Chemical modification of hyaluronan oligosaccharides differentially modulates hyaluronan–hyaladherin interactions

Authors: Dodd, Rebecca J., Blundell, Charles D., Sattelle, Benedict M., Enghild, Jan J., Milner, Caroline M., Day, Anthony J.

Source: In Journal of Biological Chemistry September 2024 300(9)

SDPD-SX: combining a single crystal X-ray diffraction setup with advanced powder data structure determination for use in early stage drug discoveryElectronic supplementary information (ESI) available: DASH profile fits, full data ranges and asymmetric unit overlays, and selected Rietveld refinement information available. See DOI: https://doi.org/10.1039/d2ce00387b

Authors: Kabova, Elena A., Blundell, Charles D., Muryn, Christopher A., Whitehead, George F. S., Vitorica-Yrezabal, Inigo J., Ross, Marta J., Shankland, Kenneth

Source: CrystEngComm. 24(24):4337-4340

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153227520.0x000001&indx=1&recIds=ETOCvdc_100153227520.0x000001

Pushing the Limits of Molecular Crystal Structure Determination From Powder Diffraction Data in High-Throughput Chemical Environments

Authors: Kabova, Elena A., Blundell, Charles D., Shankland, Kenneth

Source: In Journal of Pharmaceutical Sciences August 2018 107(8):2042-2047

Polymorph Identification for Flexible Molecules: Linear Regression Analysis of Experimental and Calculated Solution- and Solid-State NMR Data.

Authors: Rahman, Mohammed, Dannatt, Hugh R. W., Blundell, Charles D., Hughes, Leslie P., Blade, Helen, Carson, Jake, Tatman, Ben P., Johnston, Steven T., Brown, Steven P.

Source: Journal of Physical Chemistry A; 3/14/2024, Vol. 128 Issue 10, p1793-1816, 24p

A Refined Model for the TSG-6 Link Module in Complex with Hyaluronan: USE OF DEFINED OLIGOSACCHARIDES TO PROBE STRUCTURE AND FUNCTION

Authors: Higman, Victoria A., Briggs, David C., Mahoney, David J., Blundell, Charles D., Sattelle, Benedict M., Dyer, Douglas P., Green, Dixy E., DeAngelis, Paul L., Almond, Andrew, Milner, Caroline M., Day, Anthony J.

Source: In Journal of Biological Chemistry 28 February 2014 289(9):5619-5634

Measurement, Interpretation and Use of Free Ligand Solution Conformations in Drug Discovery

Authors: Blundell, Charles D., Nowak, Thorsten, Watson, Martin J.

Source: Progress in medicinal chemistry. 55:45-148

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN605048207&indx=1&recIds=ETOCRN605048207

Quantification of free ligand conformational preferences by NMR and their relationship to the bioactive conformation

Authors: Blundell, Charles D., Packer, Martin J., Almond, Andrew

Source: In Bioorganic & Medicinal Chemistry 1 September 2013 21(17):4976-4987

Comparative pharmacology and computational modelling yield insights into allosteric modulation of human α7 nicotinic acetylcholine receptors

Authors: Sattelle, David B., Buckingham, Steven D., Akamatsu, Miki, Matsuda, Kazuhiko, Pienaar, Ilse, Jones, Andrew K., Sattelle, Benedict M., Almond, Andrew, Blundell, Charles D.

Source: In Biochemical Pharmacology 2009 78(7):836-843

Determining the Molecular Basis for the pH-dependent Interaction between the Link Module of Human TSG-6 and Hyaluronan

Authors: Blundell, Charles D., Mahoney, David J., Cordell, Martin R., Almond, Andrew, Kahmann, Jan D., Perczel, András, Taylor, Jonathan D., Campbell, Iain D., Day, Anthony J.

Source: In Journal of Biological Chemistry 27 April 2007 282(17):12976-12988

Plasticity of the TSG-6 HA-binding Loop and Mobility in the TSG-6-HA Complex Revealed by NMR and X-ray Crystallography

Authors: Higman, Victoria A., Blundell, Charles D., Mahoney, David J., Redfield, Christina, Noble, Martin E.M., Day, Anthony J.

