Sézary syndrome originates from heavily mutated hematopoietic progenitors

Authors: Harro, Carly M., Sprenger, Kimberly B., Chaurio, Ricardo A., Powers, John J., Innamarato, Patrick, Anadon, Carmen M., Zhang, Yumeng, Biswas, Subir, Mandal, Gunjan, Mine, Jessica A., Cortina, Carla, Nagy, Mate Z., Martin, Alexandra L., Handley, Katelyn F., Borjas, Gustavo J., Chen, Pei-Ling, Pinilla-Ibarz, Javier, Sokol, Lubomir, Yu, Xiaoqing, Conejo-Garcia, Jose R.

Source: In Blood Advances 26 September 2023 7(18):5586-5602

Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity.

Authors: Seounghun Kang¹, Mansurov, Aslan¹, Kurtanich, Trevin¹, Hye Rin Chun², Slezak, Anna J.¹, Volpatti, Lisa R.¹, Chang, Kevin¹, Wang, Thomas¹, Alpar, Aaron T.¹, Refvik, Kirsten C.¹, Hansen, O. Isabella¹, Borjas, Gustavo J.¹, Ha-Na Shim¹, Hultgren, Kevin T.¹, Gomes, Suzana¹, Solanki, Ani³, Ishihara, Jun⁴, Swartz, Melody A.^1,2,5,6, Hubbell, Jeffrey A.^1,2,6 jhubbell@uchicago.edu

Source: Science Advances. 12/1/2023, Vol. 9 Issue 48, p1-13. 13p.

Subject Terms: *T-cell exhaustion, *T cells, *IMMUNOTHERAPY, *INTERLEUKIN-7