Cancer Organoids as reliable disease models to drive clinical development of novel therapies.

Authors: Blandino, Giovanni¹ (AUTHOR) giovanni.blandino@ifo.it, Satchi-Fainaro, Ronit² (AUTHOR), Tinhofer, Ingeborg³ (AUTHOR), Tonon, Giovanni⁴ (AUTHOR), Heilshorn, Sarah C.⁵ (AUTHOR), Kwon, Yong-Jun⁶ (AUTHOR), Pestana, Ana³ (AUTHOR), Frascolla, Carlotta¹ (AUTHOR), Pompili, Luca¹ (AUTHOR), Puce, Aurora⁷ (AUTHOR), Iachettini, Sara¹ (AUTHOR), Tocci, Annalisa⁸ (AUTHOR), Karkampouna, Sofia⁹ (AUTHOR), Kruithof-de Julio, Marianna⁹ (AUTHOR), Tocci, Piera¹⁰ (AUTHOR), Porciello, Nicla⁸ (AUTHOR), Maccaroni, Klizia⁷ (AUTHOR), Rutigliano, Daniela¹ (AUTHOR), Shen, Xiling^11,12 (AUTHOR), Ciliberto, Gennaro¹³ (AUTHOR)

Source: Journal of Experimental & Clinical Cancer Research (17569966). 12/28/2024, Vol. 43 Issue 1, p1-16. 16p.

Subject Terms: *MEDICAL sciences, *MEDICAL screening, *MEDICAL research, *INDIVIDUALIZED medicine, *CLINICAL medicine

MiR‐4734 conditionally suppresses ER stress‐associated proinflammatory responses

Authors: Michael, Dan, Feldmesser, Ester, Gonen, Chagay, Furth, Noa, Maman, Alexander, Heyman, Ori, Argoetti, Amir, Tofield, Adin, Baichman‐Kass, Amichai, Ben‐Dov, Aviyah, Benbenisti, Dan, Hen, Nadav, Rotkopf, Ron, Ganci, Federica, Blandino, Giovanni, Ulitsky, Igor, Oren, Moshe

Source: FEBS letters. 597(9):1233-1245

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196427184.0x000001&indx=1&recIds=ETOCvdc_100196427184.0x000001

It is time to improve the diagnostic workup of oropharyngeal cancer with circulating tumor HPV DNA: Systematic review and meta‐analysis

Authors: Paolini, Francesca, Campo, Flaminia, Iocca, Oreste, Manciocco, Valentina, De Virgilio, Armando, De Pascale, Valentina, Moretto, Silvia, Dalfino, Gianluca, Vidiri, Antonello, Blandino, Giovanni, Pimpinelli, Fulvia, Venuti, Aldo, Pellini, Raul

Source: Head & neck. 45(11):2945-2954

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196445238.0x000001&indx=1&recIds=ETOCvdc_100196445238.0x000001

Evidence of a SARS-CoV-2 double Spike mutation D614G/S939F potentially affecting immune response of infected subjects

Authors: Donzelli, Sara, Spinella, Francesca, di Domenico, Enea Gino, Pontone, Martina, Cavallo, Ilaria, Orlandi, Giulia, Iannazzo, Stefania, Ricciuto, Giulio Maria, Pellini, Raul, Muti, Paola, Strano, Sabrina, Ciliberto, Gennaro, Ensoli, Fabrizio, Zapperi, Stefano, La Porta, Caterina A.M., Blandino, Giovanni, Morrone, Aldo, Pimpinelli, Fulvia

Source: Computational and Structural Biotechnology Journal. 20:733-744

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190063502.0x000001&indx=1&recIds=ETOCvdc_100190063502.0x000001

Optimizing the Illumina COVIDSeq laboratorial and bioinformatics pipeline on thousands of samples for SARS-CoV-2 Variants of Concern tracking

Authors: Donzelli, Sara, Ciuffreda, Ludovica, Pontone, Martina, Betti, Martina, Massacci, Alice, Mottini, Carla, De Nicola, Francesca, Orlandi, Giulia, Goeman, Frauke, Giuliani, Eugenia, Sperandio, Eleonora, Piaggio, Giulia, Morrone, Aldo, Ciliberto, Gennaro, Fanciulli, Maurizio, Blandino, Giovanni, Pimpinelli, Fulvia, Pallocca, Matteo

Source: Computational and Structural Biotechnology Journal. 20:2558-2563

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190063196.0x000001&indx=1&recIds=ETOCvdc_100190063196.0x000001

Breast cancer metastasis: Is it a matter of OMICS and proper ex-vivo models?

