The splicing regulators RBM5 and RBM10 are subunits of the U2 snRNP engaged with intron branch sites on chromatin

Authors: Damianov, Andrey, Lin, Chia-Ho, Huang, Jeffrey, Zhou, Lin, Jami-Alahmadi, Yasaman, Peyda, Parham, Wohlschlegel, James, Black, Douglas L.

Source: In Molecular Cell 18 April 2024 84(8):1496-1511

XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells

Authors: Dror, Iris, Chitiashvili, Tsotne, Tan, Shawn Y.X., Cano, Clara T., Sahakyan, Anna, Markaki, Yolanda, Chronis, Constantinos, Collier, Amanda J., Deng, Weixian, Liang, Guohao, Sun, Yu, Afasizheva, Anna, Miller, Jarrett, Xiao, Wen, Black, Douglas L., Ding, Fangyuan, Plath, Kathrin

Source: In Cell 4 January 2024 187(1):110-129

Cancer-associated SF3B1 mutation K700E causes widespread changes in U2/branchpoint recognition without altering splicing.

Authors: Damianov, Andrey, Chia-Ho Lin, Jian Zhang, Manley, James L., Black, Douglas L.

Source: Proceedings of the National Academy of Sciences of the United States of America; 4/1/2025, Vol. 122 Issue 13, p1-9, 37p

Tracking pre-mRNA maturation across subcellular compartments identifies developmental gene regulation through intron retention and nuclear anchoring

Authors: Yeom, Kyu-Hyeon, Pan, Zhicheng, Lin, Chia-Ho, Lim, Han Young, Xiao, Wen, Xing, Yi, Black, Douglas L.

Source: Genome research. 31(6):1106-1119

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626778833&indx=1&recIds=ETOCRN626778833

Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancers

Authors: Phillips, John W., Pan, Yang, Tsai, Brandon L., Xie, Zhijie, Demirdjian, Levon, Xiao, Wen, Yang, Harry T., Zhang, Yida, Lin, Chia Ho, Cheng, Donghui, Hu, Qiang, Liu, Song, Black, Douglas L., Witte, Owen N., Xing, Yi

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Mar 01. 117(10), 5269-5279.

Access URL: https://www.jstor.org/stable/26929239

The Rbfox1/LASR complex controls alternative pre-mRNA splicing by recognition of multipart RNA regulatory modules

Authors: Peyda, Parham, Lin, Chia-Ho, Onwuzurike, Kelechi, Black, Douglas L.

Source: Genes & Development; 2025, Vol. 39 Issue: 5-6 p364-383, 20p

African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1

Authors: Álvarez Jerez, Pilar, Wild Crea, Peter, Ramos, Daniel M., Gustavsson, Emil K., Radefeldt, Mandy, Damianov, Andrey, Makarious, Mary B., Ojo, Oluwadamilola O., Billingsley, Kimberley J., Malik, Laksh, Daida, Kensuke, Bromberek, Sarah, Hu, Fangle, Schneider, Zachary, Surapaneni, Aditya L., Stadler, Julia, Rizig, Mie, Morris, Huw R., Pantazis, Caroline B., Leonard, Hampton L., Screven, Laurel, Qi, Yue A., Nalls, Mike A., Bandres-Ciga, Sara, Hardy, John, Houlden, Henry, Eng, Celeste, Burchard, Esteban González, Kachuri, Linda, Lin, Chia-Ho, Black, Douglas L., Singleton, Andrew B., Fischer, Steffen, Bauer, Peter, Reed, Xylena, Ryten, Mina, Beetz, Christian, Ward, Michael, Okubadejo, Njideka U., Blauwendraat, Cornelis

Source: Nature Structural and Molecular Biology; December 2024, Vol. 31 Issue: 12 p1955-1963, 9p

Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse

Authors: Yeom, Kyu-Hyeon, Mitchell, Simon, Linares, Anthony J., Zheng, Sika, Lin, Chia-Ho, Wang, Xiao-Jun, Hoffmann, Alexander, Black, Douglas L.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Nov . 115(47), E11061-E11070.

Access URL: https://www.jstor.org/stable/26564516

Structure of PTB Bound to RNA: Specific Binding and Implications for Splicing Regulation

Authors: Oberstrass, Florian C., Auweter, Sigrid D., Erat, Michèle, Hargous, Yann, Henning, Anke, Wenter, Philipp, Reymond, Luc, Amir-Ahmady, Batoul, Pitsch, Stefan, Black, Douglas L.

