Structure learning of Bayesian networks involving cyclic structures

Authors: Wiecek, Witold, Bois, Frederic Y., Gayraud, Ghislaine

Subject Terms: Statistics - Methodology

Access URL: http://arxiv.org/abs/1906.04992

Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors.

Authors: Niemeijer, Marije¹, Więcek, Witold², Shuai Fu², Huppelschoten, Suzanna¹, Bouwman, Peter¹, Baze, Audrey³, Parmentier, Céline³, Richert, Lysiane^3,4, Paules, Richard S.⁵, Bois, Frederic Y.², van de Water, Bob¹, b.water@lacdr.leidenuniv.nl

Source: Environmental Health Perspectives; Mar2024, Vol. 132 Issue 3, p037005-1-037005-15, 15p

Population PBPK modeling using parametric and nonparametric methods of the Simcyp Simulator, and Bayesian samplers

Authors: Wedagedera, Janak R., Afuape, Anthonia, Chirumamilla, Siri Kalyan, Momiji, Hiroshi, Leary, Robert, Dunlavey, Mike, Matthews, Richard, Abduljalil, Khaled, Jamei, Masoud, Bois, Frederic Y.

Source: CPT: pharmacometrics & systems pharmacology. 11(6):755-765

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154023379.0x000001&indx=1&recIds=ETOCvdc_100154023379.0x000001

Understanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic Framework

Authors: Zhang, Mian, Fisher, Ciarán, Gardner, Iain, Pan, Xian, Kilford, Peter, Bois, Frederic Y., Jamei, Masoud ^*

Source: In Drug Metabolism and Disposition July 2022 50(7):957-967

A quantitative AOP of mitochondrial toxicity based on data from three cell lines

Authors: Tebby, Cleo, Gao, Wang, Delp, Johannes, Carta, Giada, van der Stel, Wanda, Leist, Marcel, Jennings, Paul, van de Water, Bob, Bois, Frederic Y.

Source: In Toxicology in Vitro June 2022 81

A high-throughput analysis of ovarian cycle disruption by mixtures of aromatase inhibitors

Authors: Bois, Frederic Y., Golbamaki-Bakhtyari, Nazanin, Kovarich, Simona, Tebby, Cleo, Gabb, Henry A., Lemazurier, Emmanuel

Subject Terms: Quantitative Biology - Tissues and Organs

Access URL: http://arxiv.org/abs/1609.06547

Graph_sampler: a simple tool for fully Bayesian analyses of DAG-models

Authors: Datta, Sagnik, Gayraud, Ghislaine, Leclerc, Eric, Bois, Frederic Y.

Subject Terms: Statistics - Computation

Access URL: http://arxiv.org/abs/1505.07228

Multistate models of developmental toxicity: Application to valproic acid-induced malformations in the zebrafish embryo

Authors: Siméon, Ségolène, Beaudouin, Rémy, Brotzmann, Katharina, Braunbeck, Thomas, Bois, Frédéric Y.

Source: In Toxicology and Applied Pharmacology 1 March 2021 414

Opening a debate on open‐source modeling tools: Pouring fuel on fire versus extinguishing the flare of a healthy debate

Authors: Rostami‐Hodjegan, Amin, Bois, Frederic Y.

Source: CPT: pharmacometrics & systems pharmacology. 10(5):420-427

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164554637.0x000001&indx=1&recIds=ETOCvdc_100164554637.0x000001

Mechanistic Model for Drug Release from PLGA-Based Biodegradable Implants for In Vitro Release Testing: Development and Validation.

Authors: Mittapelly, Naresh, Djehizian, Alexandre, Telaprolu, Krishna Chaitanya, McNally, Kevin, Puttrevu, Santosh Kumar, Arjmandi-Tash, Omid, Polak, Sebastian, Bois, Frederic Y.

Source: ACS Applied Bio Materials; 11/18/2024, Vol. 7 Issue 11, p7453-7465, 13p

Applications of the Cholesterol Metabolite, 4β-Hydroxycholesterol, as a Sensitive Endogenous Biomarker for Hepatic CYP3A Activity Evaluated within a PBPK Framework.

