Targeting BCL11B in CAR-engineered lymphoid progenitors drives NK-like cell development with prolonged anti-leukemic activity

Authors: Baatz, Franziska ¹, Ghosh, Arnab ², Herbst, Jessica ¹, Polten, Saskia ³, Meyer, Johann ⁴, Rhiel, Manuel ⁵, Maetzig, Tobias ⁴, Geffers, Robert ⁶, Rothe, Michael ⁴, Bastone, Antonella Lucia ⁴, John-Neek, Philipp ^{4, 7}, Frühauf, Jörg ⁸, Eiz-Vesper, Britta ⁹, Bonifacius, Agnes ⁹, Falk, Christine S. ¹⁰, Kaisenberg, Constantin v. ¹¹, Cathomen, Toni ^{5, 12, 13}, Schambach, Axel ^{4, 14}, van den Brink, Marcel R.M. ¹⁵, Hust, Michael ³, Sauer, Martin G. ^{1, ∗}

Source: In Molecular Therapy 2 April 2025 33(4):1584-1607

Depletion of alloreactive B cells by drug-resistant chimeric alloantigen receptor T cells to prevent transplant rejection

Authors: Dragon, Anna Christina ^{1, 2}, Bonifacius, Agnes ^{1, 2}, Lienenklaus, Stefan ³, Verboom, Murielle ¹, Gerhards, Jan-Phillipp ¹, Ius, Fabio ⁴, Hinze, Christian ⁵, Hudecek, Michael ⁶, Figueiredo, Constanca ^{1, 7}, Blasczyk, Rainer ^{1, 7}, Eiz-Vesper, Britta ^{1, 7, ∗}

Source: In Molecular Therapy 5 March 2025 33(3):1031-1047

DNA methylation profiling identifies TBKBP1 as potent amplifier of cytotoxic activity in CMV-specific human CD8⁺ T cells.

Authors: Yu, Zheng¹, Sasidharan-Nair, Varun¹, Buchta, Thalea^2,3, Bonifacius, Agnes^4,5, Khan, Fawad^6,7, Pietzsch, Beate¹, Ahmadi, Hosein¹, Beckstette, Michael¹, Niemz, Jana¹, Hilgendorf, Philipp⁸, Mausberg, Philip⁴, Keller, Andreas^9,10, Falk, Christine^5,11, Busch, Dirk H.^12,13, Schober, Kilian^8,14, Cicin-Sain, Luka^5,6,7, Müller, Fabian¹⁵, Brinkmann, Melanie M.^2,3, Eiz-Vesper, Britta^4,5, Floess, Stefan¹

Source: PLoS Pathogens; 9/26/2024, Vol. 20 Issue 9, p1-30, 30p

Induced dendritic cells co-expressing GM-CSF/IFN-α/tWT1 priming T and B cells and automated manufacturing to boost GvL

Authors: Bialek-Waldmann, Julia K., Domning, Sabine, Esser, Ruth, Glienke, Wolfgang, Mertens, Mira, Aleksandrova, Krasimira, Arseniev, Lubomir, Kumar, Suresh, Schneider, Andreas, Koenig, Johannes, Theobald, Sebastian J., Tsay, Hsin-Chieh, Cornelius, Angela D.A., Bonifacius, Agnes, Eiz-Vesper, Britta, Figueiredo, Constanca, Schaudien, Dirk, Talbot, Steven R., Bleich, Andre, Spineli, Loukia M., von Kaisenberg, Constantin, Clark, Caren, Blasczyk, Rainer, Heuser, Michael, Ganser, Arnold, Köhl, Ulrike, Farzaneh, Farzin, Stripecke, Renata

Source: In Molecular Therapy - Methods & Clinical Development 11 June 2021 21:621-641

COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses

Authors: Bonifacius, Agnes, Tischer-Zimmermann, Sabine, Dragon, Anna C., Gussarow, Daniel, Vogel, Alexander, Krettek, Ulrike, Gödecke, Nina, Yilmaz, Mustafa, Kraft, Anke R.M., Hoeper, Marius M., Pink, Isabell, Schmidt, Julius J., Li, Yang, Welte, Tobias, Maecker-Kolhoff, Britta, Martens, Jörg, Berger, Marc Moritz, Lobenwein, Corinna, Stankov, Metodi V., Cornberg, Markus, David, Sascha, Behrens, Georg M.N., Witzke, Oliver, Blasczyk, Rainer, Eiz-Vesper, Britta

