bahr ^a, Kuntz, Natália Emanuele Biolosor ^b, Godoi, Benhur ^b, Bortolatto, Cristiani Folharini ^{a, ⁎, 1}, Brüning, César Augusto ^{a, ⁎}

Source: In Neuroscience Letters 16 February 2025 849

Chalcogen dihydrobenzofuran compounds as potential neuroprotective agents: An in vitro and in silico biological investigation

Authors: Hall, Tácia Katiane ^a, Magalhães, Larissa Sander ^a, Paim, Mariana Parron ^a, Rech, Taís da Silva Teixeira ^a, de Azevedo, Amanda Rebelo ^b, Nascimento, Vanessa ^b, Neto, José Sebastião Santos ^c, Brüning, César Augusto ^{a, ⁎⁎}, Bortolatto, Cristiani Folharini ^{a, ⁎}

Source: In Biochimie January 2025

Acute 2-phenyl-3-(phenylselanyl)benzofuran treatment reverses the neurobehavioral alterations induced by sleep deprivation in mice

Authors: Gonçalves, Luciane da Silva, Rusch, Gabriela, Alves, Amália Gonçalves, Krüger, Letícia Devantier, Paim, Mariana Parron, Martins, Carolina Cristóvão, da Motta, Ketlyn Pereira, Neto, José Sebastião Santos, Luchese, Cristiane, Wilhelm, Ethel Antunes, Brüning, César Augusto, Bortolatto, Cristiani Folharini

Source: In Biochemical Pharmacology August 2024 226

1-(Phenylselanyl)-2-(p-tolyl)indolizine: A selenoindolizine with potential antidepressant-like activity in mice mediated by the modulation of dopaminergic and noradrenergic systems

Authors: da Rocha, Marcia Juciele, Presa, Marcelo Heinemann, Nunes, Gustavo D'Avila, Zuge, Narryman Pinto, Pires, Camila Simões, Besckow, Evelyn Mianes, Gomes, Caroline Signorini, Dapper, Luiz Henrique, Lenardão, Eder João, Penteado, Filipe, Bortolatto, Cristiani Folharini, Brüning, César Augusto

Source: In Brain Research 1 July 2024 1834

Role of noradrenergic and dopaminergic systems in the antinociceptive effect of N-(3-(phenylselanyl)prop-2-yn-1-yl)benzamide in mice

Authors: Ledebuhr, Kauane Nayara Bahr, Nunes, Gustavo D'Avila, Presa, Marcelo Heinemann, Hartmann, Cleidi Maria, Godoi, Benhur, Bortolatto, Cristiani Folharini, Brüning, César Augusto

Source: In Toxicology and Applied Pharmacology March 2024 484

Anxiolytic-like action of 3-((4-methoxyphenyl)selanyl)-2-phenylbenzofuran (SeBZF3) in mice: A possible contribution of the serotonergic system

Authors: Magalhães, Larissa Sander ^a, Strelow, Dianer Nornberg ^a, Paim, Mariana Parron ^a, Rech, Taís da Silva Teixeira ^a, Krüger, Letícia Devantier ^a, Braga, Antonio Luiz ^b, Neto, José Sebastião Santos ^c, Brüning, César Augusto ^{a, ⁎}, Bortolatto, Cristiani Folharini ^{a, ⁎}

Source: In Pharmacology, Biochemistry and Behavior November 2023 232

Depressive-like behavior and cognitive impairment induced by acute administration of dexamethasone: Pharmacological effects of 2-phenyl-3-(phenylselanyl)benzofuran in female Swiss mice

Authors: Strelow, Dianer Nornberg ^a, Magalhães, Larissa Sander ^a, Paim, Mariana Parron ^a, Krüger, Letícia Devantier ^a, Neto, José Sebastião Santos ^b, Brüning, César Augusto ^{a, ⁎}, Bortolatto, Cristiani Folharini ^{a, ⁎}

Source: In Progress in Neuropsychopharmacology & Biological Psychiatry 13 July 2023 125

Antinociceptive effect of N-(3-(phenylselanyl)prop-2-yn-1-yl)benzamide in mice: Involvement of 5-HT1A and 5-HT2A/2C receptors

Authors: Ledebuhr, Kauane Nayara Bahr, Nunes, Gustavo D'Avila, Besckow, Evelyn Mianes, Giehl, Maira Regina, Godoi, Benhur, Bortolatto, Cristiani Folharini, Brüning, César Augusto

Source: In Chemico-Biological Interactions 25 May 2022 359

4-Phenylselanyl-7-chloroquinoline attenuates hepatic injury triggered by neonatal exposure to monosodium glutamate in rats

Authors: da Costa Rodrigues, Karline, Bortolatto, Cristiani Folharini, de Oliveira, Renata Leivas, Paltian, Jaini Janke, Larroza, Allya, Soares, Mauro Pereira, Alves, Diego, Wilhelm, Ethel Antunes, Luchese, Cristiane

Source: In Life Sciences 1 September 2021 280

Antidepressant-like effect of a selenopropargylic benzamide in mice: involvement of the serotonergic system

Authors: Besckow, Evelyn Mianes, Nonemacher, Natália Tavares, Garcia, Cleisson Schossler, da Silva Espíndola, Carlos Natã, Balbom, Éverton Berwanger, Gritzenco, Fabiane, Savegnago, Lucielli, Godoi, Benhur, Bortolatto, Cristiani Folharini, Brüning, César Augusto

Source: Psychopharmacology. 237(10):3149-3159

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167713634.0x000001&indx=1&recIds=ETOCvdc_100167713634.0x000001

P-Chloro-diphenyl diselenide attenuates plasma lipid profile changes and hepatotoxicity induced by nonionic surfactant tyloxapol in rats

Authors: Heck, Suélen Osório, Zborowski, Vanessa Angonesi, Chagas, Pietro Maria, da Luz, Sônia Cristina Almeida, Bortolatto, Cristiani Folharini

Source: Toxicology mechanisms and methods. 30(1):73-80

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097994920.0x000001&indx=1&recIds=ETOCvdc_100097994920.0x000001

N-(3-((3-(trifluoromethyl)phenyl)selanyl)prop-2-yn-1-yl) benzamide induces antidepressant-like effect in mice: involvement of the serotonergic system.