Authors: Karkhanis, Aneesh V., Harwood, Matthew D., Stader, Felix, Bois, Frederic Y., Neuhoff, Sibylle

Source: Pharmaceutics; Oct2024, Vol. 16 Issue 10, p1284, 22p

Subject Terms: CYTOCHROME P-450 CYP3A, PLASMA confinement, BIOMARKERS, CHOLESTEROL, PHARMACOKINETICS

A generic PBTK model implemented in the MCRA platform: Predictive performance and uses in risk assessment of chemicals

Authors: Tebby, Cleo, van der Voet, Hilko, de Sousa, Georges, Rorije, Emiel, Kumar, Vikas, de Boer, Waldo, Kruisselbrink, Johannes W., Bois, Frédéric Y., Faniband, Moosa, Moretto, Angelo, Brochot, Céline

Source: In Food and Chemical Toxicology August 2020 142

Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs

Authors: Siméon, Ségolène, Brotzmann, Katharina, Fisher, Ciaran, Gardner, Iain, Silvester, Steve, Maclennan, Richard, Walker, Paul, Braunbeck, Thomas, Bois, Frederic Y. ^*

Source: In Reproductive Toxicology April 2020 93:219-229

Integration of Omics Data and Systems Biology Modeling: Effect of Cyclosporine A on the Nrf2 Pathway in Human Renal Kidneys Cells

Authors: Hamon, Jérémy, Jennings, Paul, Bois, Frederic Y.

Source: BMC Systems Biology, 2014, 8:76

Subject Terms: Quantitative Biology - Quantitative Methods, Quantitative Biology - Molecular Networks

Access URL: http://arxiv.org/abs/1312.4744

Probabilistic generation of random networks taking into account information on motifs occurrence

Authors: Bois, Frederic Y., Gayraud, Ghislaine

Source: Journal of Computational Biology, 2015, 22:25-36

Subject Terms: Quantitative Biology - Quantitative Methods, Quantitative Biology - Molecular Networks

Access URL: http://arxiv.org/abs/1311.6443

Prediction of maternal and foetal exposures to perfluoroalkyl compounds in a Spanish birth cohort using toxicokinetic modelling

Authors: Brochot, Céline, Casas, Maribel, Manzano-Salgado, Cyntia, Zeman, Florence A., Schettgen, Thomas, Vrijheid, Martine, Bois, Frédéric Y.

Source: In Toxicology and Applied Pharmacology 15 September 2019 379

Application of three approaches for quantitative AOP development to renal toxicity

Authors: Zgheib, Elias, Gao, Wang, Limonciel, Alice, Aladjov, Hristo, Yang, Huan, Tebby, Cleo, Gayraud, Ghislaine, Jennings, Paul, Sachana, Magdalini, Beltman, Joost B., Bois, Frederic Y.

Source: In Computational Toxicology August 2019 11:1-13

Corrigendum to 'Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs' [Reprod. Toxicol. 93 (2020) 219⬜229]

Authors: Siméon, Ségolène, Brotzmann, Katharina, Fisher, Ciarán, Gardner, Iain, Silvester, Steve, Maclennan, Richard, Walker, Paul, Braunbeck, Thomas, Bois, Frederic Y.

Source: REPRODUCTIVE TOXICOLOGY -NEW YORK. 98:300-303

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116525543.0x000001&indx=1&recIds=ETOCvdc_100116525543.0x000001

Well-tempered MCMC simulations for population pharmacokinetic models

Authors: Bois, Frederic Y., Hsieh, Nan-Hung, Gao, Wang, Chiu, Weihsueh A., Reisfeld, Brad

Source: Journal of pharmacokinetics and pharmacodynamics. 47(6):543-559

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186594050.0x000001&indx=1&recIds=ETOCvdc_100186594050.0x000001

A guide to developing population files for physiologically‐based pharmacokinetic modeling in the Simcyp Simulator.

Authors: Curry, Liam, Alrubia, Sarah, Bois, Frederic Y., Clayton, Ruth, El‐Khateeb, Eman, Johnson, Trevor N., Faisal, Muhammad, Neuhoff, Sibylle, Wragg, Kris, Rostami‐Hodjegan, Amin

Source: CPT: Pharmacometrics & Systems Pharmacology; Sep2024, Vol. 13 Issue 9, p1429-1447, 19p

Subject Terms: CROHN'S disease, DRUG development, PHARMACOKINETICS, KIDNEY diseases, CONSUMER expertise