Development of a high-throughput screening platform to identify new therapeutic agents for Medulloblastoma Group 3

Authors: Fallon, Inés, Hernando, Henar, Almacellas-Rabaiget, Olga, Marti-Fuster, Berta, Spadoni, Cesare, Bigner, Darell D, Méndez, Eva

Source: In SLAS Discovery March 2024 29(2)

Application of mutagen sensitivity assay in a glioma case-control study

Authors: Erdal, Serap, McCarthy, Bridget J., Gurule, Natalia, Berwick, Marianne, Gonzales, Emily, Byrd, Johanna, Flores, Kristina, Shimek, JoAnna, Il’yasova, Dora, Ali-Osman, Francis, Bigner, Darell D., Davis, Faith G., Leyba, Alexis N., White, Kirsten A.M.

Source: In Toxicology Reports 2018 5:183-188

MGMT: Immunohistochemical Detection in High-Grade Astrocytomas

Authors: Lipp, Eric S, Healy, Patrick, Austin, Alan, Clark, Alysha, Dalton, Tara, Perkinson, Kathryn, Herndon, James E, Friedman, Henry S, Friedman, Allan H, Bigner, Darell D, McLendon, Roger E

Source: Journal of neuropathology and experimental neurology. 78(1):57-64

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100078430991.0x000001&indx=1&recIds=ETOCvdc_100078430991.0x000001

Unarmed, Tumor-Specific Monoclonal Antibody Effectively Treats Brain Tumors

Authors: Sampson, John H., Crotty, Laura E., Lee, Samson, Archer, Gary E., Ashley, David M., Wikstrand, Carol J., Hale, Laura P., Small, Clayton, Dranoff, Glenn, Friedman, Allan H., Friedman, Henry S., Bigner, Darell D.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2000 Jun . 97(13), 7503-7508.

Access URL: https://www.jstor.org/stable/122843

Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models

Authors: Keir, Stephen T., Chandramohan, Vidyalakshmi, Hemphill, Carlee D., Grandal, Michael M., Melander, Maria Carlsen, Pedersen, Mikkel W., Horak, Ivan D., Kragh, Michael, Desjardins, Annick, Friedman, Henry S., Bigner, Darell D.

Source: Journal of neuro-oncology. 138(3):489-498

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100118723801.0x000001&indx=1&recIds=ETOCvdc_100118723801.0x000001

Recombinant Immunotoxins Specific for a Mutant Epidermal Growth Factor Receptor: Targeting with a Single Chain Antibody Variable Domain Isolated by Phage Display

Authors: Keppler-Hafkemeyer, Andrea, Beers, Richard A., Pegram, Charles N., Bigner, Darell D., Pastan, Ira

Source: Proceedings of the National Academy of Sciences of the United States of America, 1996 Dec 01. 93(25), 14815-14820.

Access URL: https://www.jstor.org/stable/41170

Subcutaneous Vaccination with Irradiated, Cytokine-Producing Tumor Cells Stimulates CD8$^{+}$ Cell-Mediated Immunity against Tumors Located in the ``Immunologically Privileged" Central Nervous System

Authors: Sampson, John H., Archer, Gerald E., Ashley, David M., Fuchs, Herbert E., Hale, Laura P., Dranoff, Glenn, Bigner, Darell D.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1996 Sep . 93(19), 10399-10404.

