X-linked deletion of Crossfirre, Firre, and Dxz4 in vivo uncovers diverse phenotypes and combinatorial effects on autosomes

Authors: Tim P. Hasenbein, Sarah Hoelzl, Zachary D. Smith, Chiara Gerhardinger, Marion O. C. Gonner, Antonio Aguilar-Pimentel, Oana V. Amarie, Lore Becker, Julia Calzada-Wack, Nathalia R. V. Dragano, Patricia da Silva-Buttkus, Lillian Garrett, Sabine M. Hölter, Markus Kraiger, Manuela A. Östereicher, Birgit Rathkolb, Adrián Sanz-Moreno, Nadine Spielmann, Wolfgang Wurst, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Alexander Meissner, Stefan Engelhardt, John L. Rinn, Daniel Andergassen

Source: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/214c5c28a0aa4593b2cafb4d4a6ceea4

Protocol for in vivo assessment of glucose control and insulin secretion and sensitivity in the pig

Authors: Yasmin Eckstein, Barbara Kessler, Arne Hinrichs, Istvan Novak, Anne von Thaden, Timo Lorenzen, Birgit Rathkolb, Armin Scholz, Andreas Blutke, Sietse-Jan Koopmans, Martin Hrabĕ de Angelis, Berit Østergaard Christoffersen, Eckhard Wolf, Simone Renner

Source: STAR Protocols, Vol 6, Iss 2, Pp 103774- (2025)

Subject Terms: Metabolism, Model Organisms, Biotechnology and bioengineering, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166725001807; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/14b6b028bd94473f845cd24d44fbdc9e

The eATP/P2×7R Axis Drives Quantum Dot‐Nanoparticle Induced Neutrophil Recruitment in the Pulmonary Microcirculation

Authors: Chenxi Li, Qiongliang Liu, Lianyong Han, Haiyun Zhang, Roland Immler, Birgit Rathkolb, Judith Secklehner, Martin Hrabe deAngelis, Ali Önder Yildirim, Dagmar Zeuschner, Annette Nicke, Leo M. Carlin, Markus Sperandio, Tobias Stoeger, Markus Rehberg

Source: Advanced Science, Vol 11, Iss 45, Pp n/a-n/a (2024)

Subject Terms: eATP P2X7 axis, innate immune response, intravital microscopy, lung, nanoparticles, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/3af0cb7b6f5a495dae1a90d6f26d5502

LncRNA U90926 is dispensable for the development of obesity‐associated phenotypes in vivo

Authors: Bristy Sabikunnahar, Sydney Caldwell, Stella Varnum, Tyler Hogan, Karolyn G. Lahue, Birgit Rathkolb, Raffaele Gerlini, Nathalia R. V. Dragano, Antonio Aguilar‐Pimentel, Martin Irmler, Adrián Sanz‐Moreno, Patricia daSilva‐Buttkus, German Mouse Clinic Consortium, Johannes Beckers, Eckhard Wolf, Valerie Gailus‐Durner, Helmut Fuchs, Martin Hrabe de Angelis, Jennifer L. Ather, Matthew E. Poynter, Dimitry N. Krementsov

Source: Physiological Reports, Vol 12, Iss 1, Pp n/a-n/a (2024)

Subject Terms: adipogenesis, LncRNA, obesity, U90926, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2051-817X

Access URL: https://doaj.org/article/737caf1a9abf472aaf1a165f9f9cba24

Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model

Authors: Bachuki Shashikadze, Libera Valla, Salvo Danilo Lombardo, Cornelia Prehn, Mark Haid, Fabien Riols, Jan Bernd Stöckl, Radwa Elkhateib, Simone Renner, Birgit Rathkolb, Jörg Menche, Martin Hrabĕ de Angelis, Eckhard Wolf, Elisabeth Kemter, Thomas Fröhlich

Source: Molecular Metabolism, Vol 75, Iss , Pp 101768- (2023)

Subject Terms: Maternal diabetes, Neonates, Liver, Pig model, Proteomics, Metabolomics, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877823001023; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/1a3ade5bcba844d0a7579bde026e355d

Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice

Authors: Kan Xie, Helmut Fuchs, Enzo Scifo, Dan Liu, Ahmad Aziz, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Patricia da Silva-Buttkus, Julia Calzada-Wack, Yi-Li Cho, Yushuang Deng, A. Cole Edwards, Lillian Garrett, Christina Georgopoulou, Raffaele Gerlini, Sabine M. Hölter, Tanja Klein-Rodewald, Michael Kramer, Stefanie Leuchtenberger, Dimitra Lountzi, Phillip Mayer-Kuckuk, Lena L. Nover, Manuela A. Oestereicher, Clemens Overkott, Brandon L. Pearson, Birgit Rathkolb, Jan Rozman, Jenny Russ, Kristina Schaaf, Nadine Spielmann, Adrián Sanz-Moreno, Claudia Stoeger, Irina Treise, Daniele Bano, Dirk H. Busch, Jochen Graw, Martin Klingenspor, Thomas Klopstock, Beverly A. Mock, Paolo Salomoni, Carsten Schmidt-Weber, Marco Weiergräber, Eckhard Wolf, Wolfgang Wurst, Valérie Gailus-Durner, Monique M. B. Breteler, Martin Hrabě de Angelis, Dan Ehninger

Source: Nature Communications, Vol 13, Iss 1, Pp 1-29 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0113605e46d14b5694c7bb3ab07c1fa9

New C3H Kit N824K/WT cancer mouse model develops late-onset malignant mammary tumors with high penetrance

Authors: Tanja Klein-Rodewald, Kateryna Micklich, Adrián Sanz-Moreno, Monica Tost, Julia Calzada-Wack, Thure Adler, Matthias Klaften, Sibylle Sabrautzki, Bernhard Aigner, Markus Kraiger, Valerie Gailus-Durner, Helmut Fuchs, German Mouse Clinic Consortium, Albert Gründer, Heike Pahl, Eckhard Wolf, Martin Hrabe de Angelis, Birgit Rathkolb

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/14dce610731c4ac3b187cabc3137d082

Monitoring longitudinal disease progression in a novel murine Kit tumor model using high-field MRI

Authors: Markus Kraiger, Tanja Klein-Rodewald, Birgit Rathkolb, Julia Calzada-Wack, Adrián Sanz-Moreno, Helmut Fuchs, Eckhard Wolf, Valérie Gailus-Durner, Martin Hrabě de Angelis

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/8d58c3d8d20848e79a45563667501a08

Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse

Authors: Annika Müller-Eigner, Adrián Sanz-Moreno, Irene de-Diego, Anuroop Venkateswaran Venkatasubramani, Martina Langhammer, Raffaele Gerlini, Birgit Rathkolb, Antonio Aguilar-Pimentel, Tanja Klein-Rodewald, Julia Calzada-Wack, Lore Becker, Sergio Palma-Vera, Benedikt Gille, Ignasi Forne, Axel Imhof, Chen Meng, Christina Ludwig, Franziska Koch, John T. Heiker, Angela Kuhla, Vanessa Caton, Julia Brenmoehl, Henry Reyer, Jennifer Schoen, Helmut Fuchs, Valerie Gailus-Durner, Andreas Hoeflich, Martin Hrabe de Angelis, Shahaf Peleg

Source: Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/2312dbd92c5e4feba3bf2ae10fa71dba

Characterising a homozygous two‐exon deletion in UQCRH: comparing human and mouse phenotypes

Authors: Silvia Vidali, Raffaele Gerlini, Kyle Thompson, Jill E Urquhart, Jana Meisterknecht, Juan Antonio Aguilar‐Pimentel, Oana V Amarie, Lore Becker, Catherine Breen, Julia Calzada‐Wack, Nirav F Chhabra, Yi‐Li Cho, Patricia da Silva‐Buttkus, René G Feichtinger, Kristine Gampe, Lillian Garrett, Kai P Hoefig, Sabine M Hölter, Elisabeth Jameson, Tanja Klein‐Rodewald, Stefanie Leuchtenberger, Susan Marschall, Philipp Mayer‐Kuckuk, Gregor Miller, Manuela A Oestereicher, Kristina Pfannes, Birgit Rathkolb, Jan Rozman, Charlotte Sanders, Nadine Spielmann, Claudia Stoeger, Marten Szibor, Irina Treise, John H Walter, Wolfgang Wurst, Johannes A Mayr, Helmut Fuchs, Ulrich Gärtner, Ilka Wittig, Robert W Taylor, William G Newman, Holger Prokisch, Valerie Gailus‐Durner, Martin Hrabě de Angelis

Source: EMBO Molecular Medicine, Vol 13, Iss 12, Pp 1-19 (2021)

Subject Terms: complex III, mitochondrial disease, mouse model, OXPHOS, UQCRH, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/341f02162d414b2e9fd51d3fc242e6ba

Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction.