Source: In Journal of Molecular Biology 2007 371(3):669-684

NMR spectra of oligosaccharides at ultra-high field (900 MHz) have better resolution than expected due to favourable molecular tumbling

Authors: Blundell, Charles D., Reed, Michelle A.C., Overduin, Michael, Almond, Andrew

Source: In Carbohydrate Research 4 September 2006 341(12):1985-1991

Hyaluronan: The Local Solution Conformation Determined by NMR and Computer Modeling is Close to a Contracted Left-handed 4-Fold Helix

Authors: Almond, Andrew, DeAngelis, Paul L., Blundell, Charles D.

Source: In Journal of Molecular Biology 2006 358(5):1256-1269

Complete assignment of hyaluronan oligosaccharides up to hexasaccharides

Authors: Blundell, Charles D., Reed, Michelle A.C., Almond, Andrew

Source: In Carbohydrate Research 2006 341(17):2803-2815

Enzymatic and chemical methods for the generation of pure hyaluronan oligosaccharides with both odd and even numbers of monosaccharide units

Authors: Blundell, Charles D., Almond, Andrew

Source: In Analytical Biochemistry 2006 353(2):236-247

Characterization of the Interaction between Tumor Necrosis Factor-stimulated Gene-6 and Heparin: IMPLICATIONS FOR THE INHIBITION OF PLASMIN IN EXTRACELLULAR MATRIX MICROENVIRONMENTS

Authors: Mahoney, David J., Mulloy, Barbara ^¶, Forster, Mark J. ^¶, Blundell, Charles D. ^**, Fries, Eric ^‡‡, Milner, Caroline M, Day, Anthony J.

Source: In Journal of Biological Chemistry 22 July 2005 280(29):27044-27055

Towards a Structure for a TSG-6·Hyaluronan Complex by Modeling and NMR Spectroscopy: INSIGHTS INTO OTHER MEMBERS OF THE LINK MODULE SUPERFAMILY

Authors: Blundell, Charles D. ^{‡, §}, Almond, Andrew ^{§, ¶}, Mahoney, David J. ^{‡, §}, DeAngelis, Paul L. ^{∥, **}, Campbell, Iain D. ^{§, ‡‡}, Day, Anthony J. ^{‡, §, §§}

Source: In Journal of Biological Chemistry 6 May 2005 280(18):18189-18201

Structure of the Regulatory Hyaluronan Binding Domain in the Inflammatory Leukocyte Homing Receptor CD44

Authors: Teriete, Peter, Banerji, Suneale, Noble, Martin, Blundell, Charles D., Wright, Alan J., Pickford, Andrew R., Lowe, Edward, Mahoney, David J., Tammi, Markku I., Kahmann, Jan D., Campbell, Iain D., Day, Anthony J., Jackson, David G.

Source: In Molecular Cell 2004 13(4):483-496

The Link Module from Ovulation- and Inflammation-associated Protein TSG-6 Changes Conformation on Hyaluronan Binding

Authors: Blundell, Charles D. ^{‡, §, ¶}, Mahoney, David J. ^‡, Almond, Andrew ^§, DeAngelis, Paul L. ^∥, Kahmann, Jan D. ^{‡, §}, Teriete, Peter ^{‡, §}, Pickford, Andrew R. ^§, Campbell, Iain D. ^§, Day, Anthony J. ^{‡, **}

Source: In Journal of Biological Chemistry 5 December 2003 278(49):49261-49270

Mapping the Hyaluronan-binding Site on the Link Module from Human Tumor Necrosis Factor-stimulated Gene-6 by Site-directed Mutagenesis

Authors: Mahoney, David J. ^‡, Blundell, Charles D., Day, Anthony J. ^§

Source: In Journal of Biological Chemistry 22 June 2001 276(25):22764-22771

Crystal structures of tolfenamic acid polymorphic forms I and II with precise hydrogen-atom positions for nuclear magnetic resonance studies.

Authors: Blade, Helen¹, Blundell, Charles D.² charles.blundell@c4xdiscovery.com, Vitorica-Yrezabal, Iñigo J.³

Source: Acta Crystallographica Section E: Crystallographic Communications. Sep2020, Vol. 76 Issue 9, Following p1421-1426. 14p.

Subject Terms: *NUCLEAR magnetic resonance, *CRYSTAL structure, *CHEMICAL bond lengths, *COVALENT bonds, *HYDROGEN bonding, *ERGOT alkaloids