Access URL: https://www.jstor.org/stable/40397

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

Authors: Thompson, Eric M ^*, Hielscher, Thomas ^*, Bouffet, Eric, Remke, Marc, Luu, Betty, Gururangan, Sridharan, McLendon, Roger E, Bigner, Darell D, Lipp, Eric S, Perreault, Sebastien, Cho, Yoon-Jae, Grant, Gerald, Kim, Seung-Ki, Lee, Ji Yeoun, Rao, Amulya A Nageswara, Giannini, Caterina, Li, Kay Ka Wai, Ng, Ho-Keung, Yao, Yu, Kumabe, Toshihiro, Tominaga, Teiji, Grajkowska, Wieslawa A, Perek-Polnik, Marta, Low, David C Y, Seow, Wan Tew, Chang, Kenneth T E, Mora, Jaume, Pollack, Ian F, Hamilton, Ronald L, Leary, Sarah, Moore, Andrew S, Ingram, Wendy J, Hallahan, Andrew R, Jouvet, Anne, Fèvre-Montange, Michelle, Vasiljevic, Alexandre, Faure-Conter, Cecile, Shofuda, Tomoko, Kagawa, Naoki, Hashimoto, Naoya, Jabado, Nada, Weil, Alexander G, Gayden, Tenzin, Wataya, Takafumi, Shalaby, Tarek, Grotzer, Michael, Zitterbart, Karel, Sterba, Jaroslav, Kren, Leos, Hortobágyi, Tibor, Klekner, Almos, László, Bognár, Pócza, Tímea, Hauser, Peter, Schüller, Ulrich, Jung, Shin, Jang, Woo-Youl, French, Pim J, Kros, Johan M, van Veelen, Marie-Lise C, Massimi, Luca, Leonard, Jeffrey R, Rubin, Joshua B, Vibhakar, Rajeev, Chambless, Lola B, Cooper, Michael K, Thompson, Reid C, Faria, Claudia C, Carvalho, Alice, Nunes, Sofia, Pimentel, José, Fan, Xing, Muraszko, Karin M, López-Aguilar, Enrique, Lyden, David, Garzia, Livia, Shih, David J H, Kijima, Noriyuki, Schneider, Christian, Adamski, Jennifer, Northcott, Paul A, Kool, Marcel, Jones, David T W, Chan, Jennifer A, Nikolic, Ana, Garre, Maria Luisa, Van Meir, Erwin G, Osuka, Satoru, Olson, Jeffrey J, Jahangiri, Arman, Castro, Brandyn A, Gupta, Nalin, Weiss, William A, Moxon-Emre, Iska, Mabbott, Donald J, Lassaletta, Alvaro, Hawkins, Cynthia E, Tabori, Uri, Drake, James, Kulkarni, Abhaya, Dirks, Peter, Rutka, James T, Korshunov, Andrey, Pfister, Stefan M, Packer, Roger J, Ramaswamy, Vijay, Taylor, Michael D ^*

Source: In The Lancet Oncology April 2016 17(4):484-495

MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B

Authors: Hu, Jing, Sun, Tao, Wang, Hui, Chen, Zhengxin, Wang, Shuai, Yuan, Lifeng, Liu, Tingyu, Li, Hai-Ri, Wang, Pingping, Feng, Yukuan, Wang, Qinhong, McLendon, Roger E., Friedman, Allan H., Keir, Stephen T., Bigner, Darell D., Rathmell, Jeff, Fu, Xiang-dong, Li, Qi-Jing, Wang, Huibo, Wang, Xiao-Fan

Source: In Cancer Cell 11 January 2016 29(1):49-60

Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells

Alternate Title: Phosphotyrosine GSTP1 Suppresses JNK Signaling and Apoptosis (English)

Authors: Okamura, Tatsunori, Antoun, Gamil, Keir, Stephen T., Friedman, Henry, Bigner, Darell D., Ali-Osman, Francis

Source: In Journal of Biological Chemistry 25 December 2015 290(52):30866-30878

Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy

Authors: Gromeier, Matthias, Brown, Michael C., Zhang, Gao, Lin, Xiang, Chen, Yeqing, Wei, Zhi, Beaubier, Nike, Yan, Hai, He, Yiping, Desjardins, Annick, Herndon, James E., Varn, Frederick S., Verhaak, Roel G., Zhao, Junfei, Bolognesi, Dani P., Friedman, Allan H., Friedman, Henry S., McSherry, Frances, Muscat, Andrea M., Lipp, Eric S., Nair, Smita K., Khasraw, Mustafa, Peters, Katherine B., Randazzo, Dina, Sampson, John H., McLendon, Roger E., Bigner, Darell D., Ashley, David M.

Source: Nature communications. 12(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191429370.0x000001&indx=1&recIds=ETOCvdc_100191429370.0x000001

Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas

Authors: Chandramohan, Vidyalakshmi, Bryant, Jeffrey D., Piao, Hailan, Keir, Stephen T., Lipp, Eric S., Lefaivre, Michaela, Perkinson, Kathryn, Bigner, Darell D., Gromeier, Matthias, McLendon, Roger E.

Source: Archives of pathology & laboratory medicine. 141(12):1697-1704

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631237105&indx=1&recIds=ETOCRN631237105

Development and validation of a cell-based fluorescent method for measuring antibody affinity

Authors: Yu, Xin, Pegram, Charles N., Bigner, Darell D., Chandramohan, Vidyalakshmi

Source: Journal of immunological methods. 442:49-53

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100041879465.0x000001&indx=1&recIds=ETOCvdc_100041879465.0x000001

Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition

Authors: Low, Justin T., Chandramohan, Vidyalakshmi, Bowie, Michelle L., Brown, Michael C., Waitkus, Matthew S., Briley, Aaron, Stevenson, Kevin, Fuller, Rebecca, Reitman, Zachary J., Muscat, Andrea M., Hariharan, Seethalakshmi, Hostettler, Janell, Danehower, Sarah, Baker, Ali, Khasraw, Mustafa, Wong, Nicholas C., Gregory, Simon, Nair, Smita K., Heimberger, Amy, Gromeier, Matthias, Bigner, Darell D., Ashley, David M.

