The PNUTS phosphatase complex controls transcription pause release

Authors: Kelley, Jessica R. ^{1, 4}, Dimitrova, Emilia ^{1, 4, ∗}, Maciuszek, Maciej ¹, Nguyen, Hieu T. ², Szczurek, Aleksander T. ¹, Hughes, Amy L. ¹, Blackledge, Neil P. ¹, Kettenbach, Arminja N. ^{2, 3}, Klose, Robert J. ^{1, 5, ∗∗}

Source: In Molecular Cell 19 December 2024 84(24):4843-4861

BAP1 constrains pervasive H2AK119ubl to control the transcriptional potential of the genome

Authors: Fursova, Nadezda A., Turberfield, Anne H., Blackledge, Neil P., Findlater, Emma L., Lastuvkova, Anna, Huseyin, Miles K., Dobrinić, Paula, Klose, Robert J.

Source: Genes & development. 35(9/10):749-770

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626583427&indx=1&recIds=ETOCRN626583427

PRC1 Catalytic Activity Is Central to Polycomb System Function

Authors: Blackledge, Neil P., Fursova, Nadezda A., Kelley, Jessica R., Huseyin, Miles K., Feldmann, Angelika, Klose, Robert J.

Source: In Molecular Cell 20 February 2020 77(4):857-874

Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells

Authors: Rhodes, James D.P., Feldmann, Angelika, Hernández-Rodríguez, Benjamín, Díaz, Noelia, Brown, Jill M., Fursova, Nadezda A., Blackledge, Neil P., Prathapan, Praveen, Dobrinic, Paula, Huseyin, Miles K., Szczurek, Aleksander, Kruse, Kai, Nasmyth, Kim A., Buckle, Veronica J., Vaquerizas, Juan M., Klose, Robert J.

Source: In Cell Reports 21 January 2020 30(3):820-835

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

Authors: Fursova, Nadezda A., Blackledge, Neil P., Nakayama, Manabu, Ito, Shinsuke, Koseki, Yoko, Farcas, Anca M., King, Hamish W., Koseki, Haruhiko, Klose, Robert J.

Source: In Molecular Cell 6 June 2019 74(5):1020-1036

The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription

Authors: Szczurek, Aleksander T., Dimitrova, Emilia, Kelley, Jessica R., Blackledge, Neil P., Klose, Robert J.

Source: Nature Cell Biology; October 2024, Vol. 26 Issue: 10 p1700-1711, 12p

Getting under the skin of Polycomb-dependent gene regulation

Authors: Blackledge, Neil P., Klose, Robert J.

Source: Genes & development. 35(5/6):301-303

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN625744499&indx=1&recIds=ETOCRN625744499

The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin

Authors: Brown, David A., Di Cerbo, Vincenzo, Feldmann, Angelika, Ahn, Jaewoo, Ito, Shinsuke, Blackledge, Neil P., Nakayama, Manabu, McClellan, Michael, Dimitrova, Emilia, Turberfield, Anne H., Long, Hannah K., King, Hamish W., Kriaucionis, Skirmantas, Schermelleh, Lothar, Kutateladze, Tatiana G., Koseki, Haruhiko, Klose, Robert J.

Source: In Cell Reports 5 September 2017 20(10):2313-2327

Biochemical Identification of Nonmethylated DNA by BioCAP-Seq

Authors: Long, Hannah K., Rose, Nathan R., Blackledge, Neil P., Klose, Robert J.

Source: Methods in molecular biology. 1766:15-30

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN615568889&indx=1&recIds=ETOCRN615568889

Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes

Authors: King, Hamish W., Fursova, Nadezda A., Blackledge, Neil P., Klose, Robert J.

Source: Genome research. 28(10):1494-1507

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN617618033&indx=1&recIds=ETOCRN617618033

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Authors: Kerry, Jon, Godfrey, Laura, Repapi, Emmanouela, Tapia, Marta, Blackledge, Neil P., Ma, Helen, Ballabio, Erica, O'Byrne, Sorcha, Ponthan, Frida, Heidenreich, Olaf, Roy, Anindita, Roberts, Irene, Konopleva, Marina, Klose, Robert J., Geng, Huimin, Milne, Thomas A.