Authors: Dusanka Milenkovic, Adrián Sanz-Moreno, Julia Calzada-Wack, Birgit Rathkolb, Oana Veronica Amarie, Raffaele Gerlini, Antonio Aguilar-Pimentel, Jelena Misic, Marie-Lune Simard, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabě de Angelis, Nils-Göran Larsson

Source: PLoS Genetics, Vol 18, Iss 5, p e1010190 (2022)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/5717622e5f364704b033f7ed9effe976

Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk

Authors: Lillian Garrett, Patricia Da Silva-Buttkus, Birgit Rathkolb, Raffaele Gerlini, Lore Becker, Adrian Sanz-Moreno, Claudia Seisenberger, Annemarie Zimprich, Antonio Aguilar-Pimentel, Oana V. Amarie, Yi-Li Cho, Markus Kraiger, Nadine Spielmann, Julia Calzada-Wack, Susan Marschall, Dirk Busch, Carsten Schmitt-Weber, Eckhard Wolf, Wolfgang Wurst, Helmut Fuchs, Valerie Gailus-Durner, Sabine M. Hölter, Martin Hrabě de Angelis

Source: Disease Models & Mechanisms, Vol 15, Iss 3 (2022)

Subject Terms: tanc2, neurodevelopmental disorder, somatic comorbidity, mouse models, Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/15/3/dmm049205; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/e3a4ef8eee054b9aa51c928668a11de5

Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification

Authors: Maria C. Ferreira dos Santos, Cole P. Anderson, Susanne Neschen, Kimberly B. Zumbrennen-Bullough, Steven J. Romney, Melanie Kahle-Stephan, Birgit Rathkolb, Valerie Gailus-Durner, Helmut Fuchs, Eckhard Wolf, Jan Rozman, Martin Hrabe de Angelis, Weiling Maggie Cai, Malini Rajan, Jennifer Hu, Peter C. Dedon, Elizabeth A. Leibold

Source: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/53f26f3f35f1461a9fc51b7c51673141

Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus

Authors: Mattias Backman, Florian Flenkenthaler, Andreas Blutke, Maik Dahlhoff, Erik Ländström, Simone Renner, Julia Philippou-Massier, Stefan Krebs, Birgit Rathkolb, Cornelia Prehn, Michal Grzybek, Ünal Coskun, Michael Rothe, Jerzy Adamski, Martin Hrabĕ de Angelis, Rüdiger Wanke, Thomas Fröhlich, Georg J. Arnold, Helmut Blum, Eckhard Wolf

Source: Molecular Metabolism, Vol 26, Iss , Pp 30-44 (2019)

Subject Terms: Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877819301863; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/b091584035a8468ab6862d12debb2004

Functional changes of the liver in the absence of growth hormone (GH) action – Proteomic and metabolomic insights from a GH receptor deficient pig model

Authors: Evamaria O. Riedel, Arne Hinrichs, Elisabeth Kemter, Maik Dahlhoff, Mattias Backman, Birgit Rathkolb, Cornelia Prehn, Jerzy Adamski, Simone Renner, Andreas Blutke, Martin Hrabĕ de Angelis, Martin Bidlingmaier, Jochen Schopohl, Georg J. Arnold, Thomas Fröhlich, Eckhard Wolf

Source: Molecular Metabolism, Vol 36, Iss , Pp - (2020)

Subject Terms: Liver, Growth hormone, Laron syndrome, Pig model, Proteomics, Metabolomics, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877820300521; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/4c13755fb0f34d8a9cce6ab85f9e0061

Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs

Authors: Simone Renner, Andreas Blutke, Britta Dobenecker, Georg Dhom, Timo D. Müller, Brian Finan, Christoffer Clemmensen, Maren Bernau, Istvan Novak, Birgit Rathkolb, Steffanie Senf, Susanne Zöls, Mirjam Roth, Anna Götz, Susanna M. Hofmann, Martin Hrabĕ de Angelis, Rüdiger Wanke, Ellen Kienzle, Armin M. Scholz, Richard DiMarchi, Mathias Ritzmann, Matthias H. Tschöp, Eckhard Wolf

Source: Molecular Metabolism, Vol 16, Iss , Pp 180-190 (2018)

Subject Terms: Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877818303004; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/d4b307cf77fc4936afcd250c904470f7

Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver

Authors: Arne Hinrichs, Barbara Kessler, Mayuko Kurome, Andreas Blutke, Elisabeth Kemter, Maren Bernau, Armin M. Scholz, Birgit Rathkolb, Simone Renner, Sebastian Bultmann, Heinrich Leonhardt, Martin Hrabĕ de Angelis, Hiroshi Nagashima, Andreas Hoeflich, Werner F. Blum, Martin Bidlingmaier, Rüdiger Wanke, Maik Dahlhoff, Eckhard Wolf

Source: Molecular Metabolism, Vol 11, Iss , Pp 113-128 (2018)

Subject Terms: Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877818302114; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/7c74c35d25ac486abfdbf53fba4fa634