Source: Cancer cell. 40(5):439-440

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165296154.0x000001&indx=1&recIds=ETOCvdc_100165296154.0x000001

The Somatic Genomic Landscape of Glioblastoma

Authors: Benz, Christopher, Barnholtz-Sloan, Jill, Barrett, Wendi, Ostrom, Quinn, Wolinsky, Yingli, Black, Keith L., Bose, Bikash, Boulos, Paul T., Boulos, Madgy, Brown, Jenn, Czerinski, Christine, Eppley, Matthew, Iacocca, Mary, Kempista, Thelma, Kitko, Teresa, Koyfman, Yakov, Rabeno, Brenda, Rastogi, Pawan, Sugarman, Michael, Swanson, Patricia, Yalamanchii, Kennedy, Otey, Ilana P., Liu, Yingchun Spring, Xiao, Yonghong, Auman, J.Todd, Chen, Peng-Chieh, Hadjipanayis, Angela, Lee, Eunjung, Lee, Semin, Park, Peter J., Seidman, Jonathan, Yang, Lixing, Kucherlapati, Raju, Kalkanis, Steven, Mikkelsen, Tom, Poisson, Laila M., Raghunathan, Aditya, Scarpace, Lisa, Bernard, Brady, Bressler, Ryan, Eakin, Andrea, Iype, Lisa, Kreisberg, Richard B., Leinonen, Kalle, Reynolds, Sheila, Rovira, Hector, Thorsson, Vesteinn, Shmulevich, Ilya, Annala, Matti J., Penny, Robert, Paulauskis, Joseph, Curley, Erin, Hatfield, Martha, Mallery, David, Morris, Scott, Shelton, Troy, Shelton, Candace, Sherman, Mark, Yena, Peggy, Cuppini, Lucia, DiMeco, Francesco, Eoli, Marica, Finocchiaro, Gaetano, Maderna, Emanuela, Pollo, Bianca, Saini, Marco, Balu, Saianand, Hoadley, Katherine A., Li, Ling, Miller, C. Ryan, Shi, Yan, Topal, Michael D., Wu, Junyuan, Dunn, Gavin, Giannini, Caterina, O'Neill, Brian P., Aksoy, B. Arman, Antipin, Yevgeniy, Borsu, Laetitia, Berman, Samuel H., Brennan, Cameron W., Cerami, Ethan, Chakravarty, Debyani, Ciriello, Giovanni, Gao, Jianjiong, Gross, Benjamin, Jacobsen, Anders, Ladanyi, Marc, Lash, Alex, Liang, Yupu, Reva, Boris, Sander, Chris, Schultz, Nikolaus, Shen, Ronglai, Socci, Nicholas D., Viale, Agnes, Ferguson, Martin L., Chen, Qing-Rong, Demchok, John A., Dillon, Laura A.L., Shaw, Kenna R. Mills, Sheth, Margi, Tarnuzzer, Roy, Wang, Zhining, Yang, Liming, Davidsen, Tanja, Guyer, Mark S., Ozenberger, Bradley A., Sofia, Heidi J., Bergsten, Julie, Eckman, John, Harr, Jodi, Myers, Jerome, Smith, Christine, Tucker, Kelly, Winemiller, Cindy, Zach, Leigh Anne, Ljubimova, Julia Y., Eley, Greg, Ayala, Brenda, Jensen, Mark A., Kahn, Ari, Pihl, Todd D., Pot, David A., Wan, Yunhu, Eschbacher, Jennifer, Foltz, Greg, Hansen, Nathan, Hothi, Parvi, Lin, Biaoyang, Shah, Nameeta, Yoon, Jae-geun, Lau, Ching, Berens, Michael, Ardlie, Kristin, Beroukhim, Rameen, Carter, Scott L., Cherniack, Andrew D., Noble, Mike, Cho, Juok, Cibulskis, Kristian, DiCara, Daniel, Frazer, Scott, Gabriel, Stacey B., Gehlenborg, Nils, Gentry, Jeff, Heiman, David, Kim, Jaegil, Jing, Rui, Lander, Eric S., Lawrence, Michael, Lin, Pei, Mallard, Will, Meyerson, Matthew, Onofrio, Robert C., Saksena, Gordon, Schumacher, Steve, Sougnez, Carrie, Stojanov, Petar, Tabak, Barbara, Voet, Doug, Zhang, Hailei, Zou, Lihua, Getz, Gad, Dees, Nathan N., Ding, Li, Fulton, Lucinda L., Fulton, Robert S., Kanchi, Krishna-Latha, Mardis, Elaine R., Wilson, Richard K., Baylin, Stephen B., Andrews, David W., Harshyne, Larry, Cohen, Mark L., Devine, Karen, Sloan, Andrew E., VandenBerg, Scott R., Berger, Mitchel S., Prados, Michael, Carlin, Daniel, Craft, Brian, Ellrott, Kyle, Goldman, Mary, Goldstein, Theodore, Grifford, Mia, Haussler, David, Ma, Singer, Ng, Sam, Salama, Sofie R., Sanborn, J. Zachary, Stuart, Joshua, Swatloski, Teresa, Waltman, Peter, Zhu, Jing, Foss, Robin, Frentzen, Barbara, Friedman, William, McTiernan, Raquel, Yachnis, Anthony, Hayes, D. Neil, Perou, Charles M., Zheng, Siyuan, Vegesna, Rahulsimham, Mao, Yong, Akbani, Rehan, Aldape, Kenneth, Bogler, Oliver, Fuller, Gregory N., Liu, Wenbin, Liu, Yuexin, Lu, Yiling, Mills, Gordon, Protopopov, Alexei, Ren, Xiaojia, Sun, Youting, Wu, Chang-Jiun, Yung, W.K. Alfred, Zhang, Wei, Zhang, Jianhua, Chen, Ken, Weinstein, John N., Chin, Lynda, Verhaak, Roel G.W., Noushmehr, Houtan, Weisenberger, Daniel J., Bootwalla, Moiz S., Lai, Phillip H., Triche, Timothy J., Jr., Van Den Berg, David J., Laird, Peter W., Gutmann, David H., Lehman, Norman L., VanMeir, Erwin G., Brat, Daniel, Olson, Jeffrey J., Mastrogianakis, Gena M., Devi, Narra S., Zhang, Zhaobin, Bigner, Darell, Lipp, Eric, McLendon, Roger, McKenna, Aaron, Campos, Benito, Genovese, Giannicola, Shukla, Sachet A., Yung, W.K., Bigner, Darell D., Van Meir, Erwin G., Sloan, Andrew, Guha, Abhijit, O’Neill, Brian P., Gibbs, Richard, Marra, Marco, Mills, Gordon B., Lander, Eric, Spellman, Paul, Wilson, Richard, Weinstein, John, Gabriel, Stacey