Authors: Cioce, Mario, Sacconi, Andrea, Donzelli, Sara, Bonomo, Claudia, Perracchio, Letizia, Carosi, Mariantonia, Telera, Stefano, Fazio, Vito Michele, Botti, Claudio, Strano, Sabrina, Blandino, Giovanni

Source: Computational and Structural Biotechnology Journal. 20:4003-4008

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190062979.0x000001&indx=1&recIds=ETOCvdc_100190062979.0x000001

YAP and TAZ: Monocorial and bicorial transcriptional co-activators in human cancers

Authors: Lo Sardo, Federica, Canu, Valeria, Maugeri-Saccà, Marcello, Strano, Sabrina, Blandino, Giovanni

Source: In BBA - Reviews on Cancer July 2022 1877(4)

miR-1297 is frequently downmodulated in flat epithelial atypia of the breast and promotes mammary neoplastic transformation via EphrinA2 regulation.

Authors: Scafetta, Giorgia, Rampioni Vinciguerra, Gian Luca, Giglio, Simona, Faruq, Omar, Cirombella, Roberto, Segatto, Ilenia, Citron, Francesca, Mattevi, Maria Chiara, Di Renzi, Elisabetta, Cascione, Luciano, Gasparini, Pierluigi, Belletti, Barbara, Baldassarre, Gustavo, Sacconi, Andrea, Blandino, Giovanni, Vecchione, Andrea

Source: Journal of Experimental & Clinical Cancer Research (17569966); 3/14/2025, Vol. 44 Issue 1, p1-12, 12p

TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancer

Authors: Dinami, Roberto, Petti, Eleonora, Porru, Manuela, Rizzo, Angela, Ganci, Federica, Sacconi, Andrea, Ostano, Paola, Chiorino, Giovanna, Trusolino, Livio, Blandino, Giovanni, Ciliberto, Gennaro, Zizza, Pasquale, Biroccio, Annamaria

Source: In Cancer Letters 1 May 2022 533

Initial observations on age, gender, BMI and hypertension in antibody responses to SARS-CoV-2 BNT162b2 vaccine

Authors: Pellini, Raul, Venuti, Aldo, Pimpinelli, Fulvia, Abril, Elva, Blandino, Giovanni, Campo, Flaminia, Conti, Laura, De Virgilio, Armando, De Marco, Federico, Di Domenico, Enea Gino, Di Bella, Ornella, Di Martino, Simona, Ensoli, Fabrizio, Giannarelli, Diana, Mandoj, Chiara, Manciocco, Valentina, Marchesi, Paolo, Mazzola, Francesco, Moretto, Silvia, Petruzzi, Gerardo, Petrone, Fabrizio, Pichi, Barbara, Pontone, Martina, Zocchi, Jacopo, Vidiri, Antonello, Vujovic, Branka, Piaggio, Giulia, Morrone, Aldo, Ciliberto, Gennaro

Source: In EClinicalMedicine June 2021 36

YAP/TAZ and EZH2 synergize to impair tumor suppressor activity of TGFBR2 in non-small cell lung cancer

Authors: Lo Sardo, Federica, Pulito, Claudio, Sacconi, Andrea, Korita, Etleva, Sudol, Marius, Strano, Sabrina, Blandino, Giovanni

Source: In Cancer Letters 1 March 2021 500:51-63

The Conundrum of Giglio Island: Unraveling the dynamics of an apparent resistance to COVID-19 – A descriptive study

Authors: Bognanni, Antonio, Schiaffino, Armando, Pimpinelli, Fulvia, Donzelli, Sara, Celesti, Ilaria, Strano, Sabrina, Solari, Elena, Schiaffino, Giorgia, Solari, Gabriele, Solari, Domenico, Delbue, Serena, Rigoni, Marta, Nollo, Giandomenico, Muti, Greta E., Muti Schünemann, Giovanna E.U., Schünemann, Holger J, Blandino, Giovanni, Morrone, Aldo, Muti, Paola

Source: In Computational and Structural Biotechnology Journal 2021 19:1467-1471

The new world of RNA diagnostics and therapeutics.

Authors: Blandino, Giovanni¹ (AUTHOR) giovanni.blandino@ifo.it, Dinami, Roberto¹ (AUTHOR), Marcia, Marco² (AUTHOR), Anastasiadou, Eleni³ (AUTHOR), Ryan, Brid M.⁴ (AUTHOR), Palcau, Alina Catalina¹ (AUTHOR), Fattore, Luigi⁵ (AUTHOR), Regazzo, Giulia¹ (AUTHOR), Sestito, Rosanna⁶ (AUTHOR), Loria, Rossella⁷ (AUTHOR), Díaz Méndez, Ana Belén¹ (AUTHOR), Cappelletto, Maria Chiara¹ (AUTHOR), Pulito, Claudio¹ (AUTHOR), Monteonofrio, Laura⁷ (AUTHOR), Calin, George A.⁸ (AUTHOR), Sozzi, Gabriella⁹ (AUTHOR), Cheong, Jit Kong¹⁰ (AUTHOR), Aharonov, Ranit¹¹ (AUTHOR), Ciliberto, Gennaro¹² (AUTHOR)

Source: Journal of Experimental & Clinical Cancer Research (17569966). 7/29/2023, Vol. 42 Issue 1, p1-16. 16p.