Source: In Immunity 9 February 2021 54(2):340-354

Variances in Antiviral Memory T-Cell Repertoire of CD45RA- and CD62L-Depleted Lymphocyte Products Reflect the Need of Individual T-Cell Selection Strategies to Reduce the Risk of GvHD while Preserving Antiviral Immunity in Adoptive T-Cell Therapy

Authors: Mangare, Caroline, Tischer-Zimmermann, Sabine, Bonifacius, Agnes, Riese, Sebastian B., Dragon, Anna Christina, Blasczyk, Rainer, Maecker-Kolhoff, Britta, Eiz-Vesper, Britta

Source: Transfusion medicine and hemotherapy. 49(1):30-43

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139841349.0x000001&indx=1&recIds=ETOCvdc_100139841349.0x000001

Directly Isolated Allogeneic Virus–Specific T Cells in Progressive Multifocal Leukoencephalopathy.

Authors: Möhn, Nora, Grote-Levi, Lea, Wattjes, Mike P., Bonifacius, Agnes, Holzwart, Dennis, Hopfner, Franziska, Nay, Sandra, Tischer-Zimmermann, Sabine, Saßmann, Mieke Luise, Schwenkenbecher, Philipp, Sühs, Kurt-Wolfram, Mahmoudi, Nima, Warnke, Clemens, Zimmermann, Julian, Hagin, David, Goudeva, Lilia, Blasczyk, Rainer, Koch, Armin, Maecker-Kolhoff, Britta, Eiz-Vesper, Britta

Source: JAMA Neurology; Nov2024, Vol. 81 Issue 11, p1187-1198, 12p

Alveolar membrane and capillary function in COVID-19 convalescents: insights from chest MRI.

Authors: Kern, Agilo Luitger, Pink, Isabell, Bonifacius, Agnes, Kaireit, Till, Speth, Milan, Behrendt, Lea, Klimeš, Filip, Voskrebenzev, Andreas, Hohlfeld, Jens M., Hoeper, Marius M., Welte, Tobias, Wacker, Frank, Eiz-Vesper, Britta, Vogel-Claussen, Jens

Source: European Radiology; Oct2024, Vol. 34 Issue 10, p6502-6513, 12p

Subject Terms: COVID-19, ERYTHROCYTES, INTENSIVE care patients, MAGNETIC resonance imaging, PEARSON correlation (Statistics)

Engineered HCMV‐infected APCs enable the identification of new immunodominant HLA‐restricted epitopes of anti‐HCMV T‐cell immunity.

Authors: Santamorena, Maria Michela, Tischer‐Zimmermann, Sabine, Bonifacius, Agnes, Mireisz, Chiara Noemi‐Marie, Costa, Bibiana, Khan, Fawad, Kulkarni, Upasana, Lauruschkat, Chris David, Sampaio, Kerstin Laib, Stripecke, Renata, Blasczyk, Rainer, Maecker‐Kolhoff, Britta, Kraus, Sabrina, Schlosser, Andreas, Cicin‐Sain, Luka, Kalinke, Ulrich, Eiz‐Vesper, Britta

Source: HLA: Immune Response Genetics; Jun2024, Vol. 103 Issue 6, p1-27, 27p

Subject Terms: T cells, EPITOPES, CYTOTOXIC T cells, IMMUNOLOGIC memory, IMMUNITY, ALLELES, DENDRITIC cells

Combined treatment with allogeneic Epstein–Barr- and human polyomavirus 1 specific T-cells in progressive multifocal leukoencephalopathy and EBV infection: a case report.

Authors: Nay, Sandra, Möhn, Nora, Grote-Levi, Lea, Bonifacius, Agnes, Saßmann, Mieke L., Karacondi, Kevin, Tischer-Zimmermann, Sabine, Pöter, Henning, Mahmoudi, Nima, Wattjes, Mike P., Maecker-Kolhoff, Britta, Höglinger, Günter, Eiz-Vesper, Britta, Skripuletz, Thomas

Source: Therapeutic Advances in Neurological Disorders; 5/28/2024, p1-9, 9p

Subject Terms: EPSTEIN-Barr virus diseases, POLYOMAVIRUS diseases, T cells, PROGRESSIVE multifocal leukoencephalopathy, OPPORTUNISTIC infections