Source: In Cell 10 October 2013 155(2):462-477

Rational design and generation of recombinant control reagents for bispecific antibodies through CDR mutagenesis

Authors: Choi, Bryan D., Gedeon, Patrick C., Kuan, Chien-Tsun, Sanchez-Perez, Luis, Archer, Gary E., Bigner, Darell D., Sampson, John H.

Source: In Journal of Immunological Methods 30 September 2013 395(1-2):14-20

Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity

Authors: Mosaheb, Mubeen M., Dobrikova, Elena Y., Brown, Michael C., Yang, Yuanfan, Cable, Jana, Okada, Hideho, Nair, Smita K., Bigner, Darell D., Ashley, David M., Gromeier, Matthias

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131057129.0x000001&indx=1&recIds=ETOCvdc_100131057129.0x000001

Reversing the Warburg Effect as a Treatment for Glioblastoma

Authors: Poteet, Ethan, Choudhury, Gourav Roy, Winters, Ali, Li, Wenjun, Ryou, Myoung-Gwi, Liu, Ran, Tang, Lin, Ghorpade, Anuja, Wen, Yi, Yuan, Fang, Keir, Stephen T., Yan, Hai, Bigner, Darell D., Simpkins, James W., Yang, Shao-Hua

Source: In Journal of Biological Chemistry 29 March 2013 288(13):9153-9164

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

Authors: Killela, Patrick J., Reitman, Zachary J., Jiao, Yuchen, Bettegowda, Chetan, Agrawal, Nishant, Diaz,, Luis A., Friedman, Allan H., Friedman, Henry, Gallia, Gary L., Giovanella, Beppino C., Grollman, Arthur P., He, Tong-Chuan, He, Yiping, Hruban, Ralph H., Jallo, George I., Mandahl, Nils, Meeker, Alan K., Mertens, Fredrik, Netto, George J., Rasheed, B. Ahmed, Riggins, Gregory J., Rosenquist, Thomas A., Schiffman, Mark, Shih, Ie-Ming, Theodorescu, Dan, Torbenson, Michael S., Velculescu, Victor E., Wang, Tian-Li, Wentzensen, Nicolas, Wood, Laura D., Zhang, Ming, McLendon, Roger E., Bigner, Darell D., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas, Yan, Hai

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Apr 01. 110(15), 6021-6026.

Access URL: https://www.jstor.org/stable/42590347

Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma

Authors: Choi, Bryan D., Kuan, Chien-Tsun, Cai, Mingqing, Archer, Gary E., Mitchell, Duane A., Gedeon, Patrick C., Sanchez-Perez, Luis, Pastan, Ira, Bigner, Darell D., Sampson, John H.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Jan 01. 110(1), 270-275.

Access URL: https://www.jstor.org/stable/42553930