Identification of genetic elements in metabolism by high-throughput mouse phenotyping

Authors: Jan Rozman, Birgit Rathkolb, Manuela A. Oestereicher, Christine Schütt, Aakash Chavan Ravindranath, Stefanie Leuchtenberger, Sapna Sharma, Martin Kistler, Monja Willershäuser, Robert Brommage, Terrence F. Meehan, Jeremy Mason, Hamed Haselimashhadi, IMPC Consortium, Tertius Hough, Ann-Marie Mallon, Sara Wells, Luis Santos, Christopher J. Lelliott, Jacqueline K. White, Tania Sorg, Marie-France Champy, Lynette R. Bower, Corey L. Reynolds, Ann M. Flenniken, Stephen A. Murray, Lauryl M. J. Nutter, Karen L. Svenson, David West, Glauco P. Tocchini-Valentini, Arthur L. Beaudet, Fatima Bosch, Robert B. Braun, Michael S. Dobbie, Xiang Gao, Yann Herault, Ala Moshiri, Bret A. Moore, K. C. Kent Lloyd, Colin McKerlie, Hiroshi Masuya, Nobuhiko Tanaka, Paul Flicek, Helen E. Parkinson, Radislav Sedlacek, Je Kyung Seong, Chi-Kuang Leo Wang, Mark Moore, Steve D. Brown, Matthias H. Tschöp, Wolfgang Wurst, Martin Klingenspor, Eckhard Wolf, Johannes Beckers, Fausto Machicao, Andreas Peter, Harald Staiger, Hans-Ulrich Häring, Harald Grallert, Monica Campillos, Holger Maier, Helmut Fuchs, Valerie Gailus-Durner, Thomas Werner, Martin Hrabe de Angelis

Source: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7b0bd2741d2c4a34a03d78a177e5cce3

The Munich MIDY Pig Biobank – A unique resource for studying organ crosstalk in diabetes

Authors: Andreas Blutke, Simone Renner, Florian Flenkenthaler, Mattias Backman, Serena Haesner, Elisabeth Kemter, Erik Ländström, Christina Braun-Reichhart, Barbara Albl, Elisabeth Streckel, Birgit Rathkolb, Cornelia Prehn, Alessandra Palladini, Michal Grzybek, Stefan Krebs, Stefan Bauersachs, Andrea Bähr, Andreas Brühschwein, Cornelia A. Deeg, Erica De Monte, Michaela Dmochewitz, Caroline Eberle, Daniela Emrich, Robert Fux, Frauke Groth, Sophie Gumbert, Antonia Heitmann, Arne Hinrichs, Barbara Keßler, Mayuko Kurome, Miriam Leipig-Rudolph, Kaspar Matiasek, Hazal Öztürk, Christiane Otzdorff, Myriam Reichenbach, Horst Dieter Reichenbach, Alexandra Rieger, Birte Rieseberg, Marco Rosati, Manuel Nicolas Saucedo, Anna Schleicher, Marlon R. Schneider, Kilian Simmet, Judith Steinmetz, Nicole Übel, Patrizia Zehetmaier, Andreas Jung, Jerzy Adamski, Ünal Coskun, Martin Hrabě de Angelis, Christian Simmet, Mathias Ritzmann, Andrea Meyer-Lindenberg, Helmut Blum, Georg J. Arnold, Thomas Fröhlich, Rüdiger Wanke, Eckhard Wolf

Source: Molecular Metabolism, Vol 6, Iss 8, Pp 931-940 (2017)

Subject Terms: MIDY, Hyperglycemia, Insulin insufficiency, Pig model, Biobank, Random systematic sampling, Transcriptomics, Proteomics, Metabolomics, Stereology, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877817303150; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/6df6a6d42ef44752b7265a8b82fbcbb7

Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice

Authors: Sudhir Kumar, Birgit Rathkolb, Sibylle Sabrautzki, Stefan Krebs, Elisabeth Kemter, Lore Becker, Johannes Beckers, Raffi Bekeredjian, Robert Brommage, Julia Calzada-Wack, Lillian Garrett, Sabine M. Hölter, Marion Horsch, Martin Klingenspor, Thomas Klopstock, Kristin Moreth, Frauke Neff, Jan Rozman, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabe de Angelis, Eckhard Wolf, Bernhard Aigner

Source: Journal of Biomedical Science, Vol 24, Iss 1, Pp 1-12 (2017)

Subject Terms: Animal model, Kctd1, SEN syndrome, Systematic phenotype analysis, Medicine

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12929-017-0365-5; https://doaj.org/toc/1423-0127

Access URL: https://doaj.org/article/743f0c22d5854380b4885e06f531eb0e