Memory B cells anticipate SARS-CoV-2 variants through somatic hypermutation

Authors: Bruhn, Matthias, Obara, Maureen, Chiyyeadu, Abhishek, Costa, Bibiana, Salam, Abdus, Ziegler, Annett, Waltl, Inken, Pavlou, Andreas, Bonifacius, Agnes, Hoffmann, Markus, Graalmann, Theresa, Pöhlmann, Stefan, Eiz-Vesper, Britta, Schambach, Axel, Kalinke, Ulrich ^*

Source: In Journal of Infection January 2024 88(1):57-60

In Vitro Profiling of Commonly Used Post-transplant Immunosuppressants Reveals Distinct Impact on Antiviral T-cell Immunity Towards CMV.

Authors: Krueger, Markus Benedikt¹, Bonifacius, Agnes^1,2, Dragon, Anna Christina¹, Santamorena, Maria Michela¹, Nashan, Björn³, Taubert, Richard⁴, Kalinke, Ulrich⁵, Maecker-Kolhoff, Britta^2,6, Blasczyk, Rainer¹, Eiz-Vesper, Britta^1,2 eiz-vesper.britta@mhhannover.de

Source: Transplant International. 2024, p1-13. 13p.

Subject Terms: *EVEROLIMUS, *RAPAMYCIN, *T cells, *HEMATOPOIETIC stem cells, *IMMUNOSUPPRESSIVE agents, *IMMUNOLOGIC memory

Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) specific cellular and humoral immunity in Corovavirus Disease-2019 (COVID-19) convalescence after liver transplantation-a prospective six month follow-up

Authors: Kirchner, Theresa, Sauer, Hagen, Heinrich, Sophia, Bonifacius, Agnes, Louisa, Ruhl, Pink, Isabell, Engel, Bastian, Saunders, Emily, Martens, Joerg, Hoeper, Marius M., Blasczkyk, Rainer, Wedemeyer, Heiner, Jaeckel, Elmar, Falk, Christine, Eiz-Vesper, Britta, Taubert, Richard

Source: Journal of hepatology. 77(S1):S783-S784

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167264085.0x000001&indx=1&recIds=ETOCvdc_100167264085.0x000001

CAR-Ts redirected against the Thomsen-Friedenreich antigen CD176 mediate specific elimination of malignant cells from leukemia and solid tumors.

Authors: Dragon, Anna Christina, Beermann, Luca Marie, Umland, Melina, Bonifacius, Agnes, Ruhl, Louisa, Kehler, Patrik, Gellert, Johanna, Weiß, Lisa, Mayer-Hain, Sarah, Zimmermann, Katharina, Riese, Sebastian, Thol, Felicitas, Beutel, Gernot, Maecker-Kolhoff, Britta, Yamamoto, Fumiichiro, Blasczyk, Rainer, Schambach, Axel, Hust, Michael, Hudecek, Michael, Eiz-Vesper, Britta

Source: Frontiers in Immunology; 2023, p1-16, 16p

Subject Terms: CANCER cells, ANTIGENS, CYTOTOXINS, LIGAND binding (Biochemistry), VIBRIO cholerae, AGROBACTERIUM tumefaciens

Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors.

Authors: Bonifacius, Agnes¹, Lamottke, Britta², Tischer-Zimmermann, Sabine¹, Schultze-Florey, Rebecca², Goudeva, Lilia¹, Heuft, Hans-Gert¹, Arseniev, Lubomir³, Beier, Rita², Beutel, Gernot⁴, Cario, Gunnar⁵, Fröhlich, Birgit⁶, Greil, Johann⁷, Hansmann, Leo⁸, Hasenkamp, Justin⁹, Höfs, Michaela¹⁰, Hundsdoerfer, Patrick¹¹, Jost, Edgar¹², Kafa, Kinan¹³, Kriege, Oliver¹⁴, Kröger, Nicolaus¹⁵

Source: Journal of Clinical Investigation. 6/15/2023, Vol. 133 Issue 12, p1-14. 14p.

Subject Terms: *T cells, *STEM cell transplantation, *CYTOTOXIC T cells, *MANUFACTURING cells, *STEM cell donors, *IMMUNOCOMPROMISED patients

Company/Entity: DEUTSCHE Forschungsgemeinschaft

Reinforcement of cell-mediated immunity driven by tumorassociated Epstein-Barr virus (EBV)-specific T cells during targeted B-cell therapy with rituximab.