Authors: Pires, Camila Simões, da Rocha, Marcia Juciele, Presa, Marcelo Heinemann, Zuge, Narryman Pinto, Kuntz, Natália Emanuele Biolosor, Godoi, Benhur, Bortolatto, Cristiani Folharini, Brüning, César Augusto

Source: Psychopharmacology; Aug2024, Vol. 241 Issue 8, p1663-1678, 16p

Subject Terms: INDOLE alkaloids, ORGANOSELENIUM compounds, BENZAMIDE, PROPRANOLOL, BETA adrenoceptors, MENTAL depression, LABORATORY mice

Antioxidative and Antiglycative Stress Activities of Selenoglutathione Diselenide.

Authors: Kanamori, Akiko, Egawa, Nana, Yamasaki, Suyako, Ikeda, Takehito, da Rocha, Marcia Juciele, Bortolatto, Cristiani Folharini, Savegnago, Lucielli, Brüning, César Augusto, Iwaoka, Michio

Source: Pharmaceuticals (14248247); Aug2024, Vol. 17 Issue 8, p1049, 14p

Subject Terms: ADVANCED glycation end-products, GLUTATHIONE reductase, HAZARDOUS substances, GLUTATHIONE peroxidase, OXIDANT status

Dopaminergic Modulation and Computational ADMET Insights for the Antidepressant-like Effect of N‑(3-(Phenylselanyl)prop-2-yn-1-yl)benzamide.

Authors: Besckow, Evelyn Mianes, Ledebuhr, Kauane Nayara Bahr, Pires, Camila Simões, Rocha, Marcia Juciele da, Kuntz, Natália Emanuele Biolosor, Godoi, Benhur, Bortolatto, Cristiani Folharini, Brüning, César Augusto

Source: ACS Chemical Neuroscience; 5/1/2024, Vol. 15 Issue 9, p1904-1914, 11p

Pharmacological and computational analysis of the involvement of the 5-HT4 receptor in the antidepressant-like effect of N-(3-(phenylselanyl)prop-2-yn-1-yl)benzamide in mice

Authors: Besckow, Evelyn Mianes ^a, Pires, Camila Simões ^a, Giehl, Maira Regina ^b, Godoi, Benhur ^b, Bortolatto, Cristiani Folharini ^{a, ⁎}, Brüning, César Augusto ^{a, ⁎}

Source: In Brain Research 15 February 2024 1825

Three ‐(pyridin‐2‐yl)‐2‐(pyridin‐2‐ylimino)thiazolidin‐4‐one as a novel inhibitor of cerebral MAO‐B activity with antioxidant properties and low toxicity potential

Authors: Carraro Junior, Luiz Roberto, Alves, Amália Gonçalves, Rech, Taís da Silva Teixeira, Campos Júnior, José Coan, Siqueira, Geonir Machado, Cunico, Wilson, Brüning, César Augusto, Bortolatto, Cristiani Folharini

Source: Journal of biochemical and molecular toxicology. 35(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128336426.0x000001&indx=1&recIds=ETOCvdc_100128336426.0x000001

The protective effect of melatonin against brain oxidative stress and hyperlocomotion in a rat model of mania induced by ouabain

Authors: Souza, Leandro C., Wilhelm, Ethel Antunes, Bortolatto, Cristiani Folharini, Nogueira, Cristina Wayne, Boeira, Silvana P., Jesse, Cristiano R.

Source: In Behavioural Brain Research 1 September 2014 271:316-324

Depression-related behavior and mechanical allodynia are blocked by 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene in a mouse model of neuropathic pain induced by partial sciatic nerve ligation

Authors: Gai, Bibiana Mozzaquatro, Bortolatto, Cristiani Folharini, Brüning, César Augusto, Zborowski, Vanessa Angonesi, Stein, André Luiz, Zeni, Gilson, Nogueira, Cristina Wayne

Source: In Neuropharmacology April 2014 79:580-589

Pharmacological evidence for glutamatergic pathway involvement in the antidepressant-like effects of 2-phenyl-3-(phenylselanyl)benzofuran in male Swiss mice.

Authors: Rech, Taís da Silva Teixeira, Strelow, Dianer Nornberg, Krüger, Letícia Devantier, Neto, José Sebastião Santos, Blödorn, Gustavo Bierhals, Alves, Diego, Brüning, César Augusto, Bortolatto, Cristiani Folharini

Source: Naunyn-Schmiedeberg's Archives of Pharmacology; Nov2023, Vol. 396 Issue 11, p3033-3044, 12p

Subject Terms: LABORATORY mice, METHYL aspartate receptors, GLUTAMATE receptors, BENZOFURAN, KETAMINE abuse, MALES