Source: Cell reports. 18(2):482-495

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100059137879.0x000001&indx=1&recIds=ETOCvdc_100059137879.0x000001

Targeting Polycomb to Pericentric Heterochromatin in Embryonic Stem Cells Reveals a Role for H2AK119u1 in PRC2 Recruitment

Authors: Cooper, Sarah, Dienstbier, Martin, Hassan, Raihann, Schermelleh, Lothar, Sharif, Jafar, Blackledge, Neil P., De Marco, Valeria, Elderkin, Sarah, Koseki, Haruhiko, Klose, Robert, Heger, Andreas, Brockdorff, Neil

Source: In Cell Reports 12 June 2014 7(5):1456-1470

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

Authors: Blackledge, Neil P., Farcas, Anca M., Kondo, Takashi, King, Hamish W., McGouran, Joanna F., Hanssen, Lars L.P., Ito, Shinsuke, Cooper, Sarah, Kondo, Kaori, Koseki, Yoko, Ishikura, Tomoyuki, Long, Hannah K., Sheahan, Thomas W., Brockdorff, Neil, Kessler, Benedikt M., Koseki, Haruhiko, Klose, Robert J.

Source: In Cell 5 June 2014 157(6):1445-1459

Intronic Enhancers Coordinate Epithelial-Specific Looping of the Active CFTR Locus

Authors: Ott, Christopher J., Blackledge, Neil P., Kerschner, Jenny L., Leir, Shih-Hsing, Crawford, Gregory E., Cotton, Calvin U., Harris, Ann

Source: Proceedings of the National Academy of Sciences of the United States of America, 2009 Nov . 106(47), 19934-19939.

Access URL: https://www.jstor.org/stable/25593302

CpG Islands Recruit a Histone H3 Lysine 36 Demethylase

Authors: Blackledge, Neil P., Zhou, Jin C., Tolstorukov, Michael Y., Farcas, Anca M., Park, Peter J., Klose, Robert J.

Source: In Molecular Cell 23 April 2010 38(2):179-190

CpG island chromatin

Authors: Blackledge, Neil P., Klose, Robert

Source: Epigenetics. 6(2):147-152

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100053904625.0x000001&indx=1&recIds=ETOCvdc_100053904625.0x000001

A CpG island-encoded mechanism protects genes from premature transcription termination.

Authors: Hughes, Amy L., Szczurek, Aleksander T., Kelley, Jessica R., Lastuvkova, Anna, Turberfield, Anne H., Dimitrova, Emilia, Blackledge, Neil P., Klose, Robert J.

Source: Nature Communications; 2/9/2023, Vol. 14 Issue 1, p1-19, 19p

Subject Terms: REGULATOR genes, GENE expression, GENES, RNA polymerases, TRANSGENIC organisms

Targeting Polycomb systems to regulate gene expression: modifications to a complex story.

Authors: Blackledge, Neil P.¹, Rose, Nathan R.¹, Klose, Robert J.¹

Source: Nature Reviews Molecular Cell Biology. Nov2015, Vol. 16 Issue 11, p643-649. 7p. 4 Diagrams.

Subject Terms: *POLYCOMB group proteins, *GENOMICS, *VERTEBRATES, *PROTEINS, *RNA

Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes.

Authors: Sugishita, Hiroki, Kondo, Takashi, Ito, Shinsuke, Nakayama, Manabu, Yakushiji-Kaminatsui, Nayuta, Kawakami, Eiryo, Koseki, Yoko, Ohinata, Yasuhide, Sharif, Jafar, Harachi, Mio, Blackledge, Neil P., Klose, Robert J., Koseki, Haruhiko

Source: Nature Communications; 9/9/2021, Vol. 12 Issue 1, p1-12, 12p

Subject Terms: GENE silencing, EMBRYONIC stem cells, EPIGENETICS

The molecular principles of gene regulation by Polycomb repressive complexes

Authors: Blackledge, Neil P., Klose, Robert J.

Source: Nature Reviews Molecular Cell Biology; December 2021, Vol. 22 Issue: 12 p815-833, 19p