Subject Terms: *RNA, *NON-coding RNA, *CELL cycle regulation, *THERAPEUTICS

Geographic Terms: ROME

Molecular insights unlocking therapeutic potential for multiple myeloma and bone disease management.

Authors: Bruno, Tiziana, Catena, Valeria, Blandino, Giovanni, Fanciulli, Maurizio, Di Agostino, Silvia

Source: Journal of Experimental & Clinical Cancer Research (17569966); 12/18/2024, Vol. 43 Issue 1, p1-4, 4p

Subject Terms: MEDICAL sciences, MULTIPLE myeloma, RNA polymerases, BONE marrow cells, HEMATOLOGIC malignancies

The oncogenic axis YAP/MYC/EZH2 impairs PTEN tumor suppression activity enhancing lung tumorigenicity.

Authors: Lo Sardo, Federica, Turco, Chiara, Messina, Beatrice, Sacconi, Andrea, Auciello, Francesca Romana, Pulito, Claudio, Strano, Sabrina, Lev, Sima, Blandino, Giovanni

Source: Cell Death Discovery; 10/25/2024, Vol. 10 Issue 1, p1-13, 13p

Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma

Authors: Bruno, Tiziana, De Nicola, Francesca, Corleone, Giacomo, Catena, Valeria, Goeman, Frauke, Pallocca, Matteo, Sorino, Cristina, Bossi, Gianluca, Amadio, Bruno, Cigliana, Giovanni, Ricciardi, Maria Rosaria, Petrucci, Maria Teresa, Spugnini, Enrico Pierluigi, Baldi, Alfonso, Cioce, Mario, Cortese, Giancarlo, Mattei, Elisabetta, Merola, Roberta, Gianelli, Umberto, Baldini, Luca, Pisani, Francesco, Gumenyuk, Svitlana, Mengarelli, Andrea, Höpker, Katja, Benzing, Thomas, Vincenzi, Bruno, Floridi, Aristide, Passananti, Claudio, Blandino, Giovanni, Iezzi, Simona, Fanciulli, Maurizio

Source: In Blood Advances 24 November 2020 4(22):5616-5630

Endothelin-1 axis fosters YAP-induced chemotherapy escape in ovarian cancer

Authors: Tocci, Piera, Cianfrocca, Roberta, Sestito, Rosanna, Rosanò, Laura, Di Castro, Valeriana, Blandino, Giovanni, Bagnato, Anna

Source: In Cancer Letters 1 November 2020 492:84-95

Wild type- and mutant p53 proteins in mitochondrial dysfunction: emerging insights in cancer disease

Authors: Blandino, Giovanni ^*, Valenti, Fabio, Sacconi, Andrea, Di Agostino, Silvia ^*

Source: In Seminars in Cell and Developmental Biology February 2020 98:105-117

E6AP Promotes a Metastatic Phenotype in Prostate Cancer

Authors: Gamell, Cristina, Bandilovska, Ivona, Gulati, Twishi, Kogan, Arielle, Lim, Syer Choon, Kovacevic, Zaklina, Takano, Elena A., Timpone, Clelia, Agupitan, Arjelle D., Litchfield, Cassandra, Blandino, Giovanni, Horvath, Lisa G., Fox, Stephen B., Williams, Scott G., Russo, Andrea, Gallo, Enzo, Paul, Piotr J., Mitchell, Catherine, Sandhu, Shahneen, Keam, Simon P., Haupt, Sue, Richardson, Des R., Haupt, Ygal

Source: In iScience 20 December 2019 22:1-15

Circulating tumor HPV DNA in the management of HPV+ oropharyngeal cancer and its correlation with MRI.

Authors: Campo, Flaminia, Paolini, Francesca, Manciocco, Valentina, Moretto, Silvia, Pichi, Barbara, Moretti, Claudio, Blandino, Giovanni, De Pascale, Valentina, Benevolo, Maria, Pimpinelli, Fulvia, Vidiri, Antonello, Marzi, Simona, Ruggiero, Sergio, Terrenato, Irene, Iocca, Oreste, Venuti, Aldo, Pellini, Raul

Source: Head & Neck; Sep2024, Vol. 46 Issue 9, p2206-2213, 8p

Subject Terms: HUMAN papillomavirus, HUMAN DNA, LYMPHATIC metastasis, OROPHARYNGEAL cancer, SQUAMOUS cell carcinoma