Source: Science, 2005 Sep . 309(5743), 2054-2057.

Access URL: https://www.jstor.org/stable/3843667

Protein Kinase A Phosphorylation Modulates Transport of the Polypyrimidine Tract-Binding Protein

Authors: Xie, Jiuyong, Lee, Ji-Ann, Kress, Tracy L., Mowry, Kimberly L., Black, Douglas L.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2003 Jul . 100(15), 8776-8781.

Access URL: https://www.jstor.org/stable/3148298

Splicing Activation by Rbfox Requires Self-Aggregation through Its Tyrosine-Rich Domain

Authors: Ying, Yi, Wang, Xiao-Jun, Vuong, Celine K., Lin, Chia-Ho, Damianov, Andrey, Black, Douglas L.

Source: In Cell 13 July 2017 170(2):312-323

Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex

Authors: Zhang, Xiaochang, Chen, Ming Hui, Wu, Xuebing, Kodani, Andrew, Fan, Jean, Doan, Ryan, Ozawa, Manabu, Ma, Jacqueline, Yoshida, Nobuaki, Reiter, Jeremy F., Black, Douglas L., Kharchenko, Peter V., Sharp, Phillip A., Walsh, Christopher A.

Source: In Cell 25 August 2016 166(5):1147-1162

Rbfox Proteins Regulate Splicing as Part of a Large Multiprotein Complex LASR

Authors: Damianov, Andrey, Ying, Yi, Lin, Chia-Ho, Lee, Ji-Ann, Tran, Diana, Vashisht, Ajay A., Bahrami-Samani, Emad, Xing, Yi, Martin, Kelsey C., Wohlschlegel, James A., Black, Douglas L.

Source: In Cell 21 April 2016 165(3):606-619

Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes

Authors: Lee, Ji-Ann, Damianov, Andrey, Lin, Chia-Ho, Fontes, Mariana, Parikshak, Neelroop N., Anderson, Erik S., Geschwind, Daniel H., Black, Douglas L., Martin, Kelsey C.

Source: In Neuron 6 January 2016 89(1):113-128

Aging differentially alters the transcriptome and landscape of chromatin accessibility in the male and female mouse hippocampus.

Authors: Achiro, Jennifer M., Yang Tao, Fuying Gao, Chia-Ho Lin, Watanabe, Marika, Neumann, Sylvia, Coppola, Giovanni, Black, Douglas L., Martin, Kelsey C.

Source: Frontiers in Molecular Neuroscience; 2024, p1-27, 27p

Subject Terms: ALTERNATIVE RNA splicing, CHROMATIN, GENE expression, HIPPOCAMPUS (Brain), MYELIN sheath, X chromosome, RNA splicing, AGING

M^6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover

Authors: Ke, Shengdong, Pandya-Jones, Amy, Saito, Yuhki, Fak, John J., Vågbø, Cathrine Broberg, Geula, Shay, Hanna, Jacob H., Black, Douglas L., Darnell, James E., Darnell, Robert B.

Source: Genes & development. 31(10):990-1006

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN612177439&indx=1&recIds=ETOCRN612177439

Building a quantitative and predictive model of 5'SS selection by human U1 snRNP using RNA-map

Authors: White, David S., Carrocci, Tucker J., Shin, John, Lin, Chia-Ho, Black, Douglas L., Greenleaf, William, Herschlag, Daniel, Hoskins, Aaron A.

Source: Biophysical journal. 122(S1):219a-219a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185970863.0x000001&indx=1&recIds=ETOCvdc_100185970863.0x000001

PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing

Authors: Vuong, John K., Lin, Chia-Ho, Zhang, Min, Chen, Liang, Black, Douglas L., Zheng, Sika

Source: Cell reports. 17(10):2766-2775

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100061159855.0x000001&indx=1&recIds=ETOCvdc_100061159855.0x000001

Multiple determinants of splicing repression activity in the polypyrimidine tract binding proteins, PTBP1 and PTBP2

Authors: Keppetipola, Niroshika M., Yeom, Kyu-Hyeon, Hernandez, Adrian L., Bui, Tessa, Sharma, Shalini, Black, Douglas L.

Source: RNA. 22(8):1172-1180

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN607274861&indx=1&recIds=ETOCRN607274861

Alternative pre-mRNA splicing in neurons: growing up and extending its reach

Authors: Zheng, Sika, Black, Douglas L.

Source: In Trends in Genetics August 2013 29(8):442-448