p66Shc deficiency in CLL cells enhances PD-L1 expression and suppresses immune synapse formation.

Authors: Lopresti, Ludovica, Capitani, Nagaja, Tatangelo, Vanessa, Tangredi, Carmela, Boncompagni, Gioia, Frezzato, Federica, Visentin, Andrea, Marotta, Giuseppe, Ciofini, Sara, Gozzetti, Alessandro, Bocchia, Monica, Trentin, Livio, Baldari, Cosima T., Patrussi, Laura

Source: Frontiers in Cell & Developmental Biology; 2024, p1-14, 14p

Subject Terms: SYNAPTOGENESIS, CHRONIC lymphocytic leukemia, PROGRAMMED death-ligand 1, PROGRAMMED cell death 1 receptors, T cells, FLUDARABINE, ALEMTUZUMAB

Leukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia.

Authors: Boncompagni, Gioia, Tatangelo, Vanessa, Lopresti, Ludovica, Ulivieri, Cristina, Capitani, Nagaja, Tangredi, Carmela, Finetti, Francesca, Marotta, Giuseppe, Frezzato, Federica, Visentin, Andrea, Ciofini, Sara, Gozzetti, Alessandro, Bocchia, Monica, Calzada-Fraile, Diego, Martin Cofreces, Noa B., Trentin, Livio, Patrussi, Laura, Baldari, Cosima T.

Source: Cell Death & Disease; Feb2024, Vol. 15 Issue 2, p1-13, 13p

p66Shc Deficiency in Chronic Lymphocytic Leukemia Promotes Chemokine Receptor Expression Through the ROS-Dependent Inhibition of NF-κB.

Authors: Tatangelo, Vanessa, Boncompagni, Gioia, Capitani, Nagaja, Lopresti, Ludovica, Manganaro, Noemi, Frezzato, Federica, Visentin, Andrea, Trentin, Livio, Baldari, Cosima T., Patrussi, Laura

Source: Frontiers in Oncology; 6/29/2022, Vol. 12, p1-12, 12p

Subject Terms: CHRONIC lymphocytic leukemia, CHEMOKINE receptors, ADAPTOR proteins, CXCR4 receptors, FLUDARABINE, REACTIVE oxygen species, TRANSCRIPTION factors

Glycerophosphoinositol Promotes Apoptosis of Chronic Lymphocytic Leukemia Cells by Enhancing Bax Expression and Activation.

Authors: Boncompagni, Gioia, Varone, Alessia, Tatangelo, Vanessa, Capitani, Nagaja, Frezzato, Federica, Visentin, Andrea, Trentin, Livio, Corda, Daniela, Baldari, Cosima T., Patrussi, Laura

Source: Frontiers in Oncology; 3/22/2022, Vol. 12, p1-13, 13p

Subject Terms: FLUDARABINE, CHRONIC lymphocytic leukemia, BCL-2 proteins, PROTEIN-tyrosine phosphatase, APOPTOSIS, CELL physiology

Phosphoproteomics of CD2 signaling reveals AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells.

Authors: Zurli, Vanessa, Montecchi, Tommaso, Heilig, Raphael, Poschke, Isabel, Volkmar, Michael, Wimmer, Giuliana, Boncompagni, Gioia, Turacchio, Gabriele, D'Elios, Mario Milco, Campoccia, Giuseppe, Resta, Nicoletta, Offringa, Rienk, Fischer, Roman, Acuto, Oreste, Baldari, Cosima Tatiana, Kabanova, Anna

Source: Science Signaling; 5/12/2020, Vol. 13 Issue 631, p1-14, 14p

Subject Terms: CYTOTOXIC T cells, T cell receptors, T cells, HUMAN T cells, B cells, SYNAPTOGENESIS