Authors: Tischer-Zimmermann, Sabine, Bonifacius, Agnes, Santamorena, Maria Michela, Mausberg, Philip, Stoll, Sven, Döring, Marius, Kalinke, Ulrich, Blasczyk, Rainer, Maecker-Kolhoff, Britta, Eiz-Vesper, Britta

Source: Frontiers in Immunology; 3/24/2023, Vol. 14, p1-18, 18p

Subject Terms: RITUXIMAB, T cells, HISTOCOMPATIBILITY class I antigens, T helper cells, CELLULAR immunity, ANTIGEN presenting cells, EPSTEIN-Barr virus

Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV.

Authors: Theobald, Sebastian J.^1,2,3, Kreer, Christoph^4,5, Khailaie, Sahamoddin⁶, Bonifacius, Agnes⁷, Eiz-Vesper, Britta⁷, Figueiredo, Constanca⁷, Mach, Michael⁸, Backovic, Marija⁹, Ballmaier, Matthias¹⁰, Koenig, Johannes^1,2,3, Olbrich, Henning^1,2,3, Schneider, Andreas^1,2,3, Volk, Valery^1,2,3, Danisch, Simon^1,2,3, Gieselmann, Lutz^4,5,11, Ercanoglu, Meryem Seda^4,5, Messerle, Martin^3,12, Kaisenberg, Constantin von¹³, Witte, Torsten¹⁴, Klawonn, Frank^15,16

Source: PLoS Pathogens; 7/15/2020, Vol. 16 Issue 7, p1-34, 34p

Targeted proteomics identifies circulating biomarkers associated with active COVID-19 and post-COVID-19.

Authors: Zoodsma, Martijn, de Nooijer, Aline H., Grondman, Inge, Gupta, Manoj Kumar, Bonifacius, Agnes, Koeken, Valerie A. C. M., Kooistra, Emma, Kilic, Gizem, Bulut, Ozlem, Gödecke, Nina, Janssen, Nico, Kox, Matthijs, Domínguez-Andrés, Jorge, van Gammeren, Adriaan J., Ermens, Anton A. M., van der Ven, Andre J. A. M., Pickkers, Peter, Blasczyk, Rainer, Behrens, Georg M. N., van de Veerdonk, Frank L.

Source: Frontiers in Immunology; 11/3/2022, Vol. 13, p1-18, 18p

Subject Terms: SARS-CoV-2, COVID-19 pandemic, COVID-19, TRANSFORMING growth factors, PROTEOMICS, NECROSIS

Reduced humoral but stable cellular SARS-CoV-2-specific immunity in liver transplant recipients in the first year after COVID-19.

Authors: Kirchner, Theresa, Heinrich, Sophia, Bonifacius, Agnes, Engel, Bastian, Ruhl, Louisa, Pink, Isabell, Thomas, Nele, Martens, Joerg, Hoeper, Marius M., Blasczyk, Rainer, Wedemeyer, Heiner, Jaeckel, Elmar, Li, Yang, Falk, Christine S., Eiz-Vesper, Britta, Taubert, Richard

Source: PLoS ONE; 11/2/2022, Vol. 17 Issue 11, p1-16, 16p

Subject Terms: CELLULAR immunity, LIVER transplantation, PROTEIN domains, COVID-19, BOOSTER vaccines, T cell receptors, IMMUNOGLOBULINS

Chronic Active Epstein-Barr Virus (EBV) Infection Controlled by Allogeneic Stem Cell Transplantation and EBV-Specific T Cells.

Authors: Meedt, Elisabeth, Weber, Daniela, Bonifacius, Agnes, Eiz-Vesper, Britta, Maecker-Kolhoff, Britta, Delecluse, Susanne, Delecluse, Henri-Jacques, Lorenz, Myriam, Schwarz, Klaus, Meedt, Stefan T, Braess, Jan, Herr, Wolfgang, Holler, Ernst, Edinger, Matthias, Wolff, Daniel

Source: Clinical Infectious Diseases; 6/15/2023, Vol. 76 Issue 12, p2200-2202, 3p

Subject Terms: TREATMENT of Epstein-Barr virus diseases, HOMOGRAFTS, GRAFT versus host disease, CHRONIC diseases, CELLS, VIREMIA, HEMATOPOIETIC stem cell transplantation, T cells, IMMUNOSUPPRESSIVE agents, DISEASE remission